{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:54:30Z","timestamp":1785434070002,"version":"3.56.0"},"reference-count":219,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Korea government","doi-asserted-by":"publisher","award":["RS-2024-00454011"],"award-info":[{"award-number":["RS-2024-00454011"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K2426751"],"award-info":[{"award-number":["K2426751"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K2503401"],"award-info":[{"award-number":["K2503401"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"award":["K2426751"],"award-info":[{"award-number":["K2426751"]}],"id":[{"id":"https:\/\/ror.org\/047dqcg40","id-type":"ROR","asserted-by":"publisher"}]},{"award":["K2503401"],"award-info":[{"award-number":["K2503401"]}],"id":[{"id":"https:\/\/ror.org\/047dqcg40","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disorder characterized by the aggregation of Lewy bodies, composed of the protein \u03b1-synuclein, and the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta. The management of PD seeks to mitigate motor symptoms by substituting diminished endogenous dopamine; nevertheless, it does not halt disease progression. Various animal models have been employed to elucidate the etiology of PD and to discover disease-modifying treatments. Zebrafish serve as a PD model owing to their capacity for high-throughput screening. This review presents updates on the currently available zebrafish models of PD, encompassing both chemically induced and genetically based models, and discusses their advantages and limitations. This review also delineates numerous investigative strategies that utilize the zebrafish PD model and summarizes the findings of previous studies. Taken together, further studies, including the investigation of the regeneration mechanism of DA neurons, neurobehavioral testing of adult zebrafish reflecting PD-associated neurocognitive impairment, and a reliable gene-based model providing precise gene knockout and reproducibility, may assist in elucidating the critical pathways that trigger PD and its progression, alongside potential targets to hinder this progression.<\/jats:p>","DOI":"10.3390\/ijms27104578","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:30:51Z","timestamp":1779280251000},"page":"4578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zebrafish Models of Parkinson\u2019s Disease: From Pathogenesis to Drug Discovery"],"prefix":"10.3390","volume":"27","author":[{"given":"Hae-Chul","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Korea University College of Medicine, Seoul 04763, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Korea University College of Medicine, Seoul 04763, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo Jeong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Korea University College of Medicine, Seoul 04763, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Hee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Korea University College of Medicine, Korea University Medical Center, Ansan Hospital, Ansan 15355, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-1703","authenticated-orcid":false,"given":"Myung Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Korea University College of Medicine, Korea University Medical Center, Ansan Hospital, Ansan 15355, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/mds.25032","article-title":"Pathogenesis of Parkinson\u2019s disease","volume":"28","author":"Hirsch","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/mds.26477","article-title":"Autophagy and Alpha-Synuclein: Relevance to Parkinson\u2019s Disease and Related Synucleopathies","volume":"31","author":"Xilouri","year":"2016","journal-title":"Mov. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neulet.2017.08.044","article-title":"Mitochondrial calcium imbalance in Parkinson\u2019s disease","volume":"663","author":"Ludtmann","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1471-4159.1990.tb02325.x","article-title":"Mitochondrial complex I deficiency in Parkinson\u2019s disease","volume":"54","author":"Schapira","year":"1990","journal-title":"J. Neurochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3340\/jkns.2023.0189","article-title":"Neuro-Restorative Effect of Nimodipine and Calcitriol in 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Zebrafish Parkinson\u2019s Disease Model","volume":"67","author":"Kim","year":"2024","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Jan, A., Gon\u00e7alves, N.P., Vaegter, C.B., Jensen, P.H., and Ferreira, N. (2021). The Prion-Like Spreading of Alpha-Synuclein in Parkinson\u2019s Disease: Update on Models and Hypotheses. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158338"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1016\/S1353-8020(13)70022-1","article-title":"Modeling Lewy pathology propagation in Parkinson\u2019s disease","volume":"20","author":"Luk","year":"2014","journal-title":"Park. Relat. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4161\/pri.28125","article-title":"In vitro aggregation assays for the characterization of \u03b1-synuclein prion-like properties","volume":"8","author":"Narkiewicz","year":"2014","journal-title":"Prion"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ana.10106","article-title":"Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset","volume":"51","author":"Bonifati","year":"2002","journal-title":"Ann. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary early-onset Parkinson\u2019s disease caused by mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.molcel.2009.02.013","article-title":"PINK1-associated Parkinson\u2019s disease is caused by neuronal vulnerability to calcium-induced cell death","volume":"33","author":"Gandhi","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(21)00061-2","article-title":"Progress towards therapies for disease modification in Parkinson\u2019s disease","volume":"20","author":"Vijiaratnam","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuro.2016.11.006","article-title":"Parkinson\u2019s disease-like motor and non-motor symptoms in rotenone-treated zebrafish","volume":"58","author":"Wang","year":"2017","journal-title":"Neurotoxicology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1089\/zeb.2011.0697","article-title":"The influence of the zebrafish genetic background on Parkinson\u2019s disease-related aspects","volume":"8","author":"Bretaud","year":"2011","journal-title":"Zebrafish"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Doyle, J.M., and Croll, R.P. (2022). A Critical Review of Zebrafish Models of Parkinson\u2019s Disease. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.835827"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Barnhill, L.M., Murata, H., and Bronstein, J.M. (2020). Studying the Pathophysiology of Parkinson\u2019s Disease Using Zebrafish. Biomedicines, 8.","DOI":"10.3390\/biomedicines8070197"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0006-8993(00)03174-7","article-title":"The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum)","volume":"889","author":"Rink","year":"2001","journal-title":"Brain Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0361-9230(01)00696-7","article-title":"Connections of the ventral telencephalon and tyrosine hydroxylase distribution in the zebrafish brain (Danio rerio) lead to identification of an ascending dopaminergic system in a teleost","volume":"57","author":"Rink","year":"2002","journal-title":"Brain Res. Bull."},{"key":"ref_22","first-page":"61","article-title":"Genetic analysis of dopaminergic system development in zebrafish","volume":"70","author":"Ryu","year":"2006","journal-title":"J. Neural Transm. Suppl."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Vaz, R.L., Outeiro, T.F., and Ferreira, J.J. (2018). Zebrafish as an Animal Model for Drug Discovery in Parkinson\u2019s Disease and Other Movement Disorders: A Systematic Review. Front. Neurol., 9.","DOI":"10.3389\/fneur.2018.00347"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Razali, K., Othman, N., Mohd Nasir, M.H., Doolaanea, A.A., Kumar, J., Ibrahim, W.N., Mohamed Ibrahim, N., and Mohamed, W.M.Y. (2021). The Promise of the Zebrafish Model for Parkinson\u2019s Disease: Today\u2019s Science and Tomorrow\u2019s Treatment. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.655550"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2174\/0118715273367688250528122144","article-title":"Zebrafish-Based Parkinson\u2019s Disease Models: Unveiling Genetic Mechanisms and Therapeutic Pathways","volume":"24","author":"Dodiya","year":"2025","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rosa, J.G.S., Lima, C., and Lopes-Ferreira, M. (2022). Zebrafish Larvae Behavior Models as a Tool for Drug Screenings and Pre-Clinical Trials: A Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126647"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.neuron.2020.12.002","article-title":"Neural circuitry for stimulus selection in the zebrafish visual system","volume":"109","author":"Fernandes","year":"2021","journal-title":"Neuron"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/j.1460-9568.2005.03988.x","article-title":"Zebrafish embryos are susceptible to the dopaminergic neurotoxin MPTP","volume":"21","author":"Lam","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kalyn, M., Hua, K., Mohd Noor, S., Wong, C.E.D., and Ekker, M. (2019). Comprehensive Analysis of Neurotoxin-Induced Ablation of Dopaminergic Neurons in Zebrafish Larvae. Biomedicines, 8.","DOI":"10.3390\/biomedicines8010001"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1089\/zeb.2013.0923","article-title":"Long-term exposure to paraquat alters behavioral parameters and dopamine levels in adult zebrafish (Danio rerio)","volume":"11","author":"Bortolotto","year":"2014","journal-title":"Zebrafish"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Razali, K., Kumar, J., and Mohamed, W.M.Y. (2024). Characterizing the adult zebrafish model of Parkinson\u2019s disease: A systematic review of dynamic changes in behavior and physiology post-MPTP administration. Front. Neurosci., 18.","DOI":"10.3389\/fnins.2024.1432102"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chaoul, V., Dib, E.Y., Bedran, J., Khoury, C., Shmoury, O., Harb, F., and Soueid, J. (2023). Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914898"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kalyn, M., and Ekker, M. (2021). Cerebroventricular Microinjections of MPTP on Adult Zebrafish Induces Dopaminergic Neuronal Death, Mitochondrial Fragmentation, and Sensorimotor Impairments. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.718244"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/zeb.2008.0555","article-title":"A primer for morpholino use in zebrafish","volume":"6","author":"Bill","year":"2009","journal-title":"Zebrafish"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Eve, A.M., Place, E.S., and Smith, J.C. (2017). Comparison of Zebrafish tmem88a mutant and morpholino knockdown phenotypes. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172227"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/2472555220926920","article-title":"CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets","volume":"25","author":"Rubbini","year":"2020","journal-title":"SLAS Discov."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-016-1739-6","article-title":"CRISPR\/Cas9 in zebrafish: An efficient combination for human genetic diseases modeling","volume":"136","author":"Liu","year":"2017","journal-title":"Hum. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2174\/1570159X17666191001145550","article-title":"Modeling Neuronal Diseases in Zebrafish in the Era of CRISPR","volume":"18","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cornet, C., Di Donato, V., and Terriente, J. (2018). Combining Zebrafish and CRISPR\/Cas9: Toward a More Efficient Drug Discovery Pipeline. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00703"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"ref_41","first-page":"S11","article-title":"The MPTP Story","volume":"7","author":"Langston","year":"2017","journal-title":"J. Park. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Christensen, C., \u00deorsteinsson, H., Maier, V.H., and Karlsson, K. (2020). Multi-parameter Behavioral Phenotyping of the MPP+ Model of Parkinson\u2019s Disease in Zebrafish. Front. Behav. Neurosci., 14.","DOI":"10.3389\/fnbeh.2020.623924"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0006-291X(86)80483-1","article-title":"Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+","volume":"134","author":"Ramsay","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/0024-3205(85)90146-8","article-title":"Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine","volume":"36","author":"Nicklas","year":"1985","journal-title":"Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wasel, O., and Freeman, J.L. (2020). Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21175981"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.brainresbull.2007.10.043","article-title":"Functional and developmental analysis of the blood-brain barrier in zebrafish","volume":"75","author":"Jeong","year":"2008","journal-title":"Brain Res. Bull."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Xie, J., Farage, E., Sugimoto, M., and Anand-Apte, B. (2010). A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. BMC Dev. Biol., 10.","DOI":"10.1186\/1471-213X-10-76"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Omar, N.A., Kumar, J., and Teoh, S.L. (2023). Parkinson\u2019s disease model in zebrafish using intraperitoneal MPTP injection. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1236049"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/pmic.201500291","article-title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson\u2019s disease in zebrafish","volume":"16","author":"Kakara","year":"2016","journal-title":"Proteomics"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jneumeth.2019.03.008","article-title":"A simple method to study motor and non-motor behaviors in adult zebrafish","volume":"320","author":"Selvaraj","year":"2019","journal-title":"J. Neurosci. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1471-4159.2004.02190.x","article-title":"Neurochemical and behavioural changes in zebrafish Danio rerio after systemic administration of 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"88","author":"Anichtchik","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ye, H., Li, D., Zhang, L., Wang, Y., Wang, C., Jin, M., Lin, H., Li, P., Sun, C., and Li, N. (2025). Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1\/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress. Mar. Drugs, 23.","DOI":"10.20944\/preprints202503.1021.v1"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Maleski, A.L.A., da Cunha, E.S.F.A., Echeverry, M.B., and Alberto-Silva, C. (2025). Integrated Behavioral and Proteomic Characterization of MPP(+)-Induced Early Neurodegeneration and Parkinsonism in Zebrafish Larvae. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202506.1482.v1"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Intonti, S., Enzmann, V., Perna, A., Spagnolo, F., Curcio, C., and Conedera, F.M. (2026). Comparative Analysis of T-Cell Signatures and Astroglial Reactivity in Parkinson\u2019s Pathology Across Animal Models with Distinct Regenerative Capacities. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27020965"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Isik, S., Yeman Kiyak, B., Akbayir, R., Seyhali, R., and Arpaci, T. (2023). Microglia Mediated Neuroinflammation in Parkinson\u2019s Disease. Cells, 12.","DOI":"10.3390\/cells12071012"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e19818","DOI":"10.7717\/peerj.19818","article-title":"The role of T cells in the treatment of Parkinson\u2019s disease","volume":"13","author":"Lin","year":"2025","journal-title":"PeerJ"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 reasons why the brain is susceptible to oxidative stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.aam9080","article-title":"Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson\u2019s disease","volume":"357","author":"Burbulla","year":"2017","journal-title":"Science"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and \u03b1-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s12640-017-9778-x","article-title":"6-OHDA-Lesioned Adult Zebrafish as a Useful Parkinson\u2019s Disease Model for Dopaminergic Neuroregeneration","volume":"32","author":"Vijayanathan","year":"2017","journal-title":"Neurotox. Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Vorhees, N.W., Groenwold, S.L., Williams, M.T., Putt, L.S., Sanchez-Gama, N., Stalions, G.A., Taylor, G.M., Van Dort, H.E., and Calvo-Ochoa, E. (2025). Olfactory Dysfunction in a Novel Model of Prodromal Parkinson\u2019s Disease in Adult Zebrafish. Int. J. Mol. Sci., 26.","DOI":"10.1101\/2025.03.29.645796"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1523\/JNEUROSCI.2706-18.2019","article-title":"Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations","volume":"39","author":"Caldwell","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1126\/science.1228773","article-title":"Acute inflammation initiates the regenerative response in the adult zebrafish brain","volume":"338","author":"Kyritsis","year":"2012","journal-title":"Science"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.conb.2014.03.019","article-title":"Axonal regeneration in zebrafish","volume":"27","author":"Becker","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ncpneuro0924","article-title":"Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis","volume":"4","author":"Henchcliffe","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1289\/ehp.1002839","article-title":"Rotenone, paraquat, and Parkinson\u2019s disease","volume":"119","author":"Tanner","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/01.jom.0000174294.58575.3e","article-title":"Evaluation of epidemiologic and animal data associating pesticides with Parkinson\u2019s disease","volume":"47","author":"Li","year":"2005","journal-title":"J. Occup. Environ. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.tips.2008.03.007","article-title":"Parkinson\u2019s disease and pesticides: A toxicological perspective","volume":"29","author":"Hatcher","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.nbd.2009.06.017","article-title":"Chronic rotenone exposure reproduces Parkinson\u2019s disease gastrointestinal neuropathology","volume":"36","author":"Drolet","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Pan-Montojo, F., Anichtchik, O., Dening, Y., Knels, L., Pursche, S., Jung, R., Jackson, S., Gille, G., Spillantini, M.G., and Reichmann, H. (2010). Progression of Parkinson\u2019s disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS ONE, 5.","DOI":"10.1038\/npre.2010.3352.3"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Nies, Y.H., Lim, W.L., Abd Karim, N., Yahaya, M.F., and Teoh, S.L. (2025). Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson\u2019s disease. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1478013"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/s41598-023-29287-4","article-title":"Oleuropein confers neuroprotection against rotenone-induced model of Parkinson\u2019s disease via BDNF\/CREB\/Akt pathway","volume":"13","author":"Singh","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1080\/00207454.2019.1698567","article-title":"Neuroprotective effects of mitoquinone and oleandrin on Parkinson\u2019s disease model in zebrafish","volume":"130","author":"Alturfan","year":"2020","journal-title":"Int. J. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1007\/s11033-021-06532-5","article-title":"Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish","volume":"48","author":"Alturfan","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00709-015-0930-2","article-title":"Mitochondrial permeability transition pore: A promising target for the treatment of Parkinson\u2019s disease","volume":"254","author":"Rasheed","year":"2017","journal-title":"Protoplasma"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tins.2009.01.006","article-title":"Calcium homeostasis, selective vulnerability and Parkinson\u2019s disease","volume":"32","author":"Chan","year":"2009","journal-title":"Trends Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jphs.2014.11.011","article-title":"The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration","volume":"127","author":"Ruscher","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4103\/1673-5374.145351","article-title":"Sigma-1 receptor: A potential new target for Parkinson\u2019s disease?","volume":"9","author":"Francardo","year":"2014","journal-title":"Neural Regen. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1080\/01480545.2020.1846549","article-title":"Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish","volume":"45","author":"Yurtsever","year":"2022","journal-title":"Drug Chem. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"150284","DOI":"10.1016\/j.brainres.2026.150284","article-title":"Synergistic effect of carboxymethyl chitosan and phloroglucinol against rotenone induced Parkinson\u2019s disease in zebrafish model","volume":"1882","author":"Parthiban","year":"2026","journal-title":"Brain Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000071194","article-title":"Association between Parkinson\u2019s disease and exposure to pesticides in southwestern France","volume":"22","author":"Baldi","year":"2003","journal-title":"Neuroepidemiology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/aje\/kwp006","article-title":"Parkinson\u2019s disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California","volume":"169","author":"Costello","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/10599240801986215","article-title":"Pesticide\/environmental exposures and Parkinson\u2019s disease in East Texas","volume":"13","author":"Dhillon","year":"2008","journal-title":"J. Agromed."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.neuro.2006.05.012","article-title":"Paraquat exposure as an etiological factor of Parkinson\u2019s disease","volume":"27","author":"Carmo","year":"2006","journal-title":"Neurotoxicology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1212\/WNL.48.6.1583","article-title":"Environmental risk factors and Parkinson\u2019s disease: A case-control study in Taiwan","volume":"48","author":"Liou","year":"1997","journal-title":"Neurology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/15548627.2015.1058683","article-title":"Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2\/quinone oxidoreductase 2: Implications for neuroprotection","volume":"11","author":"Janda","year":"2015","journal-title":"Autophagy"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10408440701669959","article-title":"Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment","volume":"38","author":"Duarte","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"12760","DOI":"10.1073\/pnas.96.22.12760","article-title":"A mechanism of paraquat toxicity involving nitric oxide synthase","volume":"96","author":"Day","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"20766","DOI":"10.1073\/pnas.1115141108","article-title":"Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3","volume":"108","author":"Rappold","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.lfs.2016.06.009","article-title":"Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model","volume":"157","author":"Wang","year":"2016","journal-title":"Life Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1007\/s12035-016-9919-x","article-title":"Chronic Treatment with Paraquat Induces Brain Injury, Changes in Antioxidant Defenses System, and Modulates Behavioral Functions in Zebrafish","volume":"54","author":"Nunes","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.toxrep.2015.06.007","article-title":"Paraquat exposure induces behavioral deficits in larval zebrafish during the window of dopamine neurogenesis","volume":"2","author":"Nellore","year":"2015","journal-title":"Toxicol. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/nan.12297","article-title":"Review: Parkinson\u2019s disease: From synaptic loss to connectome dysfunction","volume":"42","author":"Bellucci","year":"2016","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson\u2019s disease and other synucleinopathies: From overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1038\/cddis.2012.94","article-title":"Alpha-synuclein: From secretion to dysfunction and death","volume":"3","author":"Marques","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Longhena, F., Faustini, G., Spillantini, M.G., and Bellucci, A. (2019). Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010141"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1073\/pnas.1913904117","article-title":"The process of Lewy body formation, rather than simply \u03b1-synuclein fibrillization, is one of the major drivers of neurodegeneration","volume":"117","author":"Burtscher","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zhang, J., Li, X., and Li, J.D. (2019). The Roles of Post-translational Modifications on \u03b1-Synuclein in the Pathogenesis of Parkinson\u2019s Diseases. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.00381"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.parkreldis.2015.09.007","article-title":"Autosomal dominant Parkinson\u2019s disease caused by SNCA duplications","volume":"22","author":"Konno","year":"2016","journal-title":"Park. Relat. Disord."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1074\/jbc.M111.308312","article-title":"Hypokinesia and reduced dopamine levels in zebrafish lacking \u03b2- and \u03b31-synucleins","volume":"287","author":"Milanese","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"107018","DOI":"10.1016\/j.nbd.2025.107018","article-title":"A novel stable transgenic zebrafish line expressing mCherry-tagged human alpha-synuclein in the nervous system and exhibiting all the key features of Lewy body disorders at larval stage","volume":"213","author":"Zini","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/3311","article-title":"Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease","volume":"4","author":"Conway","year":"1998","journal-title":"Nat. Med."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Lopez, A., Gorb, A., Palha, N., Fleming, A., and Rubinsztein, D.C. (2022). A New Zebrafish Model to Measure Neuronal \u03b1-Synuclein Clearance In Vivo. Genes, 13.","DOI":"10.3390\/genes13050868"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ymeth.2013.06.012","article-title":"Adoption of the Q transcriptional regulatory system for zebrafish transgenesis","volume":"66","author":"Subedi","year":"2014","journal-title":"Methods"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1001\/jama.281.4.341","article-title":"Parkinson disease in twins: An etiologic study","volume":"281","author":"Tanner","year":"1999","journal-title":"JAMA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"35661","DOI":"10.1074\/jbc.C000447200","article-title":"Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity","volume":"275","author":"Imai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/nm1001-1144","article-title":"Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease","volume":"7","author":"Chung","year":"2001","journal-title":"Nat. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_110","first-page":"276","article-title":"The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson\u2019s disease","volume":"79","author":"Lenkiewicz","year":"2019","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neuint.2013.02.004","article-title":"Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration","volume":"62","author":"Wilkaniec","year":"2013","journal-title":"Neurochem. Int."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Wilkaniec, A., Lenkiewicz, A.M., Babiec, L., Murawska, E., J\u0119\u015bko, H.M., Cie\u015blik, M., Culmsee, C., and Adamczyk, A. (2021). Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson\u2019s Disease Pathology. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.591475"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/brain\/awp108","article-title":"Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)","volume":"132","author":"Flinn","year":"2009","journal-title":"Brain"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1152\/physiol.00005.2007","article-title":"Resurgence of cardiac t-tubule research","volume":"22","author":"Brette","year":"2007","journal-title":"Physiology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nature09536","article-title":"Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1","volume":"468","author":"Guzman","year":"2010","journal-title":"Nature"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/ncomms2149","article-title":"CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson\u2019s disease","volume":"3","author":"Kang","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.nbd.2011.04.007","article-title":"The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson\u2019s disease","volume":"43","author":"Ilijic","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1016\/j.bmc.2013.04.054","article-title":"Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics","volume":"21","author":"Kang","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.expneurol.2017.08.001","article-title":"Calcium, mitochondrial dysfunction and slowing the progression of Parkinson\u2019s disease","volume":"298","author":"Surmeier","year":"2017","journal-title":"Exp. Neurol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbrc.2016.08.168","article-title":"Calcium and Parkinson\u2019s disease","volume":"483","author":"Surmeier","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1016\/j.bmc.2010.03.038","article-title":"Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2","volume":"18","author":"Chang","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1021\/bi8019178","article-title":"Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking","volume":"48","author":"Weihofen","year":"2009","journal-title":"Biochemistry"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"11364","DOI":"10.1073\/pnas.0802076105","article-title":"Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress","volume":"105","author":"Gautier","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1073\/pnas.0500617102","article-title":"Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability","volume":"102","author":"Beilina","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1523\/JNEUROSCI.0719-07.2007","article-title":"Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin","volume":"27","author":"Exner","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1073\/pnas.0709336105","article-title":"The PINK1\/Parkin pathway regulates mitochondrial morphology","volume":"105","author":"Poole","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Priyadarshini, M., Orosco, L.A., and Panula, P.J. (2013). Oxidative stress and regulation of Pink1 in zebrafish (Danio rerio). PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081851"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.1523\/JNEUROSCI.0979-08.2008","article-title":"Loss of PINK1 function affects development and results in neurodegeneration in zebrafish","volume":"28","author":"Anichtchik","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1460-9568.2010.07091.x","article-title":"Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function","volume":"31","author":"Xi","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ccr.2005.02.010","article-title":"DJ-1, a novel regulator of the tumor suppressor PTEN","volume":"7","author":"Kim","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bbrc.2008.08.046","article-title":"Expression and role of DJ-1 in leukemia","volume":"375","author":"Liu","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/brain\/awh054","article-title":"The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson\u2019s disease","volume":"127","author":"Bandopadhyay","year":"2004","journal-title":"Brain"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ana.10782","article-title":"DJ-1 colocalizes with tau inclusions: A link between parkinsonism and dementia","volume":"55","author":"Rizzu","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00401-004-0834-2","article-title":"Pathological properties of the Parkinson\u2019s disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: Relevance for multiple system atrophy and Pick\u2019s disease","volume":"107","author":"Neumann","year":"2004","journal-title":"Acta Neuropathol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainres.2006.07.057","article-title":"Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons","volume":"1113","author":"Bai","year":"2006","journal-title":"Brain Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1111\/j.1471-4159.2006.04291.x","article-title":"p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson\u2019s disease","volume":"100","author":"Bretaud","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-1326-4-12","article-title":"Increased DJ-1 expression under oxidative stress and in Alzheimer\u2019s disease brains","volume":"4","author":"Baulac","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"8306","DOI":"10.1007\/s12035-019-01667-w","article-title":"Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson\u2019s Disease-Related Protein DJ-1","volume":"56","author":"Edson","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"9525","DOI":"10.1038\/s41598-026-39692-0","article-title":"Early motor deficits, sleep dysfunction and reduction in dopaminergic neurons in a PARK7(-\/-) zebrafish larval model of Parkinson\u2019s disease","volume":"16","author":"Solheim","year":"2026","journal-title":"Sci. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/ana.10113","article-title":"A new locus for Parkinson\u2019s disease (PARK8) maps to chromosome 12p11.2-q13.1","volume":"51","author":"Funayama","year":"2002","journal-title":"Ann. Neurol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.neuron.2004.10.023","article-title":"Cloning of the gene containing mutations that cause PARK8-linked Parkinson\u2019s disease","volume":"44","author":"Jain","year":"2004","journal-title":"Neuron"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/ana.20484","article-title":"An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family","volume":"57","author":"Funayama","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-021-00509-5","article-title":"Pathological \u03b1-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain","volume":"17","author":"Xu","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuroscience.2014.09.049","article-title":"The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson\u2019s disease","volume":"302","author":"Schapansky","year":"2015","journal-title":"Neuroscience"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainres.2018.06.010","article-title":"LRRK2 and mitochondria: Recent advances and current views","volume":"1702","author":"Singh","year":"2019","journal-title":"Brain Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.stem.2011.01.013","article-title":"LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress","volume":"8","author":"Nguyen","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1007\/s11064-016-1982-1","article-title":"Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson\u2019s Disease","volume":"41","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"11151","DOI":"10.1523\/JNEUROSCI.3791-16.2017","article-title":"Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD\/LBD-Associated LRRK2 Mutants","volume":"37","author":"Verma","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"18676","DOI":"10.1073\/pnas.0508052102","article-title":"Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration","volume":"102","author":"Smith","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/jnr.23754","article-title":"LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation","volume":"94","author":"Prabhudesai","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Sheng, D., Qu, D., Kwok, K.H., Ng, S.S., Lim, A.Y., Aw, S.S., Lee, C.W., Sung, W.K., Tan, E.K., and Lufkin, T. (2010). Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect. PLoS Genet., 6.","DOI":"10.1371\/journal.pgen.1000914"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1089\/zeb.2013.0950","article-title":"Effects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvae","volume":"11","author":"Feng","year":"2014","journal-title":"Zebrafish"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Fett, M.E., Pilsl, A., Paquet, D., van Bebber, F., Haass, C., Tatzelt, J., Schmid, B., and Winklhofer, K.F. (2010). Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011783"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-neuro-071714-033857","article-title":"Zebrafish Behavior: Opportunities and Challenges","volume":"40","author":"Orger","year":"2017","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ntt.2010.03.002","article-title":"Locomotor activity in zebrafish embryos: A new method to assess developmental neurotoxicity","volume":"32","author":"Selderslaghs","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Zhang, X., Li, M., Zhang, H., Che, X., Zhang, G., and Han, B. (2026). Chicoric acid prevents motor dysfunction in zebrafish Parkinson\u2019s disease model through Nrf2-mediated antioxidant effect. BMC Complement. Med. Ther., 26.","DOI":"10.1186\/s12906-026-05271-z"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41598-020-79923-6","article-title":"A model-based quantification of startle reflex habituation in larval zebrafish","volume":"11","author":"Beppi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nbd.2011.05.016","article-title":"Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models","volume":"44","author":"Farrell","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"13647","DOI":"10.1038\/s41598-019-49614-y","article-title":"Emergence of consistent intra-individual locomotor patterns during zebrafish development","volume":"9","author":"Fitzgerald","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.beproc.2010.12.003","article-title":"Locomotor behaviors in zebrafish (Danio rerio) larvae","volume":"86","author":"Colwill","year":"2011","journal-title":"Behav. Process."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Bangeppagari, M., Manjunath, A., Srinivasa, A., and Lee, S.J. (2025). Tiny Fish, Big Hope: Zebrafish Unlocking Secrets to Fight Parkinson\u2019s Disease. Biology, 14.","DOI":"10.3390\/biology14101397"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"102084","DOI":"10.1016\/j.toxrep.2025.102084","article-title":"Comparative evaluation of MPTP and rotenone as inducing agents for Parkinson\u2019s disease in adult zebrafish: Behavioural and histopathological insights","volume":"15","author":"Ashok","year":"2025","journal-title":"Toxicol. Rep."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"178028","DOI":"10.1016\/j.scitotenv.2024.178028","article-title":"Zebra_K, a kinematic analysis automated platform for assessing sensitivity, habituation and prepulse inhibition of the acoustic startle response in adult zebrafish","volume":"958","author":"Tagkalidou","year":"2025","journal-title":"Sci. Total Environ."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Norton, W., and Bally-Cuif, L. (2010). Adult zebrafish as a model organism for behavioural genetics. BMC Neurosci., 11.","DOI":"10.1186\/1471-2202-11-90"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1038\/s41598-023-29668-9","article-title":"Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish","volume":"13","author":"Johnson","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Ogi, A., Licitra, R., Naef, V., Marchese, M., Fronte, B., Gazzano, A., and Santorelli, F.M. (2020). Social Preference Tests in Zebrafish: A Systematic Review. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.590057"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Tan, J.K., Nazar, F.H., Makpol, S., and Teoh, S.L. (2022). Zebrafish: A Pharmacological Model for Learning and Memory Research. Molecules, 27.","DOI":"10.3390\/molecules27217374"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrg2091","article-title":"Animal models of human disease: Zebrafish swim into view","volume":"8","author":"Lieschke","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/jamaneurol.2014.65","article-title":"Sleep and circadian rhythm regulation in early Parkinson disease","volume":"71","author":"Breen","year":"2014","journal-title":"JAMA Neurol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"135449","DOI":"10.1016\/j.chemosphere.2022.135449","article-title":"Disruptions of circadian rhythms, sleep, and stress responses in zebrafish: New infrared-based activity monitoring assays for toxicity assessment","volume":"305","author":"Silva","year":"2022","journal-title":"Chemosphere"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/brain\/awn102","article-title":"Sensory deficit in Parkinson\u2019s disease: Evidence of a cutaneous denervation","volume":"131","author":"Nolano","year":"2008","journal-title":"Brain"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.neuron.2017.05.004","article-title":"Dopamine Depletion Impairs Bilateral Sensory Processing in the Striatum in a Pathway-Dependent Manner","volume":"94","author":"Ketzef","year":"2017","journal-title":"Neuron"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.beproc.2005.03.001","article-title":"Visual discrimination learning in zebrafish (Danio rerio)","volume":"70","author":"Colwill","year":"2005","journal-title":"Behav. Process."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbr.2008.10.044","article-title":"Olfactory conditioning in the zebrafish (Danio rerio)","volume":"198","author":"Braubach","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1002\/dvdy.22742","article-title":"Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon","volume":"240","author":"Xi","year":"2011","journal-title":"Dev. Dyn."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Wang, M., Ye, H., Jiang, P., Liu, J., Wang, B., Zhang, S., Sik, A., Li, N., Liu, K., and Jin, M. (2023). The alleviative effect of Calendula officinalis L. extract against Parkinson\u2019s disease-like pathology in zebrafish via the involvement of autophagy activation. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1153889"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"120759","DOI":"10.1016\/j.jep.2025.120759","article-title":"Polygalae Radix extracts show anti-Parkinson\u2019s disease effects and reduce depression-like symptoms by modulating energy metabolism","volume":"356","author":"Jiao","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"111911","DOI":"10.1016\/j.cbi.2026.111911","article-title":"Cyflumetofen disrupts the blood-brain barrier and induces neurotoxicity in zebrafish larvae","volume":"426","author":"Wang","year":"2026","journal-title":"Chem. Biol. Interact."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Omar, N.A., Kumar, J., and Teoh, S.L. (2023). Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson\u2019s disease model. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1307447"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.neuron.2025.03.028","article-title":"Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition","volume":"113","author":"Son","year":"2025","journal-title":"Neuron"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"120314","DOI":"10.1016\/j.jep.2025.120314","article-title":"Neuroprotective and neurorestorative properties of Mesembryanthemum tortuosum in a Parkinson\u2019s disease zebrafish larvae model","volume":"353","author":"Lepule","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuro.2024.10.009","article-title":"Exposure to an environmentally representative mixture of polybrominated diphenyl ethers (PBDEs) alters zebrafish neuromuscular development","volume":"105","author":"McDermott","year":"2024","journal-title":"Neurotoxicology"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41419-024-06622-9","article-title":"Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment","volume":"15","author":"Zuppardo","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1022945107762","article-title":"The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update","volume":"8","author":"Ly","year":"2003","journal-title":"Apoptosis"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.semcdb.2023.07.003","article-title":"Shedding light on mitochondrial outer-membrane permeabilization and membrane potential: State of the art methods and biosensors","volume":"156","author":"Popgeorgiev","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"105421","DOI":"10.1016\/j.phrs.2021.105421","article-title":"Treatment with a triazole inhibitor of the mitochondrial permeability transition pore fully corrects the pathology of sapje zebrafish lacking dystrophin","volume":"165","author":"Stocco","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"bio044347","DOI":"10.1242\/bio.044347","article-title":"Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson\u2019s disease","volume":"8","author":"Soman","year":"2019","journal-title":"Biol. Open"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Carneiro, P., Pais, P., Oliveira, I.V., Monteiro, S.M., Ven\u00e2ncio, C., and F\u00e9lix, L. (2026). Amelioration of 6-OHDA-Induced Parkinson\u2019s Symptoms in Zebrafish Larvae by an Almond Skin Acetonic Extract. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27062590"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"e3128","DOI":"10.21769\/BioProtoc.3128","article-title":"Analysis of the Mitochondrial Membrane Potential Using the Cationic JC-1 Dye as a Sensitive Fluorescent Probe","volume":"9","author":"Sivandzade","year":"2019","journal-title":"Bio Protoc."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/zeb.2007.0508","article-title":"A rapid apoptosis assay measuring relative acridine orange fluorescence in zebrafish embryos","volume":"4","author":"Tucker","year":"2007","journal-title":"Zebrafish"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Razali, K., Mohd Nasir, M.H., Kumar, J., and Mohamed, W.M.Y. (2023). Mitophagy: A Bridge Linking HMGB1 and Parkinson\u2019s Disease Using Adult Zebrafish as a Model Organism. Brain Sci., 13.","DOI":"10.3390\/brainsci13071076"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.nbd.2013.02.002","article-title":"A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling","volume":"54","author":"Priyadarshini","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuroscience.2026.02.016","article-title":"Neuroprotective effects of idebenone in a zebrafish model of Parkinson\u2019s disease via regulating autophagy, mitigating apoptosis and oxidative stress","volume":"599","author":"Zhang","year":"2026","journal-title":"Neuroscience"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Qi, Y., Liu, G., Jin, S., Jian, R., Zou, Z., Wang, C., Zhang, Y., Zhao, M., Zhu, H., and Yan, P. (2024). Neuroprotective effect of acetoxypachydiol against oxidative stress through activation of the Keap1-Nrf2\/HO-1 pathway. BMC Complement. Med. Ther., 24.","DOI":"10.1186\/s12906-024-04474-6"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Long, H.Z., Cheng, Y., Zhou, Z.W., Luo, H.Y., Wen, D.D., and Gao, L.C. (2021). PI3K\/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer\u2019s Disease and Parkinson\u2019s Disease. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.648636"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3892\/ijmm.2016.2833","article-title":"PI3K\/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson\u2019s disease (Review)","volume":"39","author":"Nakano","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"alpha-Synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Kawahata, I., Finkelstein, D.I., and Fukunaga, K. (2022). Pathogenic Impact of \u03b1-Synuclein Phosphorylation and Its Kinases in \u03b1-Synucleinopathies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116216"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s00018-022-04263-9","article-title":"A53T mutant \u03b1-synuclein fibrils formed in macrophage are spread to neurons","volume":"79","author":"Moriya","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/dvg.20338","article-title":"Viral 2A peptides allow expression of multiple proteins from a single ORF in transgenic zebrafish embryos","volume":"45","author":"Provost","year":"2007","journal-title":"Genesis"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Lee, S.R., Li, L.H., Park, H.J., Park, J.H., Lee, K.Y., Kim, M.K., Shin, B.A., and Choi, S.Y. (2011). High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018556"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1537-1891(02)00200-8","article-title":"Tight junctions of the blood-brain barrier: Development, composition and regulation","volume":"38","author":"Wolburg","year":"2002","journal-title":"Vasc. Pharmacol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-Brain Barrier: From Physiology to Disease and Back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e70006","DOI":"10.1002\/prca.70006","article-title":"Proteomic Analysis of Substantia Nigra Reveals Molecular Insights Into the Neuroprotection Effect of Rosmarinic Acid Treatment in MPTP-Induced Mouse Model of Parkinson\u2019s Disease","volume":"19","author":"Gorshkov","year":"2025","journal-title":"Proteom. Clin. Appl."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1002\/mds.22713","article-title":"DJ-1, PINK1, and their effects on mitochondrial pathways","volume":"25","author":"Cookson","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41419-021-03441-0","article-title":"Expanding the role of proteasome homeostasis in Parkinson\u2019s disease: Beyond protein breakdown","volume":"12","author":"Bi","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"R110.006924","DOI":"10.1074\/mcp.M110.006924","article-title":"Oxidative stress-mediated regulation of proteasome complexes","volume":"10","author":"Aiken","year":"2011","journal-title":"Mol. Cell Proteom."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1242\/dev.001115","article-title":"Controlling morpholino experiments: Don\u2019t stop making antisense","volume":"135","author":"Eisen","year":"2008","journal-title":"Development"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41586-019-1064-z","article-title":"Genetic compensation triggered by mutant mRNA degradation","volume":"568","author":"Kontarakis","year":"2019","journal-title":"Nature"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Cosacak, M.I., Bhattarai, P., De Jager, P.L., Menon, V., Tosto, G., and Kizil, C. (2022). Single Cell\/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer\u2019s Disease. Cells, 11.","DOI":"10.3390\/cells11111807"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41582-023-00809-y","article-title":"Single-cell and spatial transcriptomics: Deciphering brain complexity in health and disease","volume":"19","author":"Piwecka","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Chen, T.Y., You, L., Hardillo, J.A.U., and Chien, M.P. (2023). Spatial Transcriptomic Technologies. Cells, 12.","DOI":"10.3390\/cells12162042"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"167651","DOI":"10.1016\/j.bbadis.2024.167651","article-title":"Multi-omics analyses of early-onset familial Alzheimer\u2019s disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms","volume":"1871","author":"Barthelson","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"112046","DOI":"10.1016\/j.cbi.2026.112046","article-title":"Diquat-induced central nervous system injury: Serum multi-omics and zebrafish evidence for histidine-methylmalonate imbalance and neuroinflammation","volume":"432","author":"Liu","year":"2026","journal-title":"Chem. Biol. Interact."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/978-3-030-12457-1_36","article-title":"Calcium Imaging in the Zebrafish","volume":"1131","author":"Kettunen","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1016\/j.cub.2018.10.017","article-title":"Whole-Brain Calcium Imaging during Physiological Vestibular Stimulation in Larval Zebrafish","volume":"28","author":"Migault","year":"2018","journal-title":"Curr. Biol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"107321","DOI":"10.1016\/j.aquatox.2025.107321","article-title":"Neurotoxicity and aggressive behavior induced by anesthetic etomidate exposure in zebrafish: Insights from multi-omics and machine learning","volume":"282","author":"Li","year":"2025","journal-title":"Aquat. Toxicol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/10\/4578\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:34:49Z","timestamp":1779280489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/10\/4578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":219,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ijms27104578"],"URL":"https:\/\/doi.org\/10.3390\/ijms27104578","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]}}}