{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:36:11Z","timestamp":1785436571978,"version":"3.56.0"},"reference-count":165,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Biomedical Laboratory Research & Development Service of Veterans Affairs Office of Research and Development","award":["I01 BX002137"],"award-info":[{"award-number":["I01 BX002137"]}]},{"award":["I01 BX002137"],"award-info":[{"award-number":["I01 BX002137"]}],"id":[{"id":"https:\/\/ror.org\/011qyt180","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["1R01HL164415"],"award-info":[{"award-number":["1R01HL164415"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"award":["1R01HL164415"],"award-info":[{"award-number":["1R01HL164415"]}],"id":[{"id":"https:\/\/ror.org\/012pb6c26","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cardiovascular disease and cancer remain the leading causes of death worldwide. Although numerous cancer therapies have improved survival rates, they also increase the risk of cardiomyopathy, heart failure, and arrhythmias. These cardiovascular complications can limit treatment options and adversely affect the long-term quality of life of cancer survivors. CaV1.3, an L-type calcium channel encoded by CACNA1D, emerges as a central molecular mediator linking cardiovascular disease and cancer. It regulates calcium entry into cardiomyocytes and contributes to sinoatrial pacemaking and atrioventricular conduction. It also contributes to proliferation, migration, and therapy resistance in several cancers. Chemotherapy-induced oxidative stress, inflammatory signaling, hypoxia, and transcriptional changes can modulate the expression, gating, splicing, and trafficking of CaV1.3 channels. All these changes destabilize diastolic depolarization and impair conduction, thereby promoting arrhythmias in cancer patients. This review focuses on CaV1.3 biology in cardio-oncology, along with the mechanisms of chemotherapy-induced cardiotoxicity. It outlines the role of CaV1.3 as a key mediator linking cancer therapies to subsequent nodal dysfunction and increased arrhythmia susceptibility. It also expands on how patient-specific induced pluripotent stem cell-derived cardiomyocytes can model CaV1.3 dysregulation as well as support the development of targeted therapies. We propose that CaV1.3 represents a mechanistic bridge linking cancer therapy, calcium signaling, and cardiac electrophysiology, and that elucidating its pathophysiology may guide the design of targeted strategies in cardio-oncology.<\/jats:p>","DOI":"10.3390\/ijms27135663","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:09:17Z","timestamp":1782270557000},"page":"5663","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of CaV1.3 L-Type Calcium Channels on Arrhythmogenesis in Cancer"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9309-1940","authenticated-orcid":false,"given":"Lianlen Joy Go","family":"Distor","sequence":"first","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, New York, NY 11209, USA"},{"name":"Department of Medicine, Cell Biology and Pharmacology, State University of New York Downstate Health Sciences University, New York, NY 11203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-8945","authenticated-orcid":false,"given":"Yvonne","family":"Sleiman","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, New York, NY 11209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-6670","authenticated-orcid":false,"given":"Jean-Baptiste","family":"Reisqs","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, New York, NY 11209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-1683","authenticated-orcid":false,"given":"Vamsi Krishna Murthy","family":"Ginjupalli","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, New York, NY 11209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cupelli","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, New York, NY 11209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Boutjdir","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Program, VA New York Harbor Healthcare System, New York, NY 11209, USA"},{"name":"Department of Medicine, Cell Biology and Pharmacology, State University of New York Downstate Health Sciences University, New York, NY 11203, USA"},{"name":"Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jaccao.2025.07.001","article-title":"Cancer and Cardiovascular Disease","volume":"7","author":"Alhuneafat","year":"2025","journal-title":"JACC CardioOncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5334\/gh.1288","article-title":"The Heart of the World","volume":"19","author":"Perel","year":"2024","journal-title":"Glob. Heart"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jacep.2016.03.001","article-title":"Increased Incidence of Ventricular Arrhythmias in Patients with Advanced Cancer and Implantable Cardioverter-Defibrillators","volume":"3","author":"Enriquez","year":"2017","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, Regional, and National Age-Sex-Specific Mortality for 282 Causes of Death in 195 Countries and Territories, 1980\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Roth","year":"2018","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e14841","DOI":"10.1111\/ijcp.14841","article-title":"Trends in Cardiovascular Mortality of Cancer Patients in the US over Two Decades 1999\u20132019","volume":"75","author":"Kobo","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1470-2045(19)30800-9","article-title":"Late Mortality and Chronic Health Conditions in Long-Term Survivors of Early-Adolescent and Young Adult Cancers: A Retrospective Cohort Analysis from the Childhood Cancer Survivor Study","volume":"21","author":"Suh","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s11912-023-01445-x","article-title":"Cardiac Arrhythmias in Oncological Patients\u2014Epidemiology, Risk Factors, and Management within the Context of the New ESC 2022 Guidelines","volume":"25","author":"Gawlik","year":"2023","journal-title":"Curr. Oncol. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.yjmcc.2024.06.005","article-title":"Atrial Fibrillation in Cancer, Anticancer Therapies, and Underlying Mechanisms","volume":"194","author":"Shaaban","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/cncr.11274","article-title":"Late Anthracycline Cardiotoxicity after Childhood Cancer: A Prospective Longitudinal Study","volume":"97","author":"Sorensen","year":"2003","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s44348-024-00014-5","article-title":"Cancer Therapy-Related Cardiac Dysfunction and the Role of Cardiovascular Imaging: Systemic Review and Opinion Paper from the Working Group on Cardio-Oncology of the Korean Society of Cardiology","volume":"32","author":"Cho","year":"2024","journal-title":"J. Cardiovasc. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e70123","DOI":"10.1111\/jcmm.70123","article-title":"The L-type Calcium Channel CaV1.3: A Potential Target for Cancer Therapy","volume":"28","author":"Liu","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1074\/jbc.M114.586883","article-title":"Regulation of Gene Transcription by Voltage-Gated L-Type Calcium Channel, Cav1.3","volume":"290","author":"Lu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"795602","DOI":"10.1155\/2015\/795602","article-title":"Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress","volume":"2015","author":"Angsutararux","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1113\/JP272262","article-title":"Voltage-gated Calcium Channels and Their Auxiliary Subunits: Physiology and Pathophysiology and Pharmacology","volume":"594","author":"Dolphin","year":"2016","journal-title":"J. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"a003947","DOI":"10.1101\/cshperspect.a003947","article-title":"Voltage-Gated Calcium Channels","volume":"3","author":"Catterall","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/pr.114.009654","article-title":"The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential","volume":"67","author":"Zamponi","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature12775","article-title":"Structural Basis for Ca2+ Selectivity of a Voltage-Gated Calcium Channel","volume":"505","author":"Tang","year":"2014","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1152\/jn.1992.68.4.1373","article-title":"Simulation of the Currents Involved in Rhythmic Oscillations in Thalamic Relay Neurons","volume":"68","author":"Huguenard","year":"1992","journal-title":"J. Neurophysiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10247","DOI":"10.1523\/JNEUROSCI.1089-05.2005","article-title":"Neuronal L-Type Calcium Channels Open Quickly and Are Inhibited Slowly","volume":"25","author":"Helton","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Scarnati, M.S., Clarke, S.G., Pang, Z.P., and Paradiso, K.G. (2020). Presynaptic Calcium Channel Open Probability and Changes in Calcium Influx Throughout the Action Potential Determined Using AP-Waveforms. Front. Synaptic Neurosci., 12.","DOI":"10.3389\/fnsyn.2020.00017"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2167569","DOI":"10.1080\/19336950.2023.2167569","article-title":"Advances in CaV 1.1 Gating: New Insights into Permeation and Voltage-Sensing Mechanisms","volume":"17","author":"Bibollet","year":"2023","journal-title":"Channels"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1242\/jcs.116855","article-title":"Cav1.1 Controls Frequency-Dependent Events Regulating Adult Skeletal Muscle Plasticity","volume":"126","author":"Jorquera","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41467-023-43502-w","article-title":"Selective Blockade of Cav1.2 (\u03b11C) versus Cav1.3 (\u03b11D) L-Type Calcium Channels by the Black Mamba Toxin Calciseptine","volume":"15","author":"Mesirca","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s42003-024-06313-3","article-title":"CaV1.3 Channel Clusters Characterized by Live-Cell and Isolated Plasma Membrane Nanoscopy","volume":"7","author":"Schwenzer","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s00424-021-02570-x","article-title":"Cav1.4 Dysfunction and Congenital Stationary Night Blindness Type 2","volume":"473","author":"Koschak","year":"2021","journal-title":"Pfl\u00fcg. Arch.-Eur. J. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Laird, J.G., Kopel, A., Lankford, C.K., and Baker, S.A. (2023). Mouse All-Cone Retina Models of Cav1.4 Synaptopathy. Front. Mol. Neurosci., 16.","DOI":"10.3389\/fnmol.2023.1155955"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1074\/jbc.M114.607465","article-title":"Characterization of Cav1.4 Complexes (A11.4, \u03922, and A2\u03b44) in HEK293T Cells and in the Retina","volume":"290","author":"Lee","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4161\/chan.5.3.15266","article-title":"Functional Roles of Cav1.3, Cav3.1 and HCN Channels in Automaticity of Mouse Atrioventricular Cells: Insights into the Atrioventricular Pacemaker Mechanism","volume":"5","author":"Marger","year":"2011","journal-title":"Channels"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/01.RES.0000018003.14304.E2","article-title":"Functional Roles of Cav 1.3 (\u03b11D) Calcium Channel in Sinoatrial Nodes: Insight Gained Using Gene-Targeted Null Mutant Mice","volume":"90","author":"Zhang","year":"2002","journal-title":"Circ. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00441-014-1936-3","article-title":"The Role of L-Type Voltage-Gated Calcium Channels Cav1.2 and Cav1.3 in Normal and Pathological Brain Function","volume":"357","author":"Berger","year":"2014","journal-title":"Cell Tissue Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1038\/s41598-018-25195-0","article-title":"Drosophila Voltage-Gated Calcium Channel A1-Subunits Regulate Cardiac Function in the Aging Heart","volume":"8","author":"Lam","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103608","DOI":"10.1016\/j.scr.2024.103608","article-title":"Generation of an iPSC Cell Line (VANYHHi001-A) from a Patient with Cardiac Arrythmias Carrying CACNA1D, SCN5A, and DSP Variants","volume":"81","author":"Sleiman","year":"2024","journal-title":"Stem Cell Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1073\/pnas.0935295100","article-title":"Functional Role of L-Type Cav1.3 Ca2+ Channels in Cardiac Pacemaker Activity","volume":"100","author":"Mangoni","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zaveri, S., Srivastava, U., Qu, Y.S., Chahine, M., and Boutjdir, M. (2023). Pathophysiology of Cav1.3 L-Type Calcium Channels in the Heart. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1144069"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12967-016-1038-y","article-title":"Ion Channels Expression and Function Are Strongly Modified in Solid Tumors and Vascular Malformations","volume":"14","author":"Biasiotta","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14199","DOI":"10.1038\/s41598-017-14230-1","article-title":"Ca2+ Protein Alpha 1D of CaV1.3 Regulates Intracellular Calcium Concentration and Migration of Colon Cancer Cells through a Non-Canonical Activity","volume":"7","author":"Fourbon","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1038\/s41598-023-28693-y","article-title":"CACNA1D Overexpression and Voltage-Gated Calcium Channels in Prostate Cancer during Androgen Deprivation","volume":"13","author":"McKerr","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/bioe.2022.0007","article-title":"Hypoxic Signaling Is Modulated by Calcium Channel, CaV1.3, in Androgen-Resistant Prostate Cancer","volume":"4","author":"Buchanan","year":"2022","journal-title":"Bioelectricity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1161\/CIRCULATIONAHA.104.517326","article-title":"Novel Molecular Mechanism Involving \u03b11D(Cav1.3) L-Type Calcium Channel in Autoimmune-Associated Sinus Bradycardia","volume":"111","author":"Qu","year":"2005","journal-title":"Circulation"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.hrthm.2020.02.025","article-title":"Novel Re-Expression of L-Type Calcium Channel Cav1.3 in Left Ventricles of Failing Human Heart","volume":"17","author":"Srivastava","year":"2020","journal-title":"Heart Rhythm"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"152455","DOI":"10.1016\/j.bbrc.2025.152455","article-title":"Novel Therapeutic Cav1.3-C-Terminus Normalizes L-Type Calcium Current and Ejection Fraction in Ischemia-Induced Murine Heart Failure","volume":"779","author":"Cupelli","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sleiman, Y., Srivastava, U., Reisqs, J.-B., Wadgaonkar, R., Qu, Y.S., Pouliot, V., Chahine, M., and Boutjdir, M. (2026). C-Terminus of Cav1.3 L-Type Ca2+ Channel Upregulates Its Own Gene Expression. Cells, 15.","DOI":"10.22541\/au.175859123.35837668\/v1"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"42736","DOI":"10.1074\/jbc.M111.269951","article-title":"Functional Properties of a Newly Identified C-Terminal Splice Variant of Cav1.3 L-Type Ca2+ Channels","volume":"286","author":"Bock","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"42725","DOI":"10.1074\/jbc.M111.265207","article-title":"Functional Characterization of Alternative Splicing in the C Terminus of L-Type CaV1.3 Channels","volume":"286","author":"Tan","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1523\/JNEUROSCI.2374-16.2017","article-title":"Different CaV1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells","volume":"37","author":"Vincent","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9400","DOI":"10.1021\/bi960683o","article-title":"Identification of PK-A Phosphorylation Sites in the Carboxyl Terminus of L-Type Calcium Channel R1 Subunits","volume":"35","author":"Mitterdorfer","year":"1996","journal-title":"Biochemistry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"H2123","DOI":"10.1152\/ajpheart.01023.2004","article-title":"Localization and Modulation of \u03b11D (Cav1.3) L-Type Ca Channel by Protein Kinase A","volume":"288","author":"Qu","year":"2005","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"H1614","DOI":"10.1152\/ajpheart.00095.2006","article-title":"Protein Kinase C Activation Inhibits Cav1.3 Calcium Channel at NH2-Terminal Serine 81 Phosphorylation Site","volume":"291","author":"Baroudi","year":"2006","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1113\/JP284972","article-title":"CaM-dependent Modulation of Human CaV1.3 Whole-cell and Single-channel Currents by C-terminal CaMKII Phosphorylation Site S1475","volume":"602","author":"Salamon","year":"2024","journal-title":"J. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sharma, A., Rahman, G., Gorelik, J., and Bhargava, A. (2023). Voltage-Gated T-Type Calcium Channel Modulation by Kinases and Phosphatases: The Old Ones, the New Ones, and the Missing Ones. Cells, 12.","DOI":"10.3390\/cells12030461"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e0174","DOI":"10.1199\/tab.0174","article-title":"The Ubiquitination Machinery of the Ubiquitin System","volume":"12","author":"Callis","year":"2014","journal-title":"Arab. Book"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1152\/jn.00287.2022","article-title":"The Ubiquitin E3 Ligase Parkin Regulates Neuronal CaV1.3 Channel Functional Expression","volume":"128","author":"Grimaldo","year":"2022","journal-title":"J. Neurophysiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e28029","DOI":"10.7554\/eLife.28029","article-title":"Proximal Clustering between BK and CaV1.3 Channels Promotes Functional Coupling and BK Channel Activation at Low Voltage","volume":"6","author":"Vivas","year":"2017","journal-title":"eLife"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/jn.00089.2021","article-title":"BK Channel Activation by L-Type Ca2+ Channels CaV1.2 and CaV 1.3 during the Subthreshold Phase of an Action Potential","volume":"126","author":"Plante","year":"2021","journal-title":"J. Neurophysiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e32-8","DOI":"10.1161\/01.RES.0000121566.01778.06","article-title":"Functional Basis of Sinus Bradycardia in Congenital Heart Block","volume":"94","author":"Hu","year":"2004","journal-title":"Circ. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"H2017","DOI":"10.1152\/ajpheart.00537.2008","article-title":"Impaired Ca2+ homeostasis Is Associated with Atrial Fibrillation in the \u03b11D L-Type Ca2+ Channel KO Mouse","volume":"295","author":"Mancarella","year":"2008","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Rinn\u00e9, S., Stallmeyer, B., Pinggera, A., Netter, M.F., Matschke, L.A., Dittmann, S., Kirchhefer, U., Neudorf, U., Opp, J., and Striessnig, J. (2022). Whole Exome Sequencing Identifies a Heterozygous Variant in the Cav1.3 Gene CACNA1D Associated with Familial Sinus Node Dysfunction and Focal Idiopathic Epilepsy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214215"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"27235","DOI":"10.1038\/srep27235","article-title":"An Autism-Associated Mutation in CaV1.3 Channels Has Opposing Effects on Voltage- and Ca2+-Dependent Regulation","volume":"6","author":"Limpitikul","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"102554","DOI":"10.1016\/j.ceca.2022.102554","article-title":"CaV1.3 Enhanced Store Operated Calcium Promotes Resistance to Androgen Deprivation in Prostate Cancer","volume":"103","author":"Downing","year":"2022","journal-title":"Cell Calcium"},{"key":"ref_60","first-page":"2883","article-title":"Ca2+ Channel Subunit \u03b1 1D Promotes Proliferation and Migration of Endometrial Cancer Cells Mediated by 17\u03b2-Estradiol via the G Protein-Coupled Estrogen Receptor","volume":"29","author":"Hao","year":"2015","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2012.03.041","article-title":"CaV1 and CaV2 Channels Engage Distinct Modes of Ca2+ Signaling to Control CREB-Dependent Gene Expression","volume":"149","author":"Wheeler","year":"2012","journal-title":"Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12964-022-00857-9","article-title":"tRF-Val-CAC-016 Modulates the Transduction of CACNA1D-Mediated MAPK Signaling Pathways to Suppress the Proliferation of Gastric Carcinoma","volume":"20","author":"Xu","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1158\/0008-5472.CAN-06-1966","article-title":"Expression of Variant TMPRSS2\/ERG Fusion Messenger RNAs Is Associated with Aggressive Prostate Cancer","volume":"66","author":"Wang","year":"2006","journal-title":"Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Osuru, H.P., Lavallee, M., and Thiele, R.H. (2022). Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1\u03b1 Inhibition. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.711421"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2566866","DOI":"10.1080\/07853890.2025.2566866","article-title":"Biological Roles and Potential Clinical Value of tRNA-Derived Small RNAs in Gastrointestinal Malignancies","volume":"57","author":"Shao","year":"2025","journal-title":"Ann. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8863789","DOI":"10.1155\/2021\/8863789","article-title":"Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies","volume":"2021","author":"Carrasco","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Sakellakis, M., Reet, J., Kladas, M., Hoge, G., Chalkias, A., and Radulovic, M. (2024). Cancer-Induced Resting Sinus Tachycardia: An Overlooked Clinical Diagnosis. Oncol. Rev., 18.","DOI":"10.3389\/or.2024.1439415"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"100026","DOI":"10.1016\/j.rpth.2022.100026","article-title":"Atrial Fibrillation and Cancer: Prevalence and Relative Risk from a Nationwide Study","volume":"7","author":"Ay","year":"2023","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Wu, Y., and Anderson, M.E. (2014). CaMKII in Sinoatrial Node Physiology and Dysfunction. Front. Pharmacol., 5.","DOI":"10.3389\/fphar.2014.00048"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"164","DOI":"10.18632\/aging.204466","article-title":"Doxorubicin Induced ROS-Dependent HIF1\u03b1 Activation Mediates Blockage of IGF1R Survival Signaling by IGFBP3 Promotes Cardiac Apoptosis","volume":"15","author":"Wen","year":"2023","journal-title":"Aging"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"6230","DOI":"10.1158\/0008-5472.CAN-12-1345","article-title":"Tumor Cells Upregulate Normoxic HIF-1\u03b1 in Response to Doxorubicin","volume":"73","author":"Cao","year":"2013","journal-title":"Cancer Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.eupc.2004.12.012","article-title":"Doxorubicin-Induced Second Degree and Complete Atrioventricular Block","volume":"7","author":"Kilickap","year":"2005","journal-title":"Europace"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-0041-1731907","article-title":"Bradyarrhythmias in Cardio-Oncology","volume":"10","author":"Fonseca","year":"2021","journal-title":"South Asian J. Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.RES.76.4.645","article-title":"Effects of Doxorubicin on Excitation-Contraction Coupling in Guinea Pig Ventricular Myocardium","volume":"76","author":"Wang","year":"1995","journal-title":"Circ. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e14987","DOI":"10.14814\/phy2.14987","article-title":"Differential Cardiotoxic Electrocardiographic Response to Doxorubicin Treatmentsigma in Conscious versus Anesthetized Mice","volume":"9","author":"Warhol","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Reisqs, J.-B., Sleiman, Y., Cupelli, M., and Boutjdir, M. (2025). Role of Cav1.3 Channels in Brain\u2013Heart Interactions: An Unexpected Journey. Biomedicines, 13.","DOI":"10.3390\/biomedicines13061376"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.1097\/MS9.0000000000003499","article-title":"Inflammatory Cytokines and Cardiac Arrhythmias: From Pathogenesis to Potential Therapies","volume":"87","author":"Obeagu","year":"2025","journal-title":"Ann. Med. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cophys.2017.12.005","article-title":"Regulation of Microdomain Voltage-Gated L-Type Calcium Channels in Cardiac Health and Disease","volume":"2","author":"Shuja","year":"2018","journal-title":"Curr. Opin. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e34176","DOI":"10.1016\/j.heliyon.2024.e34176","article-title":"Risk Factors for Arrhythmias Occurred in Cancer Patients after Chemotherapy: An Evidence-Based Systematic Review and Meta-Analysis","volume":"10","author":"Xu","year":"2024","journal-title":"Heliyon"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/eurheartj\/ehae222","article-title":"Coexisting Atrial Fibrillation and Cancer: Time Trends and Associations with Mortality in a Nationwide Dutch Study","volume":"45","author":"Chen","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jacep.2023.08.033","article-title":"Electrophysiological and Histopathological Characteristics of Ventricular Tachycardia Associated with Primary Cardiac Tumors","volume":"10","author":"Murata","year":"2024","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/clc.4960140216","article-title":"Metastatic Cardiac Malignant Fibrous Histiocytoma Presenting as Right Ventricular Outflow Tract Obstruction","volume":"14","author":"Kamlow","year":"1991","journal-title":"Clin. Cardiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11886-020-01420-z","article-title":"Cardiac Tumors: Diagnosis, Prognosis, and Treatment","volume":"22","author":"Bussani","year":"2020","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1056\/NEJM199103213241205","article-title":"Late Cardiac Effects of Doxorubicin Therapy for Acute Lymphoblastic Leukemia in Childhood","volume":"324","author":"Lipshultz","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1002\/cncr.11407","article-title":"Congestive Heart Failure in Patients Treated with Doxorubicin: A Retrospective Analysis of Three Trials","volume":"97","author":"Swain","year":"2003","journal-title":"Cancer"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.15420\/ecr.2020.15.1.PO10","article-title":"Mechanisms of Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in H9c2 Cells and Mice","volume":"15","author":"Bouitbir","year":"2020","journal-title":"Eur. Cardiol. Rev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_88","first-page":"199","article-title":"A Case of Ventricular Fibrillation without Left Ventricular Systolic Dysfunction Induced by Trastuzumab Emtansine for Breast Cancer","volume":"25","author":"Takeda","year":"2022","journal-title":"J. Cardiol. Cases"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/bjh.19497","article-title":"Atrial Arrhythmias Following CAR-chimeric Antigen Receptor T-cell Therapy: Incidence, Risk Factors and Biomarker Profile","volume":"205","author":"Shouval","year":"2024","journal-title":"Br. J. Haematol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3324\/haematol.2021.280009","article-title":"Cardiovascular Events in Patients Treated with Chimeric Antigen Receptor T-Cell Therapy for Aggressive B-Cell Lymphoma","volume":"107","author":"Steiner","year":"2021","journal-title":"Haematologica"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.atherosclerosis.2018.12.006","article-title":"DNA Methylation Processes in Atherosclerotic Plaque","volume":"281","author":"Aavik","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.immuni.2022.06.022","article-title":"DNA Methyltransferase 3 Alpha and TET Methylcytosine Dioxygenase 2 Restrain Mitochondrial DNA-Mediated Interferon Signaling in Macrophages","volume":"55","author":"Cobo","year":"2022","journal-title":"Immunity"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal Hematopoiesis Associated with TET2 Deficiency Accelerates Atherosclerosis Development in Mice","volume":"355","author":"Fuster","year":"2017","journal-title":"Science"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"104139","DOI":"10.1016\/j.ebiom.2022.104139","article-title":"Inhibition of DYRK1A, via Histone Modification, Promotes Cardiomyocyte Cell Cycle Activation and Cardiac Repair after Myocardial Infarction","volume":"82","author":"Lan","year":"2022","journal-title":"eBioMedicine"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1182\/blood.2021011247","article-title":"DYRK1a Mediates BAFF-Induced Noncanonical NF-\u03baB Activation to Promote Autoimmunity and B-Cell Leukemogenesis","volume":"138","author":"Li","year":"2021","journal-title":"Blood"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"10885","DOI":"10.1073\/pnas.1121524109","article-title":"Cold-Inducible RNA-Binding Protein (Cirp) Interacts with Dyrk1b\/Mirk and Promotes Proliferation of Immature Male Germ Cells in Mice","volume":"109","author":"Masuda","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1002\/jcp.26226","article-title":"Annexin A1, Annexin A2, and Dyrk 1B Are Upregulated during GAS1-induced Cell Cycle Arrest","volume":"233","author":"Estudillo","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Sajjad, M., Fradley, M., Sun, W., Kim, J., Zhao, X., Pal, T., and Ismail-Khan, R. (2017). An Exploratory Study to Determine Whether BRCA1 and BRCA2 Mutation Carriers Have Higher Risk of Cardiac Toxicity. Genes, 8.","DOI":"10.3390\/genes8020059"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1074\/jbc.M111.292664","article-title":"BRCA2 Protein Deficiency Exaggerates Doxorubicin-Induced Cardiomyocyte Apoptosis and Cardiac Failure","volume":"287","author":"Singh","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncomms1601","article-title":"BRCA1 Is an Essential Regulator of Heart Function and Survival Following Myocardial Infarction","volume":"2","author":"Shukla","year":"2011","journal-title":"Nat. Commun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s12964-025-02358-x","article-title":"Activation of Integrin Signaling Up-Regulates pro-Inflammatory Cytokines in JAK2-V617F Positive Hematopoietic Cells","volume":"23","author":"Baldauf","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jacbts.2019.05.013","article-title":"JAK2-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure","volume":"4","author":"Sano","year":"2019","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3324\/haematol.2010.033191","article-title":"The JAK2 V617F Somatic Mutation, Mortality and Cancer Risk in the General Population","volume":"96","author":"Nielsen","year":"2011","journal-title":"Haematologica"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jaccao.2025.06.008","article-title":"Cancer-Related Immune Therapies","volume":"7","author":"Miteva","year":"2025","journal-title":"JACC CardioOncol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3892\/mmr.2025.13530","article-title":"Identification of the Clinical Value and Biological Effects of TTN Mutation in Liver Cancer","volume":"31","author":"Zhang","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e006832","DOI":"10.1161\/CIRCHEARTFAILURE.119.006832","article-title":"Clinical Phenotypes and Prognosis of Dilated Cardiomyopathy Caused by Truncating Variants in the TTN Gene","volume":"13","author":"Akhtar","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e010006","DOI":"10.1161\/CIRCEP.121.010006","article-title":"Substrate Characterization and Outcomes of Ventricular Tachycardia Ablation in TTN (Titin) Cardiomyopathy: A Multicenter Study","volume":"14","author":"Enriquez","year":"2021","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/hmg\/ddt494","article-title":"Recessive TTN Truncating Mutations Define Novel Forms of Core Myopathy with Heart Disease","volume":"23","author":"Chauveau","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1161\/hh2301.100981","article-title":"The Complete Gene Sequence of Titin, Expression of an Unusual \u2248700-kDa Titin Isoform, and Its Interaction with Obscurin Identify a Novel Z-Line to I-Band Linking System","volume":"89","author":"Bang","year":"2001","journal-title":"Circ. Res."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"AlAsmari, A.F., Alghamdi, A., Ali, N., Almeaikl, M.A., Hakami, H.M., Alyousef, M.K., AlSwayyed, M., Alharbi, M., Alqahtani, F., and Alasmari, F. (2022). Venetoclax Induces Cardiotoxicity through Modulation of Oxidative-Stress-Mediated Cardiac Inflammation and Apoptosis via NF-\u03baB and BCL-2 Pathway. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116260"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Altomare, C., Lodrini, A.M., Milano, G., Biemmi, V., Lazzarini, E., Bolis, S., Pernigoni, N., Torre, E., Arici, M., and Ferrandi, M. (2021). Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined with Trastuzumab. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.658790"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1093\/oncolo\/oyab035","article-title":"Cardiotoxicity from Capecitabine Chemotherapy: Prospective Study of Incidence at Rest and During Physical Exercise","volume":"27","author":"Lestuzzi","year":"2022","journal-title":"Oncologist"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40959-022-00146-x","article-title":"Exercise-Induced Brugada Pattern and Ventricular Tachycardia during Capecitabine Treatment","volume":"8","author":"Strobel","year":"2022","journal-title":"Cardio-Oncology"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Korste, S., Settelmeier, S., Michel, L., Odersky, A., Stock, P., Reyes, F., Haj-Yehia, E., Anker, M.S., Gr\u00fcneboom, A., and Hendgen-Cotta, U.B. (2023). Anthracycline Therapy Modifies Immune Checkpoint Signaling in the Heart. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076052"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8000","DOI":"10.1021\/acsabm.0c01049","article-title":"Tissue-Specific Regulation of Reactive Oxygen Species by an ATP-Responsive Nanoregulator Enhances Anticancer Efficacy and Reduces Anthracycline-Induced Cardiotoxicity","volume":"3","author":"Zhang","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1200\/JCO.2005.05.827","article-title":"Type II Chemotherapy-Related Cardiac Dysfunction: Time to Recognize a New Entity","volume":"23","author":"Ewer","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1200\/JCO.2004.06.033","article-title":"Subclinical Late Cardiomyopathy After Doxorubicin Therapy for Lymphoma in Adults","volume":"22","author":"Hequet","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/acel.12306","article-title":"Aging and Radiation: Bad Companions","volume":"14","author":"Terradas","year":"2015","journal-title":"Aging Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"bcr0220113883","DOI":"10.1136\/bcr.02.2011.3883","article-title":"5-Fluorouracil Induced Pericarditis","volume":"2011","author":"Killu","year":"2011","journal-title":"BMJ Case Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1124\/mol.115.099614","article-title":"Oxidative Stress and Response to Thymidylate Synthase-Targeted Antimetabolites","volume":"88","author":"Ozer","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"ref_121","first-page":"54","article-title":"Coronary Vasospasm Secondary to 5-Fluorouracil and Its Management: Case Report","volume":"43","author":"Yildirim","year":"2011","journal-title":"Eurasian J. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/FPC.0000000000000005","article-title":"TPMT Genetic Variants Are Associated with Increased Rejection with Azathioprine Use in Heart Transplantation","volume":"23","author":"Liang","year":"2013","journal-title":"Pharmacogenet. Genomics."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e012798","DOI":"10.1136\/bmjopen-2016-012798","article-title":"Incidence and Risk Factors for Capecitabine-Induced Symptomatic Cardiotoxicity: A Retrospective Study of 452 Consecutive Patients with Metastatic Breast Cancer","volume":"6","author":"Polk","year":"2016","journal-title":"BMJ Open"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1182\/bloodadvances.2022007333","article-title":"Cardiac Events in Patients with Acute Myeloid Leukemia Treated with Venetoclax Combined with Hypomethylating Agents","volume":"6","author":"Johnson","year":"2022","journal-title":"Blood Adv."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1078155217702213","article-title":"A Comparison of Toxicities in Acute Myeloid Leukemia Patients with and without Renal Impairment Treated with Decitabine","volume":"24","author":"Levine","year":"2018","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1161\/CIRCULATIONAHA.111.079921","article-title":"Pulmonary Arterial Hypertension in Patients Treated by Dasatinib","volume":"125","author":"Montani","year":"2012","journal-title":"Circulation"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s40959-024-00275-5","article-title":"Cardiotoxicity of Venetoclax in Patients with Acute Myeloid Leukemia: Comparison with Anthracyclines","volume":"10","author":"Onoue","year":"2024","journal-title":"Cardio-Oncology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.hfc.2022.02.003","article-title":"Intracellular Signaling Pathways Mediating Tyrosine Kinase Inhibitor Cardiotoxicity","volume":"18","author":"Scott","year":"2022","journal-title":"Heart Fail. Clin."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.18632\/oncotarget.23386","article-title":"Combination of a Hypomethylating Agent and Inhibitors of PARP and HDAC Traps PARP1 and DNMT1 to Chromatin, Acetylates DNA Repair Proteins, down-Regulates NuRD and Induces Apoptosis in Human Leukemia and Lymphoma Cells","volume":"9","author":"Valdez","year":"2018","journal-title":"Oncotarget"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1182\/blood.V108.11.4549.4549","article-title":"Hypersensitivity Reaction of Gemtuzumab Ozogamicin (MylotargTM) Associated with Platelet Transfusion: Two Case Reports","volume":"108","author":"Hanbali","year":"2006","journal-title":"Blood"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neo.2020.12.001","article-title":"Quantifying ADC Bystander Payload Penetration with Cellular Resolution Using Pharmacodynamic Mapping","volume":"23","author":"Khera","year":"2021","journal-title":"Neoplasia"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e507","DOI":"10.1097\/MPH.0000000000002325","article-title":"Acute Left Ventricular Dysfunction Following Gemtuzumab Ozogamicin in Two Pediatric AML Patients","volume":"44","author":"McNerney","year":"2022","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/s41375-025-02642-2","article-title":"KK2845, a PBD Dimer-Containing Antibody-Drug Conjugate Targeting TIM-3-Expressing AML","volume":"39","author":"Zou","year":"2025","journal-title":"Leukemia"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"13866","DOI":"10.1038\/s41598-021-92988-1","article-title":"Genome-Wide CRISPR\/Cas9 Screening in Human iPS Derived Cardiomyocytes Uncovers Novel Mediators of Doxorubicin Cardiotoxicity","volume":"11","author":"Sapp","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"25333","DOI":"10.1038\/srep25333","article-title":"Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes","volume":"6","author":"Maillet","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_136","first-page":"84","article-title":"Doxorubicin, DNA Torsion, and Chromatin Dynamics","volume":"1845","author":"Yang","year":"2014","journal-title":"Biochim. Biophys. Acta BBA-Rev. Cancer"},{"key":"ref_137","first-page":"100828","article-title":"Persistently Increased CaMKII\u03b4 Autophosphorylation Mediates Pathologic SR Ca Loss in a Murine Model of Doxorubicin-Induced Cardiomyopathy","volume":"15","author":"Feder","year":"2026","journal-title":"J. Mol. Cell. Cardiol. Plus"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"9850","DOI":"10.1038\/s41598-019-46367-6","article-title":"Blockade of L-Type Ca2+ Channel Attenuates Doxorubicin-Induced Cardiomyopathy via Suppression of CaMKII-NF-\u03baB Pathway","volume":"9","author":"Ikeda","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e70286","DOI":"10.1002\/cam4.70286","article-title":"CAMKII Exacerbates Doxorubicin-Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition","volume":"13","author":"Yang","year":"2024","journal-title":"Cancer Med."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Chen, R., Niu, M., Hu, X., and He, Y. (2023). Targeting Mitochondrial Dynamics Proteins for the Treatment of Doxorubicin-Induced Cardiotoxicity. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1241225"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/CIRCRESAHA.119.314681","article-title":"Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy","volume":"126","author":"Wallace","year":"2020","journal-title":"Circ. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41514-024-00135-7","article-title":"A Review of the Pathophysiological Mechanisms of Doxorubicin-Induced Cardiotoxicity and Aging","volume":"10","author":"Linders","year":"2024","journal-title":"npj Aging"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Tang, X., Li, P.-H., and Chen, H.-Z. (2020). Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00280"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jaccao.2024.02.005","article-title":"Anthracycline Cardiotoxicity Induces Progressive Changes in Myocardial Metabolism and Mitochondrial Quality Control","volume":"6","author":"Oliver","year":"2024","journal-title":"JACC CardioOncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11307-024-01978-y","article-title":"2-[18F]Fluoropropionic Acid PET Imaging of Doxorubicin-Induced Cardiotoxicity","volume":"27","author":"Azcona","year":"2025","journal-title":"Mol. Imaging Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41420-025-02554-1","article-title":"The Role and Mechanism of Fatty Acid Oxidation in Cancer Drug Resistance","volume":"11","author":"Lei","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41419-020-02948-2","article-title":"Acyl-CoA Thioesterase 1 Prevents Cardiomyocytes from Doxorubicin-Induced Ferroptosis via Shaping the Lipid Composition","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_148","first-page":"12216","article-title":"Effects of PPAR\u03b1\/PGC-1\u03b1 on the Energy Metabolism Remodeling and Apoptosis in the Doxorubicin Induced Mice Cardiomyocytes in Vitro","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/europace\/eup300","article-title":"Introducing a New Entity: Chemotherapy-Induced Arrhythmia","volume":"11","author":"Guglin","year":"2009","journal-title":"Europace"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.35440\/hutfd.1403862","article-title":"Evaluating the Effects of Acute and Chronic Doxorubicin Administration on Cardiac Function Through Electrocardiographic Measurements","volume":"21","author":"Cicek","year":"2024","journal-title":"Harran \u00dcniversitesi T\u0131p Fak\u00fcltesi Derg."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Goje, I.-D., Goje, G.-I., Ordodi, V.L., Ciobotaru, V.G., Ivan, V.S., Buza\u0219, R., Tunea, O., Bojin, F., and Lighezan, D.-F. (2025). Doxorubicin-Induced Cardiotoxicity and the Emerging Role of SGLT2 Inhibitors: From Glycemic Control to Cardio-Oncology. Pharmaceuticals, 18.","DOI":"10.3390\/ph18050681"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"104839","DOI":"10.4330\/wjc.v17.i5.104839","article-title":"Mechanism of Myocardial Damage Induced by Doxorubicin via Calumenin-Regulated Mitochondrial Dynamics and the Calcium\u2013Cx43 Pathway","volume":"17","author":"Shi","year":"2025","journal-title":"World J. Cardiol."},{"key":"ref_153","first-page":"771","article-title":"Cumulative and Irreversible Cardiac Mitochondrial Dysfunction Induced by Doxorubicin","volume":"61","author":"Zhou","year":"2001","journal-title":"Cancer Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41583-023-00742-5","article-title":"Excitation\u2013Transcription Coupling, Neuronal Gene Expression and Synaptic Plasticity","volume":"24","author":"Ma","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/wmts.102","article-title":"L-type Ca2+ Channels in Heart and Brain","volume":"3","author":"Striessnig","year":"2014","journal-title":"Wiley Interdiscip. Rev. Membr. Transp. Signal."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41419-025-07887-4","article-title":"Inhibition of the Caveolin-1 Pathway Promotes Apoptosis and Overcomes Pan-Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma","volume":"16","author":"Kabir","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"McIntire, E., Barr, K.A., Gonzales, N.M., Allen, O.L., and Gilad, Y. (2023). Guided Differentiation of Pluripotent Stem Cells into Heterogeneously Differentiating Cultures of Cardiac Cells. bioRxiv.","DOI":"10.1101\/2023.07.21.550072"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.yjmcc.2010.10.002","article-title":"Expression and Roles of Cav1.3 (\u03b11D) L-Type Ca2+ Channel in Atrioventricular Node Automaticity","volume":"50","author":"Zhang","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Ryzhii, M., and Ryzhii, E. (2023). A Compact Multi-Functional Model of the Rabbit Atrioventricular Node with Dual Pathways. Front. Physiol., 14, Correction in Front. Physiol.\u00a02023, 14, 1219583. https:\/\/doi.org\/10.3389\/fphys.2023.1219583.","DOI":"10.3389\/fphys.2023.1126648"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Sarmah, S., and Marrs, J. (2016). Zebrafish as a Vertebrate Model System to Evaluate Effects of Environmental Toxicants on Cardiac Development and Function. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17122123"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s13287-024-03986-9","article-title":"Multi-Omics Evaluation of Clinical-Grade Human Umbilical Cord-Derived Mesenchymal Stem Cells in Synergistic Improvement of Aging Related Disorders in a Senescence-Accelerated Mouse Model","volume":"15","author":"Lian","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/cvr\/cvae173","article-title":"Intravenous Infusions of Mesenchymal Stromal Cells Have Cumulative Beneficial Effects in a Porcine Model of Chronic Ischaemic Cardiomyopathy","volume":"120","author":"Tang","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1532-429X-11-11","article-title":"Cell Tracking and Therapy Evaluation of Bone Marrow Monocytes and Stromal Cells Using SPECT and CMR in a Canine Model of Myocardial Infarction","volume":"11","author":"Wisenberg","year":"2009","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1158\/2643-3230.BCD-22-0167","article-title":"Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia","volume":"4","author":"Kotini","year":"2023","journal-title":"Blood Cancer Discov."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Reinal, I., Ontoria-Oviedo, I., Selva, M., Casini, M., Peir\u00f3-Molina, E., Fambuena-Santos, C., Climent, A.M., Balaguer, J., Ca\u00f1ete, A., and Mora, J. (2023). Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs. Antioxidants, 12.","DOI":"10.3390\/antiox12071378"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/5663\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:17:39Z","timestamp":1782533859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/5663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":165,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ijms27135663"],"URL":"https:\/\/doi.org\/10.3390\/ijms27135663","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}