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Although clinical observations link high-dose catecholamine exposure to increased AKI risk, experimental models and mechanistic studies remain limited. We established a rodent model of combined epinephrine and norepinephrine infusion to investigate the renoprotective effects of subtype-selective \u03b2-adrenoceptor blockers. Animals received the \u03b21-selective blockers metoprolol or atenolol, or the \u03b22-selective blocker ICI 118,551. \u03b21-adrenoceptor blockade, particularly with metoprolol, significantly attenuated renal histopathological injury and improved biochemical markers of kidney dysfunction. These protective effects were associated with suppression of ferroptosis-related pathways in the renal cortex. Atenolol partially improved biochemical parameters but did not significantly reduce tubulointerstitial damage, whereas \u03b22-adrenoceptor blockade conferred limited functional benefit despite modest morphological improvement. Collectively, our findings indicate that \u03b21-adrenoceptor activation plays a critical role in catecholamine-induced AKI by promoting ferroptosis. Targeting \u03b21-adrenoceptors, especially with metoprolol, may represent a potential therapeutic strategy for preventing renal injury during catecholamine storms.<\/jats:p>","DOI":"10.3390\/ijms27125480","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:11:22Z","timestamp":1781709082000},"page":"5480","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of Selective \u03b2-Adrenoceptor Blockade on Renal Pathophysiology in a Catecholamine Storm of Rat"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-2684","authenticated-orcid":false,"given":"Bo-Hau","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan 325208, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Zuoying Armed Forces General Hospital, Kaohsiung 813204, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Hong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-5945","authenticated-orcid":false,"given":"Hsin-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6594-9296","authenticated-orcid":false,"given":"Yi-Ting","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chieh","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pingtung Veterans General Hospital, Pingtung 900053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7266-7590","authenticated-orcid":false,"given":"Wen-Hsien","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"},{"name":"Department of Health-Business Administration, Fooyin University, Kaohsiung 831301, Taiwan"},{"name":"Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan"},{"name":"Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung 821004, Taiwan"},{"name":"College of Health and Management, Cheng Shiu University, Kaohsiung 833301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/s41390-022-01964-6","article-title":"Milrinone effects on cardiac mitochondria, hemodynamics, and death in catecholamine-infused rats","volume":"92","author":"Lin","year":"2022","journal-title":"Pediatr. 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