{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:50:25Z","timestamp":1782190225008,"version":"3.54.5"},"reference-count":100,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Postoperative inflammation is a necessary response to surgical injury that supports tissue repair and regeneration. However, successful healing depends not only on the initial inflammatory response but also on its timely resolution. Failure to resolve inflammation can impair wound healing, promote fibrosis, and increase the risk of postoperative complications. Increasing evidence suggests that effective recovery is driven by the transition from inflammation to repair and regenerative processes. Diet plays an important role in this transition, as nutrients not only provide metabolic support but also regulate key pathways involved in inflammation, tissue regeneration, redox balance, and immune function. Omega-3 polyunsaturated fatty acids could serve as precursors for specialized pro-resolving mediators that actively terminate inflammation and may promote macrophage-driven tissue repair. Polyphenols and antioxidant micronutrients modulate NF-\u03baB and Nrf2-dependent signalling, attenuating oxidative amplification of inflammatory cascades. Micronutrients and amino acids further regulate enzymatic processes governing collagen synthesis, angiogenesis, and immune competence. Concurrently, diet-driven preservation of gut barrier integrity limits endotoxin-mediated amplification of systemic inflammatory responses. By targeting interconnected molecular networks, including inflammasome activation, mitochondrial redox signalling, and metabolic programming of immune cells, anti-inflammatory dietary patterns may promote immune resolution rather than immunosuppression. This distinction is particularly relevant in the postoperative setting, where balanced inflammation is required for both host defence and regenerative healing. This review synthesizes current molecular and translational evidence linking dietary modulation to postoperative inflammatory control and tissue regeneration. By integrating insights from immunology, metabolism, and nutritional science, it positions diet as an active, biologically grounded component of perioperative management and highlights future directions for precision nutrition strategies aimed at optimizing surgical recovery.<\/jats:p>","DOI":"10.3390\/ijms27125483","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:11:22Z","timestamp":1781709082000},"page":"5483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Modulation of Postoperative Inflammation: Molecular Mechanisms and Implications for Tissue Repair and Healing"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8947-9897","authenticated-orcid":false,"given":"Charlotta Victoria","family":"Siefert","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2837-4157","authenticated-orcid":false,"given":"Lara","family":"Baticic","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile Inflammation: Sensing and Reacting to Damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-immunol-030409-101311","article-title":"The Sterile Inflammatory Response","volume":"28","author":"Rock","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00068-019-01235-w","article-title":"Damage-Associated Molecular Patterns in Trauma","volume":"46","author":"Relja","year":"2020","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern Recognition Receptors and Inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and Physiological Roles of Inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-\u039aB in Immunobiology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/S0140-6736(14)60687-5","article-title":"The Systemic Immune Response to Trauma: An Overview of Pathophysiology and Treatment","volume":"384","author":"Lord","year":"2014","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/bja\/85.1.109","article-title":"The Stress Response to Trauma and Surgery","volume":"85","author":"Desborough","year":"2000","journal-title":"Br. J. Anaesth."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of Inflammation: The Beginning Programs the End","volume":"6","author":"Serhan","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-Resolving Lipid Mediators Are Leads for Resolution Physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrd.2016.39","article-title":"Resolution of Inflammation: A New Therapeutic Frontier","volume":"15","author":"Fullerton","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/bja\/78.5.606","article-title":"Multimodal Approach to Control Postoperative Pathophysiology and Rehabilitation","volume":"78","author":"Kehlet","year":"1997","journal-title":"Br. J. Anaesth."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 Inflammasome: Molecular Activation and Regulation to Therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and Regulation of NLRP3 Inflammasome Activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A Guide to Immunometabolism for Immunologists","volume":"16","author":"Kishton","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","article-title":"Physiological Roles of Mitochondrial Reactive Oxygen Species","volume":"48","author":"Sena","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in Innate Immune Responses","volume":"11","author":"West","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri.2015.4","article-title":"Specialized Pro-Resolving Mediators: Endogenous Regulators of Infection and Inflammation","volume":"16","author":"Basil","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/nu2030355","article-title":"Omega-3 Fatty Acids and Inflammatory Processes","volume":"2","author":"Calder","year":"2010","journal-title":"Nutrients"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Suzuki, T., Ohishi, T., Tanabe, H., Miyoshi, N., and Nakamura, Y. (2023). Anti-Inflammatory Effects of Dietary Polyphenols through Inhibitory Activity against Metalloproteinases. Molecules, 28.","DOI":"10.3390\/molecules28145426"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1017\/S0007114515002093","article-title":"Low-Grade Inflammation, Diet Composition and Health: Current Research Evidence and Its Translation","volume":"114","author":"Minihane","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/0884533610385703","article-title":"Diet and Inflammation","volume":"25","author":"Galland","year":"2010","journal-title":"Nutr. Clin. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Dalli, J., and Serhan, C.N. (2017). Pro-Resolving Mediators in Regulating and Conferring Macrophage Function. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01400"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.bcp.2006.07.004","article-title":"Regulation of Inflammation and Redox Signaling by Dietary Polyphenols","volume":"72","author":"Rahman","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/cc1514","article-title":"Clinical Review: Immunodepression in the Surgical Patient and Increased Susceptibility to Infection","volume":"6","author":"Angele","year":"2002","journal-title":"Crit. Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0039-6109(16)46587-4","article-title":"Evolving Concepts in the Pathogenesis of Postinjury Multiple Organ Failure","volume":"75","author":"Moore","year":"1995","journal-title":"Surg. Clin. N. Am."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal Mucosal Barrier Function in Health and Disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s15010-018-1178-5","article-title":"Gut-Origin Sepsis in the Critically Ill Patient: Pathophysiology and Treatment","volume":"46","author":"Assimakopoulos","year":"2018","journal-title":"Infection"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic Endotoxemia Initiates Obesity and Insulin Resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.aad3369","article-title":"Population-Based Metagenomics Analysis Reveals Markers for Gut Microbiome Composition and Diversity","volume":"352","author":"Zhernakova","year":"2016","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00134-009-1744-5","article-title":"Lipid Emulsions in Parenteral Nutrition of Intensive Care Patients: Current Thinking and Future Directions","volume":"36","author":"Calder","year":"2010","journal-title":"Intensive Care Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jpen.1672","article-title":"\u03c9-3 Fatty-Acid Enriched Parenteral Nutrition in Hospitalized Patients: Systematic Review With Meta-Analysis and Trial Sequential Analysis","volume":"44","author":"Pradelli","year":"2020","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound Healing: A Cellular Perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and Metabolism in Tissue Repair and Regeneration","volume":"356","author":"Eming","year":"2017","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.18295\/2075-0528.1676","article-title":"The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as Diagnostics, Prognostics and Therapeutics in Clinical Medicine","volume":"15","author":"Land","year":"2015","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The Role of Pattern-Recognition Receptors in Innate Immunity: Update on Toll-like Receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The Nuclear Factor NF-KappaB Pathway in Inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and Immunity: Challenges and Opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.bja.2026.01.003","article-title":"Immunometabolism, an Emerging Field in Perioperative and Critical Care Medicine: A Narrative Review","volume":"136","author":"Nessel","year":"2026","journal-title":"Br. J. Anaesth."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Hassanshahi, A., Moradzad, M., Ghalamkari, S., Fadaei, M., Cowin, A.J., and Hassanshahi, M. (2022). Macrophage-Mediated Inflammation in Skin Wound Healing. Cells, 11.","DOI":"10.3390\/cells11192953"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and Molecular Mechanisms of Fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1189\/jlb.4MR0316-102R","article-title":"Angiogenesis and Wound Repair: When Enough Is Enough","volume":"100","author":"DiPietro","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate Is an Inflammatory Signal That Induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-cellbio-021820-101354","article-title":"Mitochondrial Quality Control and Restraining Innate Immunity","volume":"36","author":"Moehlman","year":"2020","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-pathol-012414-040431","article-title":"The Inflammasomes and Autoinflammatory Syndromes","volume":"10","author":"Broderick","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/path.4116","article-title":"Inflammasomes in Wound Healing and Fibrosis","volume":"229","author":"Artlett","year":"2013","journal-title":"J. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"102635","DOI":"10.1016\/j.coi.2025.102635","article-title":"Epigenetic Regulation of Inflammation Dynamics during Wound Healing: A Subtle yet Profound Shift in Histone Modifications","volume":"96","author":"Xiao","year":"2025","journal-title":"Curr. Opin. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.it.2017.03.001","article-title":"Macrophage Immunometabolism: Where Are We (Going)?","volume":"38","author":"Menon","year":"2017","journal-title":"Trends Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-Intrinsic Lysosomal Lipolysis Is Essential for Alternative Activation of Macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/ijo.2008.116","article-title":"AMPK: A Key Regulator of Energy Balance in the Single Cell and the Whole Organism","volume":"32","author":"Hardie","year":"2008","journal-title":"Int. J. Obes."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"DiPietro, L.A., Wilgus, T.A., and Koh, T.J. (2021). Macrophages in Healing Wounds: Paradoxes and Paradigms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020950"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive Oxygen Species in Inflammation and Tissue Injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e20230036","DOI":"10.1002\/SMMD.20230036","article-title":"Immunomodulation of Wound Healing Leading to Efferocytosis","volume":"3","author":"Zhao","year":"2024","journal-title":"Smart Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Krause, W., King, D., and Horsley, V. (2024). Transcriptional Analysis of Efferocytosis in Mouse Skin Wounds. bioRxiv.","DOI":"10.1101\/2024.08.12.607219"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.smim.2015.03.004","article-title":"The Resolution Code of Acute Inflammation: Novel pro-Resolving Lipid Mediators in Resolution","volume":"27","author":"Serhan","year":"2015","journal-title":"Semin. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev-pharmtox-051921-084047","article-title":"Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch","volume":"63","author":"Ji","year":"2023","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"106718","DOI":"10.1016\/j.prostaglandins.2023.106718","article-title":"Resolvins and Cysteinyl-Containing pro-Resolving Mediators Activate Resolution of Infectious Inflammation and Tissue Regeneration","volume":"166","author":"Serhan","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3892\/ijmm.2025.5631","article-title":"Function of Epigenetic Modifications in Wound Healing and Potential Therapies (Review)","volume":"56","author":"Cheng","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e28086","DOI":"10.1016\/j.heliyon.2024.e28086","article-title":"Epigenetic Modification: A Novel Insight into Diabetic Wound Healing","volume":"10","author":"Ju","year":"2024","journal-title":"Heliyon"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Liu, X.-F., Shao, J.-H., Liao, Y.-T., Wang, L.-N., Jia, Y., Dong, P.-J., Liu, Z.-Z., He, D.-D., Li, C., and Zhang, X. (2023). Regulation of Short-Chain Fatty Acids in the Immune System. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1186892"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1053\/j.gastro.2014.12.036","article-title":"Food, Immunity, and the Microbiome","volume":"148","author":"Tilg","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.plefa.2006.05.012","article-title":"Polyunsaturated Fatty Acids and Inflammation","volume":"75","author":"Calder","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"343S","DOI":"10.1093\/ajcn\/71.1.343S","article-title":"Dietary Polyunsaturated Fatty Acids and Inflammatory Mediator Production","volume":"71","author":"James","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature05877","article-title":"Resolvin E1 and Protectin D1 Activate Inflammation-Resolution Programmes","volume":"447","author":"Schwab","year":"2007","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41569-023-00984-x","article-title":"Specialized Pro-Resolving Mediators in Vascular Inflammation and Atherosclerotic Cardiovascular Disease","volume":"21","author":"Fredman","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1524-475X.2012.00853.x","article-title":"Resolvin D2 Prevents Secondary Thrombosis and Necrosis in a Mouse Burn Wound Model","volume":"21","author":"Bohr","year":"2013","journal-title":"Wound Repair Regen."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin-Sensitizing Effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.numecd.2016.07.011","article-title":"Impact of Omega-3 Polyunsaturated Fatty Acids on Vascular Function and Blood Pressure: Relevance for Cardiovascular Outcomes","volume":"27","author":"Colussi","year":"2017","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.jacc.2011.06.063","article-title":"Omega-3 Fatty Acids and Cardiovascular Disease: Effects on Risk Factors, Molecular Pathways, and Clinical Events","volume":"58","author":"Mozaffarian","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Mohsen, G., Stroemer, A., Mayr, A., Kunsorg, A., Stoppe, C., Wittmann, M., and Velten, M. (2023). Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis. Nutrients, 15.","DOI":"10.3390\/nu15153414"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"C39","DOI":"10.1152\/ajpcell.00024.2014","article-title":"Identification and Signature Profiles for Pro-Resolving and Inflammatory Lipid Mediators in Human Tissue","volume":"307","author":"Colas","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jhep.2004.08.010","article-title":"Curcumin Inhibits NF-KappaB Activation and Reduces the Severity of Experimental Steatohepatitis in Mice","volume":"41","author":"Leclercq","year":"2004","journal-title":"J. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential Therapeutic Effects of Curcumin, the Anti-Inflammatory Agent, against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 Signaling Pathway: Pivotal Roles in Inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"S\u00fcntar, I., \u00c7etinkaya, S., Panieri, E., Saha, S., Buttari, B., Profumo, E., and Saso, L. (2021). Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process. Molecules, 26.","DOI":"10.3390\/molecules26092424"},{"key":"ref_78","first-page":"6","article-title":"Physiology of Wound Healing","volume":"13","author":"Hunt","year":"2000","journal-title":"Adv. Skin Wound Care"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Pullar, J.M., Carr, A.C., and Vissers, M.C.M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9.","DOI":"10.3390\/nu9080866"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.freeradbiomed.2011.05.017","article-title":"Vitamins C and E: Beneficial Effects from a Mechanistic Perspective","volume":"51","author":"Traber","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2119\/2008-00033.Prasad","article-title":"Zinc in Human Health: Effect of Zinc on Immune Cells","volume":"14","author":"Prasad","year":"2008","journal-title":"Mol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.mam.2005.07.015","article-title":"Copper, Oxidative Stress, and Human Health","volume":"26","author":"Keen","year":"2005","journal-title":"Mol. Asp. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/eji.201445427","article-title":"Reprogramming Mitochondrial Metabolism in Macrophages as an Anti-Inflammatory Signal","volume":"46","author":"Mills","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Alves-Filho, J.C., and P\u00e5lsson-McDermott, E.M. (2016). Pyruvate Kinase M2: A Potential Target for Regulating Inflammation. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00145"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.numecd.2014.03.003","article-title":"Mediterranean Dietary Pattern, Inflammation and Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Trials","volume":"24","author":"Schwingshackl","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1407S","DOI":"10.1093\/jn\/130.5.1407S","article-title":"Zinc-Altered Immune Function and Cytokine Production","volume":"130","author":"Rink","year":"2000","journal-title":"J. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1524-475X.2006.00179.x","article-title":"Zinc in Wound Healing: Theoretical, Experimental, and Clinical Aspects","volume":"15","author":"Lansdown","year":"2007","journal-title":"Wound Repair Regen."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1753-4887.2001.tb07017.x","article-title":"Copper Homeostasis: The Role of Cellular Transporters","volume":"59","author":"Harris","year":"2001","journal-title":"Nutr. Rev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/mnfr.200700330","article-title":"The Influence of Selenium on Immune Responses","volume":"52","author":"Hoffmann","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine Metabolism: Nitric Oxide and Beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1681S","DOI":"10.1093\/jn\/137.6.1681S","article-title":"Arginine and Immunity","volume":"137","author":"Popovic","year":"2007","journal-title":"J. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2515S","DOI":"10.1093\/jn\/131.9.2515S","article-title":"Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection?","volume":"131","author":"Newsholme","year":"2001","journal-title":"J. Nutr."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Cruzat, V., Macedo Rogero, M., Noel Keane, K., Curi, R., and Newsholme, P. (2018). Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients, 10.","DOI":"10.20944\/preprints201809.0459.v1"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.surge.2012.03.003","article-title":"Gut-Origin Sepsis: Evolution of a Concept","volume":"10","author":"Deitch","year":"2012","journal-title":"Surgeon"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0074-7696(07)57004-X","article-title":"Fibroblast Differentiation in Wound Healing and Fibrosis","volume":"257","author":"Darby","year":"2007","journal-title":"Int. Rev. Cytol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41392-024-01954-6","article-title":"Metabolic Regulation of the Immune System in Health and Diseases: Mechanisms and Interventions","volume":"9","author":"Hu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut Microbiota, Intestinal Permeability, and Systemic Inflammation: A Narrative Review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Matar, A., Damianos, J.A., Jencks, K.J., and Camilleri, M. (2024). Intestinal Barrier Impairment, Preservation, and Repair: An Update. Nutrients, 16.","DOI":"10.3390\/nu16203494"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Hajj, J., Sizemore, B., and Singh, K. (2024). Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251910474"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/12\/5483\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:32:45Z","timestamp":1782189165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/12\/5483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":100,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ijms27125483"],"URL":"https:\/\/doi.org\/10.3390\/ijms27125483","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]}}}