{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:16:56Z","timestamp":1780406216842,"version":"3.54.1"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurodegenerative diseases encompass a wide range of disorders linked to aging, predominantly impacting the central nervous system and leading to progressive neural deterioration [...]<\/jats:p>","DOI":"10.3390\/ijms27114926","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:45:08Z","timestamp":1780404308000},"page":"4926","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd Edition"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2431-0308","authenticated-orcid":false,"given":"Claudia","family":"Ricci","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shimozono, K., Kim, Y.-J., Hata, T., Nan, H., Saito, K., Mori, Y., Ueno, Y., Isono, F., Iwasaki, M., and Koizumi, S. (2025). 4-Phenylbutyric Acid Improves Gait Ability of UBAP1-Related Spastic Paraplegia Mouse Model: Therapeutic Potential for SPG80. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26199779"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ansari, A., Park, G.-S., Park, S.-J., Goh, A.-R., and Je, K.-H. (2025). Sobrerol Improves Memory Impairment in the Scopolamine-Induced Amnesia Mouse Model. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26104613"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1037\/0735-7044.101.3.347","article-title":"Memory Dysfunction and Word Priming in Dementia and Amnesia","volume":"101","author":"Shimamura","year":"1987","journal-title":"Behav. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lu, C.-H., Huang, Y.-F., and Chu, I.-M. (2022). Design of Oral Sustained-Release Pellets by Modeling and Simulation Approach to Improve Compliance for Repurposing Sobrerol. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14010167"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Liu, X., Hebron, M.L., Stevenson, M., and Moussa, C. (2025). A Novel Small Molecule Enhances Stable Dopamine Delivery to the Brain in Models of Parkinson\u2019s Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094251"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1021\/acschemneuro.4c00169","article-title":"Design, Synthesis, and Evaluation of a Novel Conjugate Molecule with Dopaminergic and Neuroprotective Activities for Parkinson\u2019s Disease","volume":"15","author":"Ploper","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The Blood-Brain Barrier: Bottleneck in Brain Drug Development","volume":"2","author":"Pardridge","year":"2005","journal-title":"Neurotherapeutics"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ferrari, R.R., Fantini, V., Garofalo, M., Di Gerlando, R., Dragoni, F., Rizzo, B., Spina, E., Rossi, M., Calatozzolo, C., and Profka, X. (2024). A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011117"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nowakowska, K., Walkiewicz, G., Stec-Martyna, E., Kulczycka-Wojdala, D., Frankowska, E., Miler, P., Pawlak, A., Wo\u017aniak, K., Krejca, M., and Wilczy\u0144ski, M. (2025). Circulating Brain-Related miRNAs as Predictors of Postoperative Delirium in Cardiac Surgery Patients. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26189062"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Al Farsi, R.S., Al Alawi, A.M., Al Huraizi, A.R., Al-Saadi, T., Al-Hamadani, N., Al Zeedy, K., and Al-Maqbali, J.S. (2023). Delirium in Medically Hospitalized Patients: Prevalence, Recognition and Risk Factors: A Prospective Cohort Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12123897"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/psyg.13078","article-title":"The Prognosis of Delirium in Older Outpatients","volume":"24","author":"Zuidema","year":"2024","journal-title":"Psychogeriatrics"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Razak, N.H.A., Vijakumaran, U., Idris, I.M., Idris, J., Hassan, N.H., Zaini, F., Muhamad, N., and Daud, M.F. (2025). Hyperglycemia Modulates mTOR Signaling and Myelin Protein Expression in Schwann Cells. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26199724"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhu, J., Hu, Z., Luo, Y., Liu, Y., Luo, W., Du, X., Luo, Z., Hu, J., and Peng, S. (2024). Diabetic Peripheral Neuropathy: Pathogenetic Mechanisms and Treatment. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1265372"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sanchez, K.L., Kim, J., White, J.B., Tolan, A., Rajagopal, N.P., Anderson, D.W., Shin, A.N., Shin, S.D., Currais, A., and Soriano-Castell, D. (2025). Evidence of Oxytosis\/Ferroptosis in Niemann\u2013Pick Disease Type C. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26072915"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Yokoya, M., Takata, F., Iwao, T., Matsumoto, J., Tanaka, Y., Aridome, H., Yasunaga, M., Mizoguchi, J., Sano, K., and Dohgu, S. (2025). \u03b1-Synuclein Degradation in Brain Pericytes Is Mediated via Akt, ERK, and P38 MAPK Signaling Pathways. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26041615"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Toader, C., Tataru, C.P., Munteanu, O., Serban, M., Covache-Busuioc, R.-A., Ciurea, A.V., and Enyedi, M. (2024). Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer\u2019s, Parkinson\u2019s, and ALS. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312613"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ruiz-S\u00e1nchez, E., Rojas, C., Yescas G\u00f3mez, P., Mart\u00ednez-Rodr\u00edguez, N., Ruiz-Chow, \u00c1.A., Nava-Ruiz, C., Ib\u00e1\u00f1\u00e9z-Cervantes, G., Arciniega-Mart\u00ednez, I.M., Res\u00e9ndiz-Albor, A.A., and Rojas, P. (2025). Regulation of NR4A2 Gene Expression and Its Importance in Neurodegenerative and Psychiatric Diseases. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26189162"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhang, Y.-M., Yang, F., Li, Q., and Zhang, J.-N. (2025). Role of Histone Lactylation in Neurological Disorders. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26167949"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12974-023-02879-7","article-title":"H3K18 Lactylation of Senescent Microglia Potentiates Brain Aging and Alzheimer\u2019s Disease through the NF\u03baB Signaling Pathway","volume":"20","author":"Wei","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cmet.2022.02.013","article-title":"Positive Feedback Regulation of Microglial Glucose Metabolism by Histone H4 Lysine 12 Lactylation in Alzheimer\u2019s Disease","volume":"34","author":"Pan","year":"2022","journal-title":"Cell Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbrc.2012.10.107","article-title":"Calcium Leak through Ryanodine Receptor Is Involved in Neuronal Death Induced by Mutant Huntingtin","volume":"429","author":"Suzuki","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.2174\/13894501113149990156","article-title":"Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue","volume":"14","author":"Rajkowska","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00213-011-2190-y","article-title":"Fluoxetine Regulates the Expression of Neurotrophic\/Growth Factors and Glucose Metabolism in Astrocytes","volume":"216","author":"Allaman","year":"2011","journal-title":"Psychopharmacology"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Elazar, D., Alvarez, N., Drobeck, S., and Gunn, T.M. (2025). SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202501.2307.v1"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Athanasaki, A., Tsantzali, I., Theodorou, A., Michalopoulou, A., Constantinides, V.C., Boufidou, F., Tzartos, J.S., Tsalouchidou, P.-E., Zompola, C., and Paraskevas, S.G. (2025). The Biomarker Profile of Alzheimer\u2019s Disease for Disease-Modifying Treatment Eligibility: Questions and Debates. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26199531"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"362","DOI":"10.14283\/jpad.2023.30","article-title":"Lecanemab: Appropriate Use Recommendations","volume":"10","author":"Cummings","year":"2023","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100150","DOI":"10.1016\/j.tjpad.2025.100150","article-title":"Donanemab: Appropriate Use Recommendations","volume":"12","author":"Rabinovici","year":"2025","journal-title":"J. Prev. Alzheimer\u2019s Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/4926\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:54:40Z","timestamp":1780404880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/4926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ijms27114926"],"URL":"https:\/\/doi.org\/10.3390\/ijms27114926","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}