{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:17:29Z","timestamp":1791227849012,"version":"4.1.0"},"reference-count":181,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Discipline Peak-Climbing Plan Project of the Second Affiliated Hospital of Nanjing University of Chinese Medicine","award":["SEZDF202508"],"award-info":[{"award-number":["SEZDF202508"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite current therapies, persistent chronic inflammation remains an important contributor to residual renal risk in diabetic kidney disease (DKD). The NLRP3 inflammasome is a key driver of this inflammatory cascade, with mitochondria serving as a central hub that translates metabolic stress into NLRP3 activation via mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (ox-mtDNA). This review delineates the signaling network of the mitochondria\u2013NLRP3 inflammasome axis in DKD and evaluates its potential as a therapeutic target to improve patient outcomes.<\/jats:p>","DOI":"10.3390\/ijms27114819","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:31:56Z","timestamp":1779885116000},"page":"4819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mitochondrial Regulation of the NLRP3 Inflammasome in Diabetic Kidney Disease: From Mechanisms to Therapeutic Strategies"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7260-808X","authenticated-orcid":false,"given":"Xiangyu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Jiangsu Province Second Hospital of Chinese Medicine (The Second Affiliated Hospital of Nanjing University of Chinese Medicine), Nanjing 210017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangsu Province Second Hospital of Chinese Medicine (The Second Affiliated Hospital of Nanjing University of Chinese Medicine), Nanjing 210017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangsu Province Second Hospital of Chinese Medicine (The Second Affiliated Hospital of Nanjing University of Chinese Medicine), Nanjing 210017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangsu Province Second Hospital of Chinese Medicine (The Second Affiliated Hospital of Nanjing University of Chinese Medicine), Nanjing 210017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangsu Province Second Hospital of Chinese Medicine (The Second Affiliated Hospital of Nanjing University of Chinese Medicine), Nanjing 210017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/eurheartj\/ehab777","article-title":"Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: The FIDELITY pooled analysis","volume":"43","author":"Agarwal","year":"2022","journal-title":"Eur. 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