{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:27:28Z","timestamp":1785414448819,"version":"3.56.0"},"reference-count":67,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A671020"],"award-info":[{"award-number":["N42A671020"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"award":["N42A671020"],"award-info":[{"award-number":["N42A671020"]}],"id":[{"id":"https:\/\/ror.org\/018wfhg78","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epstein\u2013Barr virus (EBV) lytic reactivation contributes to the pathogenesis of EBV-associated epithelial malignancies, including nasopharyngeal carcinoma and gastric carcinoma, highlighting the need for therapeutic strategies targeting viral reactivation. Capsaicin exhibits anticancer and antiviral activities; however, its effects on EBV lytic reactivation remain unclear. This study investigated the effects of capsaicin on EBV lytic reactivation in EBV-positive epithelial cancer models. Capsaicin significantly suppressed the expression of lytic genes, including BZLF1, BRLF1, BMRF1, and BLLF1, and reduced EBV virion production. Proteomic analysis revealed alterations in host cellular pathways associated with metabolism, chromatin organization, and cytoskeletal regulation, whereas metabolomic profiling demonstrated perturbations in nucleotide, amino acid, and polyamine metabolism processes involved in viral DNA replication and protein synthesis. Protein\u2013protein interaction network analysis identified key host proteins, including HSP90AB1, MYH9, and ANXA2, implicated in metabolic reprogramming, cytoskeletal organization, and stress responses. Moreover, upstream regulators associated with EBV lytic activation, including p65, AP-1, HIF-1\u03b1, and SP1, were down-regulated following capsaicin treatment. Collectively, these findings demonstrate a multitarget inhibitory effect of capsaicin on EBV lytic reactivation and support its therapeutic potential against EBV-associated epithelial malignancies.<\/jats:p>","DOI":"10.3390\/ijms27115146","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:18:16Z","timestamp":1780679896000},"page":"5146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-Omics Profiling Reveals Capsaicin Suppresses EBV Lytic Reactivation in Epithelial Cancers by Targeting Viral and Host Regulatory Networks"],"prefix":"10.3390","volume":"27","author":[{"given":"Nutchanat","family":"Chatchawankanpanich","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Faculty of Science and Technology, Thammasat University, Pathumthani 12121, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanitchote","family":"Piyapittayanun","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science and Technology, Thammasat University, Pathumthani 12121, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2797-043X","authenticated-orcid":false,"given":"Chamsai","family":"Pientong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"HEC, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chukkris","family":"Heawchaiyaphum","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"HEC, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.coviro.2018.08.014","article-title":"Contribution of the KSHV and EBV lytic cycles to tumourigenesis","volume":"32","author":"Manners","year":"2018","journal-title":"Curr. Opin. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41579-019-0249-7","article-title":"Latency and lytic replication in Epstein\u2013Barr virus-associated oncogenesis","volume":"17","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kenney, S.C. (2007). Reactivation and lytic replication of EBV. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, Cambridge University Press.","DOI":"10.1017\/CBO9780511545313.026"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.7150\/ijbs.16564","article-title":"Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis","volume":"12","author":"Li","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1099\/0022-1317-76-6-1401","article-title":"Qualitative analysis of the expression of Epstein-Barr virus lytic genes in nasopharyngeal carcinoma biopsies","volume":"76","author":"Grunewald","year":"1995","journal-title":"J. Gen. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1053\/j.gastro.2014.08.036","article-title":"Integrative Identification of Epstein\u2013Barr Virus\u2013Associated Mutations and Epigenetic Alterations in Gastric Cancer","volume":"147","author":"Liang","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1471-4159.2007.04582.x","article-title":"Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation","volume":"102","author":"Amantini","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0898-6568(02)00086-4","article-title":"Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages","volume":"15","author":"Kim","year":"2003","journal-title":"Cell. Signal."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lin, C.-H., Lu, W.-C., Wang, C.-W., Chan, Y.-C., and Chen, M.-K. (2013). Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells. BMC Complement. Altern. Med., 13.","DOI":"10.1186\/1472-6882-13-46"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wu, C.-C., Chen, M.-S., Cheng, Y.-J., Ko, Y.-C., Lin, S.-F., Chiu, I.-M., and Chen, J.-Y. (2019). Emodin inhibits EBV reactivation and represses NPC tumorigenesis. Cancers, 11.","DOI":"10.3390\/cancers11111795"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Rosemarie, Q., and Sugden, B. (2020). Epstein-Barr Virus: How Its Lytic Phase Contributes to Oncogenesis. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111824"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yap, L.F., Wong, A.K.C., Paterson, I.C., and Young, L.S. (2022). Functional Implications of Epstein-Barr Virus Lytic Genes in Carcinogenesis. Cancers, 14.","DOI":"10.3390\/cancers14235780"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/labinvest.2015.69","article-title":"Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage","volume":"95","author":"Yang","year":"2015","journal-title":"Lab. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Dorothea, M., Xie, J., Yiu, S.P.T., and Chiang, A.K.S. (2023). Contribution of Epstein-Barr Virus Lytic Proteins to Cancer Hallmarks and Implications from Other Oncoviruses. Cancers, 15.","DOI":"10.3390\/cancers15072120"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"SoRelle, E.D., Haynes, L.E., Willard, K.A., Chang, B., Ch\u2019ng, J., Christofk, H., and Luftig, M.A. (2024). Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. PLoS Pathog., 20.","DOI":"10.1101\/2024.06.14.598975"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.3390\/molecules15107115","article-title":"Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle","volume":"15","author":"Yiu","year":"2010","journal-title":"Molecules"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.antiviral.2012.09.003","article-title":"Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt\u2019s lymphoma cells by affecting multiple molecular targets","volume":"96","author":"Arena","year":"2012","journal-title":"Antivir. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.antiviral.2016.05.007","article-title":"Luteolin inhibits Epstein-Barr virus lytic reactivation by repressing the promoter activities of immediate-early genes","volume":"132","author":"Wu","year":"2016","journal-title":"Antivir. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18999","DOI":"10.18632\/oncotarget.7967","article-title":"EBV reactivation as a target of luteolin to repress NPC tumorigenesis","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1271\/bbb.65.2033","article-title":"CH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans","volume":"65","author":"Ohnuki","year":"2001","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7396","DOI":"10.1021\/jf020431w","article-title":"Antioxidant activity of capsinoids","volume":"50","author":"Rosa","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/0019-509X.58860","article-title":"Capsaicin: A novel chemopreventive molecule and its underlying molecular mechanisms of action","volume":"47","author":"Oyagbemi","year":"2010","journal-title":"Indian J. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1177\/0192623312444471","article-title":"A comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin","volume":"40","author":"Bley","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/0022034513487376","article-title":"Capsaicin regulates the NF-\u03baB pathway in salivary gland inflammation","volume":"92","author":"Shin","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1007\/s13197-015-1935-8","article-title":"A comparative study of the capsaicinoid and phenolic contents and in vitro antioxidant activities of the peppers of the genus Capsicum: An application of chemometrics","volume":"52","author":"Sora","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.intimp.2015.06.007","article-title":"Capsaicin attenuates LPS-induced inflammatory cytokine production by upregulation of LXR\u03b1","volume":"28","author":"Tang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/B978-0-444-64199-1.00004-X","article-title":"Chemopreventive role of dietary phytochemicals in colorectal cancer","volume":"12","author":"Bansal","year":"2018","journal-title":"Adv. Mol. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.17582\/journal.pjz\/2017.49.1.251.255","article-title":"Antiviral activities of Capsicum annuum methanolic extract against herpes simplex virus 1 and 2","volume":"49","author":"Hafiz","year":"2017","journal-title":"Pak. J. Zool."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.apsb.2020.02.014","article-title":"Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry","volume":"10","author":"Tang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1038\/s41401-023-01111-9","article-title":"Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection","volume":"44","author":"Zhang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.3748\/wjg.v11.i40.6254","article-title":"Capsaicin-induced cell death in a human gastric adenocarcinoma cell line","volume":"11","author":"Lo","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4149\/neo_2013_048","article-title":"Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt\/mTOR and STAT-3 pathways","volume":"60","author":"Yang","year":"2013","journal-title":"Neoplasma"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.7150\/ijbs.7730","article-title":"Capsaicin Mediates Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells via Stabilizing and Activating p53","volume":"10","author":"Jin","year":"2014","journal-title":"Int. J. Biol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11561","DOI":"10.18632\/oncotarget.3427","article-title":"Inhibition of \u03b2-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear \u03b2-Catenin\/TCF-1 complex: Critical role of STAT-3","volume":"6","author":"Pramanik","year":"2015","journal-title":"Oncotarget"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.7314\/APJCP.2015.16.15.6753","article-title":"Induction of Apoptosis by Eugenol and Capsaicin in Human Gastric Cancer AGS Cells--Elucidating the Role of p53","volume":"16","author":"Sarkar","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.3892\/or.2017.5960","article-title":"Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen-activated protein kinase pathway","volume":"38","author":"Zhang","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez, B.G., Bort, A., Mora-Rodr\u00edguez, J.M., and D\u00edaz-Laviada, I. (2022). The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14020329"},{"key":"ref_38","first-page":"e69839","article-title":"Capsaicin Promotes Apoptosis and Inhibits Cell Migration via the Tumor Necrosis Factor-Alpha (TNF\u03b1) and Nuclear Factor Kappa B (NF\u03baB) Signaling Pathway in Oral Cancer Cells","volume":"16","author":"Arivalagan","year":"2024","journal-title":"Cureus"},{"key":"ref_39","first-page":"e68119","article-title":"Evaluation of Cytotoxic and Anti-cancer Potential of Capsaicin on Lung Cancer Cell Line: An In Vitro Investigation","volume":"16","author":"Vel","year":"2024","journal-title":"Cureus"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1080\/15384047.2016.1235654","article-title":"Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition","volume":"17","author":"Wang","year":"2016","journal-title":"Cancer Biol. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Malat, P., Ekalaksananan, T., Heawchaiyaphum, C., Suebsasana, S., Roytrakul, S., Yingchutrakul, Y., and Pientong, C. (2021). Andrographolide inhibits lytic reactivation of Epstein-Barr virus by modulating transcription factors in gastric cancer. Microorganisms, 9.","DOI":"10.3390\/microorganisms9122561"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Malat, P., Ekalaksananan, T., Heawchaiyaphum, C., Suebsasana, S., Roytrakul, S., Yingchutrakul, Y., and Pientong, C. (2022). Andrographolide Inhibits Epstein\u2013Barr Virus Lytic Reactivation in EBV-Positive Cancer Cell Lines through the Modulation of Epigenetic-Related Proteins. Molecules, 27.","DOI":"10.3390\/molecules27144666"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Heawchaiyaphum, C., Malat, P., Pientong, C., Roytrakul, S., Yingchutrakul, Y., Aromseree, S., Suebsasana, S., Mahalapbutr, P., and Ekalaksananan, T. (2023). The Dual Functions of Andrographolide in the Epstein\u2013Barr Virus-Positive Head-and-Neck Cancer Cells: The Inhibition of Lytic Reactivation of the Epstein\u2013Barr Virus and the Induction of Cell Death. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115867"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3390\/molecules19011258","article-title":"Inhibition of Epstein-Barr virus lytic cycle by an ethyl acetate subfraction separated from Polygonum cuspidatum root and its major component, emodin","volume":"19","author":"Yiu","year":"2014","journal-title":"Molecules"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12929-016-0313-9","article-title":"Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin","volume":"24","author":"Wu","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wu, C.C., Lee, T.Y., Cheng, Y.J., Cho, D.Y., and Chen, J.Y. (2022). The Dietary Flavonol Kaempferol Inhibits Epstein-Barr Virus Reactivation in Nasopharyngeal Carcinoma Cells. Molecules, 27.","DOI":"10.3390\/molecules27238158"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1007\/s00253-022-12029-3","article-title":"The roles of DNA methylation on the promotor of the Epstein\u2013Barr virus (EBV) gene and the genome in patients with EBV-associated diseases","volume":"106","author":"Zhang","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.virol.2022.05.005","article-title":"Epstein-Barr virus lytic replication activates and is dependent upon MAPK-interacting kinase 1\/2 in a cell-type dependent manner","volume":"572","author":"Adamson","year":"2022","journal-title":"Virology"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yan, L., Guo, J., Zhong, Y., Wei, J., and Wang, Z. (2025). Molecular Mechanisms of Cell-to-Cell Transmission in Human Herpesviruses. Viruses, 17.","DOI":"10.3390\/v17060742"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Pennisi, R., Trischitta, P., Costa, M., Venuti, A., Tamburello, M.P., and Sciortino, M.T. (2024). Update of Natural Products and Their Derivatives Targeting Epstein-Barr Infection. Viruses, 16.","DOI":"10.3390\/v16010124"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lieberman, P.M., and Tempera, I. (2025). Chromatin Control of EBV Infection and Latency. Current Topics in Microbiology and Immunology, Springer.","DOI":"10.1007\/82_2025_318"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e0050623","DOI":"10.1128\/jvi.00506-23","article-title":"Rewiring of the Host Cell Metabolome and Lipidome during Lytic Gammaherpesvirus Infection Is Essential for Infectious-Virus Production","volume":"97","author":"Clark","year":"2023","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/carcin\/bgs364","article-title":"(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1\/2 and PI3-K\/Akt signaling in EBV-positive cells","volume":"34","author":"Liu","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.semcancer.2014.01.002","article-title":"Regulation of the latent-lytic switch in Epstein\u2013Barr virus","volume":"Volume 26","author":"Kenney","year":"2014","journal-title":"Seminars in Cancer Biology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"16448","DOI":"10.1038\/s41598-025-98679-5","article-title":"TNF-\u03b1 inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Yang, T., You, C., Meng, S., Lai, Z., Ai, W., and Zhang, J. (2022). EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.935205"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"13790","DOI":"10.1038\/s41598-023-40933-9","article-title":"Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)","volume":"13","author":"Patwardhan","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e2111011118","DOI":"10.1073\/pnas.2111011118","article-title":"Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells","volume":"118","author":"Chen","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"116118","DOI":"10.1016\/j.biopha.2023.116118","article-title":"MYH9: A key protein involved in tumor progression and virus-related diseases","volume":"171","author":"Liu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4035460","DOI":"10.1155\/2019\/4035460","article-title":"ANXA2 Silencing Inhibits Proliferation, Invasion, and Migration in Gastric Cancer Cells","volume":"2019","author":"Xie","year":"2019","journal-title":"J. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.biomaterials.2015.01.023","article-title":"Cytoskeletal tension induces the polarized architecture of the nucleus","volume":"48","author":"Kim","year":"2015","journal-title":"Biomaterials"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Nathan, K.G., and Lal, S.K. (2020). The Multifarious Role of 14-3-3 Family of Proteins in Viral Replication. Viruses, 12.","DOI":"10.3390\/v12040436"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/cm.21718","article-title":"Myosin motors on the pathway of viral infections","volume":"79","author":"Matozo","year":"2022","journal-title":"Cytoskeleton"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Olson, M.F. (2022). Actin-Myosin Cytoskeleton Regulation and Function. Cells, 12.","DOI":"10.3390\/cells12010009"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Tian, Z., Shi, D., Zhang, Y., Liu, W., and Luo, B. (2025). Regulation of Fascin -1 by Epstein\u2013Barr virus-induced methylation and its encoded Zta in EBV-associated gastric cancer. Res. Sq.","DOI":"10.21203\/rs.3.rs-7598331\/v1"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"103752","DOI":"10.1016\/j.sjbs.2023.103752","article-title":"Hub genes identification and association of key pathways with hypoxia in cancer cells: A bioinformatics analysis","volume":"30","author":"Aziz","year":"2023","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Chin, C.-H., Chen, S.-H., Wu, H.-H., Ho, C.-W., Ko, M.-T., and Lin, C.-Y. (2014). cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst. Biol., 8.","DOI":"10.1186\/1752-0509-8-S4-S11"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/5146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:10:45Z","timestamp":1781237445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/11\/5146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ijms27115146"],"URL":"https:\/\/doi.org\/10.3390\/ijms27115146","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]}}}