{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:40:51Z","timestamp":1785426051542,"version":"3.56.0"},"reference-count":137,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["FURG2026-0035"],"award-info":[{"award-number":["FURG2026-0035"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]},{"award":["FURG2026-0035"],"award-info":[{"award-number":["FURG2026-0035"]}],"id":[{"id":"https:\/\/ror.org\/00ghqgy32","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Skeletal muscle loss resulting from traumatic injury, sarcopenia, and myopathies remains a major clinical challenge due to the limited regenerative capacity of adult muscle tissue. This review systematically examines advanced biomedical therapeutic approaches to restoring muscle mass and function, including gene therapy, microRNA, cell-based strategies, and tissue engineering. Key mechanisms of muscle histogenesis and regeneration are discussed, with emphasis on the roles of satellite cells, growth factors (IGF-1, VEGF), and transcriptional regulators. Preclinical studies demonstrate that viral and non-viral delivery of myogenic factors can enhance muscle repair, reduce fibrosis, and improve functional outcomes. However, translation to clinical practice is hindered by challenges such as immune responses, inadequate reinnervation, and the complexity of replicating native tissue architecture. Emerging strategies combining gene delivery with rehabilitation, immunomodulation, or exosome therapy show synergistic effects. Although clinical trials targeting sarcopenia and muscle defects using anti-myostatin antibodies, stem cell-derived products, and acellular scaffolds have reported modest gains in strength and lean mass, no definitive regenerative therapy has been approved. While significant progress has been made, achieving full structural and functional muscle regeneration will require combinatorial approaches that address vascularization, innervation, and the inflammatory microenvironment.<\/jats:p>","DOI":"10.3390\/ijms27114762","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:19:52Z","timestamp":1779877192000},"page":"4762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regenerative Medicine: Advanced Therapy for Muscle Tissue Restoration"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-3841","authenticated-orcid":false,"given":"Roman","family":"Deev","sequence":"first","affiliation":[{"name":"A.P. Avtsyn Research Institute of Human Morphology State Scientific Center of the Russian Federation B.V. Petrovsky Russian National Research Center of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9927-5608","authenticated-orcid":false,"given":"Evgeniy","family":"Kopylov","sequence":"additional","affiliation":[{"name":"A.P. Avtsyn Research Institute of Human Morphology State Scientific Center of the Russian Federation B.V. Petrovsky Russian National Research Center of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-4573","authenticated-orcid":false,"given":"Iurii","family":"Slepov","sequence":"additional","affiliation":[{"name":"A.P. Avtsyn Research Institute of Human Morphology State Scientific Center of the Russian Federation B.V. Petrovsky Russian National Research Center of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-5676","authenticated-orcid":false,"given":"Nikita","family":"Gladyshev","sequence":"additional","affiliation":[{"name":"A.P. Avtsyn Research Institute of Human Morphology State Scientific Center of the Russian Federation B.V. Petrovsky Russian National Research Center of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-9787","authenticated-orcid":false,"given":"Igor","family":"Limaev","sequence":"additional","affiliation":[{"name":"A.P. Avtsyn Research Institute of Human Morphology State Scientific Center of the Russian Federation B.V. 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