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While the CTS ouabain is known to induce mania-like behavior and oxidative damage, the effects of other CTS are less clear. This study examined the effects of 14-day intracerebroventricular administration of 1.5 \u03bcL 100 \u03bcM marinobufagenin (MBG) on locomotion, gait, monoamine metabolism, and oxidative stress markers (MDA, SOD, catalase, MAO-B) in C57BL\/6 mice. Chronic MBG caused increased locomotor activity and time spent in the center of the open field. Unlike ouabain, chronic MBG did not impair motor function, evaluated via gait analysis. MBG elevated striatal MAO-B activity and reduced prefrontal MDA levels, with no changes in SOD or catalase, indicating that it did not cause oxidative stress. However, it did affect dopamine and serotonin metabolism. Monoamine tissue content evaluation on day 15 showed increased dopamine turnover in the striatum and brain stem, and a decrease in the thalamus. Norepinephrine levels increased in the striatum and hippocampus. Serotonin turnover increased in the prefrontal cortex. These results indicate that chronic MBG increases locomotion and reduces anxiety-like behavior through region-specific modulation of dopaminergic and serotonergic signaling distinct from that caused by ouabain.<\/jats:p>","DOI":"10.3390\/ijms27135713","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:48:16Z","timestamp":1782366496000},"page":"5713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Administration of Marinobufagenin in Mice Causes Hyperlocomotion and Decrease in Anxiety by Altering Monoamine Turnover Unaccompanied by Motor Deficits or Oxidative Stress"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2194-6749","authenticated-orcid":false,"given":"Rogneda B.","family":"Kazanskaya","sequence":"first","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"},{"name":"Biological Department, St. Petersburg State University, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5994-3435","authenticated-orcid":false,"given":"Arina O.","family":"Lobaskova","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"},{"name":"Biological Department, St. Petersburg State University, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8239-8456","authenticated-orcid":false,"given":"Anna D.","family":"Iushina","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"},{"name":"Biological Department, St. Petersburg State University, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-3223","authenticated-orcid":false,"given":"Denis A.","family":"Abaimov","sequence":"additional","affiliation":[{"name":"Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga I.","family":"Kulikova","sequence":"additional","affiliation":[{"name":"Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0724-887X","authenticated-orcid":false,"given":"Anna B.","family":"Volnova","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"},{"name":"Biological Department, St. Petersburg State University, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-4379","authenticated-orcid":false,"given":"Vassiliy","family":"Tsytsarev","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5688-3899","authenticated-orcid":false,"given":"Alexander V.","family":"Lopachev","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/50100051","article-title":"A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues","volume":"5","author":"Melero","year":"2000","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-3002(57)90343-8","article-title":"The Influence of Some Cations on an Adenosine Triphosphatase from Peripheral Nerves","volume":"23","author":"Skou","year":"1957","journal-title":"Biochim. 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