{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:16:03Z","timestamp":1785417363859,"version":"3.56.0"},"reference-count":110,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, Romania"},{"id":[{"id":"https:\/\/ror.org\/051h0cw83","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Biliary atresia (BA) is the leading indication for pediatric liver transplantation. In the absence of surgical treatment, BA progresses rapidly toward hepatic fibrosis and cirrhosis. Although liver biopsy remains the gold standard for histological evaluation, its utility is limited by invasiveness, associated risks, and sampling variability. These limitations have spurred the development and validation of noninvasive tools to evaluate liver fibrosis in this patient population. Multiple imaging techniques have been developed to assess liver fibrosis and cirrhosis. In recent years, additional BA-related biomarkers have been identified, showing significant potential for diagnosis, assessment of fibrosis severity, and prediction of native liver survival outcomes. This article reviews the roles and potential clinical applications of the following biomarkers: matrix metalloproteinase-7 (MMP-7), fibroblast growth factor 19 (FGF-19), interleukin-33 (IL-33), clusterin, and osteopontin. Further research is needed to confirm the utility of these prognostic biomarkers in predicting and improving outcomes in BA.<\/jats:p>","DOI":"10.3390\/ijms27125295","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:53:10Z","timestamp":1781247190000},"page":"5295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-Invasive Biomarkers for Assessing Liver Fibrosis in Biliary Atresia: A Literature Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-8379","authenticated-orcid":false,"given":"Gabriel","family":"Ben\u021ba","sequence":"first","affiliation":[{"name":"Second Pediatric Discipline, Department of Mother and Child, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania"},{"name":"Second Pediatric Clinic, Center of Expertise in Pediatric Rare Liver Diseases, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Grama","sequence":"additional","affiliation":[{"name":"Second Pediatric Discipline, Department of Mother and Child, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania"},{"name":"Second Pediatric Clinic, Center of Expertise in Pediatric Rare Liver Diseases, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-4486","authenticated-orcid":false,"given":"Alexandra","family":"Mititelu","sequence":"additional","affiliation":[{"name":"Second Pediatric Discipline, Department of Mother and Child, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania"},{"name":"Second Pediatric Clinic, Center of Expertise in Pediatric Rare Liver Diseases, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-2302","authenticated-orcid":false,"given":"Alexandru-\u0218tefan","family":"Niculae","sequence":"additional","affiliation":[{"name":"Second Pediatric Discipline, Department of Mother and Child, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-1219","authenticated-orcid":false,"given":"Tudor Lucian","family":"Pop","sequence":"additional","affiliation":[{"name":"Second Pediatric Discipline, Department of Mother and Child, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania"},{"name":"Second Pediatric Clinic, Center of Expertise in Pediatric Rare Liver Diseases, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cld.2022.03.001","article-title":"Biliary Atresia in Children","volume":"26","author":"Antala","year":"2022","journal-title":"Clin. 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