{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:08:53Z","timestamp":1777867733350,"version":"3.51.4"},"reference-count":68,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is the second most prevalent neurodegenerative disorder. It is characterized by the accumulation of misfolded \u03b1-synuclein (\u03b1-syn) and progressive loss of dopaminergic neurons in the substantia nigra. Due to the limitations of current therapies, mesenchymal stromal cell (MSC) transplantation has emerged as a promising neuroprotective strategy. This study evaluated the neuroprotective potential of decidua-derived mesenchymal stromal cells (DMSCs) in vitro using a human neuroblastoma cell line (NB69) exposed to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) as a PD model. The NB69 cells were differentiated into a mature dopaminergic phenotype using dibutyryl cyclic adenosine monophosphate (dbcAMP) and then exposed to MPP+. In proliferative NB69 cells, the effect of DMSCs was masked by their inherent antitumor activity against the neuroblastoma phenotype. Conversely, in the differentiated NB69 model, DMSCs demonstrated a significant protective role against MPP+-induced cytotoxicity. Interestingly, the mechanism by which DMSCs might exert a neuroprotective effect against MPP+ damage in differentiated NB69 cells appears to involve improving mitochondrial function by reducing free radicals. In summary, these findings suggest that DMSCs exert a neuroprotective effect in a dopaminergic-like context and highlight the importance of using differentiated cell models to accurately evaluate cell-based therapies for PD in the striatum.<\/jats:p>","DOI":"10.3390\/ijms27093925","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:26:41Z","timestamp":1777382801000},"page":"3925","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effect of Placental Mesenchymal Stromal Cells in an In Vitro Model of Parkinson\u2019s Disease Using Differentiated Neuroblastoma Cells"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9856-6939","authenticated-orcid":false,"given":"Almudena","family":"Coto-Vilcapoma","sequence":"first","affiliation":[{"name":"Grupo de Medicina Regenerativa, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6233-8524","authenticated-orcid":false,"given":"Laura","family":"S\u00e1nchez-Carretero","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Regenerativa, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2663-7416","authenticated-orcid":false,"given":"Daniel","family":"Arenas-Gonzalez","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Regenerativa, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Molina","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda e Instituto de Investigaci\u00f3n Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-5934","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Mor\u00e1n-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Regenerativa, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Joaqu\u00edn","family":"Merino","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Regenerativa, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"},{"name":"Departamento de Farmacolog\u00eda, Farmacognosia y Bot\u00e1nica, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-4396","authenticated-orcid":false,"given":"Paz de la","family":"Torre","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Regenerativa, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-0434","authenticated-orcid":false,"given":"Ana I.","family":"Flores","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Regenerativa, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1001\/jama.2014.3654","article-title":"Pharmacological treatment of Parkinson disease: A review","volume":"311","author":"Connolly","year":"2014","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10654-011-9581-6","article-title":"Epidemiology and etiology of Parkinson\u2019s disease: A review of the evidence","volume":"26","author":"Wirdefeldt","year":"2011","journal-title":"Eur. 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