{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:00:32Z","timestamp":1785416432852,"version":"3.56.0"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2022\/12989-6"],"award-info":[{"award-number":["2022\/12989-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/08142-0"],"award-info":[{"award-number":["2023\/08142-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2024\/02936-8"],"award-info":[{"award-number":["2024\/02936-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/12271-0"],"award-info":[{"award-number":["2023\/12271-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Brazilian National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["313190\/2021-6"],"award-info":[{"award-number":["313190\/2021-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"award":["313190\/2021-6"],"award-info":[{"award-number":["313190\/2021-6"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The role of zonulin as a biomarker of intestinal permeability in the allogeneic hematopoietic stem cell transplantation (allo-HSCT) setting remains poorly understood. In this study, we aimed to evaluate serum zonulin dynamics, identify its predictors, and assess its prognostic significance in patients undergoing allo-HSCT. This multicenter, prospective cohort study was conducted across four Brazilian hospitals. Eligible participants were patients aged \u226512 years who provided at least one blood sample during the allo-HSCT course. A control group of 15 healthy adult individuals was also included. Serum zonulin levels were quantified using enzyme-linked immunosorbent assay multiple times over the allo-HSCT course. Outcomes included acute graft-versus-host disease, overall survival, and bloodstream infections. A total of 477 blood samples were collected from 140 patients. Compared with the control group, zonulin levels were persistently elevated at all evaluated time points throughout the allo-HSCT course. However, no significant differences were observed among the different time points assessed during transplantation. No clinical or transplantation-related characteristics were identified as significant predictors of elevated zonulin levels. Finally, zonulin did not demonstrate prognostic value for allo-HSCT-related outcomes. Future studies should investigate whether other intestinal permeability biomarkers have prognostic relevance in the allo-HSCT setting.<\/jats:p>","DOI":"10.3390\/ijms27114659","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:17:09Z","timestamp":1779441429000},"page":"4659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the Role of Zonulin in Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter Study"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1256-1249","authenticated-orcid":false,"given":"Alexandre","family":"Soares Ferreira Junior","sequence":"first","affiliation":[{"name":"Department of Genetics, Microbiology and Immunology, Institute of Biosciences (IBB), Sao Paulo State University (UNESP), Botucatu 18618-970, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Linares Silva","sequence":"additional","affiliation":[{"name":"Department of Genetics, Microbiology and Immunology, Institute of Biosciences (IBB), Sao Paulo State University (UNESP), Botucatu 18618-970, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1490-3699","authenticated-orcid":false,"given":"Danielle Amanda Niz","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Genetics, Microbiology and Immunology, Institute of Biosciences (IBB), Sao Paulo State University (UNESP), Botucatu 18618-970, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8627-0513","authenticated-orcid":false,"given":"Larissa","family":"da Silva Souza","sequence":"additional","affiliation":[{"name":"Department of Genetics, Microbiology and Immunology, Institute of Biosciences (IBB), Sao Paulo State University (UNESP), Botucatu 18618-970, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Dias","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Genetics, Microbiology and Immunology, Institute of Biosciences (IBB), Sao Paulo State University (UNESP), Botucatu 18618-970, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0141-5948","authenticated-orcid":false,"given":"Bianca Fernanda","family":"Rodrigues da Silva","sequence":"additional","affiliation":[{"name":"Department of Genetics, Microbiology and Immunology, Institute of Biosciences (IBB), Sao Paulo State University (UNESP), Botucatu 18618-970, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Welinton","family":"Yoshio Hirai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Hospital de Amor de Barretos, Barretos 14784-400, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozana","family":"Mesquita Ciconelli","sequence":"additional","affiliation":[{"name":"Departamento de Pesquisa da BP\u2014A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo 01323-001, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-7015","authenticated-orcid":false,"given":"Joao Victor","family":"Piccolo Feliciano","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Faculdade Regional de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FUNFARME), S\u00e3o Jos\u00e9 do Rio Preto 15090-000, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iago","family":"Colturato","sequence":"additional","affiliation":[{"name":"Hospital Amaral Carvalho, Ja\u00fa 17210-070, Sao Paulo, 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