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Hyaluronan (HA), a naturally occurring polysaccharide proven to exhibit antioxidant and anti-inflammatory functions, has garnered growing research attention in the field of food in recent years. This study demonstrates that long-term oral administration of HA exerts a protective effect against acute alcohol-induced liver injury (AALI). The findings showed that oral administration of 30, 600, and 1250 kDa HA for 2 and 4 weeks all increased serum and liver HA levels in rats and regulated the composition and abundance of gut microbiota. Meanwhile, oral HA could alleviate the symptoms of liver injury caused by alcohol, including increasing glutathione (GSH) levels, reducing malondialdehyde (MDA) and triglyceride (TG) levels, and decreasing the content of inflammatory factors interleukin-1 beta (IL-1\u03b2) and tumor necrosis factor-alpha (TNF-\u03b1) compared with the AALI model mice. Furthermore, HA could inhibit the increase in reactive oxygen species (ROS) levels in AML12 cells induced by alcohol and improve the survival rate of alcohol-damaged AML12 cells. In conclusion, this study found that oral administration of HA could increase serum and liver HA levels and has a protective effect on AALI, suggesting the application of HA in health foods for hangover relief and liver protection.<\/jats:p>","DOI":"10.3390\/ijms27093941","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:09:33Z","timestamp":1777388973000},"page":"3941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Consumption of Hyaluronan Increases Its Endogenous Levels Correlating with Attenuated Acute Alcohol-Induced Liver Injury"],"prefix":"10.3390","volume":"27","author":[{"given":"Qingkai","family":"Zeng","sequence":"first","affiliation":[{"name":"National Glycoengineering Research Center, Shandong University, Qingdao 266237, China"},{"name":"Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Glycoengineering Research Center, Shandong University, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[{"name":"Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China"},{"name":"School of Pharmaceutical Science, Shandong University, Jinan 250012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China"},{"name":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqiang","family":"Fang","sequence":"additional","affiliation":[{"name":"National Glycoengineering Research Center, Shandong University, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huarong","family":"Shao","sequence":"additional","affiliation":[{"name":"Engineering Research Center for Sugar and Sugar Complex, National-Local Joint Engineering Laboratory of Polysaccharide Drugs, Key Laboratory of Carbohydrate and Glycoconjugate Drugs, Shandong Academy of Pharmaceutical Science, Jinan 250101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peixue","family":"Ling","sequence":"additional","affiliation":[{"name":"National Glycoengineering Research Center, Shandong University, Qingdao 266237, China"},{"name":"Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1038\/s41467-024-51314-9","article-title":"Diet Modifies the Association between Alcohol Consumption and Severe Alcohol-Related Liver Disease Incidence","volume":"15","author":"Zhou","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Qiao, J.-Y., Li, H.-W., Liu, F.-G., Li, Y.-C., Tian, S., Cao, L.-H., Hu, K., Wu, X.-X., and Miao, M.-S. (2019). Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats. Molecules, 24.","DOI":"10.3390\/molecules24162887"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9250418","DOI":"10.26599\/FSHW.2024.9250418","article-title":"Hepatoprotective Efficacy of Low Molecular Weight Chicken Intestine Peptide against Acute Alcohol-Induced Liver Injury","volume":"14","author":"Yan","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tadokoro, T., Morishita, A., Himoto, T., and Masaki, T. (2023). Nutritional Support for Alcoholic Liver Disease. Nutrients, 15.","DOI":"10.3390\/nu15061360"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s41590-025-02255-y","article-title":"Single-Cell Atlas of Human Liver and Blood Immune Cells across Fatty Liver Disease Stages Reveals Distinct Signatures Linked to Liver Dysfunction and Fibrogenesis","volume":"26","author":"Martin","year":"2025","journal-title":"Nat. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.35946\/arcr.v38.2.01","article-title":"Alcoholic Liver Disease: Pathogenesis and Current Management","volume":"38","author":"Osna","year":"2017","journal-title":"Alcohol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9250031","DOI":"10.26599\/FSHW.2024.9250031","article-title":"Identification of Phenolamine in Rape Bee Pollen and Its Protective Effect and Mechanism on Alcoholic Liver Injury","volume":"14","author":"Xu","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1142\/S0192415X15500160","article-title":"Hepatoprotective Effect of Kaempferol against Alcoholic Liver Injury in Mice","volume":"43","author":"Wang","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/13510002.2016.1239867","article-title":"Protective Effect of Wild Corni Fructus Methanolic Extract against Acute Alcoholic Liver Injury in Mice","volume":"22","author":"Jiang","year":"2017","journal-title":"Redox Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4291\/wjgp.v7.i1.17","article-title":"Adipose Tissue-Liver Axis in Alcoholic Liver Disease","volume":"7","author":"Wang","year":"2016","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wei, X., Shi, X., Zhong, W., Zhao, Y., Tang, Y., Sun, W., Yin, X., Bogdanov, B., Kim, S., and McClain, C. (2013). Chronic Alcohol Exposure Disturbs Lipid Homeostasis at the Adipose Tissue-Liver Axis in Mice: Analysis of Triacylglycerols Using High-Resolution Mass Spectrometry in Combination with in Vivo Metabolite Deuterium Labeling. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055382"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Zhang, T., Kusumanchi, P., Han, S., Yang, Z., and Liangpunsakul, S. (2020). Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines, 8.","DOI":"10.3390\/biomedicines8030050"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Duki\u0107, M., Radonji\u0107, T., Jovanovi\u0107, I., Zdravkovi\u0107, M., Todorovi\u0107, Z., Krai\u0161nik, N., Aran\u0111elovi\u0107, B., Mandi\u0107, O., Popadi\u0107, V., and Nikoli\u0107, N. (2023). Alcohol, Inflammation, and Microbiota in Alcoholic Liver Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043735"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-0039-1681032","article-title":"Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis","volume":"39","author":"Maiers","year":"2019","journal-title":"Semin. Liver Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1751-2980.2011.00569.x","article-title":"Oxidative Stress and Redox Signaling Mechanisms of Alcoholic Liver Disease: Updated Experimental and Clinical Evidence","volume":"13","author":"Zhu","year":"2012","journal-title":"J. Dig. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.lfs.2007.05.005","article-title":"Alcohol-Induced Oxidative Stress","volume":"81","author":"Das","year":"2007","journal-title":"Life Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"115596","DOI":"10.1016\/j.bios.2023.115596","article-title":"A Dual-Responsive Crimson Fluorescent Probe for Real-Time Diagnosis of Alcoholic Acute Liver Injury","volume":"239","author":"Wang","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Iaconisi, G.N., Lunetti, P., Gallo, N., Cappello, A.R., Fiermonte, G., Dolce, V., and Capobianco, L. (2023). Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications-A Comprehensive Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210296"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Carton, F., and Malatesta, M. (2024). Nanotechnological Research for Regenerative Medicine: The Role of Hyaluronic Acid. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073975"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.matpr.2021.12.038","article-title":"Identification and Antioxidant Activity of Hyaluronic Acid Extracted from Local Isolates of Streptococcus thermophilus","volume":"60","author":"Mohammed","year":"2022","journal-title":"Mater. Today Proc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41586-023-06463-0","article-title":"Increased Hyaluronan by Naked Mole-Rat Has2 Improves Healthspan in Mice","volume":"621","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1111\/febs.14777","article-title":"Hyaluronan: Molecular Size-Dependent Signaling and Biological Functions in Inflammation and Cancer","volume":"286","author":"Tavianatou","year":"2019","journal-title":"FEBS J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/glycob\/cwz002","article-title":"Hyaluronan Histochemistry-a Potential New Tool to Assess the Progress of Liver Disease from Simple Steatosis to Hepatocellular Carcinoma","volume":"29","author":"Mustonen","year":"2019","journal-title":"Glycobiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e0083","DOI":"10.1097\/HC9.0000000000000083","article-title":"Hyaluronan in Liver Fibrosis: Basic Mechanisms, Clinical Implications, and Therapeutic Targets","volume":"7","author":"Kim","year":"2023","journal-title":"Hepatol. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/acer.15127","article-title":"Hyaluronan Synthesis Inhibition Normalizes Ethanol-Enhanced Hepatic Stellate Cell Activation","volume":"47","author":"Kotulkar","year":"2023","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hep.510270115","article-title":"Stimulation of Inducible Nitric Oxide Synthase in Rat Liver by Hyaluronan Fragments","volume":"27","author":"Rockey","year":"1998","journal-title":"Hepatology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ghose, S., Biswas, S., Datta, K., and Tyagi, R.K. (2018). Dynamic Hyaluronan Drives Liver Endothelial Cells towards Angiogenesis. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4532-1"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.21873\/invivo.12540","article-title":"Recovery of Liver Sinusoidal Endothelial Cells Following Monocrotaline-Induced Liver Injury","volume":"35","author":"Otaka","year":"2021","journal-title":"Vivo"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1475-2891-13-70","article-title":"Ingested Hyaluronan Moisturizes Dry Skin","volume":"13","author":"Kawada","year":"2014","journal-title":"Nutr. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12937-016-0128-2","article-title":"Oral Hyaluronan Relieves Knee Pain: A Review","volume":"15","author":"Oe","year":"2016","journal-title":"Nutr. J."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Xu, L., Yu, Y., Sang, R., Li, J., Ge, B., and Zhang, X. (2018). Protective Effects of Taraxasterol against Ethanol-Induced Liver Injury by Regulating CYP2E1\/Nrf2\/HO-1 and NF-\u03baB Signaling Pathways in Mice. Oxid. Med. Cell. Longev., 2018.","DOI":"10.1155\/2018\/8284107"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"120880","DOI":"10.1016\/j.carbpol.2023.120880","article-title":"Molecular Weight and Gut Microbiota Determine the Bioavailability of Orally Administered Hyaluronic Acid","volume":"313","author":"Schwarzer","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"122074","DOI":"10.1016\/j.carbpol.2024.122074","article-title":"Degradation and Fermentation of Hyaluronic Acid by Bacteroides Spp. from the Human Gut Microbiota","volume":"334","author":"Fang","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/s41467-026-68542-w","article-title":"1,3-and 1,4-Linked Polysaccharides Uptake in Intestinal Cells Relies on Clathrin\/Dynamin 1\/Rab5-Dependent Endocytosis","volume":"17","author":"Liao","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2147\/CCID.S141845","article-title":"Oral Hyaluronan Relieves Wrinkles: A Double-Blinded, Placebo-Controlled Study over a 12-Week Period","volume":"10","author":"Oe","year":"2017","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1080\/09168451.2016.1146065","article-title":"Orally Administered Hyaluronan Affects Skin Dryness and Epidermal Thickening in Photoaged Hairless Mice","volume":"80","author":"Kawada","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/hep.510230648","article-title":"Biosynthesis and Degradation of Hyaluronan by Nonparenchymal Liver Cells during Liver Regeneration","volume":"23","author":"Vrochides","year":"1996","journal-title":"Hepatology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100039","DOI":"10.1016\/j.jdsct.2024.100039","article-title":"Recent Advances in Exploring the Properties and Applications of Hyaluronan","volume":"1","author":"Zeng","year":"2024","journal-title":"J. Dermatol. Sci. Cosmet. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30610","DOI":"10.1074\/jbc.M112.356238","article-title":"Specific-Sized Hyaluronan Fragments Promote Expression of Human \u03b2-Defensin 2 in Intestinal Epithelium","volume":"287","author":"Hill","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"030501","DOI":"10.11613\/BM.2022.030501","article-title":"Clinical Importance of Laboratory Biomarkers in Liver Fibrosis","volume":"32","author":"Banys","year":"2022","journal-title":"Biochem. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"56S","DOI":"10.1111\/j.1530-0277.1999.tb04535.x","article-title":"Histochemical Study of Hyaluronate in Alcoholic Liver Disease","volume":"23","author":"Urashima","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"9250135","DOI":"10.26599\/FSHW.2024.9250135","article-title":"Characterization of the Effects of Hyaluronan Oligosaccharides on Human Gut Microbiota Using a Simulated Batch Fermentation System","volume":"14","author":"Gao","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"118313","DOI":"10.1016\/j.carbpol.2021.118313","article-title":"In Vitro Fermentation of Hyaluronan by Human Gut Microbiota: Changes in Microbiota Community and Potential Degradation Mechanism","volume":"269","author":"Pan","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Zhao, R., Zhang, C., Yu, L., Zhang, C., Zhao, J., Narbad, A., Zhai, Q., and Tian, F. (2023). In Vitro Fermentation of Hyaluronan with Different Molecular Weights by Human Gut Microbiota: Differential Effects on Gut Microbiota Structure and Metabolic Function. Polymers, 15.","DOI":"10.3390\/polym15092103"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Stojanov, S., Berlec, A., and \u0160trukelj, B. (2020). The Influence of Probiotics on the Firmicutes\/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel Disease. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111715"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.3945\/jn.112.162388","article-title":"Total Parenteral Nutrition Induces a Shift in the Firmicutes to Bacteroidetes Ratio in Association with Paneth Cell Activation in Rats","volume":"142","author":"Hodin","year":"2012","journal-title":"J. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1194\/jlr.R119000547","article-title":"Alcohol Effects on Hepatic Lipid Metabolism","volume":"61","author":"Jeon","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"zqac039","DOI":"10.1093\/function\/zqac039","article-title":"Cellular Bioenergetics: Experimental Evidence for Alcohol-Induced Adaptations","volume":"3","author":"Simon","year":"2022","journal-title":"Function"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"17756","DOI":"10.3748\/wjg.v20.i47.17756","article-title":"Pathogenesis of Alcoholic Liver Disease: Role of Oxidative Metabolism","volume":"20","author":"Ceni","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1089\/jmf.2008.0138","article-title":"Effect of Kolaviron, a Biflavonoid Complex from Garcinia Kola Seeds, on Ethanol-Induced Oxidative Stress in Liver of Adult Wistar Rats","volume":"12","author":"Adaramoye","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"125145","DOI":"10.1016\/j.carbpol.2026.125145","article-title":"High-Molecular Weight Hyaluronic Acid Protects against Colitis by Remodeling Microbiota and Restoring Barrier Function","volume":"381","author":"Gao","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"ref_52","first-page":"277","article-title":"Alcohol, Oxidative Stress, and Free Radical Damage","volume":"27","author":"Wu","year":"2003","journal-title":"Alcohol. Res. Health"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-4939-8751-1_9","article-title":"Alcohol-Induced Epigenetic Changes in Cancer","volume":"1856","author":"Dumitrescu","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.chom.2024.06.008","article-title":"Dietary Fiber Alleviates Alcoholic Liver Injury via Bacteroides acidifaciens and Subsequent Ammonia Detoxification","volume":"32","author":"Shen","year":"2024","journal-title":"Cell Host Microbe"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.matbio.2022.11.008","article-title":"35kDa Hyaluronan Ameliorates Ethanol Driven Loss of Anti-Microbial Defense and Intestinal Barrier Integrity in a TLR4-Dependent Manner","volume":"115","author":"Ray","year":"2023","journal-title":"Matrix Biol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"De C\u00f3l, J.P., de Lima, E.P., Pompeu, F.M., Ara\u00fajo, A.C., Goulart, R.d.A., Bechara, M.D., Laurindo, L.F., M\u00e9ndez-S\u00e1nchez, N., and Barbalho, S.M. (2024). Underlying Mechanisms behind the Brain\u2013Gut\u2013Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073694"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1530-0277.2006.00063.x","article-title":"Silymarin Protects against Acute Ethanol-Induced Hepatotoxicity in Mice","volume":"30","author":"Song","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Rambaldi, A., Jacobs, B.P., and Gluud, C. (2007). Milk Thistle for Alcoholic and\/or Hepatitis B or C Virus Liver Diseases. Cochrane Database Syst. Rev., 2007.","DOI":"10.1002\/14651858.CD003620.pub3"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Zhao, T.-M., Wang, Y., Deng, Y., Fan, X.-F., Cao, X.-C., Hou, L.-J., Mao, L.-H., Lin, L., Zhao, W., and Wang, B.-M. (2020). Bicyclol Attenuates Acute Liver Injury by Activating Autophagy, Anti-Oxidative and Anti-Inflammatory Capabilities in Mice. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00463"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A Simple Practice Guide for Dose Conversion between Animals and Human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e13531","DOI":"10.1111\/srt.13531","article-title":"Oral Administration of Hyaluronic Acid to Improve Skin Conditions via a Randomized Double-Blind Clinical Test","volume":"29","author":"Gao","year":"2023","journal-title":"Skin Res. Technol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1038\/s41598-025-32758-5","article-title":"Oral Sodium Hyaluronate Improves Skin Hydration, Barrier Function and Signs of Aging: A Randomized, Double-Blind, Placebo-Controlled Trial in 150 Healthy Adults","volume":"16","author":"Berka","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1039\/D0FO02688C","article-title":"Effect of Auricularia Auricula Fermentation Broth on the Liver and Stomach of Mice with Acute Alcoholism","volume":"12","author":"Yu","year":"2021","journal-title":"Food Funct."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"9250151","DOI":"10.26599\/FSHW.2024.9250151","article-title":"Recent Advances of Rodent Models for Alcoholic Liver Disease in Evaluating Healthy Effects of Food Bioactive Ingredients","volume":"14","author":"Yu","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"155058","DOI":"10.1016\/j.cyto.2020.155058","article-title":"Dendrobium Officinale Polysaccharides Protected against Ethanol-Induced Acute Liver Injury in Vivo and in Vitro via the TLR4\/NF-\u03baB Signaling Pathway","volume":"130","author":"Yang","year":"2020","journal-title":"Cytokine"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/9\/3941\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:13:07Z","timestamp":1777389187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/9\/3941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":65,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ijms27093941"],"URL":"https:\/\/doi.org\/10.3390\/ijms27093941","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}