{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:39:00Z","timestamp":1792132740508,"version":"4.4.0"},"reference-count":67,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"St. George\u2019s University School of Medicine"},{"id":[{"id":"https:\/\/ror.org\/01m1s6313","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine\u2013metabolic disorder affecting 5.5\u201311.5% of women of reproductive age. While reduced adiponectin levels have been consistently demonstrated in adult women with PCOS, findings in adolescents remain less clearly defined. A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines. PubMed, Embase, Scopus, and Google Scholar were searched from inception to 31 October 2025. Observational studies comparing adiponectin levels in post-pubertal adolescents with PCOS and controls were included. Data were pooled using random-effects meta-analysis in RStudio, with subgroup, sensitivity, heterogeneity, and publication bias analyses conducted. Eighteen studies comprising 1590 participants were analyzed. The pooled analysis demonstrated significantly lower adiponectin levels in adolescents with PCOS compared to controls (mean difference [MD]: \u22123.19 \u00b5g\/mL; 95% CI: \u22124.90 to \u22121.49; p = 0.0010), with substantial heterogeneity (I2 &gt; 90%). Subgroup analyses by diagnostic criteria, geographic region, study design, and weight status consistently showed reduced adiponectin levels in PCOS, with no significant subgroup differences. In conclusion, adolescents with PCOS exhibit significantly lower adiponectin levels, consistent with findings in adult populations. These results support an early association between adiponectin dysregulation and PCOS, although further longitudinal studies are needed to clarify clinical utility.<\/jats:p>","DOI":"10.3390\/ijms27093950","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:46:11Z","timestamp":1777455971000},"page":"3950","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adiponectin and Polycystic Ovary Syndrome in Adolescent Girls: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1761-6509","authenticated-orcid":false,"given":"Sheran P. W.","family":"Fernando","sequence":"first","affiliation":[{"name":"Department of Public Health and Preventive Medicine, St. George\u2019s University School of Medicine, St. George FZ818, Grenada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-0671","authenticated-orcid":false,"given":"Prakash V. A. K.","family":"Ramdass","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, St. George\u2019s University School of Medicine, St. George FZ818, Grenada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic Ovary Syndrome: Definition, Aetiology, Diagnosis and Treatment","volume":"14","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00404-024-07607-x","article-title":"Global Prevalence of Polycystic Ovary Syndrome in Women Worldwide: A Comprehensive Systematic Review and Meta-Analysis","volume":"310","author":"Salari","year":"2024","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4239\/wjd.v13.i1.5","article-title":"Polycystic Ovary Syndrome and Type 2 Diabetes Mellitus: A State-of-the-Art Review","volume":"13","author":"Livadas","year":"2022","journal-title":"World J. Diabetes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1161\/CIRCULATIONAHA.123.065827","article-title":"Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury","volume":"148","author":"Gao","year":"2023","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Guo, F., Gong, Z., Fernando, T., Zhang, L., Zhu, X., and Shi, Y. (2022). The Lipid Profiles in Different Characteristics of Women with PCOS and the Interaction Between Dyslipidemia and Metabolic Disorder States: A Retrospective Study in Chinese Population. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.892125"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/bs.acc.2018.02.007","article-title":"Chapter Five\u2014Adiponectin and Its Isoforms in Pathophysiology","volume":"Volume 85","author":"Makowski","year":"2018","journal-title":"Advances in Clinical Chemistry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1152\/physiol.00031.2020","article-title":"Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space","volume":"36","author":"Liu","year":"2021","journal-title":"Physiology"},{"key":"ref_8","first-page":"346","article-title":"Adiponectin as a Serum Marker of Adipose Tissue Dysfunction in Women with Polycystic Ovary Syndrome: Correlation with Indicators of Metabolic Disturbances","volume":"14","year":"2018","journal-title":"Acta Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1007\/s13277-013-1595-0","article-title":"Low Circulating Adiponectin Levels in Women with Polycystic Ovary Syndrome: An Updated Meta-Analysis","volume":"35","author":"Li","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lin, K., Sun, X., Wang, X., Wang, H., and Chen, X. (2021). Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.537809"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Guan, Y., Zuo, F., Zhao, J., Nian, X., Shi, L., Xu, Y., Huang, J., Kazumi, T., and Wu, B. (2023). Relationships of Adiponectin to Regional Adiposity, Insulin Sensitivity, Serum Lipids, and Inflammatory Markers in Sedentary and Endurance-Trained Japanese Young Women. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1097034"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Orszulak, D., Nizi\u0144ski, K., Maton\u00f3g, A., Zi\u0119ba-Domalik, M., Stojko, R., and Drosdzol-Cop, A. (2025). Adipokines as Biochemical Marker of Polycystic Ovary Syndrome in Adolescents\u2014Review. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1475465"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1364","DOI":"10.1210\/clinem\/dgaf606","article-title":"Adolescent \u201cLean PCOS\u201d Is Characterized by Higher Insulin Resistance and Adverse Adipokine Profile","volume":"111","author":"Whooten","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/humupd\/dmp006","article-title":"Adiponectin Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and a Meta-Analysis","volume":"15","author":"Toulis","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group (2004). Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome. Fertil. Steril., 81, 19\u201325.","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"ref_17","unstructured":"Zawadzki, J., Dunaif, A., Givens, J., Haseltine, F., and Merriam, G. (1992). Current Issues in Endocrinology and Metabolism: Polycystic Ovary Syndrome, Blackwell Scientific Publications."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wan, X., Wang, W., Liu, J., and Tong, T. (2014). Estimating the Sample Mean and Standard Deviation from the Sample Size, Median, Range and\/or Interquartile Range. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-135"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/09513590903159540","article-title":"Adiponectin and Resistin Concentrations after Glucose Load in Adolescents with Polycystic Ovary Syndrome","volume":"26","year":"2010","journal-title":"Gynecol. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"389317","DOI":"10.1155\/2011\/389317","article-title":"Il-6 Serum Levels and Production Is Related to an Altered Immune Response in Polycystic Ovary Syndrome Girls with Insulin Resistance","volume":"2011","author":"Fulghesu","year":"2011","journal-title":"Mediat. Inflamm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jpag.2010.11.003","article-title":"Serum Adiponectin Levels in High School Girls with Polycystic Ovary Syndrome and Hyperandrogenism","volume":"24","author":"Yasar","year":"2011","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/oby.21651","article-title":"Hepatic Steatosis Is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but Not Insulin Resistance","volume":"24","author":"Bergman","year":"2016","journal-title":"Obesity"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/pedi.12778","article-title":"Using Simple Clinical Measures to Predict Insulin Resistance or Hyperglycemia in Girls with Polycystic Ovarian Syndrome","volume":"19","author":"Cai","year":"2018","journal-title":"Pediatr. Diabetes"},{"key":"ref_24","first-page":"150","article-title":"Alteraciones metab\u00f3licas sutiles en adolescentes con obesidad y s\u00edndrome de ovario poliqu\u00edstico","volume":"153","year":"2019","journal-title":"Gac. Medica Mex."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cca.2015.07.012","article-title":"Reference Values for Serum Total Adiponectin in Healthy Non-Obese Children and Adolescents","volume":"450","author":"Christiansen","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1210\/jc.2008-1198","article-title":"Prevalence of Metabolic Syndrome and Related Characteristics in Obese Adolescents with and without Polycystic Ovary Syndrome","volume":"93","author":"Rossi","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","first-page":"603","article-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Case-Control Studies in Meta-Analyses","volume":"25","author":"Wells","year":"2011","journal-title":"Eur. J. Epidemiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in Meta-Analysis Detected by a Simple, Graphical Test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating Characteristics of a Rank Correlation Test for Publication Bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1365-2265.2009.03604.x","article-title":"Adiponectin Levels in Adolescent Girls with Polycystic Ovary Syndrome (PCOS)","volume":"71","author":"Singer","year":"2009","journal-title":"Clin. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1684\/ecn.2011.0279","article-title":"Evaluation of New Adipocytokines and Insulin Resistance in Adolescents with Polycystic Ovary Syndrome","volume":"22","author":"Cekmez","year":"2011","journal-title":"Eur. Cytokine Netw."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jpag.2012.09.002","article-title":"Adiponectin, Leptin and Ghrelin Levels in Obese Adolescent Girls with Polycystic Ovary Syndrome","volume":"26","author":"Akhan","year":"2013","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.fertnstert.2014.05.032","article-title":"Insulin Resistance and Its Relationship with High Molecular Weight Adiponectin in Adolescents with Polycystic Ovary Syndrome and a Maternal History of Polycystic Ovary Syndrome","volume":"102","author":"Cankaya","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/jgh.13241","article-title":"Adverse Metabolic Phenotype of Adolescent Girls with Non-alcoholic Fatty Liver Disease plus Polycystic Ovary Syndrome Compared with Other Girls and Boys","volume":"31","author":"Ayonrinde","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jpeds.2015.09.082","article-title":"Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome","volume":"168","author":"Hughan","year":"2016","journal-title":"J. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/1358863X16682107","article-title":"Obese Adolescents with Polycystic Ovarian Syndrome Have Elevated Cardiovascular Disease Risk Markers","volume":"22","author":"Patel","year":"2017","journal-title":"Vasc. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1210\/jc.2017-01958","article-title":"Impaired Lipolysis, Diminished Fat Oxidation, and Metabolic Inflexibility in Obese Girls with Polycystic Ovary Syndrome","volume":"103","author":"Kim","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"bvaa032","DOI":"10.1210\/jendso\/bvaa032","article-title":"Toward a Treatment Normalizing Ovulation Rate in Adolescent Girls with Polycystic Ovary Syndrome","volume":"4","author":"Malpique","year":"2020","journal-title":"J. Endocr. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e2023064894","DOI":"10.1542\/peds.2023-064894","article-title":"Associations of Childhood Adiposity and Cardiometabolic Biomarkers with Adolescent PCOS","volume":"153","author":"Whooten","year":"2024","journal-title":"Pediatrics"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Fory\u015b, E., Drosdzol-Cop, A., Ma\u0142ecka-Tendera, E., Gawlik-Starzyk, A.M., Skrzy\u0144ska, K., Olszanecka-Glinianowicz, M., and Zachurzok, A. (2025). Adipokine Profile Signature in Adolescent Girls with Menstrual Disorders and Hyperandrogenism Differs from That of Regularly Menstruating Girls. J. Clin. Med., 14.","DOI":"10.3390\/jcm14227987"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"G43","DOI":"10.1093\/ejendo\/lvad096","article-title":"Recommendations from the 2023 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome","volume":"189","author":"Teede","year":"2023","journal-title":"Eur. J. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejogrb.2011.12.012","article-title":"Relationship of Serum Adipocyte-Derived Proteins with Insulin Sensitivity and Reproductive Features in Pre-Pubertal and Pubertal Daughters of Polycystic Ovary Syndrome Women","volume":"161","author":"Maliqueo","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Pe\u00f1a, A.S., Witchel, S.F., Hoeger, K.M., Oberfield, S.E., Vogiatzi, M.G., Misso, M., Garad, R., Dabadghao, P., and Teede, H. (2020). Adolescent Polycystic Ovary Syndrome According to the International Evidence-Based Guideline. BMC Med., 18.","DOI":"10.1186\/s12916-020-01516-x"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1530\/eje.1.02207","article-title":"Evaluation of Metabolic Risk Markers in Polycystic Ovary Syndrome (PCOS). Adiponectin, Ghrelin, Leptin and Body Composition in Hirsute PCOS Patients and Controls","volume":"155","author":"Glintborg","year":"2006","journal-title":"Eur. J. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"B\u0142a\u017cejewska, W., D\u0105browska, J., Micha\u0142owska, J., and Bogda\u0144ski, P. (2025). The Role of Adiponectin and ADIPOQ Variation in Metabolic Syndrome: A Narrative Review. Genes, 16.","DOI":"10.3390\/genes16060699"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and Adiponectin Receptors in Insulin Resistance, Diabetes, and the Metabolic Syndrome","volume":"116","author":"Kadowaki","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tem.2017.03.004","article-title":"Cardiovascular Adiponectin Resistance: The Critical Role of Adiponectin Receptor Modification","volume":"28","author":"Wang","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3803\/EnM.2020.771","article-title":"Cross-Sectional and Longitudinal Examination of Insulin Sensitivity and Secretion across Puberty among Non-Hispanic Black and White Children","volume":"35","author":"Marwitz","year":"2020","journal-title":"Endocrinol. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1210\/jc.2008-2836","article-title":"Metabolic and Reproductive Features before and during Puberty in Daughters of Women with Polycystic Ovary Syndrome","volume":"94","author":"Codner","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ni, M., Lei, H., Ye, T., and Wang, Y. (2025). Adipose-Androgen Crosstalk in Polycystic Ovary Syndrome: Mechanisms and Therapeutic Implications. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1731179"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1210\/jc.2009-2286","article-title":"Hypoadiponectinemia\u2014Cause or Consequence of Human \u201cInsulin Resistance\u201d?","volume":"95","author":"Cook","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e240269","DOI":"10.1530\/JOE-24-0269","article-title":"Reappraising the Relationship between Hyperinsulinemia and Insulin Resistance in PCOS","volume":"265","author":"Houston","year":"2025","journal-title":"J. Endocrinol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"bqaa209","DOI":"10.1210\/endocr\/bqaa209","article-title":"Puberty, a Sensitive Window of Hypothalamic Development and Plasticity","volume":"162","author":"Maione","year":"2021","journal-title":"Endocrinology"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kury\u0142owicz, A. (2023). Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030690"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1210\/jc.2014-4290","article-title":"Adolescent Polycystic Ovary Syndrome Due to Functional Ovarian Hyperandrogenism Persists into Adulthood","volume":"100","author":"Rosenfield","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"114648","DOI":"10.1016\/j.ejogrb.2025.114648","article-title":"Adolescent PCOS and Metabolic Health: An Analysis of Fat, Muscle, and Hormones","volume":"314","author":"Kara","year":"2025","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Dhokte, S., and Czaja, K. (2024). Visceral Adipose Tissue: The Hidden Culprit for Type 2 Diabetes. Nutrients, 16.","DOI":"10.3390\/nu16071015"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2200264","DOI":"10.1002\/mnfr.202200264","article-title":"Loss of Visceral Fat Is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome","volume":"67","author":"Casas","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Reneau, J., Goldblatt, M., Gould, J., Kindel, T., Kastenmeier, A., Higgins, R., Rengel, L.R., Schoyer, K., James, R., and Obi, B. (2018). Effect of Adiposity on Tissue-Specific Adiponectin Secretion. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198889"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/jmcb\/mjw012","article-title":"Adiponectin: A Versatile Player of Innate Immunity","volume":"8","author":"Luo","year":"2016","journal-title":"J. Mol. Cell. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Rudnicka, E., Suchta, K., Grymowicz, M., Calik-Ksepka, A., Smolarczyk, K., Duszewska, A.M., Smolarczyk, R., and Meczekalski, B. (2021). Chronic Low Grade Inflammation in Pathogenesis of PCOS. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073789"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wu, Y., Zhong, L., Li, G., Han, L., Fu, J., Li, Y., Li, L., Zhang, Q., Guo, Y., and Xiao, X. (2021). Puberty Status Modifies the Effects of Genetic Variants, Lifestyle Factors and Their Interactions on Adiponectin: The BCAMS Study. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.737459"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Liu, Z., Liang, S., Que, S., Zhou, L., Zheng, S., and Mardinoglu, A. (2018). Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01238"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kim, J.Y., Barua, S., Jeong, Y.J., and Lee, J.E. (2020). Adiponectin: The Potential Regulator and Therapeutic Target of Obesity and Alzheimer\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176419"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cytogfr.2018.01.004","article-title":"Adiponectin: A Potential Therapeutic Target for Metabolic Syndrome","volume":"39","author":"Ghadge","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"111076","DOI":"10.1016\/j.diabres.2023.111076","article-title":"The Effect of Metformin on Adipokines Levels: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials","volume":"207","author":"Zhao","year":"2024","journal-title":"Diabetes Res. Clin. Pract."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/9\/3950\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:48:21Z","timestamp":1777456101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/9\/3950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":67,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ijms27093950"],"URL":"https:\/\/doi.org\/10.3390\/ijms27093950","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]}}}