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While the efficacy of biologics in treating psoriasis is well-established, these treatments are also associated with frequent adverse reactions. Consequently, there is an urgent need to develop new treatment strategies for psoriasis. Pomegranate peel, which is widely used in skincare and protection, has not been fully studied for its therapeutic potential in psoriasis. This article investigates the therapeutic effectiveness of pomegranate peel ethanol extract (PEE) on psoriasis. A total of 2872 compounds were identified in PEE. The topical application of PEE alleviated primary psoriasis-like skin lesions and reduced lesion recurrence in mice. PEE simultaneously activates AhR and inhibits the Th17\/IL-17 axis and neuronal-related pathways, which may serve as a mechanism for PEE in the treatment of psoriasis. In conclusion, our study establishes that PEE may serve as a novel therapeutic agent for psoriasis, with a unique mechanism of action that simultaneously activates AhR and suppresses neuronal-related pathways.<\/jats:p>","DOI":"10.3390\/ijms27125171","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:43:46Z","timestamp":1780897426000},"page":"5171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pomegranate Peel Extract Alleviates Psoriasis-like Skin Lesions in Mice Through the Suppression of AhR-Activating Th17\/IL-17 Axis and Neuronal-Related Pathways"],"prefix":"10.3390","volume":"27","author":[{"given":"Jiale","family":"Qi","sequence":"first","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8771-0079","authenticated-orcid":false,"given":"Yujia","family":"Fu","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3407-3492","authenticated-orcid":false,"given":"Bing","family":"Ge","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6480-7952","authenticated-orcid":false,"given":"Xingkang","family":"Wu","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-025-00630-5","article-title":"The Psoriasis","volume":"11","author":"Armstrong","year":"2025","journal-title":"Nat. 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Immunol."},{"key":"ref_5","first-page":"221","article-title":"Psoriasis Comorbidity: Prevalence, Diagnosis and Treatment","volume":"22","author":"Yuling","year":"2023","journal-title":"J. Diagn. Concepts Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1111\/jdv.20738","article-title":"Risk of Adverse Events of Psoriasis Treatment with Biologic Agents and New Small Molecules-Biobadaderm Registry","volume":"39","author":"Carrascosa","year":"2025","journal-title":"J. Eur. Acad. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"123631","DOI":"10.1016\/j.biomaterials.2025.123631","article-title":"Liposomal Emodin: A Nanomedicine for Two-Photon Imaging and Mitochondria-Targeted Photodynamic Therapy of Psoriasis","volume":"325","author":"Sun","year":"2026","journal-title":"Biomaterials"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","article-title":"Therapeutics Targeting the Il-23 and Il-17 Pathway in Psoriasis","volume":"397","author":"Ghoreschi","year":"2021","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","article-title":"Signaling Pathways and Targeted Therapies for Psoriasis","volume":"8","author":"Guo","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1021\/acs.jafc.4c05428","article-title":"Pomegranate: A Comprehensive Review of Functional Components, Health Benefits, Processing, Food Applications, and Food Safety","volume":"73","author":"Zhang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"113877","DOI":"10.1016\/j.jep.2021.113877","article-title":"A Unique Understanding of Traditional Medicine of Pomegranate, Punica granatum L. And Its Current Research Status","volume":"271","author":"Ge","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1958395","DOI":"10.1155\/2023\/1958395","article-title":"Investigation on Pomegranate (Punica granatum) Skin as a Potentially Effective Natural Food Preservative","volume":"2023","author":"Hossain","year":"2023","journal-title":"Int. J. Food Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1002\/jsfa.11067","article-title":"Pomegranate Peel Attenuates Dextran Sulfate Sodium-Induced Lipid Peroxidation in Rat Small Intestine by Enhancing the Glutathione\/Glutathione Disulfide Redox Potential","volume":"101","author":"Laher","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11130-019-00776-0","article-title":"Pomegranate Juice and Peel Extracts Are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt\/Mtor\/S6k Signaling Pathway","volume":"75","author":"Chaves","year":"2020","journal-title":"Plant Food. Hum. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1529-8019.2007.00147.x","article-title":"Less-Known Botanical Cosmeceuticals","volume":"20","author":"Baumann","year":"2007","journal-title":"Dermatol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"El-Hamid, M.I.A., Ibrahim, D., Abdelfattah-Hassan, A., Mohammed, O.B., Pet, I., Khalil, S.S., El-Badry, S.M., Metwally, A.S., Azouz, A.A., and Elnegiry, A.A. (2024). Silver Nanoparticles Loaded with Pomegranate Peel Extract and Hyaluronic Acid Mediate Recovery of Cutaneous Wounds Infected with Candida albicans. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1469493"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dimitrijevic, J., Tomovic, M., Bradic, J., Petrovic, A., Jakovljevic, V., Andjic, M., \u017divkovi\u0107, J., Milo\u0161evi\u0107, S., Simanic, I., and Dragicevic, N. (2024). Punica granatum L. (Pomegranate) Extracts and Their Effects on Healthy and Diseased Skin. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16040458"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tang, L., Li, T., Zhang, B., Zhang, Z., Sun, X., Zhu, Y., Feng, B., Su, Z., Yang, L., and Li, H. (2022). Punicalagin Alleviates Psoriasis by Inhibiting Nf-\u039ab-Mediated Il-1\u03b2 Transcription and Caspase-1-Regulated Il-1\u03b2 Secretion. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.817526"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jaad.2018.06.057","article-title":"Psoriasis: Which Therapy for Which Patient","volume":"80","author":"Kaushik","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kamiya, K., Kishimoto, M., Sugai, J., Komine, M., and Ohtsuki, M. (2019). Risk Factors for the Development of Psoriasis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184347"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1136\/ard-2023-223850","article-title":"Selectivity, Efficacy and Safety of Jakinibs: New Evidence for a Still Evolving Story","volume":"83","author":"Bonelli","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"108411","DOI":"10.1016\/j.pharmthera.2023.108411","article-title":"Lipid Metabolism in Th17 Cell Function","volume":"245","author":"Kanno","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaci.2024.05.008","article-title":"Inflammatory Memory in Psoriasis: From Remission to Recurrence","volume":"154","author":"Francis","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s40257-022-00679-y","article-title":"Time to Relapse after Discontinuing Systemic Treatment for Psoriasis: A Systematic Review","volume":"23","author":"Regnault","year":"2022","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0140-6736(25)01576-4","article-title":"Once-Daily Oral Icotrokinra Versus Placebo and Once-Daily Oral Deucravacitinib in Participants with Moderate-to-Severe Plaque Psoriasis (Iconic-Advance 1 & 2): Two Phase 3, Randomised, Placebo-Controlled and Active-Comparator-Controlled Trials","volume":"406","author":"Gold","year":"2025","journal-title":"Lancet"},{"key":"ref_26","unstructured":"Wang, J. (2019). Study on Compatibility Rules of Lu Chuanjian\u2019s External Bath Prescriptions for Psoriasis Vulgaris Based on Data Mining. [Master\u2019s Thesis, Guangzhou University of Chinese Medicine]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"35452","DOI":"10.1021\/acsomega.3c02586","article-title":"Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review","volume":"8","author":"Singh","year":"2023","journal-title":"ACS Omega"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/ptr.8071","article-title":"Oral Administration of Punicalagin Attenuates Imiquimod-Induced Psoriasis by Reducing Ros Generation and Inflammation via Mapk\/Erk and Nf-Kappab Signaling Pathways","volume":"38","author":"Wang","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Colic, M., Bekic, M., Tomic, S., Dokic, J., Radojevic, D., Savikin, K., Miljus, N., Markovic, M., and Skrbic, R. (2022). Immunomodulatory Properties of Pomegranate Peel Extract in a Model of Human Peripheral Blood Mononuclear Cell Culture. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061140"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mansour, A.T., Khater, S.I., Eissa, H.M., Al-Harthi, H.F., Eskandrani, A.A., Hakami, M.A., Alansari, W.S., Albaqami, A., Alharbi, H.M., and Khamis, T. (2025). Therapeutic Application of Nano-Encapsulated Pomegranate Peel Extract Attenuated Dss-Induced Colitis: Antioxidant and Anti-Inflammatory Role and Reduction of Exaggerated Response of Endoplasmic Reticulum Stress. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0323605"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/jamadermatol.2025.0288","article-title":"Association of Obesity and Innate Immune Markers with Resistance to Biologic Therapy in Psoriasis","volume":"161","author":"Kim","year":"2025","journal-title":"JAMA Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"18280","DOI":"10.1021\/acs.jafc.5c02320","article-title":"Identification of Punicalagin as a Key Bioactive Compound Responsible for the Antimicrobial Properties of Punica granatum L. Peel Extract against Staphylococcus aureus","volume":"73","author":"Salim","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4918239","DOI":"10.1155\/2020\/4918239","article-title":"Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating Nf-\u039ab-Th17\/Jak2\/Stat3 Signaling and Oxidative Stress","volume":"2020","author":"Feng","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1186\/s12964-024-01847-9","article-title":"Punicalagin as a Novel Selective Aryl Hydrocarbon Receptor (Ahr) Modulator Upregulates Ahr Expression through the Pdk1\/P90rsk\/Ap-1 Pathway to Promote the Anti-Inflammatory Response and Bactericidal Activity of Macrophages","volume":"22","author":"Dai","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"167879","DOI":"10.1016\/j.bbadis.2025.167879","article-title":"Quercetin Induces Keratinocytes Apoptosis Via Triple Inhibition of Notch, Pi3k\/Akt Signaling and Glut1 in the Treatment of Psoriasis","volume":"1871","author":"Chen","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"157256","DOI":"10.1016\/j.phymed.2025.157256","article-title":"Quercetagetin Alleviates Ischemic Stroke Injury by Preserving Macrophage\/Microglia Homeostasis via Inhibiting Acp5","volume":"148","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"107599","DOI":"10.1016\/j.bioorg.2024.107599","article-title":"Discovery of Novel Chrysin Derivatives as Potential Anti-Psoriasis Agents","volume":"150","author":"Zhao","year":"2024","journal-title":"Bioorg. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"115212","DOI":"10.1016\/j.intimp.2025.115212","article-title":"Myricetin Alleviates Dncb-Induced Atopic Dermatitis by Modulating Macrophage M1\/M2 Polarization","volume":"163","author":"Zhang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s13346-023-01418-4","article-title":"Preparation of Luteolin Loaded Nanostructured Lipid Carrier Based Gel and Effect on Psoriasis of Mice","volume":"14","author":"Xu","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1021\/acs.molpharmaceut.3c00729","article-title":"Development of a Deep Eutectic Solvent-Assisted Kaempferol Hydrogel: A Promising Therapeutic Approach for Psoriasis-Like Skin Inflammation","volume":"20","author":"Su","year":"2023","journal-title":"Mol. Pharm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"156486","DOI":"10.1016\/j.phymed.2025.156486","article-title":"Apigenin Suppresses Keratinocyte Hyperproliferation and Inflammation in Psoriasis by Inhibiting Cdk2\/E2f2 Pathway","volume":"144","author":"Alimujiang","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109562","DOI":"10.1016\/j.intimp.2022.109562","article-title":"The Small-Molecule Compound Baicalein Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Pathogenetic Cxcr6+ Cd4 Cells","volume":"114","author":"Ying","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41573-025-01172-x","article-title":"The Aryl Hydrocarbon Receptor: A Rehabilitated Target for Therapeutic Immune Modulation","volume":"24","author":"Polonio","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00018-022-04299-x","article-title":"Cutaneous Nerve Fibers Participate in the Progression of Psoriasis by Linking Epidermal Keratinocytes and Immunocytes","volume":"79","author":"Chen","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1038\/s41467-024-49577-3","article-title":"Sensory Asic3 Channel Exacerbates Psoriatic Inflammation via a Neurogenic Pathway in Female Mice","volume":"15","author":"Huang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1038\/s41467-023-37798-x","article-title":"Tenascin C+ Papillary Fibroblasts Facilitate Neuro-Immune Interaction in a Mouse Model of Psoriasis","volume":"14","author":"Cai","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive Sensory Neurons Drive Interleukin-23-Mediated Psoriasiform Skin Inflammation","volume":"510","author":"Perro","year":"2014","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, X., and He, Y. (2020). The Role of Nociceptive Neurons in the Pathogenesis of Psoriasis. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01984"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1365-2133.2012.10843.x","article-title":"Serum Neurotensin (Nt) Is Increased in Psoriasis and Nt Induces Vascular Endothelial Growth Factor Release from Human Mast Cells","volume":"166","author":"Vasiadi","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"110497","DOI":"10.1016\/j.neuropharm.2025.110497","article-title":"P2 Purinergic Signaling and Pruritus","volume":"275","author":"Liu","year":"2025","journal-title":"Neuropharmacology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"107057","DOI":"10.1016\/j.intimp.2020.107057","article-title":"Depressive-Like Behaviors in Mice with Imiquimod-Induced Psoriasis","volume":"89","author":"Guo","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"116205","DOI":"10.1016\/j.foodres.2025.116205","article-title":"Metabolic Profiles, Bioactive Compounds, and Antioxidant Capacity of Prunus sibirica L. Seed Kernels","volume":"209","author":"Yang","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Neu, S.D., Strzepa, A., Martin, D., Sorci-Thomas, M.G., Pritchard, K.A., and Dittel, B.N. (2021). Myeloperoxidase Inhibition Ameliorates Plaque Psoriasis in Mice. Antioxidants, 10.","DOI":"10.3390\/antiox10091338"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/12\/5171\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:35:22Z","timestamp":1781073322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/12\/5171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,7]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ijms27125171"],"URL":"https:\/\/doi.org\/10.3390\/ijms27125171","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,7]]}}}