{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:22:19Z","timestamp":1783052539504,"version":"3.54.6"},"reference-count":27,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Urolithin A (UA) is a gut microbiota-derived postbiotic generated from dietary ellagitannins, while urinary 6-sulfatoxymelatonin (6-SMT) is a surrogate marker of nocturnal melatonin output. We explored whether dysbiosis, UA depletion, and low 6-SMT define an ordered biomarker pattern across healthy aging, salt-sensitive hypertension, and advanced cancer. In this pilot observational study, patients with advanced solid tumors were classified as Cancer Group 1 (higher aggressiveness; n = 231) or Cancer Group 2 (lower aggressiveness; n = 118) and compared with healthy older controls (n = 117) and elderly participants with salt-sensitive hypertension (n = 333). Plasma UA decreased stepwise from controls (2.24 [1.38\u20133.12] nmol\/L) to salt-sensitive hypertension (1.20 [0.76\u20131.89] nmol\/L), Cancer Group 2 (0.60 [0.32\u20130.91] nmol\/L), and Cancer Group 1, in which most samples were at or below the assay limit (overall p &lt; 0.0001; trend p &lt; 0.0001). Twenty-four-hour urinary 6-SMT declined in parallel, whereas the dysbiosis score, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-\u03b1), interleukin-8 (IL-8), and malondialdehyde (MDA) increased, and antioxidant indices decreased across the ordered groups (all p &lt; 0.0001). These cross-sectional findings support a hypothesis-generating biomarker framework linking dysbiosis, postbiotic depletion, circadian disruption, inflammation, and redox imbalance across age-related disease states.<\/jats:p>","DOI":"10.3390\/ijms27135753","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:49:23Z","timestamp":1782434963000},"page":"5753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Dysbiosis\u2013Urolithin A Depletion\u2013Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-7417","authenticated-orcid":false,"given":"Alexandre","family":"Tavartkiladze","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia"},{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"},{"name":"Department of Biotechnology, Foconsci Chemical Industry, Shaoxing 312000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levan","family":"Tavartkiladze","sequence":"additional","affiliation":[{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaiane","family":"Simonia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia"},{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-8487","authenticated-orcid":false,"given":"Michel","family":"Burnier","sequence":"additional","affiliation":[{"name":"Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-4225","authenticated-orcid":false,"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Cellular & Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruite","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Foconsci Chemical Industry, Shaoxing 312000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinara","family":"Kasradze","sequence":"additional","affiliation":[{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Okrostsvaridze","sequence":"additional","affiliation":[{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pati","family":"Revazishvili","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia"},{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irine","family":"Andronikashvili","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia"},{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirdara","family":"Nozadze","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia"},{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusudan","family":"Khutsishvili","sequence":"additional","affiliation":[{"name":"Institute for Personalized Medicine, 0186 Tbilisi, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2101019","DOI":"10.1002\/mnfr.202101019","article-title":"Urolithins: A Comprehensive Update on Their Metabolism, Bioactivity, and Associated Gut Microbiota","volume":"66","author":"Selma","year":"2022","journal-title":"Mol. 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