{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:31:36Z","timestamp":1785407496997,"version":"3.56.0"},"reference-count":158,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LTGC23H200005"],"award-info":[{"award-number":["LTGC23H200005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"award":["LTGC23H200005"],"award-info":[{"award-number":["LTGC23H200005"]}],"id":[{"id":"https:\/\/ror.org\/04aqat463","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Medical and Health Science and Technology Project","award":["2021428879"],"award-info":[{"award-number":["2021428879"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, characterized by a multi-step carcinogenesis process involving genetic mutations and epigenetic alterations. Despite advances in screening and therapy, challenges such as treatment resistance, recurrence, and metastasis persist. Emerging evidence highlights the critical role of epigenetic modifications, particularly N7-methylguanosine (m7G), in post-transcriptional regulation. This ubiquitous RNA modification participates extensively in tumor biological behaviors by regulating RNA stability, processing, and translation. Studies have shown that dysregulation of m7G modification is closely associated with adverse clinical outcomes in CRC. This review systematically summarizes the biological functions of m7G modification and its key regulatory proteins (such as METTL1\/WDR4, eIF4E, etc.), with a focus on their roles in the pathogenesis, progression, prognosis, and diagnosis of, as well as therapy for, colorectal cancer. m7G modification and related molecules hold potential as novel biomarkers and therapeutic targets, thereby providing new strategies for the precision diagnosis and treatment of colorectal cancer.<\/jats:p>","DOI":"10.3390\/ijms27125228","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:33:44Z","timestamp":1781073224000},"page":"5228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["N7-Methylguanosine Modification in Colorectal Cancer: Molecular Insights and Clinical Implications"],"prefix":"10.3390","volume":"27","author":[{"given":"Qin","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Basic Research, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchun","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Basic Research, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Basic Research, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Basic Research, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Basic Research, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Basic Research, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-5279","authenticated-orcid":false,"given":"Jiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Center for Basic Research, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0140-6736(24)00360-X","article-title":"Colorectal cancer","volume":"404","author":"Eng","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1470-2045(24)00600-4","article-title":"Colorectal cancer incidence trends in younger versus older adults: An analysis of population-based cancer registry data","volume":"26","author":"Sung","year":"2025","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1097\/JS9.0000000000003869","article-title":"Research progress on the correlation between vitamin D and colorectal cancer: Opportunities and challenges","volume":"112","author":"Ge","year":"2026","journal-title":"Int. J. Surg."},{"key":"ref_4","first-page":"e240029","article-title":"Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology","volume":"22","author":"Benson","year":"2024","journal-title":"J. Natl. Compr. Cancer Netw. JNCCN"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/cac2.12639","article-title":"The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update","volume":"45","author":"Wang","year":"2025","journal-title":"Cancer Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41586-022-05202-1","article-title":"The co-evolution of the genome and epigenome in colorectal cancer","volume":"611","author":"Heide","year":"2022","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s11658-025-00823-6","article-title":"DNA, RNA, and histone methylation regulation enzymes and their crosstalk in colorectal carcinogenesis and progression: A review of molecular mechanisms, clinical implications, and future perspectives","volume":"30","author":"Qian","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ccell.2025.12.001","article-title":"Epitranscriptomic control of cancer hallmarks: Functions, mechanisms, and therapeutics of RNA modifications","volume":"44","author":"Deng","year":"2026","journal-title":"Cancer Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41576-023-00645-2","article-title":"RNA modifications in physiology and disease: Towards clinical applications","volume":"25","author":"Delaunay","year":"2024","journal-title":"Nat. Rev. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e70521","DOI":"10.1002\/ctm2.70521","article-title":"m7G RNA methylation in cancer: Effect, mechanism and clinical application","volume":"15","author":"Dang","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41580-023-00622-x","article-title":"Regulation and functions of non-m6A mRNA modifications","volume":"24","author":"Sun","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.molcel.2019.03.036","article-title":"Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA","volume":"74","author":"Zhang","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tomikawa, C. (2018). 7-Methylguanosine Modifications in Transfer RNA (tRNA). Int. J. Mol. Sci., 19.","DOI":"10.20944\/preprints201811.0384.v1"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3724\/abbs.2024201","article-title":"RNA modifications: Emerging players in the regulation of reproduction and development","volume":"57","author":"Wen","year":"2024","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.omtn.2023.01.003","article-title":"Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases","volume":"31","author":"Xia","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"142940","DOI":"10.1016\/j.ijbiomac.2025.142940","article-title":"The m7G methylation modification: An emerging player of cardiovascular diseases","volume":"309","author":"Xu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Imbriano, C., Moresi, V., Belluti, S., Renzini, A., Cavioli, G., Maretti, E., and Molinari, S. (2023). Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202309.1141.v1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"189511","DOI":"10.1016\/j.bbcan.2025.189511","article-title":"Role of N7-methylguanosine in gastrointestinal tumors: Molecular mechanisms and therapeutic targets","volume":"1881","author":"Li","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41422-019-0230-z","article-title":"Dynamic methylome of internal mRNA N7-methylguanosine and its regulatory role in translation","volume":"29","author":"Malbec","year":"2019","journal-title":"Cell Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.cell.2023.05.047","article-title":"QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism","volume":"186","author":"Zhao","year":"2023","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1038\/s41467-024-51634-w","article-title":"IGF2BP3 promotes mRNA degradation through internal m7G modification","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13578-023-01131-2","article-title":"Mettl1-mediated internal m7G methylation of Sptbn2 mRNA elicits neurogenesis and anti-alzheimer\u2019s disease","volume":"13","author":"Li","year":"2023","journal-title":"Cell Biosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/s41418-023-01179-0","article-title":"TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.molcel.2018.06.001","article-title":"Mettl1\/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation","volume":"71","author":"Lin","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e177220","DOI":"10.1172\/JCI177220","article-title":"Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism","volume":"134","author":"Li","year":"2024","journal-title":"J. Clin. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1038\/s41467-024-49796-8","article-title":"Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging","volume":"15","author":"Fu","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jare.2024.09.010","article-title":"tsRNA modifications: An emerging layer of biological regulation in disease","volume":"74","author":"Liang","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-024-02013-w","article-title":"Membraneless organelles in health and disease: Exploring the molecular basis, physiological roles and pathological implications","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s10565-025-10072-0","article-title":"METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of m7G- 3\u2032 tiRNA MetCAT","volume":"41","author":"Hu","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"122903","DOI":"10.1016\/j.biomaterials.2024.122903","article-title":"m7G-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes","volume":"314","author":"Long","year":"2025","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.molcel.2019.03.040","article-title":"METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation","volume":"74","author":"Pandolfini","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41420-022-01236-6","article-title":"METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m7G-modified miR-760-dependent manner","volume":"8","author":"Xie","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12943-024-02090-z","article-title":"Targeting m7G-enriched circKDM1A prevents colorectal cancer progression","volume":"23","author":"Sun","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/s41419-024-07248-7","article-title":"A N7-methylguanosine modified circular RNA, circIPP2A2, promotes malignant behaviors in hepatocellular carcinoma by serving as a scaffold in modulating the Hornerin\/PI3K\/AKT\/GSK3\u03b2 axis","volume":"15","author":"Guo","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_36","first-page":"8675","article-title":"Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: Insights from accelerated molecular dynamics simulations","volume":"47","author":"Cowling","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1093\/nar\/gkw551","article-title":"mRNA capping: Biological functions and applications","volume":"44","author":"Ramanathan","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"112786","DOI":"10.1016\/j.celrep.2023.112786","article-title":"Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility","volume":"42","author":"Dohnalkova","year":"2023","journal-title":"Cell Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.molcel.2016.02.008","article-title":"CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription","volume":"61","author":"Aregger","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/1947601910378025","article-title":"Myc Regulation of mRNA Cap Methylation","volume":"1","author":"Cowling","year":"2010","journal-title":"Genes Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6722","DOI":"10.1093\/nar\/gkab465","article-title":"Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation","volume":"49","author":"Galloway","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Unap, K., Leetsi, L., Matsoo, M., and Kurg, R. (2015). The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133841"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1261\/rna.047910.114","article-title":"WBSCR22\/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA","volume":"21","author":"Haag","year":"2015","journal-title":"RNA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1091\/mbc.E15-02-0073","article-title":"The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis","volume":"26","author":"Zorbas","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1016\/j.molcel.2023.08.014","article-title":"18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis","volume":"83","author":"Liberman","year":"2023","journal-title":"Mol. Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/jmcb\/mjy023","article-title":"Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation","volume":"11","author":"Lyu","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Shentu, T., Wu, T., Zhou, Z., Yeh, C., Zhu, J., Li, J., Miao, B.A., Lee, T., Zhang, L., and Huang, R. (2025). Mechanosensitive Endothelial METTL7A Regulates Internal m7G mRNA Methylation and Protects Against Atherosclerosis. bioRxiv, 655328.","DOI":"10.1101\/2025.05.22.655328"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s10565-024-09918-w","article-title":"TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis","volume":"40","author":"Zhao","year":"2024","journal-title":"Cell Biol. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"103087","DOI":"10.1016\/j.redox.2024.103087","article-title":"METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer","volume":"71","author":"Li","year":"2024","journal-title":"Redox Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41568-025-00889-6","article-title":"N6-Methyladenosine: An RNA modification as a central regulator of cancer","volume":"26","author":"Luo","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"149130","DOI":"10.1016\/j.ijbiomac.2025.149130","article-title":"Demethylase, ALKBH1, regulates osteosarcoma chemosensitivity through FZD8\/Wnt\/\u03b2-catenin signaling pathway in the m7G manner","volume":"334","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e70647","DOI":"10.1002\/jbt.70647","article-title":"N7-Methylguanine Modification of SHMT2 Mediated by GEMIN5 Inhibits Cell Ferroptosis of Colorectal Cancer Cells","volume":"39","author":"Wang","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1101\/gad.339986.120","article-title":"The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing","volume":"34","author":"Rambout","year":"2020","journal-title":"Genes Dev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/nar\/gkac1250","article-title":"The hnRNP C tetramer binds to CBC on mRNA and impedes PHAX recruitment for the classification of RNA polymerase II transcripts","volume":"51","author":"Dantsuji","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/s41594-025-01595-5","article-title":"Structural basis for the synergistic assembly of the snRNA export complex","volume":"32","author":"Dubiez","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Bradrick, S.S., and Gromeier, M. (2009). Identification of gemin5 as a novel 7-methylguanosine cap-binding protein. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007030"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1101\/gad.288340.116","article-title":"Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly","volume":"30","author":"Xu","year":"2016","journal-title":"Genes Dev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"8261","DOI":"10.1093\/nar\/gkab579","article-title":"Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF-DDX19B interaction","volume":"49","author":"Park","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"175867","DOI":"10.1016\/j.ejphar.2023.175867","article-title":"Molecular interplay between EIF4 family and circular RNAs in cancer: Mechanisms and therapeutics","volume":"954","author":"Song","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/nar\/gkab1205","article-title":"The flip-flop configuration of the PABP-dimer leads to switching of the translation function","volume":"50","author":"Gu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Chen, X., An, Y., Tan, M., Xie, D., Liu, L., and Xu, B. (2023). Biological functions and research progress of eIF4E. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1076855"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2360196","DOI":"10.1080\/19491034.2024.2360196","article-title":"eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production","volume":"15","author":"Mars","year":"2024","journal-title":"Nucleus"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Mars, J., Embree, C.M., Carlile, A.W.B., Gendron, P., and Borden, K.L.B. (2025). Nuclear RNA cap-chaperones eIF4E and NCBP2 govern distinct fates for 1000s of mRNAs uncovering an unexpected regulatory point in gene expression. bioRxiv, 666897.","DOI":"10.1101\/2025.07.25.666897"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.neuron.2013.06.039","article-title":"CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation","volume":"79","author":"Pasciuto","year":"2013","journal-title":"Neuron"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.cell.2007.05.016","article-title":"An mRNA m7G cap binding-like motif within human Ago2 represses translation","volume":"129","author":"Kiriakidou","year":"2007","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e24146","DOI":"10.7554\/eLife.24146","article-title":"La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs","volume":"6","author":"Lahr","year":"2017","journal-title":"eLife"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"eabg9275","DOI":"10.1126\/sciadv.abg9275","article-title":"The 40S-LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity","volume":"7","author":"Fuentes","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8663","DOI":"10.1093\/nar\/gku580","article-title":"Hypermethylated-capped selenoprotein mRNAs in mammals","volume":"42","author":"Wurth","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1093\/nar\/gkp249","article-title":"Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1","volume":"37","author":"Monecke","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_70","first-page":"10","article-title":"New insights into decapping enzymes and selective mRNA decay","volume":"8","author":"Kiledjian","year":"2017","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molcel.2013.02.017","article-title":"A mammalian pre-mRNA 5\u2032 end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing","volume":"50","author":"Jiao","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1038\/s41467-021-25105-5","article-title":"m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome","volume":"12","author":"Sun","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41422-019-0270-4","article-title":"METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing","volume":"30","author":"Chen","year":"2020","journal-title":"Cell Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Zhou, S., Wang, Y., Wei, J., An, K., Shi, Y., Zhang, X., Wang, H., Feng, L., He, L., and Zhang, Y. (2025). METTL1\/WDR4-mediated m7G Hypermethylation of SCLT1 mRNA Promotes Gefitinib Resistance in NSCLC. Genom. Proteom. Bioinform., qzaf076.","DOI":"10.1093\/gpbjnl\/qzaf076"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/s12276-025-01512-2","article-title":"METTL1-driven epitranscriptomic enhancement of TXNDC12 boosts c-Myc stability through USP5 in HNSCC","volume":"57","author":"Mai","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41419-025-07716-8","article-title":"METTL1-mediated m7G tRNA modification drives papillary thyroid cancer progression and metastasis by regulating the codon-specific translation of TNF-\u03b1","volume":"16","author":"Li","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1002\/hep.32615","article-title":"Methyltransferase 1 is required for nonhomologous end-joining repair and renders hepatocellular carcinoma resistant to radiotherapy","volume":"77","author":"Liao","year":"2023","journal-title":"Hepatology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.gendis.2023.04.011","article-title":"METTL1 promotes colorectal cancer cell proliferation by attenuating CHEK2-induced G1\/S phase arrest","volume":"11","author":"Jiang","year":"2023","journal-title":"Genes Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/mc.23892","article-title":"METTL1 Enhances RRP9 mRNA Stability Through m7G Modification to Drive Colorectal Tumorigenesis","volume":"64","author":"Li","year":"2025","journal-title":"Mol. Carcinog."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1007\/s11010-025-05293-0","article-title":"METTL1-mediated m7G modification promotes colorectal cancer metastasis via stabilization of ICAM-1","volume":"480","author":"Cai","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"30755","DOI":"10.1038\/s41598-024-80885-2","article-title":"N7-methyladenosine-induced SLC7A7 serves as a prognostic biomarker in pan-cancer and promotes CRC progression in colorectal cancer","volume":"14","author":"Wang","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_82","first-page":"64","article-title":"Exosomes from Cancer-Associated Fibroblasts Promote Colorectal Cancer Progression and Glutamine Metabolism Through METTL1-Mediated m7G Modification of SLC1A5 mRNA","volume":"24","author":"Zhang","year":"2026","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"114999","DOI":"10.1016\/j.isci.2026.114999","article-title":"Circ_0003323 binds METTL1 to mediate KLK6 m7G methylation modification and promote the progression of colorectal cancer","volume":"29","author":"Zhang","year":"2026","journal-title":"iScience"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.molmed.2022.09.007","article-title":"Dysfunctional tRNA reprogramming and codon-biased translation in cancer","volume":"28","author":"Dedon","year":"2022","journal-title":"Trends Mol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1016\/j.molcel.2021.07.003","article-title":"N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression","volume":"81","author":"Dai","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s13402-025-01137-7","article-title":"METTL1-mediated m7G tRNA modification promotes colorectal cancer progression and liver metastasis via translational regulation","volume":"49","author":"Chen","year":"2026","journal-title":"Cell. Oncol."},{"key":"ref_87","first-page":"230","article-title":"tsRNA-GlyGCC promotes colorectal cancer progression and 5-FU resistance by regulating SPIB","volume":"43","author":"Xu","year":"2024","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1186\/s12967-024-05991-1","article-title":"METTL1 mediates PKM m7G modification to regulate CD155 expression and promote immune evasion in colorectal cancer","volume":"22","author":"Wang","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12943-024-02155-z","article-title":"A multidimensional recommendation framework for identifying biological targets to aid the diagnosis and treatment of liver metastasis in patients with colorectal cancer","volume":"23","author":"Qi","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"149385","DOI":"10.1016\/j.bbrc.2023.149385","article-title":"HIF-1\u03b1\/METTL1\/m7G axis is involved in CRC response to hypoxia","volume":"693","author":"Mi","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_91","first-page":"1","article-title":"WDR4 promotes colorectal cancer progression by activating the GSK3\u03b2\/\u03b2-catenin pathway","volume":"103","author":"Wang","year":"2025","journal-title":"Biochem. Cell Biol. Biochim. Biol. Cell."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"111996","DOI":"10.1016\/j.cellsig.2025.111996","article-title":"The P300\/ETV4-WDR4 axis promotes colorectal cancer progression via m7G-mediated SPP1 mRNA stabilization and autophagy suppression","volume":"135","author":"Deng","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_93","first-page":"215","article-title":"P300\/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC","volume":"42","author":"Zhang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"12328","DOI":"10.18632\/aging.102575","article-title":"Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p\/S100A4\/p53 axis","volume":"11","author":"Liu","year":"2019","journal-title":"Aging"},{"key":"ref_95","first-page":"404","article-title":"Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis","volume":"8","author":"Habib","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_96","first-page":"815","article-title":"Overexpression of eIF4E in colorectal cancer patients is associated with liver metastasis","volume":"9","author":"Xu","year":"2016","journal-title":"Onco Targets Ther."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.prp.2017.02.004","article-title":"Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma","volume":"213","author":"Chen","year":"2017","journal-title":"Pathol. Res. Pract."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1038\/s41467-024-48386-y","article-title":"mTORC1 regulates cell survival under glucose starvation through 4EBP1\/2-mediated translational reprogramming of fatty acid metabolism","volume":"15","author":"Levy","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e60151","DOI":"10.7554\/eLife.60151","article-title":"eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis","volume":"9","author":"Ruan","year":"2020","journal-title":"eLife"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1093\/nar\/gkab604","article-title":"capCLIP: A new tool to probe translational control in human cells through capture and identification of the eIF4E-mRNA interactome","volume":"49","author":"Jensen","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s10020-020-0139-5","article-title":"Aspirin has a better effect on PIK3CA mutant colorectal cancer cells by PI3K\/Akt\/Raptor pathway","volume":"26","author":"Chen","year":"2020","journal-title":"Mol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature13896","article-title":"mTORC1-mediated translational elongation limits intestinal tumour initiation and growth","volume":"517","author":"Faller","year":"2015","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"25560","DOI":"10.1073\/pnas.1912772117","article-title":"Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity","volume":"117","author":"Smit","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s10528-020-09949-y","article-title":"WBSCR22 Competes with Long Non-coding RNA Linc00346 for miR-509-5p Binding Site to Regulate Cancer Stem Cell Phenotypes of Colorectal Cancer","volume":"58","author":"Zhao","year":"2020","journal-title":"Biochem. Genet."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"15443","DOI":"10.1038\/s41598-017-15749-z","article-title":"WBSCR22 confers oxaliplatin resistance in human colorectal cancer","volume":"7","author":"Yan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_106","first-page":"824","article-title":"Natural killer cells inhibit oxaliplatin-resistant colorectal cancer by repressing WBSCR22 via upregulating microRNA-146b-5p","volume":"8","author":"Zhao","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"137135","DOI":"10.1016\/j.ijbiomac.2024.137135","article-title":"Circular RNA circWBSCR22 facilitates colorectal cancer metastasis by enhancing CHD4\u2032s protein stability","volume":"282","author":"Luo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"489","DOI":"10.21873\/anticanres.11341","article-title":"Clinical Significance of Methylation and Reduced Expression of the Quaking Gene in Colorectal Cancer","volume":"37","author":"Iwata","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/procel\/pwaf022","article-title":"BiFC and FACS-based CRISPR screening revealed that QKI promotes PABPN1 LLPS in colorectal cancer cells","volume":"16","author":"Li","year":"2025","journal-title":"Protein Cell"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1038\/s12276-025-01531-z","article-title":"Comprehensive profiling of RNA modification-related genes identifies RNA m7G binding protein CBP20 as a therapeutic target for tumor growth inhibition","volume":"57","author":"Cho","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00018-021-04093-1","article-title":"Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis","volume":"79","author":"Desi","year":"2022","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Li, K., and Wang, W. (2022). Establishment of m7G-related gene pair signature to predict overall survival in colorectal cancer. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.981392"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Zhao, Z., Thandar, M., Cheng, J., Chi, P., and Huang, S. (2023). Expression patterns and prognostic value of key regulators associated with m7G RNA modification based on all gene expression in colon adenocarcinoma. BMC Gastroenterol., 23.","DOI":"10.1186\/s12876-023-02657-y"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s13167-022-00305-1","article-title":"Comprehensive multi-omics analysis of the m7G in pan-cancer from the perspective of predictive, preventive, and personalized medicine","volume":"13","author":"Huang","year":"2022","journal-title":"EPMA J."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Chen, J., Song, Y., Liang, G., Zhang, Z., Wen, X., Li, R., Chen, Y., Pan, W., He, X., and Hu, T. (2022). A Novel m7G-Related Gene Signature Predicts the Prognosis of Colon Cancer. Cancers, 14.","DOI":"10.3390\/cancers14225527"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.7150\/jca.99173","article-title":"A novel m7G-related miRNA prognostic signature for predicting clinical outcome and immune microenvironment in colon cancer","volume":"15","author":"Zhu","year":"2024","journal-title":"J. Cancer"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41392-024-01979-x","article-title":"Cold and hot tumors: From molecular mechanisms to targeted therapy","volume":"9","author":"Wu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Wu, J., Song, Q., Huang, C., Shao, Y., Wang, Z., Zhang, H., and Fu, Z. (2022). N7-methylguanosine-related lncRNAs: Predicting the prognosis and diagnosis of colorectal cancer in the cold and hot tumors. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.952836"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1038\/s41598-025-89944-8","article-title":"Integration of 101 machine learning algorithm combinations to unveil m6A\/m1A\/m5C\/m7G-associated prognostic signature in colorectal cancer","volume":"15","author":"Wei","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.canlet.2013.07.032","article-title":"Chronic ulcerative colitis and colorectal cancer","volume":"345","author":"Rogler","year":"2014","journal-title":"Cancer Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s00011-023-01806-z","article-title":"Identification of novel N7-methylguanine-related gene signatures associated with ulcerative colitis and the association with biological therapy","volume":"72","author":"Yang","year":"2023","journal-title":"Inflamm. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"203","DOI":"10.21037\/jgo-23-980","article-title":"Construction and validation of a prognostic signature for mucinous colonic adenocarcinoma based on N7-methylguanosine-related long non-coding RNAs","volume":"15","author":"Gao","year":"2024","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"189337","DOI":"10.1016\/j.bbcan.2025.189337","article-title":"RNA methylation: A new promising biomaker in cancer liquid biopsy","volume":"1880","author":"Xu","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"123968","DOI":"10.1016\/j.jchromb.2023.123968","article-title":"Exploring urinary modified nucleosides as biomarkers for diabetic retinopathy: Development and validation of a ultra performance liquid chromatography-tandem mass spectrometry method","volume":"1232","author":"Yao","year":"2024","journal-title":"J. Chromatogr. B"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Chen, Y., Xie, Y., Bi, L., Ci, H., Li, W., and Liu, D. (2024). A novel serum m7G-harboring microRNA signature for cancer detection. Front. Genet., 15.","DOI":"10.3389\/fgene.2024.1270302"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/acsbiomedchemau.3c00030","article-title":"Small-Molecule Inhibitors of the m7G-RNA Writer METTL1","volume":"4","author":"Nai","year":"2023","journal-title":"ACS Bio Med Chem Au"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1136\/gutjnl-2022-327608","article-title":"Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis","volume":"72","author":"Roelands","year":"2023","journal-title":"Gut"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"eadv4810","DOI":"10.1126\/sciimmunol.adv4810","article-title":"METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury","volume":"10","author":"Hou","year":"2025","journal-title":"Sci. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41586-022-05566-4","article-title":"Structural basis of regulated m7G tRNA modification by METTL1-WDR4","volume":"613","author":"Li","year":"2023","journal-title":"Nature"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41586-022-05565-5","article-title":"Structures and mechanisms of tRNA methylation by METTL1-WDR4","volume":"613","author":"Raj","year":"2023","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/ijc.30199","article-title":"Modulation of tumor eIF4E by antisense inhibition: A phase I\/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer","volume":"139","author":"Duffy","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13572","article-title":"eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies","volume":"513","author":"Boussemart","year":"2014","journal-title":"Nature"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"10734","DOI":"10.1021\/acs.jmedchem.3c00917","article-title":"Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer","volume":"66","author":"Menon","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s40203-024-00206-3","article-title":"Molecular interaction and MD-simulations: Investigation of Sizofiran as a promising anti-cancer agent targeting eIF4E in colorectal cancer","volume":"12","author":"Samykannu","year":"2024","journal-title":"Silico Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.bbrc.2018.06.150","article-title":"Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer","volume":"503","author":"Xi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"115450","DOI":"10.1016\/j.taap.2021.115450","article-title":"Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation","volume":"415","author":"Ge","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Vega-Hern\u00e1ndez, G., Duque, J., Klein, B.J.C., Soueid, D.M., Rech, J.C., Wang, H., Zhou, W., and Garner, A.L. (2025). CRISPR RiPCA for Investigating eIF4E-m7GpppX Capped mRNA Interactions. bioRxiv, 660603.","DOI":"10.1021\/acschembio.5c00471"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/13543776.2024.2446225","article-title":"A patent review of mitogen-activated protein kinase-interacting kinases (MNKs) modulators (2019-present)","volume":"35","author":"Li","year":"2024","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_139","first-page":"1083","article-title":"Dual mTOR\/PI3K inhibitor NVP-BEZ235 arrests colorectal cancer cell growth and displays differential inhibition of 4E-BP1","volume":"40","author":"Alqurashi","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e176093","DOI":"10.1172\/JCI176093","article-title":"Small-molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells","volume":"135","author":"Lum","year":"2025","journal-title":"J. Clin. Investig."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/1878-0261.12384","article-title":"Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling","volume":"12","author":"Shen","year":"2018","journal-title":"Mol. Oncol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"115781","DOI":"10.1016\/j.ejmech.2023.115781","article-title":"MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation","volume":"260","author":"Li","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"112037","DOI":"10.1016\/j.intimp.2024.112037","article-title":"The dawn of a new Era: mRNA vaccines in colorectal cancer immunotherapy","volume":"132","author":"Song","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1021\/acs.chemrev.5c00347","article-title":"Beyond the Sequence: Chemical and Topological Design and Innovations in mRNA Therapeutics","volume":"126","author":"Liu","year":"2026","journal-title":"Chem. Rev."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"(2026). Covalently or non-covalently attached m7G cap enhances protein production from circular mRNA. Nat. Biotechnol., 44, 46\u201347.","DOI":"10.1038\/s41587-025-02580-5"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1038\/s41467-021-21758-4","article-title":"FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell","volume":"12","author":"Relier","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1515\/hsz-2023-0260","article-title":"N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4","volume":"405","author":"Zhang","year":"2023","journal-title":"Biol. Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e1787633174","DOI":"10.1073\/pnas.2507334122","article-title":"Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation","volume":"122","author":"Miller","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/s41594-023-01117-1","article-title":"CRISPR-Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames","volume":"30","author":"Zheng","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"6870","DOI":"10.1021\/acs.analchem.4c01326","article-title":"Abundance of Modifications in Mature miRNAs Revealed by LC-MS\/MS Method Coupled with a Two-Step Hybridization Purification Strategy","volume":"96","author":"Xu","year":"2024","journal-title":"Anal. Chem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1093\/nar\/gkz736","article-title":"Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing","volume":"47","author":"Enroth","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13045-025-01665-7","article-title":"N7-methylguanosine modification in cancers: From mechanisms to therapeutic potential","volume":"18","author":"Wu","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1093\/nar\/gkz751","article-title":"Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA","volume":"47","author":"Wang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"190306","DOI":"10.1098\/rsob.190306","article-title":"CAP-MAP: Cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures","volume":"10","author":"Galloway","year":"2020","journal-title":"Open Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e202414537","DOI":"10.1002\/anie.202414537","article-title":"The P(III)-Amidite Based Synthesis of Stable Isotope Labeled mRNA-Cap-Structures Enables their Sensitive Quantitation from Brain Tissue","volume":"64","author":"Ripp","year":"2025","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"6230","DOI":"10.1021\/acs.jcim.4c00802","article-title":"Moss-m7G: A Motif-Based Interpretable Deep Learning Method for RNA N7-Methlguanosine Site Prediction","volume":"64","author":"Zhao","year":"2024","journal-title":"J. Chem. Inf. Model."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"bbaf447","DOI":"10.1093\/bib\/bbaf447","article-title":"MCAMEF-BERT: An efficient deep learning method for RNA N7-methylguanosine site prediction via multi-branch feature integration","volume":"26","author":"Yu","year":"2025","journal-title":"Brief. Bioinform."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"145341","DOI":"10.1016\/j.ijbiomac.2025.145341","article-title":"Deep-m7G: A contrastive learning-based deep biological language model for identifying RNA N7-methylguanosine sites","volume":"318","author":"Zhang","year":"2025","journal-title":"Int. J. Biol. 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