{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:53:30Z","timestamp":1777046010158,"version":"3.51.4"},"reference-count":71,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Coronary artery disease (CAD), including acute coronary syndromes, frequently co-occurs with depression and is associated with adverse outcomes. Trace elements may influence shared biological pathways, including oxidative stress, inflammation, and neurovascular signaling. This study evaluated the association between trace element status and depressive symptoms in CAD. A systematic review was conducted in accordance with PRISMA 2020 guidelines and prospectively registered in PROSPERO (CRD420251231129). PubMed, Scopus, and the Cochrane Library were searched from inception to 2 December 2025. Studies assessing trace element concentrations in adults with CAD and depressive symptoms were eligible. Due to limited direct evidence, partially aligned and indirect studies were also included. Data were synthesized narratively. Of 699 records, four studies were included. No studies fulfilled Tier 1 criteria. The available evidence consisted of partially aligned (Tier 2) and indirect (Tier 3) studies. Lower zinc and magnesium levels and higher copper concentrations were suggested to be associated, based exclusively on Tier 2\u20133, low-certainty, predominantly indirect evidence. Interventional studies reported modest improvements following zinc or combined magnesium and zinc supplementation, although not in CAD-specific populations. Evidence directly addressing trace elements and depression in CAD is extremely limited and largely indirect. Current data do not support causal inference or clinical recommendations. Findings should be considered exploratory and hypothesis-generating.<\/jats:p>","DOI":"10.3390\/ijms27093805","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:28:23Z","timestamp":1777040903000},"page":"3805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trace Elements and Depressive Symptoms in Coronary Artery Disease: A Systematic Review of Sparse and Predominantly Indirect Evidence"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1682-5867","authenticated-orcid":false,"given":"Jakub Marek","family":"Baran","sequence":"first","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3745-6933","authenticated-orcid":false,"given":"Zuzanna","family":"Waszak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7085-0066","authenticated-orcid":false,"given":"Joanna","family":"Jarz\u0119bska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4882-4733","authenticated-orcid":false,"given":"Damian","family":"Grusiecki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4771-8508","authenticated-orcid":false,"given":"Maja","family":"\u015amigielska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7706-0648","authenticated-orcid":false,"given":"Wac\u0142aw","family":"Kochman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"},{"name":"Centre of Postgraduate Medical Education (CMKP), 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9912-3240","authenticated-orcid":false,"given":"Ewelina A.","family":"Dziedzic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"},{"name":"Centre of Postgraduate Medical Education (CMKP), 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bottardi, A., Prado, G.F.A., Lunardi, M., Fezzi, S., Pesarini, G., Tavella, D., Scarsini, R., and Ribichini, F. (2024). Clinical updates in coronary artery disease: A comprehensive review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13164600"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the Management of Chronic Coronary Syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Apostolos, A., Konstantinou, K., Ktenopoulos, N., Vlachakis, P.K., Skalidis, I., Chrysostomidis, G., Panoulas, V., and Tsioufis, K. (2025). Depression and coronary artery disease\u2014Where we stand?. J. Clin. Med., 14.","DOI":"10.3390\/jcm14124281"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhu, B. (2026). Molecular Mechanisms Underlying Atherosclerosis and Current Advances in Targeted Therapeutics. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27020634"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s44200-024-00062-8","article-title":"Oxidative Stress and Its Biomarkers in Cardiovascular Diseases","volume":"30","year":"2024","journal-title":"Artery Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Han, Y., Xu, H., Yao, X., Li, Z., Zhu, C., Li, X., Chen, B., and Sun, H. (2026). Molecular mechanisms and therapeutic progress in atherosclerosis: Bridging immune inflammation and precision medicine. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1737662"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Gan, Y., Gong, Y., Tong, X., Sun, H., Cong, Y., Dong, X., Yin, X., Deng, J., Li, L., and Cao, S. (2014). Depression and the risk of coronary heart disease: A meta-analysis of prospective cohort studies. BMC Psychiatry, 14.","DOI":"10.1186\/s12888-014-0371-z"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.genhosppsych.2011.02.007","article-title":"Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: A meta-analysis of 25 years of research","volume":"33","author":"Meijer","year":"2011","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_9","first-page":"38","article-title":"Depression and coronary artery disease: The association, mechanisms, and therapeutic implications","volume":"6","author":"Khawaja","year":"2009","journal-title":"Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s11920-013-0400-5","article-title":"Inflammation, heart disease, and depression","volume":"15","author":"Halaris","year":"2013","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fioranelli, M., Bottaccioli, A.G., Bottaccioli, F., Bianchi, M., Rovesti, M., and Roccia, M.G. (2018). Stress and inflammation in coronary artery disease: A review psychoneuroendocrineimmunology-based. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02031"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"42822","DOI":"10.31083\/RCM42822","article-title":"Three-Dimensional Perspectives on Inflammatory Regulation in Coronary Atherosclerosis: Integrated Mechanisms of Endothelial Priming, Lipid Metabolism, and Cytokine Synergy","volume":"27","author":"Liu","year":"2026","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mushenkova, N.V., Bezsonov, E.E., Orekhova, V.A., Popkova, T.V., Starodubova, A.V., and Orekhov, A.N. (2021). Recognition of Oxidized Lipids by Macrophages and Its Role in Atherosclerosis Development. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080915"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Tsioufis, P., Theofilis, P., Tsioufis, K., and Tousoulis, D. (2022). The Impact of Cytokines in Coronary Atherosclerotic Plaque: Current Therapeutic Approaches. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415937"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41380-022-01806-1","article-title":"Molecular pathways of major depressive disorder converge on the synapse","volume":"28","author":"Fries","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kowalczyk, M., Aebisher, D., Szpara, J., Czech, S., Bartusik-Aebisher, D., and Henrykowska, G. (2025). Molecular Mechanisms of Emerging Antidepressant Strategies: From Ketamine to Neuromodulation. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27010344"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/physiolgenomics.00041.2017","article-title":"Nrf2 at the heart of oxidative stress and cardiac protection","volume":"50","author":"Chen","year":"2018","journal-title":"Physiol. Genomics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4287711","DOI":"10.1155\/2022\/4287711","article-title":"The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis","volume":"2022","author":"Huang","year":"2022","journal-title":"Cardiol. Res. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sani, G., Margoni, S., Brugnami, A., Ferrara, O.M., Bernardi, E., Simonetti, A., Monti, L., Mazza, M., Janiri, D., and Moccia, L. (2023). The Nrf2 Pathway in Depressive Disorders: A Systematic Review of Animal and Human Studies. Antioxidants, 12.","DOI":"10.3390\/antiox12040817"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102522","DOI":"10.1016\/j.redox.2022.102522","article-title":"Nrf2: An All-Rounder in Depression","volume":"58","author":"Zuo","year":"2022","journal-title":"Redox Biol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sadaf, S., Zhang, X., Lei, L., Shen, J., Jamal, I., Modugu, G., and Dutta, P. (2025). Macrophage efferocytosis is controlled by epigenetic modifications mediated by RBPJ. bioRxiv.","DOI":"10.1101\/2025.10.10.681723"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Yurdagul, A., Doran, A.C., Cai, B., Fredman, G., and Tabas, I. (2018). Mechanisms and consequences of defective efferocytosis in atherosclerosis. Front. Cardiovasc. Med., 5.","DOI":"10.3389\/fcvm.2017.00086"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"O\u2019Rourke, S.A., Dunne, A., and Monaghan, M.G. (2019). The role of macrophages in the infarcted myocardium: Orchestrators of ECM remodeling. Front. Cardiovasc. Med., 6.","DOI":"10.3389\/fcvm.2019.00101"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"Pearce","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.5604\/17322693.1229074","article-title":"Trace elements as an activator of antioxidant enzymes","volume":"70","author":"Milewska","year":"2016","journal-title":"Postepy Hig. Med. Dosw."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1042\/BST20230490","article-title":"Interactions between Zinc and NRF2 in Vascular Redox Signalling","volume":"52","author":"Yang","year":"2024","journal-title":"Biochem. Soc. Trans."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"102777","DOI":"10.1016\/j.redox.2023.102777","article-title":"Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by Nrf2 signaling under hypoxia\/reoxygenation","volume":"64","author":"Yang","year":"2023","journal-title":"Redox Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hara, T., Yoshigai, E., Ohashi, T., and Fukada, T. (2023). Zinc in Cardiovascular Functions and Diseases: Epidemiology and Molecular Mechanisms for Therapeutic Development. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087152"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Maier, J.A.M., Locatelli, L., Fedele, G., Cazzaniga, A., and Mazur, A. (2023). Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010223"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: New insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e1230","DOI":"10.1002\/cl2.1230","article-title":"PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis","volume":"18","author":"Haddaway","year":"2022","journal-title":"Campbell Syst. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/JYWP4049","article-title":"The effectiveness, cost-effectiveness and policy processes of regulatory, voluntary and partnership policies to improve food environments: An evidence synthesis","volume":"12","author":"Blanchard","year":"2024","journal-title":"Public Health Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Carra, M.C., Romandini, P., and Romandini, M. (2025). Risk of bias evaluation of cross-sectional studies: Adaptation of the Newcastle\u2013Ottawa Scale. J. Periodontal Res., early view.","DOI":"10.1111\/jre.13405"},{"key":"ref_36","first-page":"14898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e2165","DOI":"10.1002\/hsr2.2165","article-title":"The Cochrane risk of bias assessment tool 2 (RoB 2) versus the original RoB: A perspective on the pros and cons","volume":"7","author":"Nejadghaderi","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"200254","DOI":"10.1016\/j.hnm.2024.200254","article-title":"The higher dietary inflammation is associated with a higher burden of multimorbidity of cardio-metabolic and mental health disorders in an urbanizing community of southern India: A cross-sectional analysis for the APCAPS cohort","volume":"36","author":"Mahajan","year":"2024","journal-title":"Hum. Nutr. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1017\/S1092852921000432","article-title":"A pathway phenotype linking metabolic, immune, oxidative, and opioid pathways with comorbid depression, atherosclerosis, and unstable angina","volume":"27","author":"Mousa","year":"2022","journal-title":"CNS Spectr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12944-020-01298-4","article-title":"The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease","volume":"19","author":"Hamedifard","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110601","DOI":"10.1016\/j.nut.2019.110601","article-title":"Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 \u00d7 2 factorial design, double-blind, randomized, placebo-controlled trial","volume":"71","author":"Yosaee","year":"2020","journal-title":"Nutrition"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/ije\/dyt128","article-title":"Cohort profile: Andhra Pradesh children and parents study (APCAPS)","volume":"43","author":"Kinra","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness","year":"2020","journal-title":"Res. Synth. Methods"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/156482651303400210","article-title":"Zinc as a potential coadjuvant in therapy for type 2 diabetes","volume":"34","author":"Ruz","year":"2013","journal-title":"Food Nutr. Bull."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ebiom.2019.08.014","article-title":"New insights into the role of iron in inflammation and atherosclerosis","volume":"47","author":"Cornelissen","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13578-020-00500-5","article-title":"Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis","volume":"10","author":"Cai","year":"2020","journal-title":"Cell Biosci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Wang, Z., Dang, Y., Li, Y., Zhang, Y., Zhou, S., Zhang, Z., and Wang, Y. (2025). Recent advances in the interaction of ferroptosis and immune-mediated inflammation in cardiovascular disease: Mechanisms and therapeutic potential. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1691705"},{"key":"ref_48","first-page":"31","article-title":"Study of trace elements (serum copper and zinc) in patients of coronary artery diseases","volume":"5","author":"Sanghani","year":"2018","journal-title":"Int. J. Clin. Biochem. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.psychres.2018.05.049","article-title":"Copper in depressive disorder: A systematic review and meta-analysis of observational studies","volume":"267","author":"Ni","year":"2018","journal-title":"Psychiatry Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s10534-025-00723-4","article-title":"The serum trace metal signature distinguishes patients with psychiatric disorders from healthy controls","volume":"38","author":"Squitti","year":"2025","journal-title":"Biometals"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Doligalska-Dolina, A., Dolina, M., Zo\u0144, A., G\u0142\u00f3wczewska-Siedlecka, E., Osi\u0144ska, K., Margossian, G.A., Margossian, C.L., and Napi\u00f3rkowska-Baran, K. (2025). Effects of micronutrients and heavy metals on endothelial function and cardiovascular risk in the face of environmental changes. Curr. Issues Mol. Biol., 48.","DOI":"10.3390\/cimb48010041"},{"key":"ref_52","first-page":"199","article-title":"The Role of Magnesium Deficiency in Cardiovascular and Intestinal Inflammation","volume":"23","author":"Weglicki","year":"2010","journal-title":"Magnes. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbadis.2004.01.002","article-title":"Low Magnesium Promotes Endothelial Cell Dysfunction: Implications for Atherosclerosis, Inflammation and Thrombosis","volume":"1689","author":"Maier","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Pickering, G., Mazur, A., Trousselard, M., Bienkowski, P., Yaltsewa, N., Amessou, M., Noah, L., and Pouteau, E. (2020). Magnesium status and stress: The vicious circle concept revisited. Nutrients, 12.","DOI":"10.3390\/nu12123672"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/ajcn\/nqz256","article-title":"Serum magnesium and the incidence of coronary artery disease over a median 27 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) Study and a meta-analysis","volume":"111","author":"Rooney","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4330574","DOI":"10.1155\/mi\/4330574","article-title":"NLRP3 Inflammasome: A New Target for the Treatment of CVD and Depression Comorbidity","volume":"2025","author":"Chen","year":"2025","journal-title":"Mediators Inflamm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.3892\/mmr.2017.7236","article-title":"Zinc Inhibits High Glucose-Induced NLRP3 Inflammasome Activation in Human Peritoneal Mesothelial Cells","volume":"16","author":"Fan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/cns.13460","article-title":"Zinc Provides Neuroprotection by Regulating NLRP3 Inflammasome through Autophagy and Ubiquitination in a Spinal Contusion Injury Model","volume":"27","author":"Lin","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e13798","DOI":"10.1002\/advs.202513798","article-title":"Macrophage-Targeted Magnesium Ion-Nourisher for NLRP3 Inflammasome Inhibition to Enhance Liver Inflammatory Disease Treatment","volume":"13","author":"Wang","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Baj, J., Bargie\u0142, J., Cabaj, J., Skierkowski, B., Hunek, G., Portincasa, P., Flieger, J., and Smole\u0144, A. (2023). Trace elements levels in major depressive disorder\u2014Evaluation of potential threats and possible therapeutic approaches. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015071"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1177271918812467","DOI":"10.1177\/1177271918812467","article-title":"Peripheral biomarker for vascular disorders","volume":"13","author":"Shad","year":"2018","journal-title":"Biomark. Insights"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jad.2022.01.008","article-title":"Dietary inflammatory index and depression risk in patients with chronic diseases and comorbidity","volume":"301","author":"Jiang","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Shivappa, N., Godos, J., H\u00e9bert, J.R., Wirth, M.D., Piuri, G., Speciani, A.F., and Grosso, G. (2018). Dietary inflammatory index and cardiovascular risk and mortality\u2014A meta-analysis. Nutrients, 10.","DOI":"10.3390\/nu10020200"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1017\/S0007114510003004","article-title":"The Capacity of Foodstuffs to Induce Innate Immune Activation of Human Monocytes In Vitro Is Dependent on Food Content of Stimulants of Toll-like Receptors 2 and 4","volume":"105","author":"Erridge","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 Signal Transduction Pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.1073\/pnas.0502257102","article-title":"Interleukin-6 Regulates the Zinc Transporter ZIP14 in Liver and Pancreas","volume":"102","author":"Liuzzi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","first-page":"685","article-title":"Role of zinc in the development and treatment of mood disorders","volume":"13","author":"Cope","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_68","first-page":"1","article-title":"Magnesium in man: Implications for health and disease","volume":"95","author":"Hoenderop","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"i25","DOI":"10.1093\/ndtplus\/sfr165","article-title":"Magnesium in disease","volume":"5","author":"Geiger","year":"2012","journal-title":"Clin. Kidney J."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Bravo, C., Soler-Iborte, E., Lozano-Lorca, M., Kouiti, M., Gonz\u00e1lez-Palacios Torres, C., Barrios-Rodriguez, R., and Jimenez-Moleon, J.J. (2023). Serum copper levels and risk of major adverse cardiovascular events: A systematic review and meta-analysis. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1217748"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1093\/eurheartj\/ehaf191","article-title":"2025 ESC Clinical Consensus Statement on Mental Health and Cardiovascular Disease: Developed under the Auspices of the ESC Clinical Practice Guidelines Committee","volume":"46","author":"Bueno","year":"2025","journal-title":"Eur. Heart J."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/9\/3805\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:29:37Z","timestamp":1777040977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/9\/3805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":71,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ijms27093805"],"URL":"https:\/\/doi.org\/10.3390\/ijms27093805","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]}}}