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Given safety concerns with laser sources, light-emitting diodes (LED)-sourced red light represents a promising alternative. This study investigated the effects of LED-sourced red light (RL) on cellular response in vitro and ocular growth in normal and lens-induced myopic chicks. In vitro, the mouse photoreceptor 661W cell line was exposed to 625 and 664 nm LED-sourced RL (3 min, twice daily) for 3 days, and cytochrome c oxidase (CCO) activity and cell viability were assessed. In vivo, chicks were randomly assigned to normal visual conditions or monocular \u22125D lens-induced myopia (LIM). Treatment groups received 664 nm LED-sourced RL (30 min, twice daily) at low, moderate, or high intensities for 10 days. In vitro, LED-sourced RL at 664 nm more effectively activated CCO and enhanced cell viability in 661W cells than RL at 625 nm and white light. In vivo, low-intensity RL exposure of 10 days significantly inhibited vitreous chamber depth (VCD) and axial length (AL) elongation compared to the normal light group (p &lt; 0.05) in normally growing chicks but showed no significant effect in LIM eyes. By contrast, moderate- and high-intensity RL exposure for 10 days attenuated myopia progression in LIM eyes, as reflected by slower VCD and AL elongation and less myopic shift, compared to the normal light group (all p &lt; 0.05). Notably, high-intensity RL also protected the untouched fellow eyes of the LIM chick models against myopic shift and excessive elongation. LED-sourced RL at 664 nm was effective in activating CCO, reducing apoptosis, and promoting cell viability. In chick models, it can also inhibit ocular growth in both normally growing and \u22125D lens-induced myopic chicks.<\/jats:p>","DOI":"10.3390\/ijms27125427","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:27:21Z","timestamp":1781666841000},"page":"5427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential Inhibitory Effect of LED-Sourced Red Light Therapy on Ocular Growth in Normal and Myopic Chicks"],"prefix":"10.3390","volume":"27","author":[{"given":"Fengjuan","family":"Yu","sequence":"first","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong 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Sze-Wan","family":"Shan","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong"},{"name":"Centre for Eye and Vision Research (CEVR), Units 901-903, 17W, Hong Kong Science Park, Pak Shek Kok, Shatin, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-8397","authenticated-orcid":false,"given":"Chi-Ho","family":"To","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong"},{"name":"Centre for Eye and Vision Research (CEVR), Units 901-903, 17W, Hong Kong Science Park, Pak Shek Kok, Shatin, Hong 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