{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:15:13Z","timestamp":1783574113222,"version":"3.55.0"},"reference-count":170,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Universidad Alfonso X el Sabio","award":["1.020.014"],"award-info":[{"award-number":["1.020.014"]}]},{"name":"Fundaci\u00f3n Universidad Alfonso X el Sabio","award":["1.020.021"],"award-info":[{"award-number":["1.020.021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Recent evidence reveals that several psychotropic compounds exert significant biological effects on the skin through neurochemical and immunomodulatory pathways. Cannabinoids such as tetrahydrocannabinol (THC) show potent anti-inflammatory, antipruritic, and anti-aging properties when applied topically, and may hold therapeutic potential. Antidepressants, particularly fluoxetine (Prozac), have been shown to regulate the expression of pro-inflammatory cytokines in keratinocytes, suggesting benefits applied in allergic pathologies. Additionally, fluoxetine promotes wound healing and cell regeneration, indicating broader dermatological applications. Psychedelics, acting as serotonin receptor agonists (5-HTR), may influence cellular aging and immune modulation via the serotonergic system. Studies report that 5-HT receptor agonists can prevent UV-induced photocarcinogenesis, while psilocybin has been observed to reduce aging markers in human fibroblasts. Furthermore, recent data suggests that psilocin may alleviate acute itch involving the kynurenine pathway. These findings highlight the emerging relevance of psychoactive compounds in cutaneous biology, bridging neuropharmacology and dermatology toward novel therapeutic strategies.<\/jats:p>","DOI":"10.3390\/ijms27135808","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:55:11Z","timestamp":1782780911000},"page":"5808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skin on Drugs: Psychotropic Compounds in Cutaneous Biology"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-0730","authenticated-orcid":false,"given":"Montserrat","family":"Fern\u00e1ndez-Guarino","sequence":"first","affiliation":[{"name":"Dermatology Service, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain"},{"name":"Grupo de Investigaci\u00f3n de Fotobiolog\u00eda, Terapias con Fuentes de Luz y Prevenci\u00f3n de C\u00e1ncer Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7082-4717","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Yag\u00fce-Septi\u00e9n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mar\u00edn-Ochoa","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Hern\u00e1ndez Bule","sequence":"additional","affiliation":[{"name":"Department of Preclinical Dentistry I, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-229X","authenticated-orcid":false,"given":"Stefano","family":"Bacci","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n de Fotobiolog\u00eda, Terapias con Fuentes de Luz y Prevenci\u00f3n de C\u00e1ncer Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"},{"name":"Research Unit of Histology and Embriology, Department of Biology, University of Florence, Viale Pieraccini 6, 50134 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Banzo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-464X","authenticated-orcid":false,"given":"Daniel","family":"Pe\u00f1a-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jin, R., Luo, L., and Zheng, J. 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