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(2026, May 21). Biochemistry, Lipids, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK525952\/."},{"key":"ref_2","unstructured":"Feingold, K.R., Adler, R.A., Ahmed, S.F., Anawalt, B., Blackman, M.R., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., and Dungan, K. (2026, May 21). Introduction to Lipids and Lipoproteins, Endotext [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK305896\/."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gurr, M.I., and Harwood, J.L. (1991). Lipid functions. Lipid Biochemistry: An Introduction, Springer.","DOI":"10.1007\/978-94-011-3062-2"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1194\/jlr.TR119000427","article-title":"Lipid rafts and neurodegeneration: Structural and functional roles in physiologic aging and neurodegenerative diseases: Thematic Review Series: Biology of Lipid Rafts","volume":"61","author":"Grassi","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1126\/science.1174621","article-title":"Lipid Rafts As a Membrane-Organizing Principle","volume":"327","author":"Lingwood","year":"2010","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-025-02357-x","article-title":"Lipid metabolism in homeostasis and disease","volume":"11","author":"Li","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101235","DOI":"10.1016\/j.plipres.2023.101235","article-title":"Lipid metabolism around the body clocks","volume":"91","author":"Petrenko","year":"2023","journal-title":"Prog. Lipid Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: Where they are and how they behave","volume":"9","author":"Voelker","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nri3793","article-title":"Cholesterol, inflammation and innate immunity","volume":"15","author":"Tall","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100164","DOI":"10.1016\/j.jlr.2021.100164","article-title":"The foundations and development of lipidomics","volume":"63","author":"Han","year":"2022","journal-title":"J. Lipid Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nrd1776","article-title":"The emerging field of lipidomics","volume":"4","author":"Wenk","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-biochem-060409-092612","article-title":"Applications of Mass Spectrometry to Lipids and Membranes","volume":"80","author":"Harkewicz","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrm2934","article-title":"Lipidomics: Coming to grips with lipid diversity","volume":"11","author":"Shevchenko","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1194\/jlr.R800095-JLR200","article-title":"Update of the LIPID MAPS comprehensive classification system for lipids1","volume":"50","author":"Fahy","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5851\/kosfa.2021.e59","article-title":"A Comprehensive Review of Lipidomics and Its Application to Assess Food Obtained from Farm Animals","volume":"42","author":"Song","year":"2022","journal-title":"Food Sci. Anim. Resour."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Yilmaz, A., Akyol, S., Ashrafi, N., Saiyed, N., Turkoglu, O., and Graham, S.F. (2025). Lipidomics of Huntington\u2019s Disease: A Comprehensive Review of Current Status and Future Directions. Metabolites, 15.","DOI":"10.3390\/metabo15010010"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wang, Y. (2024). Fasting Triglycerides in the Upper Normal Range Are Independently Associated with an Increased Risk of Diabetes Mortality in a Large Representative US Population. J. Cardiovasc. Dev. Dis., 11.","DOI":"10.20944\/preprints202402.1739.v1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/cvr\/cvac124","article-title":"Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes","volume":"119","author":"Wang","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wang, Y., Fang, Y., and Vrablik, M. (2024). Homeostasis Model Assessment for Insulin Resistance Mediates the Positive Association of Triglycerides with Diabetes. Diagnostics, 14.","DOI":"10.20944\/preprints202403.0158.v1"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2015.01.036","article-title":"A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins","volume":"161","author":"Goldstein","year":"2015","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.290.5497.1721","article-title":"How Cells Handle Cholesterol","volume":"290","author":"Simons","year":"2000","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12944-021-01614-6","article-title":"Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults","volume":"20","author":"Wang","year":"2021","journal-title":"Lipids Health Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e642","DOI":"10.1002\/hsr2.642","article-title":"Fasting status modifies the association between triglyceride and all-cause mortality: A cohort study","volume":"5","author":"Fang","year":"2022","journal-title":"Health Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101459","DOI":"10.37349\/eemd.2026.101459","article-title":"Normal triglyceride levels are positively associated with plasma glucose levels and type 2 diabetes diagnosis in Chinese adults","volume":"3","author":"Wang","year":"2026","journal-title":"Explor. Endocr. Metab. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/targets2020006","article-title":"Non-Fasting Plasma Triglycerides Are Positively Associated with Diabetes Mortality in a Representative US Adult Population","volume":"2","author":"Wang","year":"2024","journal-title":"Targets"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. 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Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1111\/j.1742-4658.2012.08644.x","article-title":"Lipid metabolism in cancer","volume":"279","author":"Santos","year":"2012","journal-title":"FEBS J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5729498","DOI":"10.1155\/2019\/5729498","article-title":"Dietary Lipids in Health and Disease","volume":"2019","author":"Amin","year":"2019","journal-title":"J. Lipids"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Andersen, C.J. (2022). Lipid Metabolism in Inflammation and Immune Function. Nutrients, 14.","DOI":"10.3390\/nu14071414"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"111527","DOI":"10.1016\/j.mad.2021.111527","article-title":"The role of lipid-based signalling in wound healing and senescence","volume":"198","author":"Pils","year":"2021","journal-title":"Mech. 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Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. 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Lipid Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/mas.20023","article-title":"Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples","volume":"24","author":"Han","year":"2005","journal-title":"Mass Spectrom. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.cell.2010.11.033","article-title":"Lipidomics: new tools and applications","volume":"143","author":"Wenk","year":"2010","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1039\/D5AN00851D","article-title":"Single-cell lipidomics: Performance evaluation across four liquid chromatography mass spectrometry (LC-MS) systems","volume":"150","author":"Saunders","year":"2025","journal-title":"Analyst"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mutuku, S.M., Spotbeen, X., Trim, P.J., Snel, M.F., Butler, L.M., and Swinnen, J.V. (2022). Unravelling Prostate Cancer Heterogeneity Using Spatial Approaches to Lipidomics and Transcriptomics. Cancers, 14.","DOI":"10.3390\/cancers14071702"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"100169","DOI":"10.1016\/j.bbadva.2025.100169","article-title":"Unravelling lipid heterogeneity: Advances in single-cell lipidomics in cellular metabolism and disease","volume":"8","author":"Sarkar","year":"2025","journal-title":"BBA Adv."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/s42255-024-01118-4","article-title":"Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer","volume":"6","author":"Buglakova","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Rong, W., and Zhou, Y. (2025). Decoding cardiac metabolic reprogramming through single-cell multi-omics: From mechanisms to therapeutic applications. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1710474"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1038\/s42255-025-01365-z","article-title":"The Neurolipid Atlas: A lipidomics resource for neurodegenerative diseases","volume":"7","author":"Feringa","year":"2025","journal-title":"Nat. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Pomares, O., P\u00e9rez-Nadador, I., Mejorado-Molano, F.J., Parra-Rodr\u00edguez, A., Soriano-Guill\u00e9n, L., and Garc\u00e9s, C. (2025). Leptin-Independent Association Between SNVs in the Leptin Gene and HDL-C and Apo-AI in Children. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262411906"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Molotkovsky, R.J., Denieva, Z.G., Senchikhin, I.N., Urodkova, E.K., Konarev, P.V., Peters, G.S., Galimzyanov, T.R., Pavlov, R.V., and Bashkirov, P.V. (2025). Quantifying the Activation Barrier for Phospholipid Monolayer Fusion Governing Lipid Droplet Coalescence. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262311664"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Mahmood, H.M., Bengoechea-Alonso, M.T., Al-Ansari, D.E., Machaca, K., and Ericsson, J. (2025). The Functional Interaction Between PRDM16 and the SREBP Pathway Controls Lipid Metabolism. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202509.0096.v1"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Best, H.L., Cook, S.R., Waller-Evans, H., and Lloyd-Evans, E. (2025). Niemann-Pick C-like Endolysosomal Dysfunction in DHDDS Patient Cells, a Congenital Disorder of Glycosylation, Can Be Treated with Miglustat. Int. J. Mol. Sci., 26.","DOI":"10.1101\/2025.01.08.631939"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Aloliqi, A.A., Alnuqaydan, A.M., Alshebremi, M., Khan, A., and Khan, M.A. (2026). Invariant Natural Killer T Cells in Cancer Immunotherapy: Lipid-Based Modulation, Nanotechnology, and Translational Advances. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27062528"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Damiza-Detmer, A., Pawe\u0142czyk, M., and G\u0142\u0105bi\u0144ski, A. (2026). The Role of Lipid Alteration in Multiple Sclerosis. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27020812"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Merk, V.M., Boonen, G., and Butterweck, V. (2025). St. John\u2019s Wort for Depression: From Neurotransmitters to Membrane Plasticity. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262411925"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Wang, Y. (2025). Triglycerides, Glucose Metabolism, and Type 2 Diabetes. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26209910"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Karbowska, J., and Kochan, Z. (2025). Crosstalk Between Dietary Fatty Acids and MicroRNAs in the Regulation of Hepatic ApoB-Containing Lipoprotein Synthesis in Humans. Int. J. Mol. 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