{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:22Z","timestamp":1787762002752,"version":"build-2784847793"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["BR24992760"],"award-info":[{"award-number":["BR24992760"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Due to the increasing threat of antibiotic resistance and the emergence of new pathogenic strains, the development of effective combined therapeutic agents represents a crucial direction in the fight against infections. Within this study, several compounds were synthesized in which iodine is present in a coordination complex with antibiotics\u2014sodium sulfadimidine and gentamicin sulfate. The physicochemical parameters of these compounds were investigated using capillary electrophoresis and UV spectroscopy, along with their cytotoxicity, antimicrobial, and antiviral activities. As a result of this work, two stable compounds, KC-246 and KC-248, were synthesized, demonstrating virus-inhibitory activity against herpes simplex virus and influenza A under extremely low cytotoxicity levels of 0.018\u20130.106 mg\/mL. Additionally, they exhibited antimicrobial activity against representatives of the families Staphylococcaceae, Pseudomonadaceae, Enterobacteriaceae, Enterococcaceae, and yeast-like fungi. The minimum bactericidal concentrations (MBCs) ranged from 0.794 \u00b5g\/mL to 0.198 \u00b5g\/mL (KC-246) and from 2.093 \u00b5g\/mL to 0.523 \u00b5g\/mL (KC-248).<\/jats:p>","DOI":"10.3390\/ijms27104292","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:04:36Z","timestamp":1778601876000},"page":"4292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Iodine-Based Coordination Compounds: A Strategy Toward Antibiotic Potentiation"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0471-0587","authenticated-orcid":false,"given":"Daniil","family":"Shepilov","sequence":"first","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Askarova","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7791-3145","authenticated-orcid":false,"given":"Anar","family":"Seisembekova","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-3534","authenticated-orcid":false,"given":"Seitzhan","family":"Turganbay","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences, Kazakh National Women\u2019s Teacher Training University, Almaty 050000, Kazakhstan"},{"name":"Kazakh-British Technical University, School of Petroleum Engineering, \u201cOne Belt, One Road\u201d Research Center, Almaty 050000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-7321","authenticated-orcid":false,"given":"Ardak","family":"Jumagaziyeva","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-6523","authenticated-orcid":false,"given":"Tamara","family":"Bukeyeva","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-0307","authenticated-orcid":false,"given":"Gulnara","family":"Yuldasheva","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8533-3029","authenticated-orcid":false,"given":"Nurdaulet","family":"Temir","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-0556","authenticated-orcid":false,"given":"Lyudmila N.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6436-803X","authenticated-orcid":false,"given":"Natalya","family":"Zubenko","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-1424","authenticated-orcid":false,"given":"Sabina","family":"Kenesheva","sequence":"additional","affiliation":[{"name":"JSC Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/cid\/ciab672","article-title":"Advancing diagnostic stewardship for healthcare-associated infections, antibiotic resistance, and sepsis","volume":"74","author":"Curren","year":"2022","journal-title":"Clin. 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