{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:07:08Z","timestamp":1779340028822,"version":"3.51.4"},"reference-count":53,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pediatric sepsis is a life-threatening systemic infectious response syndrome. Its core pathophysiological process involves a systemic imbalance between oxygen delivery and demand, coupled with cellular energy metabolism dysfunction, which collectively contribute to high mortality rates. Parameters of oxygen metabolism serve as critical indicators reflecting tissue perfusion and cellular oxygen utilization. Consequently, these parameters hold significant value for the early identification, severity stratification, therapeutic guidance, and prognostic evaluation of pediatric sepsis. This review systematically elucidates the pathophysiological mechanisms underlying oxygen metabolism disorders in pediatric sepsis. Furthermore, it highlights the current clinical applications and significance of key monitoring indices, including blood lactate, central venous oxygen saturation, oxygen delivery, and oxygen consumption. By integrating recent research advancements, this paper also explores therapeutic strategies aimed at optimizing oxygen metabolism, such as blood purification, microcirculation-targeted therapies, and extracorporeal membrane oxygenation. Finally, we provide future perspectives on emerging biomarkers and metabolomic approaches, aiming to establish a theoretical foundation for the optimized clinical management of pediatric sepsis.<\/jats:p>","DOI":"10.3390\/ijms27104454","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:40:31Z","timestamp":1779115231000},"page":"4454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monitoring and Targeted Regulation of Oxygen Metabolism in Pediatric Sepsis: Current Paradigms and Future Perspectives"],"prefix":"10.3390","volume":"27","author":[{"given":"Hong","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Surgical Intensive Care Unit, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2185-2122","authenticated-orcid":false,"given":"Yiyao","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s12519-023-00689-8","article-title":"Sepsis heterogeneity","volume":"19","author":"Wang","year":"2023","journal-title":"World J. Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/tropej\/fmaa025","article-title":"Outcomes Following Intensive Care Unit Admission in a Pediatric Cohort in Malawi","volume":"66","author":"Purcell","year":"2020","journal-title":"J. Trop. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Neu, C., Baumbach, P., Plooij, A.K., Skitek, K., Gotze, J., von Loeffelholz, C., Schmidt-Winter, C., and Coldewey, S.M. (2020). Non-invasive Assessment of Mitochondrial Oxygen Metabolism in the Critically Ill Patient Using the Protoporphyrin IX-Triplet State Lifetime Technique\u2014A Feasibility Study. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00757"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Belu, A., Filip, N., Trandafir, L.M., Spoiala, E.L., Tarca, E., Zamosteanu, D., Ghiga, G., Bernic, J., Jehac, A., and Cojocaru, E. (2025). Lactate, an Essential Metabolic Marker in the Diagnosis and Management of Pediatric Conditions. Diagnostics, 15.","DOI":"10.3390\/diagnostics15070816"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/SHK.0000000000002559","article-title":"Mortality of Septic Shock Secondary to Pediatric Primary Peritonitis Predicted by Respiratory Quotient Combined with Lactate: A Survey from Two Children\u2019s Hospitals in Northwest China","volume":"63","author":"Wang","year":"2025","journal-title":"Shock"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Casas, C., Fernandez-Sarmiento, J., Sarta-Mantilla, M., Mulett, H., Acevedo, L., Beltran, B., Medina, J., Compres, C.D.C., Serrano, P.N., and Sarta-Mantilla, M.E. (2025). Advancing Microcirculatory Therapies in Pediatric Sepsis: Current Opportunities and Future Directions. J. Intensive Care Med.","DOI":"10.1177\/08850666251340601"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Arteaga, G.M., and Crow, S. (2023). End organ perfusion and pediatric microcirculation assessment. Front. Pediatr., 11.","DOI":"10.3389\/fped.2023.1123405"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ccm.2025.11.004","article-title":"Microcirculatory Dysfunction in Sepsis","volume":"47","author":"Kravitz","year":"2026","journal-title":"Clin. Chest Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/SHK.0000000000002765","article-title":"Effects of Dobutamine and Vasopressin on Microcirculation and Mitochondrial Function in the Liver and Colon of Septic Rats: A Randomized Placebo-Controlled Trial","volume":"65","author":"Marcus","year":"2026","journal-title":"Shock"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5847\/wjem.j.1920-8642.2025.093","article-title":"Endothelial cell injury: A crucial link in microcirculatory dysfunction associated with sepsis","volume":"17","author":"Pan","year":"2026","journal-title":"World J. Emerg. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Orellana Plaza, I., Dankelman, J., and Bakker, J. (2026). Peripheral perfusion noninvasive monitoring technologies\u2014A literature and patent review. J. Clin. Monit. Comput.","DOI":"10.1007\/s10877-026-01412-4"},{"key":"ref_12","first-page":"502090","article-title":"Hemodynamic coherence in 2025: A year in review from the Fluid Therapy and Hemodynamic Group of the Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR)","volume":"73","author":"Espinosa","year":"2026","journal-title":"Rev. Esp. Anestesiol. Reanim. (Engl. Ed.)"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Serova, V., Klibus, M., Marcinkevics, Z., Rubins, U., Grabovskis, A., and Sabelnikovs, O. (2026). Microcirculation Monitoring in Septic Shock: Focused Review. Medicina, 62.","DOI":"10.3390\/medicina62020346"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Fatmi, A., Saadi, W., Beltr\u00e1n-Garc\u00eda, J., Garc\u00eda-Gim\u00e9nez, J.L., and Pallard\u00f3, F.V. (2023). The Endothelial Glycocalyx and Neonatal Sepsis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010364"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/PCC.0000000000003123","article-title":"Endothelial and Glycocalyx Biomarkers in Children with Sepsis After One Bolus of Unbalanced or Balanced Crystalloids","volume":"24","author":"Acevedo","year":"2023","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Vieira de Almeida, M.C., Zotin, M.C.Z., and Miranda, C.H. (2025). Systemic endothelial glycocalyx shedding mediates vascular hyperpermeability after traumatic brain injury. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1706102"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/SHK.0000000000001486","article-title":"Mitochondrial Dysfunction is Associated with an Immune Paralysis Phenotype in Pediatric Sepsis","volume":"54","author":"Weiss","year":"2020","journal-title":"Shock"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/s41390-020-01358-6","article-title":"Mitochondrial gene mutations in pediatric septic shock","volume":"90","author":"Park","year":"2021","journal-title":"Pediatr. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/archdischild-2020-319601","article-title":"How to interpret lactate","volume":"106","author":"Marikar","year":"2021","journal-title":"Arch. Dis. Child. Educ. Pract. Ed."},{"key":"ref_20","first-page":"e79172","article-title":"Comparison of the Pediatric Sequential Organ Failure Assessment (p SOFA) Score and Lactate Clearance as Predictors of Morbidity and Mortality in Pediatric Sepsis: A Prospective Observational Study","volume":"17","author":"Aggarwal","year":"2025","journal-title":"Cureus"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e1112","DOI":"10.1097\/PEC.0000000000002520","article-title":"Initial Fluid Balance Associated Outcomes in Children With Severe Sepsis and Septic Shock","volume":"38","author":"Hasan","year":"2022","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"22579","DOI":"10.1038\/s41598-024-73112-5","article-title":"Association between the lactate-albumin ratio and microcirculation changes in Pediatric Septic patients","volume":"14","author":"Perez","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_23","first-page":"114","article-title":"A Different Perspective of Elevated Lactate in Pediatric Patients with Diabetic Ketoacidosis","volume":"16","author":"Unal","year":"2020","journal-title":"Acta Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/PEC.0000000000003254","article-title":"Central Venous Oxygen Saturation in Children with Cancer","volume":"40","author":"Vissing","year":"2024","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ma, H., Wang, Z., Geng, J., Zhao, J., Wang, T., Liu, L., Xu, Y., Liu, W., Wang, M., and Zhao, L. (2024). Effects of integrated blood purification on haemodynamics and oxygen metabolism in children with severe sepsis. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1400154"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/jama.2024.0179","article-title":"International Consensus Criteria for Pediatric Sepsis and Septic Shock","volume":"331","author":"Schlapbach","year":"2024","journal-title":"JAMA"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zheng, H., Sharma, P., Johnson, M., Danieletto, M., Alleva, E., Charney, A.W., Nadkarni, G.N., Sarabu, C., Eskofier, B.M., and Ahuja, Y. (2025). Integration of Artificial Intelligence and Wearable Devices in Pediatric Clinical Care: A Review. Bioengineering, 12.","DOI":"10.37766\/inplasy2025.10.0096"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Sheridan, D.C., Cloutier, R., Kibler, A., and Hansen, M.L. (2020). Cutting-Edge Technology for Rapid Bedside Assessment of Capillary Refill Time for Early Diagnosis and Resuscitation of Sepsis. Front. Med., 7.","DOI":"10.3389\/fmed.2020.612303"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1177\/000313481508101231","article-title":"Evaluation of Microvascular Perfusion and Resuscitation after Severe Injury","volume":"81","author":"Lee","year":"2015","journal-title":"Am. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Xu, J., Li, J., Kong, X., Zhang, C., Qi, B., Zhu, X., Zhu, Y., and Xu, Y. (2025). Dysbiosis and metabolic pathway shifts in the gut microbiome of children with sepsis: A comparative analysis. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1715990"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cca.2022.11.028","article-title":"Heparin-binding protein as a biomarker of severe sepsis in the pediatric intensive care unit: A multicenter, prospective study","volume":"539","author":"Liu","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"30302","DOI":"10.1038\/s41598-025-14600-0","article-title":"Machine learning based screening of biomarkers associated with cell death and immunosuppression of multiple life stages sepsis populations","volume":"15","author":"Yang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00101-009-1537-9","article-title":"Pathomechanisms of organ failure. Mitochondrial dysfunction in sepsis","volume":"58","author":"Wendel","year":"2009","journal-title":"Anaesthesist"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"You, J., Li, Y., and Chong, W. (2024). The role and therapeutic potential of SIRTs in sepsis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1394925"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tian, Y., Zhang, Y., Wang, Y., Chen, Y., Fan, W., Zhou, J., Qiao, J., and Wei, Y. (2021). Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.789507"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bj.2021.10.004","article-title":"Hemodynamic monitoring and management of pediatric septic shock","volume":"45","author":"Lee","year":"2022","journal-title":"Biomed. J."},{"key":"ref_37","first-page":"100968","article-title":"Sepsis in the urgent care setting","volume":"51","author":"Klick","year":"2021","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zinter, M.S., Dvorak, C.C., and Auletta, J.J. (2020). How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.581447"},{"key":"ref_39","first-page":"e1056","article-title":"Sociodemographic Factors are Associated with Care Delivery and Outcomes in Pediatric Severe Sepsis","volume":"6","author":"Webb","year":"2024","journal-title":"Crit. Care Explor."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e12829","DOI":"10.1111\/micc.12829","article-title":"The association between hypoalbuminemia and microcirculation, endothelium, and glycocalyx disorders in children with sepsis","volume":"30","author":"Salazar","year":"2023","journal-title":"Microcirculation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e864","DOI":"10.1097\/CCM.0000000000004491","article-title":"Automated Algorithm Analysis of Sublingual Microcirculation in an International Multicentral Database Identifies Alterations Associated With Disease and Mechanism of Resuscitation","volume":"48","author":"Hilty","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fernandez-Sarmiento, J., Ranjit, S., Sanchez-Pinto, L.N., Nadkarni, V.M., Jabornisky, R., and Kissoon, N. (2025). The Resuscitation, Equilibrium and De-escalation (RED) strategy: A phased, personalized hemodynamic support in children with sepsis. Front. Pediatr., 13.","DOI":"10.3389\/fped.2025.1530984"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1097\/PCC.0000000000002266","article-title":"The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis","volume":"21","author":"Carcillo","year":"2020","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Fernandez-Sarmiento, J., Lamprea, S., Barrera, S., Acevedo, L., Duque, C., Trujillo, M., Aguirre, V., and Jimenez, C. (2024). The association between prolonged capillary refill time and microcirculation changes in children with sepsis. BMC Pediatr., 24.","DOI":"10.1186\/s12887-024-04524-5"},{"key":"ref_45","first-page":"911","article-title":"Clinical application of extracorporeal membrane oxygenation in the treatment of burn patients with acute respiratory distress syndrome: A retrospective analysis and systematic review","volume":"37","author":"Li","year":"2021","journal-title":"Zhonghua Shao Shang Za Zhi"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1177\/02676591231172607","article-title":"Prolonged extracorporeal membrane oxygenation in pediatrics: How long did we wait?","volume":"39","author":"Kahveci","year":"2024","journal-title":"Perfusion"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"104178","DOI":"10.1016\/j.mvr.2021.104178","article-title":"The protective role of YTHDF1-knock down macrophages on the immune paralysis of severe sepsis rats with ECMO","volume":"137","author":"Xing","year":"2021","journal-title":"Microvasc. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00134-024-07336-4","article-title":"Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: Analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry","volume":"50","author":"Stenson","year":"2024","journal-title":"Intensive Care Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"898","DOI":"10.21037\/hbsn-23-34","article-title":"Peri-operative extracorporeal membrane oxygenation in adult and pediatric living donor liver transplantation: A single-center experience","volume":"12","author":"Chen","year":"2023","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/jcpt.13344","article-title":"Pharmacokinetics of meropenem in children with sepsis undergoing extracorporeal life support: A prospective observational study","volume":"46","author":"Wang","year":"2021","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/INF.0000000000003354","article-title":"Individual Meropenem Clearance in Infants on ECMO and CVVHDF is Difficult to Predict: A Case Report and Review of the Literature","volume":"41","author":"Jabareen","year":"2022","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.21037\/tp-2025-638","article-title":"Herpes simplex virus 2-associated symmetrical peripheral gangrene in an immunocompetent fourteen-year-old girl: A case report","volume":"14","author":"Huang","year":"2025","journal-title":"Transl. Pediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41390-024-03693-4","article-title":"Wearable biosensors for pediatric hospitals: A scoping review","volume":"98","author":"Hyun","year":"2025","journal-title":"Pediatr. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/10\/4454\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:13:57Z","timestamp":1779336837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/10\/4454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":53,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ijms27104454"],"URL":"https:\/\/doi.org\/10.3390\/ijms27104454","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]}}}