{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:54:03Z","timestamp":1781517243497,"version":"3.54.1"},"reference-count":61,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010857","name":"Key Research and Development Program of Jiangxi Province, China","doi-asserted-by":"publisher","award":["20232ACB206053"],"award-info":[{"award-number":["20232ACB206053"]}],"id":[{"id":"10.13039\/501100010857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010857","name":"Key Research and Development Program of Jiangxi Province, China","doi-asserted-by":"publisher","award":["20203BBGL73205"],"award-info":[{"award-number":["20203BBGL73205"]}],"id":[{"id":"10.13039\/501100010857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cathepsin C (CTSC), also known as dipeptidyl peptidase I, is an upstream activator of serine protease networks that may promote metastatic progression through inflammatory amplification and microenvironmental remodeling. Increasing evidence suggests that CTSC contributes to cancer progression not simply as an overexpressed lysosomal protease, but as a context-dependent regulator of metastatic traits. This review summarizes the structure, maturation, and biological functions of CTSC, with emphasis on its protease-activating capacity and its links to tumor-associated inflammation. Current evidence connecting CTSC to epithelial\u2013mesenchymal transition, extracellular matrix remodeling, neutrophil extracellular trap formation, and immune microenvironment reprogramming is then synthesized across hepatocellular carcinoma, renal cell carcinoma, breast cancer, colorectal cancer, non-small-cell lung cancer, and glioma. Available data most strongly support a pro-metastatic role for CTSC in breast cancer and colorectal cancer, whereas evidence in several other malignancies remains predominantly preclinical and mechanistically incomplete. Importantly, CTSC is better viewed as a targetable protease network hub than as a universal pan-cancer metastatic driver. The biomarker potential and therapeutic relevance of CTSC are also evaluated, with particular attention to the opportunities and limitations of current DPP-1\/CTSC inhibitors and the need for tumor-specific translational strategies. Overall, CTSC represents a promising but still incompletely validated target in oncology, and future work should prioritize tissue-specific dependency, biomarker qualification, and rational combination approaches.<\/jats:p>","DOI":"10.3390\/ijms27125369","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:57:58Z","timestamp":1781513878000},"page":"5369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Cathepsin C in Cancer Metastasis: Protease Network Activation, Inflammatory Crosstalk, and Therapeutic Opportunities"],"prefix":"10.3390","volume":"27","author":[{"given":"Yahui","family":"Liu","sequence":"first","affiliation":[{"name":"College of Life Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbapap.2011.10.002","article-title":"Cysteine cathepsins: From structure, function and regulation to new frontiers","volume":"1824","author":"Turk","year":"2012","journal-title":"Biochim. Biophys. Acta BBA Proteins Proteom."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pharmthera.2018.05.011","article-title":"Therapeutic targeting of cathepsin C: From pathophysiology to treatment","volume":"190","author":"Korkmaz","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chalmers, J.D., Kettritz, R., and Korkmaz, B. (2023). Dipeptidyl peptidase 1 inhibition as a potential therapeutic approach in neutrophil-mediated inflammatory disease. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1239151"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12943-024-02107-7","article-title":"Neutrophils in the premetastatic niche: Key functions and therapeutic directions","volume":"23","author":"Jia","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"114803","DOI":"10.1016\/j.bcp.2021.114803","article-title":"Cathepsin C inhibition as a potential treatment strategy in cancer","volume":"194","author":"Korkmaz","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.immuni.2020.03.001","article-title":"CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity","volume":"52","author":"Teijeira","year":"2020","journal-title":"Immunity"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ccell.2020.12.012","article-title":"Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation","volume":"39","author":"Xiao","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Vizovisek, M., Ristanovic, D., Menghini, S., Christiansen, M.G., and Schuerle, S. (2021). The Tumor Proteolytic Landscape: A Challenging Frontier in Cancer Diagnosis and Therapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052514"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.prp.2008.04.010","article-title":"The cathepsin family and their role in colorectal cancer","volume":"204","author":"Kuester","year":"2008","journal-title":"Pathol.-Res. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1186\/s12967-024-05589-7","article-title":"Cathepsin C in health and disease: From structural insights to therapeutic prospects","volume":"22","author":"Chitsamankhun","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Varda, N., and Novinec, M. (2022). Evolutionary Analysis of Dipeptidyl Peptidase I. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031852"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113818","DOI":"10.1016\/j.ejmech.2021.113818","article-title":"Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities","volume":"225","author":"Shen","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1172\/JCI0213462","article-title":"Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis","volume":"109","author":"Adkison","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pep.2019.01.009","article-title":"The catalytic domain of cathepsin C (dipeptidyl-peptidase I) alone is a fully functional endoprotease","volume":"157","author":"Rebernik","year":"2019","journal-title":"Protein Expr. Purif."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8486","DOI":"10.1074\/jbc.M115.707109","article-title":"Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases","volume":"291","author":"Hamon","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lamort, A.-S., Hamon, Y., Czaplewski, C., Gieldon, A., Seren, S., Coquet, L., Lecaille, F., Lesner, A., Lalmanach, G., and Gauthier, F. (2019). Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194747"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tcb.2023.06.005","article-title":"Lysosomal enzyme trafficking: From molecular mechanisms to human diseases","volume":"34","author":"Braulke","year":"2023","journal-title":"Trends Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1002\/med.22047","article-title":"Targeting lysosomal quality control as a therapeutic strategy against aging and diseases","volume":"44","author":"He","year":"2024","journal-title":"Med. Res. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Rudzi\u0144ska, M., Parodi, A., Soond, S.M., Vinarov, A.Z., Korolev, D.O., Morozov, A.O., Daglioglu, C., Tutar, Y., and Zamyatnin, A.A. (2019). The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143602"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1172\/JCI67484","article-title":"Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis","volume":"123","author":"Spicer","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12935-021-01820-3","article-title":"miR-129-5p inhibits clear cell renal cell carcinoma cell proliferation, migration and invasion by targeting SPN","volume":"21","author":"Gao","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4143\/crt.2019.145","article-title":"Cathepsin C Interacts with TNF-\u03b1\/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma","volume":"52","author":"Zhang","year":"2020","journal-title":"Cancer Res. Treat."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.62347\/VNKV1642","article-title":"Cathepsin C regulates tumor progression via the Yes-associated protein signaling pathway in non-small cell lung cancer","volume":"14","author":"Kim","year":"2024","journal-title":"Am. J. Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"147948","DOI":"10.1016\/j.gene.2023.147948","article-title":"CTSC promoted the migration and invasion of glioma cells via activation of STAT3\/SERPINA3 axis","volume":"893","author":"Li","year":"2023","journal-title":"Gene"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4149\/neo_2023_220726N757","article-title":"Cathepsin C promotes colorectal cancer metastasis by regulating immune escape through upregulating CSF1","volume":"70","author":"Dang","year":"2023","journal-title":"Neoplasma"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41392-024-01955-5","article-title":"Multi-stage mechanisms of tumor metastasis and therapeutic strategies","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Avci, C.B., Harmankaya, I., and Buyukpinarbasili, N. (2024). Tumor microenvironment and cancer metastasis: Molecular insights and therapeutic interventions. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1442888"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1002\/mco2.647","article-title":"Neutrophil extracellular traps in cancer","volume":"5","author":"Ma","year":"2024","journal-title":"MedComm"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/ijc.34750","article-title":"Regulation of neutrophil extracellular traps in cancer","volume":"154","author":"Xia","year":"2023","journal-title":"Int. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/imr.13277","article-title":"NETosis: Sculpting tumor metastasis and immunotherapy","volume":"321","author":"Hu","year":"2023","journal-title":"Immunol. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-020-2394-6","article-title":"DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25","volume":"583","author":"Yang","year":"2020","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"eaao4227","DOI":"10.1126\/science.aao4227","article-title":"Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice","volume":"361","author":"Albrengues","year":"2018","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Carnevale, S., Di Ceglie, I., Grieco, G., Rigatelli, A., Bonavita, E., and Jaillon, S. (2023). Neutrophil diversity in inflammation and cancer. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1180810"},{"key":"ref_35","first-page":"849","article-title":"Complex role of neutrophils in the tumor microenvironment: An avenue for novel immunotherapies","volume":"21","author":"Zhang","year":"2024","journal-title":"Cancer Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"13332","DOI":"10.1002\/jcp.28010","article-title":"Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT\/miR-129-5p axis","volume":"234","author":"Chiang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13046-025-03370-2","article-title":"C-FOS promotes the formation of neutrophil extracellular traps and the recruitment of neutrophils in lung metastasis of triple-negative breast cancer","volume":"44","author":"Yan","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41392-024-01885-2","article-title":"Mechanism insights and therapeutic intervention of tumor metastasis: Latest developments and perspectives","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_39","first-page":"116401","article-title":"Unraveling the tumor microenvironment: Insights into cancer metastasis and therapeutic strategies","volume":"228","author":"Rabbani","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Hern\u00e1ndez, L., Garc\u00eda-Ortega, M.B., Ruiz-Alcal\u00e1, G., Carrillo, E., Marchal, J.A., and Garc\u00eda, M.\u00c1. (2021). The p38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010370"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.canlet.2018.07.001","article-title":"Tumor necrosis factor-\u03b1 promotes hepatocellular carcinogenesis through the activation of hepatic progenitor cells","volume":"434","author":"Jing","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_42","first-page":"2022-vol3","article-title":"Renal cell carcinoma: An overview of the epidemiology, diagnosis, and treatment","volume":"39","author":"Bahadoram","year":"2022","journal-title":"G. Ital. Nefrol. Organo Uff. Della Soc. Ital. Nefrol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.3390\/curroncol31080359","article-title":"Contemporary Management of Renal Cell Carcinoma: A Review for General Practitioners in Oncology","volume":"31","author":"Tejura","year":"2024","journal-title":"Curr. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Park, M., Kim, D., Ko, S., Kim, A., Mo, K., and Yoon, H. (2022). Breast Cancer Metastasis: Mechanisms and Therapeutic Implications. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126806"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Masucci, M.T., Minopoli, M., Del Vecchio, S., and Carriero, M.V. (2020). The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01749"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"117211","DOI":"10.1016\/j.biopha.2024.117211","article-title":"How neutrophils shape the immune response of triple-negative breast cancer: Novel therapeutic strategies targeting neutrophil extracellular traps","volume":"178","author":"Liang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.7150\/jca.94669","article-title":"Neutrophil Extracellular Traps in Breast Cancer: Roles in Metastasis and Beyond","volume":"15","author":"Xu","year":"2024","journal-title":"J. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"107126","DOI":"10.1016\/j.phrs.2024.107126","article-title":"CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer","volume":"202","author":"Lv","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00408-020-00407-5","article-title":"Update 2020: Management of Non-Small Cell Lung Cancer","volume":"198","author":"Alexander","year":"2020","journal-title":"Lung"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41416-024-02698-4","article-title":"Epithelial\u2212mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer","volume":"131","author":"Jeong","year":"2024","journal-title":"Br. J. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12935-021-02417-6","article-title":"Cysteine cathepsin C: A novel potential biomarker for the diagnosis and prognosis of glioma","volume":"22","author":"Cheng","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ding, X., Zhang, C., Chen, H., Ren, M., and Liu, X. (2022). Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma. Cells, 11.","DOI":"10.3390\/cells11244108"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1158\/2326-6066.CIR-23-0211","article-title":"Single-Cell Transcriptomics Reveals the Heterogeneity of the Immune Landscape of IDH\u2013Wild-Type High-Grade Gliomas","volume":"12","author":"Ran","year":"2023","journal-title":"Cancer Immunol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1007\/s12672-025-04124-4","article-title":"A pan-cancer analysis of CTSC as a candidate prognostic and immune-related biomarker","volume":"16","author":"Zheng","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1056\/NEJMoa2411664","article-title":"Phase 3 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis","volume":"392","author":"Chalmers","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00011-023-01774-4","article-title":"BI 1291583: A novel selective inhibitor of cathepsin C with superior in vivo profile for the treatment of bronchiectasis","volume":"72","author":"Kreideweiss","year":"2023","journal-title":"Inflamm. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.apsb.2020.05.008","article-title":"Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment","volume":"10","author":"Li","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41565-018-0319-4","article-title":"In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment","volume":"14","author":"Chen","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kenchegowda, M., Rahamathulla, M., Hani, U., Begum, M.Y., Guruswamy, S., Osmani, R.A.M., Gowrav, M.P., Alshehri, S., Ghoneim, M.M., and Alshlowi, A. (2021). Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review. Molecules, 27.","DOI":"10.3390\/molecules27010146"},{"key":"ref_60","first-page":"28","article-title":"Targeting NETosis: Nature\u2019s alarm system in cancer progression","volume":"7","author":"Liang","year":"2024","journal-title":"Cancer Drug Resist."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Mi, J., Guo, J., Kang, K., Wang, S., and Huang, M. (2025). Advances in targeting neutrophil extracellular traps as a promising approach for breast cancer treatment. Combinatorial Chemistry & High Throughput Screening, Bentham Science Publishers.","DOI":"10.2174\/0113862073376243250130060239"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/12\/5369\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:15:42Z","timestamp":1781514942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/12\/5369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,14]]},"references-count":61,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ijms27125369"],"URL":"https:\/\/doi.org\/10.3390\/ijms27125369","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,14]]}}}