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We performed a comparative analysis of human (GTEx) and mouse (GSE144046, GSE144277) transcriptomes, complemented by RT-qPCR in DAT-KO rats, to identify dopaminergic gene associations in the normal cerebellum and neurodevelopmental disorder models. Pairwise dopaminergic gene correlations were generally weak, with a slight increase in interaction complexity in ASD models. However, weighted gene co-expression network analysis identified a robust gene module involving Comt, which was consistently associated with synaptic translation across mouse datasets. These associations reflect regulatory processes in the whole cerebellum, which is commonly represented in rodent studies but absent in human data, which are acquired in studies of cerebellar subregions. ASD modeling exerted contrasting effects: Cul3 haploinsufficiency increased the number of genes involved in the module with a decrease in connectivity, while Mbd5 haploinsufficiency led to module collapse. These findings confirm neurodevelopmental disorders as a heterogeneous condition where divergent backgrounds uniquely rewire cerebellar dopaminergic networks. Considering the cerebellum\u2019s role in ASD and that some ASD medications target the dopamine system, further investigation of these identified trends may support the development of more personalized therapeutic approaches.<\/jats:p>","DOI":"10.3390\/ijms27125508","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:59:38Z","timestamp":1781773178000},"page":"5508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Opposing Changes in Cerebellar Dopaminergic Genes Co-Expression Networks in Different Models of Neurodevelopmental Disorders"],"prefix":"10.3390","volume":"27","author":[{"given":"Anastasia D.","family":"Belskaya","sequence":"first","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2074-9081","authenticated-orcid":false,"given":"Zoia S.","family":"Fesenko","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0724-887X","authenticated-orcid":false,"given":"Anna B.","family":"Volnova","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"},{"name":"Center for Transgenesis and Genome Editing, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul R.","family":"Gainetdinov","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0101-1065","authenticated-orcid":false,"given":"Anastasia N.","family":"Vaganova","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Amore, G., Spoto, G., Ieni, A., Vetri, L., Quatrosi, G., Di Rosa, G., and Nicotera, A.G. 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