{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:04:57Z","timestamp":1779447897587,"version":"3.53.1"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Projects of the Sichuan Science and Technology Department","award":["2021 YFN0015"],"award-info":[{"award-number":["2021 YFN0015"]}]},{"name":"Key Projects of the Sichuan Science and Technology Department","award":["2022YFS0444"],"award-info":[{"award-number":["2022YFS0444"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study aimed to evaluate the protective effects of soluble dietary fiber (SDF) derived from Polygonatum cyrtonema Hua residues on cyclophosphamide (CTX)-induced intestinal injury in mice. A total of 60 C57BL\/6 mice (6\u20138 weeks old; body weight, 23.8 \u00b1 0.5 g) were randomly allocated to six groups (n = 10 per group): a control group (CON), a CTX model group (CTX), a levamisole-treated positive control group (PC), and low-, medium-, and high-dose SDF groups (125, 250, and 500 mg\/kg body weight, respectively). Mice received oral administration of SDF or an equal volume of water for 21 consecutive days and were intraperitoneally injected with CTX (80 mg\/kg body weight) on days 19\u201321 to induce intestinal injury. The results demonstrate that SDF possessed a porous, sponge-like network structure and comprised multiple monosaccharides. SDF intervention, particularly at medium and high doses, significantly attenuated CTX-induced body weight loss and immune organ atrophy; restored villus height and the villus-to-crypt ratio; increased the numbers of goblet cells and intraepithelial lymphocytes; elevated intestinal levels of sIgA, \u03b2-defensins, and lysozyme; and reduced serum levels of LPS, D-lactic acid, and DAO (p &lt; 0.05). In conclusion, SDF derived from Polygonatum cyrtonema effectively mitigates CTX-induced intestinal injury by enhancing intestinal mucosal immunity and preserving intestinal barrier integrity, thereby highlighting its potential as a functional ingredient for promoting gut health.<\/jats:p>","DOI":"10.3390\/ijms27104537","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:35:43Z","timestamp":1779176143000},"page":"4537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Soluble Dietary Fiber from Polygonatum cyrtonema Hua Attenuates Cyclophosphamide-Induced Intestinal Injury in Mice"],"prefix":"10.3390","volume":"27","author":[{"given":"Lingqiao","family":"Zeng","sequence":"first","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxin","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41575-021-00512-7","article-title":"Leveraging diet to engineer the gut microbiome","volume":"18","author":"Wolter","year":"2021","journal-title":"Nat. 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