{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:42:31Z","timestamp":1786326151886,"version":"build-2736575974"},"reference-count":90,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"crossref","award":["2024B1111160002"],"award-info":[{"award-number":["2024B1111160002"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2024B1111160002"],"award-info":[{"award-number":["2024B1111160002"]}],"id":[{"id":"https:\/\/ror.org\/00tjzgn92","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008109","name":"Wuxi Science and Technology Bureau","doi-asserted-by":"crossref","award":["XD24006"],"award-info":[{"award-number":["XD24006"]}],"id":[{"id":"10.13039\/501100008109","id-type":"DOI","asserted-by":"crossref"}]},{"award":["XD24006"],"award-info":[{"award-number":["XD24006"]}],"id":[{"id":"https:\/\/ror.org\/01zzv0338","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>As emerging global environmental contaminants, organic ultraviolet absorbers (OUVAs) are widely used in personal care formulations and exhibit environmental persistence and potential bioaccumulation. Among these compounds, 2-ethylhexyl salicylate (EHS) and homosalate (HMS) are the most frequently used salicylate-type UV filters in cosmetic formulations. Although an increasing number of studies have demonstrated their environmental hazards, little is known about the molecular mechanisms underlying their cytotoxicity in mammalian systems, a fundamental knowledge gap for both human health protection and the development of more environmentally friendly consumer goods. In this study, we used mouse embryonic fibroblasts (MEFs, 3T6) and zebrafish as models to assess the toxicological phenotypes of EHS and HMS in vitro and in vivo, respectively. We found that both EHS and HMS induced cellular damage characterized by oxidative stress, disrupted intracellular calcium homeostasis, mitochondrial impairment, and DNA damage. Importantly, molecular analyses further suggested the concurrent activation of two distinct regulated cell death programs: pyroptosis, as suggested by Caspase-11-mediated GSDMD cleavage, and necroptosis, as suggested by ZBP1-RIPK3-Caspase-8-mediated MLKL phosphorylation. The in vitro data have been partially validated at the level of gene expression and in developmental toxicity in the zebrafish model, providing some in vivo phenotypic and molecular correlates. While the upstream events were experimentally verified, the causal links among them remain to be further elucidated. Taken together, this work suggested that OUVA-induced toxicity is not limited to isolated oxidative damage, but may also involve the activation of two different cell death programs. These findings provide important molecular clues to understanding the potential health and ecological risks of widely used UV filters and offer a scientific basis for their more environmentally friendly safety evaluation and regulatory management, which are crucial for advancing more sustainable chemistry and safer consumer goods.<\/jats:p>","DOI":"10.3390\/ijms27114777","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:02:51Z","timestamp":1779793371000},"page":"4777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pyroptosis- and Necroptosis-Related Signaling in Salicylate UV Absorber-Induced Toxicity: Implications for Sustainable Chemistry and Human Health"],"prefix":"10.3390","volume":"27","author":[{"given":"Chunlu","family":"He","sequence":"first","affiliation":[{"name":"The Key Laboratory of Pollution Control and Ecosystem Restoration in Industrial Clusters, The Ministry of Education, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Pollution Control and Ecosystem Restoration in Industrial Clusters, The Ministry of Education, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China"},{"name":"South China Institute of Collaborative Innovation, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Lin","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Pollution Control and Ecosystem Restoration in Industrial Clusters, The Ministry of Education, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China"},{"name":"South China Institute of Collaborative Innovation, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Yu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Pollution Control and Ecosystem Restoration in Industrial Clusters, The Ministry of Education, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China"},{"name":"South China Institute of Collaborative Innovation, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Pollution Control and Ecosystem Restoration in Industrial Clusters, The Ministry of Education, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-7938","authenticated-orcid":false,"given":"Jianhua","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Pollution Control and Ecosystem Restoration in Industrial Clusters, The Ministry of Education, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China"},{"name":"South China Institute of Collaborative Innovation, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Pollution Control and Ecosystem Restoration in Industrial Clusters, The Ministry of Education, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litao","family":"Hu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Pollution Control and Ecosystem Restoration in Industrial Clusters, The Ministry of Education, College of Environment and Energy, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.2105\/AJPH.2006.091736","article-title":"SOLAR Ultraviolet Radiation AND Vitamin D: A Historical Perspective","volume":"97","author":"Rajakumar","year":"2007","journal-title":"Am. J. Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2010.07.047","article-title":"Effect of Emblica Officinalis (Fruit) against UVB-Induced Photo-Aging in Human Skin Fibroblasts","volume":"132","author":"Adil","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/cod.13777","article-title":"Ultraviolet Filters in Sunscreens and Cosmetic Products\u2014A Market Survey","volume":"85","author":"Chaiyabutr","year":"2021","journal-title":"Contact Dermat."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Jesus, A., Sousa, E., Cruz, M.T., Cidade, H., Lobo, J.M.S., and Almeida, I.F. (2022). UV Filters: Challenges and Prospects. Pharmaceuticals, 15.","DOI":"10.3390\/ph15030263"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1021\/es2004057","article-title":"Determination of Benzotriazole and Benzophenone UV Filters in Sediment and Sewage Sludge","volume":"45","author":"Zhang","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"176008","DOI":"10.1016\/j.scitotenv.2024.176008","article-title":"Understudied and Underestimated Impacts of Organic UV Filters on Terrestrial Ecosystems","volume":"953","author":"Gautam","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.watres.2014.09.013","article-title":"Occurrence, Distribution and Ecological Risk Assessment of Multiple Classes of UV Filters in Surface Waters from Different Countries","volume":"67","author":"Tsui","year":"2014","journal-title":"Water Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2015.03.012","article-title":"Environmental Occurrence and Risk of Organic UV Filters and Stabilizers in Multiple Matrices in Norway","volume":"80","author":"Langford","year":"2015","journal-title":"Environ. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ecoenv.2019.05.075","article-title":"Organic Ultraviolet (UV) Filters in the South China Sea Coastal Region: Environmental Occurrence, Toxicological Effects and Risk Assessment","volume":"181","author":"Tsui","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107405","DOI":"10.1016\/j.envint.2022.107405","article-title":"Assessment of Human Exposure to Benzophenone-Type UV Filters: A Review","volume":"167","author":"Mao","year":"2022","journal-title":"Environ. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.abn2600","article-title":"Conversion of Oxybenzone Sunscreen to Phototoxic Glucoside Conjugates by Sea Anemones and Corals","volume":"376","author":"Vuckovic","year":"2022","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.envint.2018.09.020","article-title":"Urinary Excretion of Phenols, Parabens and Benzophenones in Young Men: Associations to Reproductive Hormones and Semen Quality Are Modified by Mutations in the Filaggrin Gene","volume":"121","author":"Joensen","year":"2018","journal-title":"Environ. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.reprotox.2014.11.006","article-title":"Concentrations of Environmental Phenols and Parabens in Milk, Urine and Serum of Lactating North Carolina Women","volume":"54","author":"Hines","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"ref_14","first-page":"1345","article-title":"Identifications and characteristics of organic ultraviolet filters in indoor air","volume":"38","author":"Lu","year":"2021","journal-title":"J. Environ. Occup. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"107375","DOI":"10.1016\/j.marenvres.2025.107375","article-title":"The UV Filters Ethyl-Hexyl Salicylate and Octocrylene Affects Feeding and Reproduction in the Marine Copepod Acartia Tonsa","volume":"211","author":"Picone","year":"2025","journal-title":"Mar. Environ. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"108334","DOI":"10.1016\/j.envint.2023.108334","article-title":"Increasing Exposure to the UV Filters Octocrylene and 2-Ethylhexyl Salicylate in Germany from 1996 to 2020: Human Biomonitoring in 24-h Urine Samples of the German Environmental Specimen Bank (ESB)","volume":"182","author":"Bury","year":"2023","journal-title":"Environ. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1021\/acs.chemrestox.3c00287","article-title":"Identification, Organic Synthesis, and Sensitive Analysis of a Cis -Homosalate-Specific Exposure Biomarker","volume":"37","author":"Ebert","year":"2024","journal-title":"Chem. Res. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"142486","DOI":"10.1016\/j.scitotenv.2020.142486","article-title":"Risks of Organic UV Filters: A Review of Environmental and Human Health Concern Studies","volume":"755","author":"Huang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e00079","DOI":"10.1016\/j.teac.2019.e00079","article-title":"Organic UV Filters in Marine Environments: An Update of Analytical Methodologies, Occurrence and Distribution","volume":"25","year":"2020","journal-title":"Trends Environ. Anal. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00248-002-1033-0","article-title":"Sunscreen Products Increase Virus Production through Prophage Induction in Marine Bacterioplankton","volume":"45","author":"Danovaro","year":"2003","journal-title":"Microb. Ecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chemosphere.2013.10.053","article-title":"Ecotoxicological Evaluation of Four UV Filters Using Marine Organisms from Different Trophic Levels Isochrysis Galbana, Mytilus Galloprovincialis, Paracentrotus Lividus, and Siriella Armata","volume":"104","author":"Paredes","year":"2014","journal-title":"Chemosphere"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.envpol.2018.09.092","article-title":"Homosalate Aggravates the Invasion of Human Trophoblast Cells as Well as Regulates Intracellular Signaling Pathways Including PI3K\/AKT and MAPK Pathways","volume":"243","author":"Yang","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"107658","DOI":"10.1016\/j.envint.2022.107658","article-title":"Human Health Risk Assessment of Cinnamate UV Absorbers: In Vitro and in Silico Investigations","volume":"171","author":"Tian","year":"2023","journal-title":"Environ. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"027011","DOI":"10.1289\/EHP13696","article-title":"Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish","volume":"132","author":"Ye","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"125134","DOI":"10.1016\/j.envpol.2024.125134","article-title":"Environmental Fate of Organic UV Filters: Global Occurrence, Transformation, and Mitigation via Advanced Oxidation Processes","volume":"363","author":"McGachy","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101901","DOI":"10.1016\/j.scp.2024.101901","article-title":"Promoting Health and Sustainability: Exploring Safer Alternatives in Cosmetics and Regulatory Perspectives","volume":"43","author":"Couceiro","year":"2025","journal-title":"Sustain. Chem. Pharm."},{"key":"ref_27","unstructured":"(2026, March 22). Chemicals and Waste Management: Essential to Achieving the Sustainable Development Goals. Available online: https:\/\/iomc.info\/publications\/m\/item\/iomc-brochure-on-sdg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"128029","DOI":"10.1016\/j.chemosphere.2020.128029","article-title":"Effects of Pyriproxyfen on Zebrafish Brain Mitochondria and Acetylcholinesterase","volume":"263","author":"Azevedo","year":"2021","journal-title":"Chemosphere"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"116277","DOI":"10.1016\/j.envpol.2020.116277","article-title":"Evaluation and Comparison of the Mitochondrial and Developmental Toxicity of Three Strobilurins in Zebrafish Embryo\/Larvae","volume":"270","author":"Yang","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"114643","DOI":"10.1016\/j.ecoenv.2023.114643","article-title":"Structure-Based Developmental Toxicity and ASD-Phenotypes of Bisphenol A Analogues in Embryonic Zebrafish","volume":"253","author":"Bai","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.envpol.2018.08.085","article-title":"Water Extract of Indoor Dust Induces Tight Junction Disruption in Normal Human Corneal Epithelial Cells","volume":"243","author":"Xiang","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_32","unstructured":"(2026, March 15). Safety and Technical Standards for Cosmetics. State Food and Drug Administration, Announcement No. 268, Available online: https:\/\/www.nmpa.gov.cn\/hzhp\/hzhpfgwj\/hzhpgzwj\/20151223120001986.html?type=pc&m=."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009616228304","article-title":"Role of Reactive Oxygen Species (ROS) in Apoptosis Induction","volume":"5","author":"Simon","year":"2001","journal-title":"Apoptosis"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.bbamcr.2018.05.015","article-title":"Calcium Signaling and the Therapeutic Targeting of Cancer Cells","volume":"1865","author":"Bong","year":"2018","journal-title":"Biochim. Biophys. Acta BBA Mol. Cell Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.lfs.2010.09.013","article-title":"Calcium Wave Signaling in Cancer Cells","volume":"87","author":"Parkash","year":"2010","journal-title":"Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101666","DOI":"10.1016\/j.mtbio.2025.101666","article-title":"Ultrasound-Actuated Ion Homeostasis Perturbator for Oxidative Damage-Augmented Ca2+ Interference Therapy and Combined Immunotherapy","volume":"32","author":"Yang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1745-7254.2006.00390.x","article-title":"Cross-Talk between Calcium and Reactive Oxygen Species","volume":"27","author":"Yan","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"De Nicolo, B., Cataldi-Stagetti, E., Diquigiovanni, C., and Bonora, E. (2023). Calcium and Reactive Oxygen Species Signaling Interplays in Cardiac Physiology and Pathologies. Antioxidants, 12.","DOI":"10.3390\/antiox12020353"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"144127","DOI":"10.1016\/j.ijbiomac.2025.144127","article-title":"MICU1 Is the Nexus for CaV3.3 Regulation of Mitochondrial Calcium, Redox Balance and Chondrocyte Viability","volume":"312","author":"Huang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"102344","DOI":"10.1016\/j.ceca.2020.102344","article-title":"Mitochondrial Reactive Oxygen Species in Physiology and Disease","volume":"94","author":"Antonucci","year":"2021","journal-title":"Cell Calcium"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"103288","DOI":"10.1016\/j.redox.2024.103288","article-title":"Redox-Active Vitamin C Suppresses Human Osteosarcoma Growth by Triggering Intracellular ROS-Iron\u2013Calcium Signaling Crosstalk and Mitochondrial Dysfunction","volume":"75","author":"Vaishampayan","year":"2024","journal-title":"Redox Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.cdd.4401231","article-title":"Mitochondrial Membrane Potential Regulates Matrix Configuration and Cytochrome c Release during Apoptosis","volume":"10","author":"Gottlieb","year":"2003","journal-title":"Cell Death Differ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e3128","DOI":"10.21769\/BioProtoc.3128","article-title":"Analysis of the Mitochondrial Membrane Potential Using the Cationic JC-1 Dye as a Sensitive Fluorescent Probe","volume":"9","author":"Sivandzade","year":"2019","journal-title":"Bio-Protocol"},{"key":"ref_44","first-page":"20","article-title":"Functional Significance of the Mitochondrial Membrane Potential","volume":"12","author":"Zorova","year":"2018","journal-title":"Biochem. Mosc. Suppl. A Membr. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/cyto.a.20089","article-title":"Analysis of Mitochondrial Generation and Release of Reactive Oxygen Species","volume":"62A","author":"Mattiasson","year":"2004","journal-title":"Cytom. Pt. A"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"103871","DOI":"10.1016\/j.redox.2025.103871","article-title":"Noninvasive in Vivo Discrimination between Mitochondrial ROS and Global ROS Production in Solid Tumors Using EPR Spectroscopy","volume":"87","author":"Mathieu","year":"2025","journal-title":"Redox Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"102044","DOI":"10.1016\/j.redox.2021.102044","article-title":"An Update on Methods and Approaches for Interrogating Mitochondrial Reactive Oxygen Species Production","volume":"45","author":"Mailloux","year":"2021","journal-title":"Redox Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1111\/j.1471-4159.2007.04516.x","article-title":"\u2018Mild Uncoupling\u2019 Does Not Decrease Mitochondrial Superoxide Levels in Cultured Cerebellar Granule Neurons but Decreases Spare Respiratory Capacity and Increases Toxicity to Glutamate and Oxidative Stress","volume":"101","author":"Jekabsons","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0041-008X(03)00254-0","article-title":"Evaluation of Genotoxic Risk and Oxidative DNA Damage in Mammalian Cells Exposed to Mycotoxins, Patulin and Citrinin","volume":"191","author":"Liu","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chemosphere.2015.08.051","article-title":"Oxidative Stress, DNA Damage and Antioxidant Enzyme Activities in the Pacific White Shrimp (Litopenaeus vannamei) When Exposed to Hypoxia and Reoxygenation","volume":"144","author":"Li","year":"2016","journal-title":"Chemosphere"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in Oxidative Stress, Inflammation and Aging: From Mechanisms to Therapeutic Advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.molimm.2025.12.002","article-title":"Mitochondria in Pyroptosis: Mechanisms and Implications","volume":"189","author":"Eldakhakhny","year":"2026","journal-title":"Mol. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s11658-025-00751-5","article-title":"Bypassing the Guardian: Regulated Cell Death Pathways in P53-Mutant Cancers","volume":"30","author":"Chung","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/cbf.290020302","article-title":"Lactate Dehydrogenase. Biochemistry and Function of Lactate Dehydrogenase","volume":"2","author":"Markert","year":"1984","journal-title":"Cell Biochem. Funct."},{"key":"ref_55","first-page":"240","article-title":"Ultraviolet Filters Differentially Impact the Expression of Key Endocrine and Stress Genes in Embryos and Larvae of Chironomus Riparius","volume":"557\u2013558","author":"Morcillo","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ecoenv.2017.05.005","article-title":"Toxicity of Organic UV-Filters to the Aquatic Midge Chironomus Riparius","volume":"143","author":"Campos","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s00244-017-0399-4","article-title":"Ecotoxicological Evaluation of the UV Filters Ethylhexyl Dimethyl P-Aminobenzoic Acid and Octocrylene Using Marine Organisms Isochrysis Galbana, Mytilus Galloprovincialis and Paracentrotus Lividus","volume":"72","author":"Giraldo","year":"2017","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.toxrep.2017.05.006","article-title":"Neurotoxic Effect of Active Ingredients in Sunscreen Products, a Contemporary Review","volume":"4","author":"Ruszkiewicz","year":"2017","journal-title":"Toxicol. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s00204-019-02462-1","article-title":"A Long-Wave UVA Filter Avobenzone Induces Obesogenic Phenotypes in Normal Human Epidermal Keratinocytes and Mesenchymal Stem Cells","volume":"93","author":"Ahn","year":"2019","journal-title":"Arch. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"117148","DOI":"10.1016\/j.lfs.2019.117148","article-title":"High Glucose Augments ROS Generation Regulates Mitochondrial Dysfunction and Apoptosis via Stress Signalling Cascades in Keratinocytes","volume":"241","author":"Rizwan","year":"2020","journal-title":"Life Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.freeradbiomed.2018.09.032","article-title":"Disruption of the Superoxide Anions-Mitophagy Regulation Axis Mediates Copper Oxide Nanoparticles-Induced Vascular Endothelial Cell Death","volume":"129","author":"Zhang","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4161\/auto.5119","article-title":"A Critical Role of Superoxide Anion in Selenite-Induced Mitophagic Cell Death","volume":"4","author":"Kim","year":"2008","journal-title":"Autophagy"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.cell.2024.01.015","article-title":"PARP1-DNA Co-Condensation Drives DNA Repair Site Assembly to Prevent Disjunction of Broken DNA Ends","volume":"187","author":"Chappidi","year":"2024","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.biomaterials.2016.01.059","article-title":"Early BMP, Wnt and Ca2+\/PKC Pathway Activation Predicts the Bone Forming Capacity of Periosteal Cells in Combination with Calcium Phosphates","volume":"86","author":"Bolander","year":"2016","journal-title":"Biomaterials"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1152\/physrev.00003.2021","article-title":"The Roles of Calcium and ATP in the Physiology and Pathology of the Exocrine Pancreas","volume":"101","author":"Petersen","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1182\/blood-2004-05-1699","article-title":"Cell Death of Bioenergetically Compromised and Transcriptionally Challenged CLL Lymphocytes by Chlorinated ATP","volume":"105","author":"Balakrishnan","year":"2005","journal-title":"Blood"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41419-019-1785-9","article-title":"Autophagosome Accumulation-Mediated ATP Energy Deprivation Induced by Penfluridol Triggers Nonapoptotic Cell Death of Lung Cancer via Activating Unfolded Protein Response","volume":"10","author":"Hung","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The Machineries, Regulation and Cellular Functions of Mitochondrial Calcium","volume":"19","author":"Giorgi","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 Cleaves Gasdermin D for Non-Canonical Inflammasome Signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell Death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1007\/s12035-017-0793-y","article-title":"Cell Death Pathways: A Novel Therapeutic Approach for Neuroscientists","volume":"55","author":"Morris","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41580-019-0201-8","article-title":"A Matter of Life and Death for Caspase 8","volume":"21","author":"Willson","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"111444","DOI":"10.1016\/j.isci.2024.111444","article-title":"Bat RNA Viruses Employ Viral RHIMs Orchestrating Species-Specific Cell Death Programs Linked to Z-RNA Sensing and ZBP1-RIPK3 Signaling","volume":"27","author":"Mishra","year":"2024","journal-title":"iScience"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s12871-025-03220-w","article-title":"Esketamine Mitigates Endotoxin-Induced Acute Lung Injury by Suppressing Caspase-11-Driven Pyroptosis","volume":"25","author":"Bao","year":"2025","journal-title":"BMC Anesthesiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"eabq0837","DOI":"10.1126\/scisignal.abq0837","article-title":"Canonical Cellular Stress Granules Are Required for Arsenite-Induced Necroptosis Mediated by Z-DNA\u2013Binding Protein 1","volume":"16","author":"Szczerba","year":"2023","journal-title":"Sci. Signal."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Tye, H., Conos, S.A., Djajawi, T.M., Abdoulkader, N., Kong, I.Y., Kammoun, H.L., Narayana, V.K., Speir, M., Gottschalk, T.A., and Emery, J. (2023). Divergent Roles for Caspase-8 and MLKL in High-Fat Diet Induced Obesity and NAFLD in Mice. bioRxiv.","DOI":"10.1101\/2023.03.14.532682"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Drummer, C., Saaoud, F., Jhala, N.C., Cueto, R., Sun, Y., Xu, K., Shao, Y., Lu, Y., Shen, H., and Yang, L. (2023). Caspase-11 Promotes High-Fat Diet-Induced NAFLD by Increasing Glycolysis, OXPHOS, and Pyroptosis in Macrophages. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1113883"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of Embryonic Development of the Zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity","volume":"86","author":"Hill","year":"2005","journal-title":"Toxicol. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"164073","DOI":"10.1016\/j.scitotenv.2023.164073","article-title":"UV Filter Ethylhexyl Salicylate Affects Cardiovascular Development by Disrupting Lipid Metabolism in Zebrafish Embryos","volume":"888","author":"Zhao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Lu, X., Sun, L., Chen, J., Wang, J., Guan, M., and Xu, S. (2025). Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish. Integr. Zool., Early View.","DOI":"10.1111\/1749-4877.13036"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"157365","DOI":"10.1016\/j.scitotenv.2022.157365","article-title":"Melanin Interference Toxicity or Transgenerational Toxicity of Organic UV Filter Ethylhexyl Salicylate on Zebrafish","volume":"845","author":"Xie","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"104404","DOI":"10.1016\/j.dci.2022.104404","article-title":"Gasdermin E Mediates Pyroptotic Cell Death of Neutrophils and Macrophages in a Zebrafish Model of Chronic Skin Inflammation","volume":"132","author":"Tyrkalska","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41420-022-00891-z","article-title":"Loss of Ripk3 Attenuated Neutrophil Accumulation in a Lipopolysaccharide-Induced Zebrafish Inflammatory Model","volume":"8","author":"Wen","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41418-018-0212-6","article-title":"Pyroptosis versus Necroptosis: Similarities, Differences, and Crosstalk","volume":"26","author":"Frank","year":"2019","journal-title":"Cell Death Differ."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13045-020-00985-0","article-title":"HMGB1 Released from GSDME-Mediated Pyroptotic Epithelial Cells Participates in the Tumorigenesis of Colitis-Associated Colorectal Cancer through the ERK1\/2 Pathway","volume":"13","author":"Tan","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"115945","DOI":"10.1016\/j.ecoenv.2024.115945","article-title":"Single-Cell RNA Sequencing Reveals the Role of Mitochondrial Dysfunction in the Cardiogenic Toxicity of Perfluorooctane Sulfonate in Human Embryonic Stem Cells","volume":"270","author":"Qiu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3847\/1538-4357\/aa9993","article-title":"Formation and Properties of Tangential Discontinuities in Three-Dimensional Compressive MHD Turbulence","volume":"851","author":"Yang","year":"2017","journal-title":"Astrophys. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"102475","DOI":"10.1016\/j.redox.2022.102475","article-title":"Mitochondrial Ferritin Alleviates Apoptosis by Enhancing Mitochondrial Bioenergetics and Stimulating Glucose Metabolism in Cerebral Ischemia Reperfusion","volume":"57","author":"Wang","year":"2022","journal-title":"Redox Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41419-024-06688-5","article-title":"Iron Promotes Ovarian Cancer Malignancy and Advances Platinum Resistance by Enhancing DNA Repair via FTH1\/FTL\/POLQ\/RAD51 Axis","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/4777\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:25:39Z","timestamp":1779942339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/4777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":90,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ijms27114777"],"URL":"https:\/\/doi.org\/10.3390\/ijms27114777","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]}}}