{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:53:55Z","timestamp":1785405235491,"version":"3.56.0"},"reference-count":53,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81601335"],"award-info":[{"award-number":["81601335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["81601335"],"award-info":[{"award-number":["81601335"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis (EMs) is an estrogen-dependent inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity, yet its precise pathogenesis remains incompletely elucidated. TICAM1, a key adaptor protein in the Toll-like receptor (TLR) signaling pathway, is known to be involved in inflammatory responses; however, its specific role in EMs has not been defined. This study integrated evidence from clinical tissue samples of patients with ovarian endometriomas, in vitro studies, and in vivo models to explore the role of TICAM1 in EMs. TICAM1 expression was significantly upregulated in both eutopic and ectopic endometrium, with the highest levels observed in ectopic lesions, where it was primarily localized to stromal and glandular epithelial cells. Functional experiments showed that TICAM1 overexpression promoted the proliferation, migration, and invasion of human endometrial stromal cells (hESCs), while TICAM1 knockdown suppressed these activities. Concurrently, TLR3 and TLR4 were also upregulated in EMs tissues, and their activation increased TICAM1 expression. Knockdown of TICAM1 attenuated the enhanced cellular activities induced by TLR3\/TLR4 activation. Mechanistically, IRF3 and IFN-\u03b2 levels were elevated in both EMs tissues and TICAM1-overexpressing hESCs, while TICAM1 knockdown inhibited TLR3\/TLR4-induced IRF3 phosphorylation and subsequent IFN-\u03b2 production. These findings were further corroborated in a mouse model of EMs. Together, our findings suggest that TICAM1 may enhance the proliferation, migration, and invasion of hESCs by mediating TLR3\/TLR4 signaling and promoting IRF3 phosphorylation and subsequent IFN-\u03b2 production, thereby potentially contributing to EMs progression. Therefore, targeting TICAM1 may represent a potential therapeutic direction for ovarian endometrioma-associated EMs, while its relevance to superficial peritoneal and deep infiltrating EMs requires further investigation.<\/jats:p>","DOI":"10.3390\/ijms27115089","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:23:21Z","timestamp":1780622601000},"page":"5089","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TICAM1-Mediated TLR3\/TLR4 Signaling Promotes Endometrial Stromal Cell Proliferation, Migration, and Invasion in Endometriosis via IRF3\/IFN-\u03b2 Axis"],"prefix":"10.3390","volume":"27","author":[{"given":"HaLiSai","family":"MuDanLiFu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, 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Endometriosis","volume":"379","author":"Horne","year":"2022","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jad.2015.10.030","article-title":"Risk of Developing Major Depression and Anxiety Disorders among Women with Endometriosis: A Longitudinal Follow-up Study","volume":"190","author":"Chen","year":"2016","journal-title":"J. Affect Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/er.2018-00242","article-title":"Endometriosis","volume":"40","author":"Bulun","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: Pathogenesis and Treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_7","first-page":"93","article-title":"Metastatic or Embolic Endometriosis, Due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation","volume":"3","author":"Sampson","year":"1927","journal-title":"Am. J. Pathol."},{"key":"ref_8","first-page":"151","article-title":"Retrograde Menstruation in Healthy Women and in Patients with Endometriosis","volume":"64","author":"Halme","year":"1984","journal-title":"Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41574-019-0245-z","article-title":"Rethinking Mechanisms, Diagnosis and Management of Endometriosis","volume":"15","author":"Chapron","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_10","first-page":"241","article-title":"Promotion and Enhancement of Research on Endometriosis","volume":"45","author":"Lang","year":"2010","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","article-title":"Endometriosis: Etiology, Pathobiology, and Therapeutic Prospects","volume":"184","author":"Saunders","year":"2021","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.fertnstert.2023.03.032","article-title":"Gut Dysbiosis-Derived \u03b2-Glucuronidase Promotes the Development of Endometriosis","volume":"120","author":"Wei","year":"2023","journal-title":"Fertil. Steril."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.fertnstert.2021.11.024","article-title":"Endometrial Cytokines in Patients with and without Endometriosis Evaluated for Infertility","volume":"117","author":"Fedorcsak","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR Signaling Pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sobstyl, A., Mertowska, P., Mertowski, S., Tarkowski, R., Dudzi\u0144ski, D., Kotowski, M., Bojarski, K., Stelmach, B., Chermu\u0142a, B., and Br\u0105zert, M. (2025). Expression of Toll-like Receptors on Lymphocyte Subpopulations and Their Soluble Forms in Serum and Urine of Women with Endometriosis. Cells, 14.","DOI":"10.3390\/cells14161273"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0962-8924(01)02004-9","article-title":"Toll Receptors in Innate Immunity","volume":"11","author":"Imler","year":"2001","journal-title":"Trends Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.addr.2007.11.005","article-title":"TLR3: Interferon Induction by Double-Stranded RNA Including Poly(I:C)","volume":"60","author":"Matsumoto","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49751","DOI":"10.1074\/jbc.M305820200","article-title":"TIR-Containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-Beta","volume":"278","author":"Oshiumi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7365","DOI":"10.1038\/s41598-017-07859-5","article-title":"The Expression of Toll-like Receptors in Eutopic and Ectopic Endometrium and Its Implication in the Inflammatory Pathogenesis of Adenomyosis","volume":"7","author":"Jiang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_20","unstructured":"Koval, H., Chopiak, V., and Kamyshnyi, A. (2015). mRNA TLR2 and TLR4 expression in the endometrium tissue in women with endometriosis assosiated with infertility. Georgian Med. News, 7\u201311."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of Adaptor TRIF in the MyD88-Independent Toll-like Receptor Signaling Pathway","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nature01889","article-title":"Identification of Lps2 as a Key Transducer of MyD88-Independent TIR Signalling","volume":"424","author":"Hoebe","year":"2003","journal-title":"Nature"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molimm.2016.03.010","article-title":"14-3-3-Zeta Participates in TLR3-Mediated TICAM-1 Signal-Platform Formation","volume":"73","author":"Funami","year":"2016","journal-title":"Mol. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.humimm.2011.07.307","article-title":"Association of Polymorphisms in TLR Genes and in Genes of the Toll-like Receptor Signaling Pathway with Cancer Risk","volume":"72","author":"Kutikhin","year":"2011","journal-title":"Hum. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1111\/jog.14710","article-title":"The Role of Mitogen-Activated Protein Kinase Signaling Pathway in Endometriosis","volume":"47","author":"Bora","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1600-079X.2012.01002.x","article-title":"Melatonin Modulates TLR4-Mediated Inflammatory Genes through MyD88- and TRIF-Dependent Signaling Pathways in Lipopolysaccharide-Stimulated RAW264.7 Cells","volume":"53","author":"Xia","year":"2012","journal-title":"J. Pineal Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/carcin\/bgw047","article-title":"Selected Single-Nucleotide Polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 Are Associated with Papillary and Follicular Thyroid Cancer Risk: Replication Study in a German Population","volume":"37","author":"Sigurdson","year":"2016","journal-title":"Carcinogenesis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102153","DOI":"10.1016\/j.jogoh.2021.102153","article-title":"Evaluation of Toll-like Receptor 3 (TLR3) Signaling Pathway Genes and Its Genetic Polymorphisms in Ectopic and Eutopic Endometrium of Women with Endometriosis","volume":"50","author":"Almasi","year":"2021","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jmig.2013.07.021","article-title":"Cellular, Histologic, and Molecular Changes Associated with Endometriosis and Ovarian Cancer","volume":"21","author":"Neto","year":"2014","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"103752","DOI":"10.1016\/j.autrev.2025.103752","article-title":"Endometriosis and Autoimmunity","volume":"24","author":"Blanco","year":"2025","journal-title":"Autoimmun. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1084\/jem.20111706","article-title":"MyD88 Inhibition Amplifies Dendritic Cell Capacity to Promote Pancreatic Carcinogenesis via Th2 Cells","volume":"209","author":"Ochi","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-Sensing Receptors in Sterile Inflammation and Inflammatory Diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Guo, B., Chen, J.H., Zhang, J.H., Fang, Y., Liu, X.J., Zhang, J., Zhu, H.Q., and Zhan, L. (2023). Pattern-Recognition Receptors in Endometriosis: A Narrative Review. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1161606"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3892\/mmr.2013.1755","article-title":"Pathogenesis of Endometriosis: The Role of Initial Infection and Subsequent Sterile Inflammation (Review)","volume":"9","author":"Kobayashi","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Wr\u00f3bel, M., Zuzanna, Z., O\u0142dak, \u0141., Kalicka, A., Ma\u0144ka, G., Kiecka, M., Spaczy\u0144ski, R.Z., Piekarski, P., Banaszewska, B., and Jakimiuk, A. (2023). Evaluation of Proteasome and Immunoproteasome Levels in Plasma and Peritoneal Fluid in Patients with Endometriosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814363"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kacperczyk-Bartnik, J., Bartnik, P., Go\u0142awski, K., Sierdzi\u0144ski, J., Ma\u0144ka, G., Kiecka, M., Lipa, M., Warzecha, D., Spaczy\u0144ski, R., and Piekarski, P. (2022). Plasma and Peritoneal Poly (ADP-Ribose) Polymerase Levels in Patients with Endometriosis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10102451"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11418-024-01842-x","article-title":"Azamollugin, a Mollugin Derivative, Has Inhibitory Activity on MyD88- and TRIF-Dependent Pathways","volume":"79","author":"Nakajima","year":"2025","journal-title":"J. Nat. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0092-8674(02)00827-9","article-title":"IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling","volume":"110","author":"Kobayashi","year":"2002","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.autrev.2012.01.005","article-title":"Is There an Association between Autoimmunity and Endometriosis?","volume":"11","author":"Eisenberg","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lamceva, J., Uljanovs, R., and Strumfa, I. (2023). The Main Theories on the Pathogenesis of Endometriosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054254"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/j.1476-5381.2009.00297.x","article-title":"Analysis of Binding Site for the Novel Small-Molecule TLR4 Signal Transduction Inhibitor TAK-242 and Its Therapeutic Effect on Mouse Sepsis Model","volume":"157","author":"Takashima","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"a011247","DOI":"10.1101\/cshperspect.a011247","article-title":"Toll-like Receptor Signaling","volume":"5","author":"Lim","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lu, J., Kornmann, M., and Traub, B. (2023). Role of Epithelial to Mesenchymal Transition in Colorectal Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914815"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Shoari, A., Ashja Ardalan, A., Dimesa, A.M., and Coban, M.A. (2024). Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy. Biomolecules, 15.","DOI":"10.3390\/biom15010035"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"106927","DOI":"10.1016\/j.imlet.2024.106927","article-title":"Acute Effects of TLR3 Agonist Poly(I:C) on Bone Marrow Hematopoietic Progenitor Cells in Mice","volume":"270","author":"Shu","year":"2024","journal-title":"Immunol. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 Trafficking and Its Influence on LPS-Induced pro-Inflammatory Signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"ref_47","first-page":"51513","article-title":"Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens","volume":"23","author":"Jividen","year":"2014","journal-title":"J. Vis. Exp."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.rbmo.2020.06.011","article-title":"Impaired Pathogen-Induced Autophagy and Increased IL-1\u03b2 and TNF\u03b1 Release in Response to Pathogenic Triggers in Secretory Phase Endometrial Stromal Cells of Endometriosis Patients","volume":"41","author":"Matsuzaki","year":"2020","journal-title":"Reprod. BioMed Online"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2523563","DOI":"10.1080\/07853890.2025.2523563","article-title":"1,25-Dihydroxy Vitamin D3 Inhibits LPS-Mediated Inflammatory Responses in Endometriosis","volume":"57","author":"Zhong","year":"2025","journal-title":"Ann. Med."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Liu, Y., Lu, T., Liu, Z., Ning, W., Li, S., Chen, Y., Ge, X., Guo, C., Zheng, Y., and Wei, X. (2022). Six Macrophage-Associated Genes in Synovium Constitute a Novel Diagnostic Signature for Osteoarthritis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.936606"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s13287-024-03910-1","article-title":"PROTAC-Mediated Vimentin Degradation Promotes Terminal Erythroid Differentiation of Pluripotent Stem Cells","volume":"15","author":"Yan","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e23410","DOI":"10.1096\/fj.202302251R","article-title":"\u03b1-Catenin Promotes Dermal Fibroblasts Proliferation and Migration during Wound Healing via FAK\/YAP Activation","volume":"38","author":"Wang","year":"2024","journal-title":"FASEB J."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Laomethakorn, P., Tayeh, M., Samosorn, S., Tananyuthawongse, C., and Watanapokasin, R. (2023). 13-Butoxyberberine Bromide Inhibits Migration and Invasion in Skin Cancer A431 Cells. Molecules, 28.","DOI":"10.3390\/molecules28030991"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/5089\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:14:11Z","timestamp":1780719251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/5089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":53,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ijms27115089"],"URL":"https:\/\/doi.org\/10.3390\/ijms27115089","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]}}}