{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:07:45Z","timestamp":1785424065246,"version":"3.56.0"},"reference-count":61,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Peking University Medical-Qingyan Boshi Joint Laboratory for Skin Nutrition and Anti-Aging","award":["L202206"],"award-info":[{"award-number":["L202206"]}]},{"award":["L202206"],"award-info":[{"award-number":["L202206"]}],"id":[{"id":"https:\/\/ror.org\/02v51f717","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Androgenetic alopecia (AGA) is associated with follicular miniaturization, oxidative stress, and microinflammation. Hydroxytyrosol (HT) has antioxidant and anti-inflammatory activities, but its mechanisms in AGA remain unclear. Differentially expressed genes (DEGs) from GSE212301 were intersected with predicted HT targets to identify candidate targets. Enrichment analysis, PPI-based hub gene screening, molecular docking, and molecular dynamics (MD) simulations were performed. A total of 506 DEGs and 24 HT-related AGA candidate targets were identified. These targets were enriched in inflammation- and oxidative stress-related pathways, including MAPK, NF-\u03baB, TNF, and HIF-1 signaling. HMOX1, PTGS2, FOS, and JUN were identified as hub genes. Docking showed favorable binding between HT and these targets, particularly PTGS2. The 50 ns MD simulation supported the relative stability of the HT\u2013PTGS2 complex. HT may modulate AGA-related inflammatory and oxidative stress networks, particularly through HMOX1 and PTGS2, providing a basis for further experimental validation.<\/jats:p>","DOI":"10.3390\/ijms27114858","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:00:36Z","timestamp":1779955236000},"page":"4858","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Potential Role of Hydroxytyrosol in Androgenetic Alopecia: An Integrated Bioinformatics and Molecular Simulation Study"],"prefix":"10.3390","volume":"27","author":[{"given":"Leying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"An","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7201-6982","authenticated-orcid":false,"given":"Meihong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing 100191, China"},{"name":"Institute of Medical Technology, Peking University Health Science Center, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1684\/ejd.2025.4815","article-title":"Research progress on the pathogenesis of androgenetic alopecia","volume":"35","author":"Chen","year":"2025","journal-title":"Eur. J. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1080\/15384101.2017.1327492","article-title":"An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia","volume":"16","author":"Stamatas","year":"2017","journal-title":"Cell Cycle"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.reth.2022.10.005","article-title":"Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature","volume":"21","author":"Shimizu","year":"2022","journal-title":"Regen. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/npmj.npmj_47_24","article-title":"Androgenetic Alopecia: A Review","volume":"31","author":"Oiwoh","year":"2024","journal-title":"Niger. Postgrad. Med. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14764172.2024.2362126","article-title":"Management of androgenic alopecia: A systematic review of the literature","volume":"26","author":"Rosenthal","year":"2024","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sekhavat, H., Bar Yehuda, S., and Asotra, S. (2025). Using the Mechanisms of Action Involved in the Pathogenesis of Androgenetic Alopecia to Treat Hair Loss. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262110712"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1517\/14728222.2014.922956","article-title":"Potential targets in the discovery of new hair growth promoters for androgenic alopecia","volume":"18","author":"Jain","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-2133.1992.tb00121.x","article-title":"Characterization of inflammatory infiltrates in male pattern alopecia: Implications for pathogenesis","volume":"127","author":"Jaworsky","year":"1992","journal-title":"Br. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0190-9622(93)70106-4","article-title":"Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia","volume":"28","author":"Whiting","year":"1993","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1046\/j.1365-4362.2000.00612.x","article-title":"Androgenetic alopecia and microinflammation","volume":"39","author":"Michelet","year":"2000","journal-title":"Int. J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7349","DOI":"10.2147\/DDDT.S542000","article-title":"Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment","volume":"19","author":"Chen","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12016-025-09034-5","article-title":"Immune and Non-immune Interactions in the Pathogenesis of Androgenetic Alopecia","volume":"68","author":"Xiao","year":"2025","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/exd.14536","article-title":"Observations that suggest a contribution of altered dermal papilla mitochondrial function to androgenetic alopecia","volume":"31","author":"Chew","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e22377","DOI":"10.1002\/jbt.22377","article-title":"Hydroxytyrosol prevents dermal papilla cells inflammation under oxidative stress by inducing autophagy","volume":"33","author":"Chen","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00403-017-1799-z","article-title":"Mediterranean diet: Fresh herbs and fresh vegetables decrease the risk of Androgenetic Alopecia in males","volume":"310","author":"Fortes","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"ref_16","first-page":"228","article-title":"An overview of the genetic aspects of hair loss and its connection with nutrition","volume":"63","author":"Gokce","year":"2022","journal-title":"Prev. Med. Hyg. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Zamora, L., Pe\u00f1alver, R., Ros, G., and Nieto, G. (2021). Olive Tree Derivatives and Hydroxytyrosol: Their Potential Effects on Human Health and Its Use as Functional Ingredient in Meat. Foods, 10.","DOI":"10.3390\/foods10112611"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jbiotec.2019.12.016","article-title":"Hydroxytyrosol: A natural compound with promising pharmacological activities","volume":"309","author":"Bertelli","year":"2020","journal-title":"J. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1700283","DOI":"10.1002\/mnfr.201700283","article-title":"Olive Oil Phenolics Prevent Oxysterol-Induced Proinflammatory Cytokine Secretion and Reactive Oxygen Species Production in Human Peripheral Blood Mononuclear Cells, Through Modulation of p38 and JNK Pathways","volume":"61","author":"Serra","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"108984","DOI":"10.1016\/j.foodres.2020.108984","article-title":"Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-\u03baB and NRF2 pathways","volume":"131","author":"Saguie","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12020-017-1280-y","article-title":"Androgenetic alopecia: A review","volume":"57","author":"Lolli","year":"2017","journal-title":"Endocrine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155122","DOI":"10.1016\/j.prp.2024.155122","article-title":"Targeting MAPK signaling: A promising approach for treating inflammatory lung disease","volume":"254","author":"Saleem","year":"2024","journal-title":"Pathol.\u2014Res. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.2147\/DDDT.S501823","article-title":"Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1\/JNK\/p38 MAPK Pathway","volume":"19","author":"Huang","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13287-020-01700-z","article-title":"Tetramethylpyrazine enhanced the therapeutic effects of human umbilical cord mesenchymal stem cells in experimental autoimmune encephalomyelitis mice through Nrf2\/HO-1 signaling pathway","volume":"11","author":"Zhang","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1039\/C5FO00097A","article-title":"Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells","volume":"6","author":"Peng","year":"2015","journal-title":"Food Funct."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1017\/S0007114515000884","article-title":"Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db\/db mice: Role of AMP-activated protein kinase activation","volume":"113","author":"Zheng","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e70233","DOI":"10.1111\/cns.70233","article-title":"Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia\/Reperfusion Injury via Regulation of the JAK3\/STAT3\/HIF-1\u03b1 Signaling Pathway","volume":"31","author":"Zhou","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/dth.12390","article-title":"Multi-therapies in androgenetic alopecia: Review and clinical experiences","volume":"29","author":"Rossi","year":"2016","journal-title":"Dermatol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"150149","DOI":"10.1016\/j.ijbiomac.2026.150149","article-title":"Bletilla striata polysaccharide (BSP) promotes hair growth and suppresses oxidative stress and senescence of dermal papilla cells by inhibiting prostaglandin-endoperoxide synthase 2 (PTGS2)","volume":"342","author":"Huang","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"148247","DOI":"10.1016\/j.brainres.2023.148247","article-title":"Tongqiao Huoxue decoction alleviates neurological impairment following ischemic stroke via the PTGS2\/NF-kappa B axis","volume":"1805","author":"Zhou","year":"2023","journal-title":"Brain Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100696","DOI":"10.1016\/j.repbio.2022.100696","article-title":"LPS-induced PTGS2 manipulates the inflammatory response through trophoblast invasion in preeclampsia via NF-\u03baB pathway","volume":"22","author":"Li","year":"2022","journal-title":"Reprod. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejphar.2015.03.055","article-title":"Effects of dihydrotestosterone on rat dermal papilla cells in vitro","volume":"757","author":"Kang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1046\/j.1523-1747.2003.12473.x","article-title":"Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression","volume":"121","author":"Leder","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8571","DOI":"10.1080\/07391102.2022.2135599","article-title":"Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) by resveratrol derivatives in cancer therapy: In silico approach","volume":"41","author":"Doiphode","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Doiphode, S., Ghosh, P., Swamy, K.V., and Nagar, S. (2026). An In Silico Study of Resveratrol Derivatives as Dual Inhibitors of Cyclooxygenase-2 (COX-2) and 5-Lipoxygenase (5-LOX) in Cancer Therapy. Biotechnol. Appl. Biochem.","DOI":"10.1002\/bab.70150"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"44551","DOI":"10.1038\/s41598-025-28358-y","article-title":"Unraveling the mechanism of curcumin in coronary slow flow phenomenon through network pharmacology and molecular docking","volume":"15","author":"Xue","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1080\/07391102.2023.2291832","article-title":"Anti-inflammatory effect of curcumin in an accelerated senescence model of Wistar rat: An in vivo and in-silico study","volume":"43","author":"Singh","year":"2025","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Moetlediwa, M.T., Ramashia, R., Mangale, M.B., Pheiffer, C., Jack, B.U., Salifu, E.Y., and Ramharack, P. (2026). Identification of Enhanced Cyclooxygenase-2 (COX-2) Inhibitors Beyond Curcumin Through Virtual Screening to Target Inflammation-Related Metabolic Complications. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27041624"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"D138","DOI":"10.1093\/nar\/gkad965","article-title":"NCBI GEO: Archive for gene expression and epigenomics data sets: 23-year update","volume":"52","author":"Clough","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/bjd.21783","article-title":"Insights into male androgenetic alopecia using comparative transcriptome profiling: Hypoxia-inducible factor-1 and Wnt\/\u03b2-catenin signalling pathways","volume":"187","author":"Liu","year":"2022","journal-title":"Br. J. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: Updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: A web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"D1633","DOI":"10.1093\/nar\/gkae1075","article-title":"BindingDB in 2024: A FAIR knowledgebase of protein-small molecule binding data","volume":"53","author":"Liu","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"D380","DOI":"10.1093\/nar\/gkv1277","article-title":"STITCH 5: Augmenting protein\u2013chemical interaction networks with tissue and affinity data","volume":"44","author":"Szklarczyk","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.12688\/f1000research.172567.1","article-title":"Linking chemical data from the Comparative Toxicogenomics Database with adverse outcome pathways from the AOP-Wiki: A mechanistic data-oriented approach to help inform environmental health","volume":"14","author":"Davis","year":"2025","journal-title":"F1000Research"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"D1227","DOI":"10.1093\/nar\/gkad1040","article-title":"DGIdb 5.0: Rebuilding the drug\u2013gene interaction database for precision medicine and drug discovery platforms","volume":"52","author":"Cannon","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: A database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinform."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"19800","DOI":"10.1021\/acs.jmedchem.5c00920","article-title":"Drug and Clinical Candidate Drug Data in ChEMBL","volume":"68","author":"Hunter","year":"2025","journal-title":"J. Med. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry","volume":"25","author":"Keiser","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10822-016-9915-2","article-title":"TargetNet: A web service for predicting potential drug\u2013target interaction profiling via multi-target SAR models","volume":"30","author":"Yao","year":"2016","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bardou, P., Mariette, J., Escudi\u00e9, F., Djemiel, C., and Klopp, C. (2014). jvenn: An interactive Venn diagram viewer. BMC Bioinform., 15.","DOI":"10.1186\/1471-2105-15-293"},{"key":"ref_55","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Chen, L., Zhang, Y.H., Wang, S., Zhang, Y., Huang, T., and Cai, Y.D. (2017). Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184129"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: Protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"D1516","DOI":"10.1093\/nar\/gkae1059","article-title":"PubChem 2025 update","volume":"53","author":"Kim","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"W547","DOI":"10.1093\/nar\/gkaf394","article-title":"The UniProt website API: Facilitating programmatic access to protein knowledge","volume":"53","author":"Ahmad","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"D564","DOI":"10.1093\/nar\/gkae1091","article-title":"Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank","volume":"53","author":"Burley","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.33011\/livecoms.1.1.5068","article-title":"From Proteins to Perturbed Hamiltonians: A Suite of Tutorials for the GROMACS-2018 Molecular Simulation Package [Article v1.0]","volume":"1","author":"Lemkul","year":"2018","journal-title":"Living J. Comput. Mol. Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/4858\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:04:16Z","timestamp":1779955456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/4858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":61,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ijms27114858"],"URL":"https:\/\/doi.org\/10.3390\/ijms27114858","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]}}}