{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:01:37Z","timestamp":1789588897953,"version":"build-2803163510"},"reference-count":18,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We aimed to evaluate the clinical characteristics of male and female patients with sepsis and to investigate their potential sex-specific differences in the prognostic weight. Retrospective analysis, including all patients with sepsis admitted to the Emergency Department High-Dependency Unit, between June 2008 and October 2025. Clinical data were collected using a standardized template. The endpoints were day-7 and day-28 mortality rates. The study population included 1527 patients, with a mean age of 74 \u00b1 13 years, and female sex comprising 44%. Women were older (77 \u00b1 13 vs. 73 \u00b1 13 yrs, p \u2264 0.001), with a lower prevalence of cancer (19% vs. 27%, p = 0.009) than men. Conversely, a pulmonary (34% vs. 66%) or abdominal (40% vs. 60%) sepsis source was more frequent in men (both &lt;0.05). The SOFA score was significantly lower in women than in men (5 [3\u20136] vs. 5 [3\u20137], p &lt; 0.05), whereas day-7 and day-28 mortality rates were 11% and 22%, respectively, in both sexes. Multivariate analysis identified several independent predictors of 7-day mortality for both sexes. Women and men showed similar clinical characteristics and short- and medium-term mortality, despite a lower grade of organ dysfunction among women.<\/jats:p>","DOI":"10.3390\/ijms27093753","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:04:42Z","timestamp":1776945882000},"page":"3753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sepsis in the Emergency Department: Different Faces, Same Fate? A Sex-Based Prognostic Analysis"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0562-3019","authenticated-orcid":false,"given":"Francesco","family":"Pepe","sequence":"first","affiliation":[{"name":"High Dependency Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonella","family":"Pinelli","sequence":"additional","affiliation":[{"name":"High Dependency Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Giuliante","sequence":"additional","affiliation":[{"name":"High Dependency Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sabatino","sequence":"additional","affiliation":[{"name":"High Dependency Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Sari","sequence":"additional","affiliation":[{"name":"High Dependency Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Visintainer","sequence":"additional","affiliation":[{"name":"High Dependency Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Fuciarelli","sequence":"additional","affiliation":[{"name":"High Dependency Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-7619","authenticated-orcid":false,"given":"Francesca","family":"Innocenti","sequence":"additional","affiliation":[{"name":"High Dependency Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13054-020-02950-2","article-title":"Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019\u2014Results from a systematic review and meta-analysis","volume":"24","author":"Bauer","year":"2020","journal-title":"Crit. 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