{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:00:47Z","timestamp":1792155647561,"version":"4.4.0"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0503900"],"award-info":[{"award-number":["2017YFA0503900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A pair of enantiomeric stilbene\u2013lignan hybrids, (\u2212)- and (+)-dracaenolignan A (1), and four new flavonoid derivatives, xuejieins F\u2013I (2\u20135), were isolated from Dracaena cochinchinensis exudates. Compound 1 features an unprecedented carbon skeleton with a 6\/6\/5\/6-fused ring system and four consecutive chiral carbons. Their structures were clarified by spectroscopic data, theoretical NMR calculations, and ECD calculations. Furthermore, a potential biogenetic pathway for 1 is put forward. Biological evaluations inspired by the chemical defense of D. cochinchinensis revealed that (\u2212)-1 significantly alleviates LPS-induced neuroinflammation and depression-like behaviors, suggesting potential antidepressant lead structure.<\/jats:p>","DOI":"10.3390\/ijms27093966","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:32:22Z","timestamp":1777469542000},"page":"3966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skeletal Stilbenolignan Enantiomers and Flavonoid Derivatives Against Depression in Mice from Dracaena cochinchinensis Exudates"],"prefix":"10.3390","volume":"27","author":[{"given":"Tian-Chang","family":"He","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Fang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Fen","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Yao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Qi","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Nanchang 330022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-9598","authenticated-orcid":false,"given":"Yong-Xian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113128","DOI":"10.1016\/j.phytochem.2022.113128","article-title":"Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review","volume":"197","author":"Teka","year":"2022","journal-title":"Phytochemistry"},{"key":"ref_2","first-page":"1","article-title":"Non-conventional lignans: Coumarinolignans, flavonolignans, and stilbenolignans","volume":"Volume 93","author":"Begum","year":"2010","journal-title":"Fortschritte der Chemie Organischer Naturstoffe\/Progress in the Chemistry of Organic Natural Products"},{"key":"ref_3","unstructured":"Su, X., Zhou, D., and Li, N. 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