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Although their individual signaling pathways have been extensively investigated, the integrated mechanisms underlying NO\u2013H2S crosstalk and its potential agronomic applications remain unclear. This review summarizes current advances in understanding the biochemical interplay between NO and H2S in plants, emphasizing their synergistic roles in redox regulation, antioxidant activation, ion homeostasis, and photosynthetic protection under abiotic and biotic stresses. Special attention has been given to recent progress in nanotechnology-based delivery systems that enable the controlled, localized, and sustained release of gasotransmitters, thereby improving bioavailability and minimizing environmental losses. Studies on foliar, seed, and nutrient-solution applications have demonstrated that combined NO\/H2S treatments increase stress tolerance by activating the ascorbate\u2013glutathione (AsA\u2013GSH) cycle, reducing the expression of oxidative markers such as hydrogen peroxide (H2O2) and malondialdehyde (MDA), and improving both short-term (Fv\/Fm, antioxidant enzyme activity) and long-term (biomass, SPAD index, yield) physiological outcomes. By integrating molecular insights with applied strategies, this review outlines the emerging potential of NO\u2013H2S signaling as a sustainable tool for crop management in the context of climate change and food security.<\/jats:p>","DOI":"10.3390\/ijms27114962","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:45:08Z","timestamp":1780404308000},"page":"4962","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nitric Oxide and Hydrogen Sulfide Crosstalk in Plants: Redox Regulation, Stress Adaptation, and Emerging Applications"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-2533","authenticated-orcid":false,"given":"Roberta A.","family":"dos Reis","sequence":"first","affiliation":[{"name":"Center for Natural and Human Sciences, Federal University of ABC (UFABC), Santo Andr\u00e9 09210-580, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-0380","authenticated-orcid":false,"given":"Amedea B.","family":"Seabra","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences, Federal University of ABC (UFABC), Santo Andr\u00e9 09210-580, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cec\u00edlia Brilhante","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences, Federal University of ABC (UFABC), Santo Andr\u00e9 09210-580, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgana","family":"Halfeld","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences, Federal University of ABC (UFABC), Santo Andr\u00e9 09210-580, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan S.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences, Federal University of ABC (UFABC), Santo Andr\u00e9 09210-580, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Aplicadas, Facultad de Ingenier\u00eda, Universidad Aut\u00f3noma de Chile, Temuco 4810101, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-4315","authenticated-orcid":false,"given":"Adalberto","family":"Benavides-Mendoza","sequence":"additional","affiliation":[{"name":"Department of Horticulture, Antonio Narro Autonomous Agrarian University, Calzada Antonio Narro 1923, Saltillo 25315, Mexico"},{"name":"Conacyt Laboratory of Plant Ecophysiology and Food Safety (LANCEVSA), Antonio Narro Autonomous Agrarian University, Saltillo 25315, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Rubilar","sequence":"additional","affiliation":[{"name":"Centro de Excelencia en Investigaci\u00f3n Biotecnol\u00f3gica Aplicada al Medio Ambiente (CIBAMA), Facultad de Ingenier\u00eda y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, Facultad de Ingenier\u00eda y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-7454","authenticated-orcid":false,"given":"Gonzalo R.","family":"Tortella","sequence":"additional","affiliation":[{"name":"Centro de Excelencia en Investigaci\u00f3n Biotecnol\u00f3gica Aplicada al Medio Ambiente (CIBAMA), Facultad de Ingenier\u00eda y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, Facultad de Ingenier\u00eda y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187433152207050","DOI":"10.2174\/18743315-v16-e2207050","article-title":"Gasotransmitters in Plants: Mechanisms of Participation in Adaptive Responses","volume":"16","author":"Kolupaev","year":"2022","journal-title":"Open Agric. 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