{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:02:15Z","timestamp":1785402135287,"version":"3.56.0"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"crossref","award":["S-LLT-20-1"],"award-info":[{"award-number":["S-LLT-20-1"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"crossref","award":["P-LLT-20-4"],"award-info":[{"award-number":["P-LLT-20-4"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"crossref"}]},{"award":["S-LLT-20-1"],"award-info":[{"award-number":["S-LLT-20-1"]}],"id":[{"id":"https:\/\/ror.org\/02gs16m83","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P-LLT-20-4"],"award-info":[{"award-number":["P-LLT-20-4"]}],"id":[{"id":"https:\/\/ror.org\/02gs16m83","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Research Foundation of the Lithuanian University of Health Sciences"},{"name":"Kaunas Regional Association of Dermatovenereologists"},{"name":"Lithuanian University of Health Sciences, Kaunas, Lithuania"},{"id":[{"id":"https:\/\/ror.org\/0069bkg23","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin disease increasingly prevalent in adults. Vitamin D plays an important role in regulating immune responses, cellular differentiation, and inflammation. Several single-nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene have been suggested as biomarkers of AD susceptibility and severity. The aim of this study was to investigate six SNPs in the VDR gene (rs3847987, rs731236, rs7975232, rs1544410, rs2228570, and rs11168293) and their association with AD and blood biomarkers. Genotyping was performed in 91 adult patients with AD and 102 controls using real-time polymerase chain reaction. The genotype and allele distributions did not differ significantly between AD patients and controls. However, the G and T alleles of VDR rs731236 and rs1544410 were more frequently detected in individuals with serum 25-hydroxyvitamin D (25(OH)D) levels above 30 ng\/mL. In contrast, the VDR rs7975232 C allele appears to be associated with lower odds of having a serum 25(OH)D level above 30 ng\/mL. In genotype-stratified analysis, the T allele of VDR rs11168293 was more prevalent among individuals with eosinophil counts of 300 cells\/\u03bcL. These findings suggest that VDR polymorphisms may contribute to variability in vitamin D status and inflammatory responses in adults with AD.<\/jats:p>","DOI":"10.3390\/ijms27104217","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:49:09Z","timestamp":1778572149000},"page":"4217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Vitamin D Receptor Gene Polymorphisms with Serum 25-Hydroxyvitamin D Levels in Lithuanian Adults with Atopic Dermatitis: A Case\u2014Control Study"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-6403","authenticated-orcid":false,"given":"Kamilija","family":"Bried\u0117","sequence":"first","affiliation":[{"name":"Department of Skin and Venereal Diseases, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daina","family":"Pavalkien\u0117","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Lab of Immunology, Department of Immunology and Allergology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5086-8893","authenticated-orcid":false,"given":"Brigita","family":"Gradauskien\u0117","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-2032","authenticated-orcid":false,"given":"Agn\u0117","family":"Bartnykait\u0117","sequence":"additional","affiliation":[{"name":"Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Leonavi\u010dius","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasa","family":"Ugenskien\u0117","sequence":"additional","affiliation":[{"name":"Oncology Research Laboratory, Oncology Institute, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Department of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7157-4090","authenticated-orcid":false,"given":"Dalia","family":"Luk\u0161ien\u0117","sequence":"additional","affiliation":[{"name":"Laboratory of Population Studies, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50103 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-1550","authenticated-orcid":false,"given":"Vacis","family":"Tatar\u016bnas","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50103 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skaidra","family":"Valiukevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic Dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Eisen, M., Gradauskiene, B., Grigaitiene, J., Hartmane, I., Kingo, K., Mikazans, I., Raam, L., and Toomela, K. 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