{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:51:44Z","timestamp":1777431104071,"version":"3.51.4"},"reference-count":59,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado (SIP) of Instituto Polit\u00e9cnico Nacional","award":["20260152"],"award-info":[{"award-number":["20260152"]}]},{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado (SIP) of Instituto Polit\u00e9cnico Nacional","award":["20260155"],"award-info":[{"award-number":["20260155"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this study was to assess the effect of sertraline on the gene expression of placental transporters for hormones, folates, nutrients and drugs over the course of pregnancy in rats. The studies were conducted on gestational days (GDs) 16 and 20 following oral treatment with 10 mg\/kg\/day sertraline or the vehicle, administered from weaning onward. The weight and area of the fetuses and placentas were analyzed, and maternal plasma sertraline concentrations were measured. Gene expression of ATP-binding cassette transporter b1a and b1b (Abcb1a and Abcb1b), organic anion-transporting polypeptide 4a1(Slco4A1\/Oatp4a1), folate receptor-\u03b1 (Folr1), reduced folate carrier (Slc19A1\/Rfc), and L-type amino acid transporter (Slc7A5\/Lat1) was evaluated in the placenta. Sertraline reduced fetal weight (p &lt; 0.001) and fetal area (p &lt; 0.01) at GD 16, while no significant differences were observed in placental weight or area between exposed and unexposed groups. Sertraline concentration was significantly lower at GD20 than at GD16 (p &lt; 0.001). At GD 16, sertraline reduced the expression of Abcb1a (p = 0.027), Abcb1b (p &lt; 0.01), and Oatp4a1 (p = 0.037) compared with controls. Conversely, sertraline induced Folr1 expression in both GDs and increased Rfc expression at GD 20, while Lat1 was not affected. These findings indicate that sertraline alters placental drug transporter gene expression and may impair nutrient transfer to the fetus.<\/jats:p>","DOI":"10.3390\/ijms27093858","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:33:37Z","timestamp":1777376017000},"page":"3858","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Sertraline on Fetoplacental Growth Parameters and Placental Transporter Gene Expression in Rats"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-8871","authenticated-orcid":false,"given":"Daniel","family":"Enriquez-Mendiola","sequence":"first","affiliation":[{"name":"Genomics Academy, CIIDIR-Durango, Instituto Polit\u00e9cnico Nacional, Durango 34220, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge E.","family":"Sifuentes-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Genomics Academy, CIIDIR-Durango, Instituto Polit\u00e9cnico Nacional, Durango 34220, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-6668","authenticated-orcid":false,"given":"Laura J.","family":"Barrag\u00e1n-Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Centro Estatal de Cancerolog\u00eda, Secretaria de Salud de Durango, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-8303","authenticated-orcid":false,"given":"Angel A.","family":"V\u00e9rtiz-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica Regional Altiplano, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed 78600, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca P.","family":"Lazalde-Ramos","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Ciencia y Tecnolog\u00eda Qu\u00edmica, Unidad Acad\u00e9mica de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia E.","family":"Damiano","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biol\u00f3gicas, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina"},{"name":"Instituto de Fisiolog\u00eda y Biof\u00edsica Bernardo Houssay, Universidad de Buenos Aires-CONICET, Buenos Aires C1121ABG, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Galaviz-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Genomics Academy, CIIDIR-Durango, Instituto Polit\u00e9cnico Nacional, Durango 34220, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Sosa-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Genomics Academy, CIIDIR-Durango, Instituto Polit\u00e9cnico Nacional, Durango 34220, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00228-021-03122-z","article-title":"Sertraline concentrations in pregnant women are steady and the drug transfer to their infants is low","volume":"77","author":"Heinonen","year":"2021","journal-title":"Eur. 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