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This study evaluated the expression of EMT markers and transcription factors and their associations with clinicopathological features and survival in OSCC. Immunohistochemical expression of E-cadherin, N-cadherin, vimentin, and EMT-associated transcription factors (Snail1, Slug, Twist, ZEB1, ZEB2, and E47) was assessed in OSCC samples. Associations with clinicopathological variables were analyzed using \u03c72 or Fisher\u2019s exact test, while survival outcomes were evaluated using Kaplan\u2013Meier and Cox regression analyses. E-cadherin, vimentin, and N-cadherin were expressed in 54.5%, 39.6%, and 2.5% of cases, respectively. Loss of E-cadherin and vimentin expression was associated with adverse clinicopathological features, including advanced stage, lymph node metastasis, and poor differentiation. Vimentin expression was significantly associated with reduced disease-specific and overall survival in univariate analysis. Based on combined E-cadherin and vimentin expression, tumors were classified as non-EMT, partial EMT, or complete EMT. Complete EMT was associated with significantly poorer survival, whereas partial EMT showed no prognostic impact. Vimentin independently predicted disease-specific survival, while EMT-related alterations overall appeared strongly influenced by established clinicopathological factors, particularly tumor stage.<\/jats:p>","DOI":"10.3390\/ijms27115002","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:45:08Z","timestamp":1780404308000},"page":"5002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Significance of Epithelial\u2013Mesenchymal Transition in Oral Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"27","author":[{"given":"Paloma","family":"Lequerica-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Carretera de Rub\u00edn, s\/n, 33011 Oviedo, Asturias, Spain"},{"name":"Department of Biochemistry, Hospital Universitario Central de Asturias (HUCA), C\/Carretera de Rub\u00edn, s\/n, 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Vallina-Fern\u00e1ndez-Kelly","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), C\/Carretera de Rub\u00edn, s\/n, 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0890","authenticated-orcid":false,"given":"Juan Pablo","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Carretera de Rub\u00edn, s\/n, 33011 Oviedo, Asturias, Spain"},{"name":"Department of Otolaryngology, Hospital Universitario Central de Asturias (HUCA), C\/Carretera de Rub\u00edn, s\/n, 33011 Oviedo, Asturias, Spain"},{"name":"Department of Surgery, Universidad de Oviedo, 33011 Oviedo, Asturias, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III, Av. 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Monforte de Lemos, 3-5, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5891-9488","authenticated-orcid":false,"given":"Juana M.","family":"Garc\u00eda-Pedrero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Carretera de Rub\u00edn, s\/n, 33011 Oviedo, Asturias, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-9465","authenticated-orcid":false,"given":"Juan Carlos","family":"de Vicente","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA), Universidad de Oviedo, C\/Carretera de Rub\u00edn, s\/n, 33011 Oviedo, Asturias, Spain"},{"name":"Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), C\/Carretera de Rub\u00edn, s\/n, 33011 Oviedo, Asturias, Spain"},{"name":"Department of Surgery, Universidad de Oviedo, 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijom.2021.03.015","article-title":"What has the National Cancer Database taught us about oral cavity squamous cell carcinoma?","volume":"51","author":"Graillon","year":"2022","journal-title":"Int. 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