{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:18:47Z","timestamp":1785403127983,"version":"3.56.0"},"reference-count":36,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Innovation Leading Talent Project of Zhejiang Province","award":["2022R52023"],"award-info":[{"award-number":["2022R52023"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20249"],"award-info":[{"award-number":["U21A20249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["U21A20249"],"award-info":[{"award-number":["U21A20249"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2023YFD1301303"],"award-info":[{"award-number":["2023YFD1301303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Succinate, a tricarboxylic acid (TCA) cycle intermediate, is the essential signal molecule that links metabolic signals and inflammation. Dietary succinate supplementation has been reported to prevent obesity induced by a high-fat diet (HFD). However, the underlying mechanism remains elusive. Here, we found that dietary succinate elevated the serum succinate levels. Meanwhile, we found succinate increased methyltransferaselike 3 (METTL3) protein expression in brown adipocytes, thereby elevating N6-methyladenosine (m6A) levels in Hypoxia-inducible factor1-alpha (Hif1a) mRNA. Hif1a mRNA is recognized by the m6A-binding protein YTH domain-containing family protein 1 (YTHDF1), facilitating HIF1A protein expression. HIF1A activates the transcription of thermogenic genes, ultimately increasing brown adipose energy expenditure. Together, our research provided new insights into the effect of succinate on m6A modification in brown adipose tissue thermogenesis.<\/jats:p>","DOI":"10.3390\/ijms27125348","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:57:58Z","timestamp":1781513878000},"page":"5348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Succinate Prevents Mice Obesity by Enhancing Brown Adipocyte Thermogenesis via the SDH-METTL3-HIF1A Pathway"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-3277","authenticated-orcid":false,"given":"Yaojun","family":"Luo","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Green Feeds and Healthy Livestock Industry, Zhejiang University, Hangzhou 310058, China"},{"name":"College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, China"},{"name":"Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Ministry of Education, Hangzhou 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture and Rural Affairs, Hangzhou 310058, China"},{"name":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimeng","family":"Xin","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Green Feeds and Healthy Livestock Industry, Zhejiang University, Hangzhou 310058, China"},{"name":"College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, China"},{"name":"Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Ministry of Education, Hangzhou 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture and Rural Affairs, Hangzhou 310058, China"},{"name":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhua","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Green Feeds and Healthy Livestock Industry, Zhejiang University, Hangzhou 310058, China"},{"name":"College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, China"},{"name":"Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Ministry of Education, Hangzhou 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture and Rural Affairs, Hangzhou 310058, China"},{"name":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiti","family":"Ren","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Green Feeds and Healthy Livestock Industry, Zhejiang University, Hangzhou 310058, China"},{"name":"College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, China"},{"name":"Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Ministry of Education, Hangzhou 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture and Rural Affairs, Hangzhou 310058, China"},{"name":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxia","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Green Feeds and Healthy Livestock Industry, Zhejiang University, Hangzhou 310058, China"},{"name":"College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, China"},{"name":"Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Ministry of Education, Hangzhou 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science (Eastern China), Ministry of Agriculture and Rural Affairs, Hangzhou 310058, China"},{"name":"Zhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: Global epidemiology and pathogenesis","volume":"15","author":"Bluher","year":"2019","journal-title":"Nat. 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