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New Zealand White rabbits were fed a high-fat\/high-sucrose diet for 28 weeks to induce experimental MetS. Systemic phenotype, cardiac structure (echocardiography), myocardial fibrosis (Picrosirius red histology), myosin\/collagen gene expression (qRT-PCR), and chamber-specific proteomics were assessed across left\/right atria and ventricles. The model reproduced central obesity, glucose intolerance, dyslipidemia, and mild hypertension, with concentric left ventricular hypertrophy and selective ventricular fibrosis, as follows: increased collagen in left ventricle (LV) and right ventricle (RV), unchanged in atria. Ventricular \u03b1-myosin heavy-chain gene expression was upregulated, while collagen I and \u03b1-smooth muscle actin transcripts showed ventricular-specific downregulation. Proteomics revealed atrial metabolic and cytoskeletal adaptations with minimal extracellular matrix involvement; ventricles displayed early profibrotic cues (galectin-3 in LV), metabolic inefficiency (impaired glycolysis\/ATP production in LV; lipid oxidation shift in RV), and diminished provisional matrix support. Conclusions: concentric LV hypertrophy and great vessel enlargement occurred without systolic\/diastolic dysfunction; ventricular-selective fibrosis, \u03b1-myosin heavy-chain upregulation, type I collagen\/\u03b1-smooth muscle actin downregulation, and chamber-specific proteomic changes showed atrial adaptation versus ventricular early profibrotic\/metabolic inefficiency.<\/jats:p>","DOI":"10.3390\/ijms27104427","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:40:31Z","timestamp":1779115231000},"page":"4427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chamber-Specific Structural, Fibrotic, and Molecular Remodeling of the Heart in Experimental Metabolic Syndrome"],"prefix":"10.3390","volume":"27","author":[{"given":"\u00d3scar J.","family":"Arias-Mutis","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, CEU Cardinal Herrera University, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Such-Miquel","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBER-CV), 28029 Madrid, Spain"},{"name":"Department of Physiotherapy, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-4161","authenticated-orcid":false,"given":"Antonio","family":"Alberola","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBER-CV), 28029 Madrid, Spain"},{"name":"Department of Physiology, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Chorro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBER-CV), 28029 Madrid, Spain"},{"name":"Department of Medicine, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrado J.","family":"Calvo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBER-CV), 28029 Madrid, Spain"},{"name":"Department of Physiology, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"Instrumentation for Molecular Imaging Technologies Research Institute (I3M), Joint Research Center Spanish National Research Council\u2013Polytechnic University of Valencia (CSIC-UPV), 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Zarzoso","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBER-CV), 28029 Madrid, Spain"},{"name":"Department of Physiotherapy, 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J. Sports Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Fahed, G., Aoun, L., Bou Zerdan, M., Allam, S., Bou Zerdan, M., Bouferraa, Y., and Assi, H.I. (2022). Metabolic Syndrome: Updates on Pathophysiology and Management in 2021. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020786"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"346985","DOI":"10.4061\/2011\/346985","article-title":"Cardiac Hypertrophy and Fibrosis in the Metabolic Syndrome: A Role for Aldosterone and the Mineralocorticoid Receptor","volume":"2011","author":"Essick","year":"2011","journal-title":"Int. J. Hypertens."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1007\/s10741-021-10195-6","article-title":"Imaging Techniques for the Assessment of Adverse Cardiac Remodeling in Metabolic Syndrome","volume":"27","author":"Preda","year":"2022","journal-title":"Heart Fail. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.trsl.2014.05.001","article-title":"Obesity, Metabolic Dysfunction, and Cardiac Fibrosis: Pathophysiological Pathways, Molecular Mechanisms, and Therapeutic Opportunities","volume":"164","author":"Cavalera","year":"2014","journal-title":"Transl. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/ejechocard\/jer291","article-title":"Integrated Backscatter as a Fibrosis Marker in the Metabolic Syndrome: Association with Biochemical Evidence of Fibrosis and Left Ventricular Dysfunction","volume":"13","author":"Kosmala","year":"2012","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhou, D., Lin, S., Liu, Z., Yuan, J., Ren, H., Tan, H., Guo, Y., and Jiang, X. (2025). Metabolic Syndrome, Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejective Fraction. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1544908"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1002\/oby.21936","article-title":"Preclinical Alterations in Myocardial Microstructure in People with Metabolic Syndrome","volume":"25","author":"Ho","year":"2017","journal-title":"Obesity"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Qi, R., Lin, E., Song, J., Wang, Y., and Lin, L. (2022). Proteomic Insights into Cardiac Fibrosis: From Pathophysiological Mechanisms to Therapeutic Opportunities. Molecules, 27.","DOI":"10.3390\/molecules27248784"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.26502\/fccm.92920302","article-title":"Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration","volume":"7","author":"Singh","year":"2023","journal-title":"Cardiol. Cardiovasc. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A Novel Paradigm for Heart Failure with Preserved Ejection Fraction","volume":"62","author":"Paulus","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac Fibrosis: Cell Biological Mechanisms, Molecular Pathways and Therapeutic Opportunities","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"351982","DOI":"10.1155\/2011\/351982","article-title":"Rodent Models for Metabolic Syndrome Research","volume":"2011","author":"Panchal","year":"2011","journal-title":"BioMed Res. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.jacc.2020.03.019","article-title":"Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3\/4","volume":"75","author":"Kovacic","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yjmcc.2013.10.018","article-title":"Cardiac Fibrosis and Arrhythmogenesis: The Road to Repair Is Paved with Perils","volume":"70","author":"Nguyen","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_16","first-page":"423","article-title":"Cardiac Remodeling in a Rat Model of Diet-Induced Obesity","volume":"26","author":"Leopoldo","year":"2010","journal-title":"Can. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20835","DOI":"10.1038\/srep20835","article-title":"Effects of Heterogeneous Diffuse Fibrosis on Arrhythmia Dynamics and Mechanism","volume":"6","author":"Kazbanov","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Calligaris, S.D., Lecanda, M., Solis, F., Ezquer, M., Guti\u00e9rrez, J., Brandan, E., Leiva, A., Sobrevia, L., and Conget, P. (2013). Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060931"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Arias-Mutis, O.J., Marrachelli, V.G., Ruiz-Saur\u00ed, A., Alberola, A., Morales, J.M., Such-Miquel, L., Monleon, D., Chorro, F.J., Such, L., and Zarzoso, M. (2017). Development and Characterization of an Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178315"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Liu, J., Oba, Y., Kondo, Y., Nakaki, R., and Yamano, S. (2025). Lethal Arrhythmogenic Role of Left Ventricular Myocardial Interstitial Fibrosis in Apolipoprotein E\/Low-Density Lipoprotein Receptor Double-Knockout Mice with Metabolic Dysfunction-Associated Steatohepatitis. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26010144"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1113\/JP283710","article-title":"Cardiac Fibrosis in Three Dimensions\u2014Mechanistic Insights into Arrhythmic Risk Due to Hypertrophy","volume":"601","author":"Shivkumar","year":"2023","journal-title":"J. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1113\/JP286516","article-title":"Ventricular Arrhythmogenic Remodelling in Diet-Induced Metabolic Syndrome Driven by Right-to-Left Regional Differences in Action Potential Duration and Dominant Frequency Gradients","volume":"603","author":"Calvo","year":"2025","journal-title":"J. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/FJC.0b013e3181feb90a","article-title":"High-Carbohydrate High-Fat Diet-Induced Metabolic Syndrome and Cardiovascular Remodeling in Rats","volume":"57","author":"Panchal","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Chan, A.M.L., Ng, A.M.H., Mohd Yunus, M.H., Idrus, R.B.H., Law, J.X., Yazid, M.D., Chin, K.-Y., Shamsuddin, S.A., and Lokanathan, Y. (2021). Recent Developments in Rodent Models of High-Fructose Diet-Induced Metabolic Syndrome: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13082497"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e13081","DOI":"10.1111\/obr.13081","article-title":"Diet-induced Rodent Models of Obesity-related Metabolic Disorders\u2014A Guide to a Translational Perspective","volume":"21","author":"Alves","year":"2020","journal-title":"Obes. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"H976","DOI":"10.1152\/ajpheart.00398.2009","article-title":"Myocardial Lysyl Oxidase Regulation of Cardiac Remodeling in a Murine Model of Diet-Induced Metabolic Syndrome","volume":"297","author":"Zibadi","year":"2009","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"108625","DOI":"10.1016\/j.jnutbio.2021.108625","article-title":"The Effects of Two Types of Western Diet on the Induction of Metabolic Syndrome and Cardiac Remodeling in Obese Rats","volume":"92","author":"Vileigas","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lozano, W.M., Arias-Mutis, O.J., Calvo, C.J., Chorro, F.J., and Zarzoso, M. (2019). Diet-Induced Rabbit Models for the Study of Metabolic Syndrome. Animals, 9.","DOI":"10.3390\/ani9070463"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ferron, A.J.T., Francisqueti, F.V., Minatel, I.O., Silva, C.C.V.d.A., Bazan, S.G.Z., Kitawara, K.A.H., Garcia, J.L., Corr\u00eaa, C.R., Moreto, F., and Ferreira, A.L.A. (2018). Association between Cardiac Remodeling and Metabolic Alteration in an Experimental Model of Obesity Induced by Western Diet. Nutrients, 10.","DOI":"10.3390\/nu10111675"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/hr.2013.2","article-title":"Progression of Cardiovascular and Endocrine Dysfunction in a Rabbit Model of Obesity","volume":"36","author":"Eppel","year":"2013","journal-title":"Hypertens. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13062-023-00363-z","article-title":"Long-Term Administration of Western Diet Induced Metabolic Syndrome in Mice and Causes Cardiac Microvascular Dysfunction, Cardiomyocyte Mitochondrial Damage, and Cardiac Remodeling Involving Caveolae and Caveolin-1 Expression","volume":"18","author":"Liu","year":"2023","journal-title":"Biol. Direct"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Xia, J., Zhang, Y., Xin, L., Kong, S., Chen, Y., Yang, S., and Li, K. (2015). Global Transcriptomic Profiling of Cardiac Hypertrophy and Fatty Heart Induced by Long-Term High-Energy Diet in Bama Miniature Pigs. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132420"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/apha.12185","article-title":"Ventricular Remodelling in Rabbits with Sustained High-fat Diet","volume":"211","author":"Zarzoso","year":"2014","journal-title":"Acta Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Moughaizel, M., Dagher, E., Jablaoui, A., Thorin, C., Rhimi, M., Desfontis, J.C., and Mallem, Y. (2022). Long-Term High-Fructose High-Fat Diet Feeding Elicits Insulin Resistance, Exacerbates Dyslipidemia and Induces Gut Microbiota Dysbiosis in WHHL Rabbits. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0264215"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.7150\/ijbs.105513","article-title":"Exacerbation by Knocking-out Metallothionein Gene of Obesity-Induced Cardiac Remodeling Is Associated with the Activation of CARD9 Signaling","volume":"21","author":"Zhang","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physiolgenomics.00044.2024","article-title":"A Matter of Food and Substrain: Obesogenic Diets Induce Differential Severity of Cardiac Remodeling in C57Bl\/6J and C57Bl\/6N Substrains","volume":"56","author":"Cascarano","year":"2024","journal-title":"Physiol. Genom."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kruszewska, J., Cudnoch-Jedrzejewska, A., and Czarzasta, K. (2022). Remodeling and Fibrosis of the Cardiac Muscle in the Course of Obesity\u2014Pathogenesis and Involvement of the Extracellular Matrix. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084195"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e14107","DOI":"10.1111\/jfbc.14107","article-title":"Pathological Involvement of Apoptotic and Inflammatory Molecules in Cardiovascular Remodeling in Rats on High Fructose Diet-Induced Metabolic Syndrome","volume":"46","author":"Vashishth","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Aimaretti, E., Chimienti, G., Rubeo, C., Di Lorenzo, R., Trisolini, L., Dal Bello, F., Moradi, A., Collino, M., Lezza, A.M.S., and Aragno, M. (2023). Different Effects of High-Fat\/High-Sucrose and High-Fructose Diets on Advanced Glycation End-Product Accumulation and on Mitochondrial Involvement in Heart and Skeletal Muscle in Mice. Nutrients, 15.","DOI":"10.3390\/nu15234874"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ahmad Najib, M.S., Elias, M.H., Juliana, N., Sheikh Abdul Kadir, S.H., Ibrahim, E., and Abdul Hamid, N. (2025). The Effects of High-Fat Diet on the Molecular Pathways in Cardiac Tissue: A Systematic Review of In Vivo Rodent Studies and Integrated Bioinformatic Analysis. Biomedicines, 13.","DOI":"10.3390\/biomedicines13092071"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"H974","DOI":"10.1152\/ajpheart.00359.2025","article-title":"Guidelines for Diet-Induced Models of Cardiometabolic Syndrome","volume":"329","author":"Sveeggen","year":"2025","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Seropian, I.M., Cassaglia, P., Miksztowicz, V., and Gonz\u00e1lez, G.E. (2023). Unraveling the Role of Galectin-3 in Cardiac Pathology and Physiology. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1304735"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"18050","DOI":"10.1038\/s41598-019-54522-2","article-title":"Landscape of Heart Proteome Changes in a Diet-Induced Obesity Model","volume":"9","author":"Vileigas","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s13098-025-01913-3","article-title":"Deep Phenotyping of a Modified Diabetic Cardiomyopathy Mouse Model Which Reflects Clinical Disease Progression","volume":"17","author":"Karuna","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e006040","DOI":"10.1161\/CIRCEP.117.006040","article-title":"Interleukin 10 Treatment Ameliorates High-Fat Diet-Induced Inflammatory Atrial Remodeling and Fibrillation","volume":"11","author":"Kondo","year":"2018","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Verheule, S., and Schotten, U. (2021). Electrophysiological Consequences of Cardiac Fibrosis. Cells, 10.","DOI":"10.3390\/cells10113220"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.93.25.14440","article-title":"Linking Genome and Proteome by Mass Spectrometry: Large-Scale Identification of Yeast Proteins from Two Dimensional\u2009Gels","volume":"93","author":"Shevchenko","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/10\/4427\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:15:48Z","timestamp":1779268548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/10\/4427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":47,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ijms27104427"],"URL":"https:\/\/doi.org\/10.3390\/ijms27104427","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]}}}