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The kidney expresses numerous rhythmic genes and exhibits circadian physiological function regulation. Circadian rhythm abnormalities, such as sleep disorders and excessive daytime sleepiness, are particularly frequent in patients with chronic kidney disease (CKD). Furthermore, reduced amplitude and phase disruption in clock gene expression rhythms have been reported in mouse CKD models. These results suggest that circadian disruption is associated with renal pathophysiology. However, the role of BMAL1 in the repair process following acute kidney injury (AKI) remains unclear; therefore, this study aimed to elucidate its role in kidney repair following ischemia\u2013reperfusion injury (IRI). We found that the tamoxifen (TAM)-inducible global Bmal1 knockout (BKO) mouse kidneys exhibited increased lipid accumulation, enhanced fibrosis, and delayed kidney repair post-IRI, and that these abnormalities were associated with reduced Peroxisome proliferator-activated receptor alpha (Ppar\u03b1) expression. Furthermore, treatment with a PPAR\u03b1 agonist reduced these abnormalities in BKO mice. Collectively, our findings demonstrate that the BMAL1\u2013PPAR\u03b1 axis promotes post-AKI kidney repair.<\/jats:p>","DOI":"10.3390\/ijms27094091","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:12:09Z","timestamp":1777857129000},"page":"4091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deletion of Bmal1, a Component of the Molecular Clock, Exacerbates Kidney Damage After Ischemia\u2013Reperfusion by Decreasing Ppar\u03b1 Expression"],"prefix":"10.3390","volume":"27","author":[{"given":"Satoshi","family":"Kitaura","sequence":"first","affiliation":[{"name":"Department of Health Science, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi 274-8555, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taira","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Health Science, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi 274-8555, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Health Science, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi 274-8555, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-8387","authenticated-orcid":false,"given":"Shigeki","family":"Shimba","sequence":"additional","affiliation":[{"name":"Department of Health Science, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi 274-8555, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/B978-0-12-387690-4.00006-4","article-title":"Genetics of Circadian Rhythms in Mammalian Model Organisms","volume":"74","author":"Lowrey","year":"2011","journal-title":"Adv. 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