{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:10:11Z","timestamp":1779117011166,"version":"3.51.4"},"reference-count":51,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is an immune-mediated inflammatory disease with a genetic component, characterized by dysregulation of cytokine signaling and activation of T lymphocytes. This study investigated genetic variants associated with psoriasis, psoriatic arthritis (PsA), and response to tumor necrosis factor alpha (TNF-\u03b1) inhibitors (adalimumab, infliximab, and etanercept) in a Russian cohort. A genome-wide association study (GWAS) was conducted in 1026 psoriasis patients and 9212 controls using Infinium Global Screening Array-24 v3.0 microarrays. Exploratory analyses of treatment response (n = 48) and PsA (n = 96) were performed without covariate adjustment or explicit modeling of population structure. Polygenic risk scores (PRS) were derived from internally estimated effect sizes in a split-sample design. The GWAS replicated a robust association in the major histocompatibility complex (MHC) region (rs12189871 near HLA-C, p = 3.2 \u00d7 10\u221250, OR = 2.99 [2.59\u20133.45]). Additional loci included variants in ZC3H8 and PLCL2. Nominal signals were observed for IL18R1\/IL18RAP in treatment response (including rs17027071) and for RCL1 and FBLIM1 in PsA; these findings remain exploratory. PRS demonstrated moderate predictive performance (AUC = 0.6355) and should be interpreted with caution given the study design. Overall, the results highlight a strong MHC signal in psoriasis, while findings for PsA and treatment response remain hypothesis-generating and require independent validation.<\/jats:p>","DOI":"10.3390\/ijms27104422","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:40:31Z","timestamp":1779115231000},"page":"4422","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-Wide Association Study of Psoriasis, Psoriatic Arthritis, Anti\u2013TNF-\u03b1 Response, and Polygenic Risk Score in a Russian Cohort"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-8489","authenticated-orcid":false,"given":"Arfenya E.","family":"Karamova","sequence":"first","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, 3, bld. 6, Korolenko St., 107076 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-9222","authenticated-orcid":false,"given":"Anastasiia A.","family":"Buianova","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Genomics and Bioinformatics, Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University, 2, bld. 1, Taldomskaya St., 125412 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasiia A.","family":"Vorontsova","sequence":"additional","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, 3, bld. 6, Korolenko St., 107076 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey A.","family":"Kubanov","sequence":"additional","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, 3, bld. 6, Korolenko St., 107076 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"O\u017c\u00f3g, M.K., Derkacz, A., Klimczak, D., Winkler, S., and Wojciuch, L. 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