{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:45:15Z","timestamp":1782539115591,"version":"3.54.5"},"reference-count":80,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Matrilysins and stromelysins play a vital role in cancer, facilitating tumor invasion and metastasis. The aim of this study was to investigate the diagnostic significance of selected matrilysins and stromelysins in comparison to routine tumor markers in gynecological malignancies, relative to a control group (benign tumors and healthy women). Preoperative plasma levels of selected metalloproteinases were determined using ELISA, while levels of CA125, SCC-Ag, and HE4 by CMIA. In endometrial and cervical cancers, matrilysins (MMP-7 and MMP-26) exhibited higher diagnostic utility than routine markers. Similarly, all stromelysins in cervical cancer outperformed CA125; furthermore, MMP-10 also outperformed SCC-Ag, achieving the highest diagnostic utility among all parameters tested in cervical cancer. For ovarian cancer, diagnostic utility remained highest for routine markers. In endometrial and cervical cancers, the AUCs for all studied parameters exceeded those of standard markers, while in ovarian cancer, MMP-7 had an AUC higher than HE4 and comparable to CA 125. Combined analysis of the studied parameters in diagnostic panels demonstrated that their introduction into routine diagnostics could provide tangible benefits in the detection of malignant gynecological lesions, especially the combination of MMP-7 or MMP-10 with routine markers. These results indicate the usefulness and high diagnostic power of selected MMPs in the detection of these malignancies.<\/jats:p>","DOI":"10.3390\/ijms27125592","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:09:17Z","timestamp":1782270557000},"page":"5592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Potential of Selected Matrilysins and Stromelysins in the Diagnosis of Gynecological Malignancies Based on ROC Curve Analysis"],"prefix":"10.3390","volume":"27","author":[{"given":"Ewa","family":"Gacuta","sequence":"first","affiliation":[{"name":"Department of Perinatology, University Clinical Hospital of Bialystok, 15-276 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-0722","authenticated-orcid":false,"given":"Monika","family":"Zajkowska","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bia\u0142ystok, 15-269 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"\u0141awicki","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Lifestyle Diseases Prevention, University of Bia\u0142ystok, 15-269 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Lifestyle Diseases Prevention, University of Bia\u0142ystok, 15-269 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8955-8198","authenticated-orcid":false,"given":"Piotr","family":"Lauda\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, 03-242 Warsaw, Poland"},{"name":"Women\u2019s Health Research Institute, Calisia University, 62-800 Kalisz, Poland"},{"name":"OVIklinika Infertility Center, 01-377 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Zbucka-Kr\u0119towska","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Adolescent Gynecology, Medical University of Bia\u0142ystok, ul. M. Sk\u0142odowskiej-Curie 24a, 15-276 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz Antoni","family":"J\u00f3zefczak","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Oncology, Specialist Hospital in Pu\u0142awy, 24-100 Pu\u0142awy, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Guszczyn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopaedics and Traumatology, Medical University of Bia\u0142ystok, 15-269 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-085X","authenticated-orcid":false,"given":"Pawe\u0142","family":"\u0141awicki","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Lifestyle Diseases Prevention, University of Bia\u0142ystok, 15-269 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-0745","authenticated-orcid":false,"given":"Marlena","family":"Dubat\u00f3wka","sequence":"additional","affiliation":[{"name":"Population Research Center, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kicman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Faculty of Medicine, Medical University of Bialystok, 15-269 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"\u0141awicki","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Lifestyle Diseases Prevention, University of Bia\u0142ystok, 15-269 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Glob. 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