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In particular, microRNA-597 has been associated with poor survival rates but is not yet well characterized. Seventy-five clinical samples, four cell lines, and two patient-derived organoids were evaluated for the expression of microRNA-597 and its target genes. microRNA-597 was transiently transfected for analysis of cell migration, invasion, wound healing, colony formation, and cell viability, and its regulation by long non-coding RNAs was explored using the TCGA-STAD and LncBook tools. In clinical samples, low expression of microRNA-597 was associated with the intestinal subtype (p = 0.002) and stages III and IV (p = 0.048). All functional readouts were reduced after microRNA-597 transfection, including colony formation, in patient-derived organoids. Among target genes, RUNX1 was directly regulated by microRNA-597. Other cell invasion genes were dependent on RUNX1 as a hub for regulation. Analysis of the Intersection between long non-coding RNAs co-expressed with RUNX1 and those with the highest microRNA-597 prediction binding identified KCNQ1OT1 as the top transcript. Silencing of KCNQ1OT1 and co-expression in clinical samples suggest the existence of a KCNQ1OT1\/microRNA-597\/RUNX1 network. The results indicate that microRNA-597 directly suppresses RUNX1, while KCNQ1OT1 modulates this interaction. Our approach enabled the simultaneous analysis of dysregulation in three families of transcripts in gastric cancer progression.<\/jats:p>","DOI":"10.3390\/ijms27125368","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:57:58Z","timestamp":1781513878000},"page":"5368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA-597 Suppresses Gastric Cancer Invasion and Progression via RUNX1 Targeting, an Effect Attenuated by the Long Non-Coding RNA KCNQ1OT1"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1632-6449","authenticated-orcid":false,"given":"Alejandra","family":"Sandoval-Borquez","sequence":"first","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Medical Technology School, Faculty of Sciences, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valparaiso 2370363, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6875-9027","authenticated-orcid":false,"given":"Wilda","family":"Olivares","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330032, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9775-6083","authenticated-orcid":false,"given":"Francisco J.","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330032, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4342-8069","authenticated-orcid":false,"given":"Pablo M.","family":"Santoro","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330032, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Bizama","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Department of Pathology, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00e1reni","family":"\u00c1valos-Guajardo","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Department of Pathology, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-6438","authenticated-orcid":false,"given":"Keila","family":"Torres","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330032, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Garrido","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330032, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Norero","sequence":"additional","affiliation":[{"name":"Esophagogastric Surgery Unit, Department of Digestive Surgery, Hospital Dr. Sotero del Rio, Santiago 8207257, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F. 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