{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:10:37Z","timestamp":1789175437489,"version":"build-2803163510"},"reference-count":52,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003822","name":"JINR","doi-asserted-by":"crossref","award":["05-7-1077-1-2024\/2028"],"award-info":[{"award-number":["05-7-1077-1-2024\/2028"]}],"id":[{"id":"10.13039\/501100003822","id-type":"DOI","asserted-by":"crossref"}]},{"award":["05-7-1077-1-2024\/2028"],"award-info":[{"award-number":["05-7-1077-1-2024\/2028"]}],"id":[{"id":"https:\/\/ror.org\/044yd9t77","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study investigated cytogenetic damage in peripheral blood lymphocytes of 10 differentiated thyroid cancer patients who received multiple 131I radioiodine (RAI) treatments following total thyroidectomy. Blood samples were collected before the RAI therapy course and 2\u20133 days after the course for a few selected courses (from 1 to 3) for each patient. The cumulative average number of chromosome aberrations (CAs) per cell and its increment due to a selected RAI course were evaluated using the multiplex fluorescence in situ hybridization method (mFISH). An increase in the number of CAs was observed with the accumulation of RAI activity. The yield of these CAs per unit of accumulated RAI activity was, however, approximately three-fold lower than the respective yield for the incremented number of CAs in a selected course, thus demonstrating the elimination of CAs and\/or aberrant cells with time. Biological dosimetry was performed based on the number of all types of CAs and in vitro mFISH calibration curves. With an average administered RAI activity of 3.40 \u00b1 0.39 GBq, the average absorbed blood dose was 0.61 Gy (0.31\u20130.89:95% CI). Our results demonstrate that one-time administration of such activities of RAI was safe, since the commonly accepted threshold of 2 Gy for the blood dose was not exceeded.<\/jats:p>","DOI":"10.3390\/ijms27094049","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:50:01Z","timestamp":1777618201000},"page":"4049","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Monitoring Cytogenetic Effects in Peripheral Blood Lymphocytes of Thyroid Cancer Patients Receiving Radioiodine Treatment"],"prefix":"10.3390","volume":"27","author":[{"given":"Igor K.","family":"Khvostunov","sequence":"first","affiliation":[{"name":"Department of Radiation Biophysics, A. Tsyb Medical Radiological Research Center (MRRC)\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (NMRRC), 10, Marshal Zhukov St., 249031 Obninsk, Kaluga Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-7472","authenticated-orcid":false,"given":"Elena","family":"Nasonova","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Biology, Joint Institute for Nuclear Research (JINR), 6 Joliot-Curie St., 141980 Dubna, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-7625","authenticated-orcid":false,"given":"Pavel","family":"Lobachevsky","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Biology, Joint Institute for Nuclear Research (JINR), 6 Joliot-Curie St., 141980 Dubna, Moscow Region, Russia"},{"name":"Department of Biophysics, Faculty of Natural Sciences and Engineering, Dubna State University (DSU), Universitetskaya St. 19, 141980 Dubna, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriy","family":"Krylov","sequence":"additional","affiliation":[{"name":"Department of Radiation Biophysics, A. Tsyb Medical Radiological Research Center (MRRC)\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (NMRRC), 10, Marshal Zhukov St., 249031 Obninsk, Kaluga Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Shurinov","sequence":"additional","affiliation":[{"name":"Department of Radiation Biophysics, A. Tsyb Medical Radiological Research Center (MRRC)\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (NMRRC), 10, Marshal Zhukov St., 249031 Obninsk, Kaluga Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-3975","authenticated-orcid":false,"given":"Andrei","family":"Rodichev","sequence":"additional","affiliation":[{"name":"Department of Radiation Biophysics, A. Tsyb Medical Radiological Research Center (MRRC)\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (NMRRC), 10, Marshal Zhukov St., 249031 Obninsk, Kaluga Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Korovchuk","sequence":"additional","affiliation":[{"name":"Department of Radiation Biophysics, A. Tsyb Medical Radiological Research Center (MRRC)\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (NMRRC), 10, Marshal Zhukov St., 249031 Obninsk, Kaluga Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Geraskina","sequence":"additional","affiliation":[{"name":"Department of Radiation Biophysics, A. Tsyb Medical Radiological Research Center (MRRC)\u2014Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (NMRRC), 10, Marshal Zhukov St., 249031 Obninsk, Kaluga Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Shipilova","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Biology, Joint Institute for Nuclear Research (JINR), 6 Joliot-Curie St., 141980 Dubna, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Shegai","sequence":"additional","affiliation":[{"name":"National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (NMRRC), 4, Korolev St., 249036 Obninsk, Kaluga Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Kaprin","sequence":"additional","affiliation":[{"name":"National Medical Research Radiological Center of the Ministry of Health of the Russian Federation (NMRRC), 4, Korolev St., 249036 Obninsk, Kaluga Region, Russia"},{"name":"Medical Institute, Peoples\u2019 Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1053\/j.semnuclmed.2024.05.002","article-title":"Radioactive Iodine Therapy in Differentiated Thyroid Cancer: An Update on Dose Recommendations and Risk of Secondary Primary Malignancies","volume":"54","author":"Nguyen","year":"2024","journal-title":"Semin. 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