{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:53:41Z","timestamp":1785405221876,"version":"3.56.0"},"reference-count":91,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EEQ\/2022\/000548"],"award-info":[{"award-number":["EEQ\/2022\/000548"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"award":["EEQ\/2022\/000548"],"award-info":[{"award-number":["EEQ\/2022\/000548"]}],"id":[{"id":"https:\/\/ror.org\/03ffdsr55","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This review investigates biomaterial-based strategies for improved treatment of MPXV. We focus on emerging synthetic biomedical approaches to combating the virus. These include peptide nucleic acids, CRISPR-based systems, and small-molecule therapeutics. These methods work by targeting and blocking viral proteins and enzymes. Such synthetic platforms may help reduce viral transmission and minimize side effects. They also offer potential solutions to challenges such as viral resistance in humans. In addition, biomaterials contribute to the development of more stable and effective vaccines. Combining these biomaterials with mRNA technology provides a promising framework for future vaccine development. Overall, this review underscores biomaterial-driven antiviral systems as a major frontier in translational medicine with profound implications for global health and pandemic awareness.<\/jats:p>","DOI":"10.3390\/ijms27104307","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:04:36Z","timestamp":1778601876000},"page":"4307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Innovations for Monkeypox Inhibition"],"prefix":"10.3390","volume":"27","author":[{"given":"Nayan","family":"De","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, John A. White, Jr. Engr. Hall Fayetteville, University of Arkansas, Fayetteville, AR 72701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhuma","family":"Bhadra","sequence":"additional","affiliation":[{"name":"School of Applied & Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Kolkata 700032, India"},{"name":"Department of Chemistry, Sarojini Naidu College for Women, Kolkata 700028, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Sorique Aziz","family":"Momin","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy, College of Science, Rochester Institute of Technology, Rochester, NY 14623, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamala","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Prasanta Chandra Mahalanobis Mahavidyalaya, Kolkata 700108, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-0466","authenticated-orcid":false,"given":"Debmalya","family":"Bhunia","sequence":"additional","affiliation":[{"name":"Cold Spring Harbor Laboratory, 1 Bungtown Rd., Cold Spring Harbor, NY 11724, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achinta","family":"Sannigrahi","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0140-6736(22)02075-X","article-title":"Monkeypox","volume":"401","author":"Ogoina","year":"2023","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101030","DOI":"10.1016\/j.onehlt.2025.101030","article-title":"MPOX unveiled: Global epidemiology, treatment advances, and prevention strategies","volume":"20","author":"Bogacka","year":"2025","journal-title":"One Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100394","DOI":"10.1016\/j.clinpr.2024.100394","article-title":"Mpox 2024: New variant, new challenges, and the looming pandemic","volume":"24","author":"Verma","year":"2024","journal-title":"Clin. 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