{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:33:46Z","timestamp":1790660026023,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-74-10098"],"award-info":[{"award-number":["24-74-10098"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"award":["24-74-10098"],"award-info":[{"award-number":["24-74-10098"]}],"id":[{"id":"https:\/\/ror.org\/03y2gwe85","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Integrating proteomic and metabolomic data remains challenging due to the many-to-many relationships between metabolites and proteins and the spatial constraints of cellular compartmentalization. To address this, we developed PMconv, a web-based application for bidirectional, knowledge-based mapping of proteomic and metabolomic datasets. Leveraging curated associations from the Human Metabolome Database (HMDB) and protein interaction data from STRING, PMconv infers potential biochemical connections between experimentally detected molecules and pathway-annotated partners. The tool supports interactive network visualization and exports compartment annotations from the Human Protein Atlas to facilitate spatial contextualization of inferred interactions. PMconv is designed as an exploratory resource for hypothesis generation and feature engineering in multi-omics research, with the explicit understanding that knowledge-derived associations require experimental validation for compartment-specific interpretation.<\/jats:p>","DOI":"10.3390\/ijms27115086","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:23:21Z","timestamp":1780622601000},"page":"5086","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["PMconv: How to Compare Proteomes and Metabolomes?"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-6679","authenticated-orcid":false,"given":"Anna","family":"Kozlova","sequence":"first","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9230-1238","authenticated-orcid":false,"given":"Anna","family":"Kliuchnikova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina","family":"Gordeeva","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Lisitsa","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ponomarenko","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Ilgisonis","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"ref_1","first-page":"tr5","article-title":"Introduction to Network Analysis in Systems Biology","volume":"4","year":"2011","journal-title":"Sci. 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