{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:39:17Z","timestamp":1785418757617,"version":"3.56.0"},"reference-count":59,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Project of national interest Research 2022","award":["2022ZY7ATN"],"award-info":[{"award-number":["2022ZY7ATN"]}]},{"DOI":"10.13039\/100007479","name":"Fondazione Cassa di Risparmio di Padova e Rovigo","doi-asserted-by":"publisher","award":["59583"],"award-info":[{"award-number":["59583"]}],"id":[{"id":"10.13039\/100007479","id-type":"DOI","asserted-by":"publisher"}]},{"award":["59583"],"award-info":[{"award-number":["59583"]}],"id":[{"id":"https:\/\/ror.org\/02jecj653","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["27271"],"award-info":[{"award-number":["27271"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"award":["27271"],"award-info":[{"award-number":["27271"]}],"id":[{"id":"https:\/\/ror.org\/02g2x7380","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["CN00000041"],"award-info":[{"award-number":["CN00000041"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"award":["CN00000041"],"award-info":[{"award-number":["CN00000041"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Worldwide Cancer Research","award":["22-0348"],"award-info":[{"award-number":["22-0348"]}]},{"award":["22-0348"],"award-info":[{"award-number":["22-0348"]}],"id":[{"id":"https:\/\/ror.org\/031tfbz57","id-type":"ROR","asserted-by":"publisher"}]},{"name":"pHIoniC International Training Network"},{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["PID2023-148085OB-I00"],"award-info":[{"award-number":["PID2023-148085OB-I00"]}]},{"award":["PID2023-148085OB-I00"],"award-info":[{"award-number":["PID2023-148085OB-I00"]}],"id":[{"id":"https:\/\/ror.org\/05r0vyz12","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"AEI","doi-asserted-by":"publisher","award":["10.13039\/501100011033"],"award-info":[{"award-number":["10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spain and European Regional Development Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Potassium (K+) channels have been frequently linked to cancer progression; however, their contribution varies across tumour types and experimental models. This heterogeneity indicates that gene-level characteristics such as expression, co-expression, or mutational status are inadequate for explaining channel involvement in oncogenic signalling. Here, we performed a cross-study comparison of experimentally validated K+ channel interactomes, we show that K+ channel regulation is highly context-dependent and does not exhibit conserved pan-cancer signatures. By directly comparing proximity-labeling and affinity-purification datasets across different K+ channel families, we identify a limited number of recurrent organizational architectures rather than universal signalling modules. KCa3.1 (encoded by KCNN4), Kir2.1 (KCNJ2), and TASK-1 (KCNK3) assemble signalling-permissive interactomes integrating adhesion complexes, junctional scaffolds, vesicular trafficking pathways, and receptor-associated signalling nodes. In contrast, Kv11.1 (encoded by KCNH2) displays an interactome predominantly enriched for proteostasis and endoplasmic reticulum\u2013associated components, indicating a proteostasis-centered organizational profile with comparatively limited signalling integration. Kv1.3 (encoded by KCNA3), instead, consistently associates with mitochondrial and metabolism-linked proteins and functionally connects metabolic state to downstream transcriptional regulators, rather than regulating its own transcription. Higher-order intersection and pathway-specific analyses indicate that functional convergence across the above channels emerges from shared architectural principles rather than extensive molecular overlap. In conclusion, this study identifies interactome architecture as a central organizational level for understanding K+ channel function in cancer. The integration of pan-cancer gene-level analyses with systematic comparison of interaction architectures offers a coherent framework for interpreting the functional heterogeneity observed across channels, families, and tumor contexts. This perspective suggests that therapeutic strategies may benefit from targeting channel-centered network architectures rather than isolated channels alone, highlighting ion channels as structural components of broader signalling systems rather than solely bioelectrical regulators.<\/jats:p>","DOI":"10.3390\/ijms27135862","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:55:11Z","timestamp":1782780911000},"page":"5862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Interactome Analysis Reveals Architectural Principles Governing K+ Channel Function in Cancer"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-3743","authenticated-orcid":false,"given":"Soha","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-7725","authenticated-orcid":false,"given":"Jesusa","family":"Capera","sequence":"additional","affiliation":[{"name":"Molecular Physiology Laboratory, Department de Bioqu\u0131mica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain"},{"name":"Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, The Kennedy Institute of Rheumatology, University of Oxford, Oxford OX1 2JD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Battistello","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7080-4868","authenticated-orcid":false,"given":"Veronica","family":"Carpanese","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-6431","authenticated-orcid":false,"given":"Antonio","family":"Felipe","sequence":"additional","affiliation":[{"name":"Molecular Physiology Laboratory, Department de Bioqu\u0131mica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildik\u00f2","family":"Szab\u00f2","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8911-6146","authenticated-orcid":false,"given":"Vanessa","family":"Checchetto","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00044.2016","article-title":"Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?","volume":"98","author":"Prevarskaya","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Imbrici, P., Liantonio, A., Camerino, G.M., De Bellis, M., Camerino, C., Mele, A., Giustino, A., Pierno, S., De Luca, A., and Tricarico, D. (2016). Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00121"},{"key":"ref_3","first-page":"1","article-title":"Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges","volume":"183","author":"Capatina","year":"2022","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/bioe.2022.0014","article-title":"Voltage-Gated Potassium Channels Beyond the Action Potential","volume":"4","author":"Pardo","year":"2022","journal-title":"Bioelectricity"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e70183","DOI":"10.1111\/apha.70183","article-title":"pH-Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma","volume":"242","author":"Schwab","year":"2026","journal-title":"Acta Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2147\/OTT.S326614","article-title":"Potassium Channels as a Target for Cancer Therapy: Current Perspectives","volume":"15","author":"Cayo","year":"2022","journal-title":"OncoTargets Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1038\/sj.leu.2402572","article-title":"HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors","volume":"16","author":"Pillozzi","year":"2002","journal-title":"Leukemia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"115774","DOI":"10.1016\/j.bcp.2023.115774","article-title":"SKCa- and Kv1-type potassium channels and cancer: Promising therapeutic targets?","volume":"216","author":"Dupuy","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.4161\/cc.8.21.9888","article-title":"Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle","volume":"8","author":"Blackiston","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1136\/annrheumdis-2017-211773","article-title":"ANCA-associated vasculitis: Mission incomplete","volume":"77","author":"Moiseev","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20130094","DOI":"10.1098\/rstb.2013.0094","article-title":"Potassium channels in cell cycle and cell proliferation","volume":"369","author":"Urrego","year":"2014","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107465","DOI":"10.1016\/j.jbc.2024.107465","article-title":"The proteostasis interactomes of trafficking-deficient KV11. 1 variants associated with Long QT Syndrome and pharmacological chaperone rescue","volume":"300","author":"Egly","year":"2024","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nbt.4201","article-title":"Efficient proximity labeling in living cells and organisms with TurboID","volume":"36","author":"Branon","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.201112098","article-title":"A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells","volume":"196","author":"Roux","year":"2012","journal-title":"J. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1177\/2472555219864894","article-title":"Targeting the Mitochondrial Potassium Channel Kv1.3 to Kill Cancer Cells: Drugs, Strategies, and New Perspectives","volume":"24","author":"Prosdocimi","year":"2019","journal-title":"SLAS Discov. Adv. Sci. Drug Discov."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/rcmb.2023-0185OC","article-title":"Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction","volume":"71","author":"Ribeuz","year":"2024","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e70092","DOI":"10.1002\/jcp.70092","article-title":"Intermediate Conductance Calcium-Dependent Potassium Channel","volume":"240","author":"Carpanese","year":"2025","journal-title":"J. Cell. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1074\/mcp.RA120.002071","article-title":"Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents","volume":"19","author":"Park","year":"2020","journal-title":"Mol. Cell. Proteom."},{"key":"ref_19","first-page":"159443","article-title":"Interaction of ROMK2 channel with lipid kinases DGKE and AGK: Potential channel activation by localized anionic lipid synthesis","volume":"1869","author":"Krajewska","year":"2023","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100809","DOI":"10.1016\/j.mcpro.2024.100809","article-title":"Proximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia","volume":"23","author":"Bowen","year":"2024","journal-title":"Mol. Cell. Proteom."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"eadn9361","DOI":"10.1126\/sciadv.adn9361","article-title":"BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway","volume":"10","author":"Prosdocimi","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Capera, J., Navarro-P\u00e9rez, M., Moen, A.S., Szab\u00f3, I., and Felipe, A. (2022). The Mitochondrial Routing of the Kv1.3 Channel. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.865686"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s13277-014-2746-7","article-title":"KCNJ1 inhibits tumor proliferation and metastasis and is a prognostic factor in clear cell renal cell carcinoma","volume":"36","author":"Guo","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/07357907.2012.654872","article-title":"Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas","volume":"30","author":"Bielanska","year":"2012","journal-title":"Cancer Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3892\/ol.2012.718","article-title":"Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness","volume":"4","author":"Bielanska","year":"2012","journal-title":"Oncol. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Comes, N., Bielanska, J., Vallejo-Gracia, A., Serrano-Albarr\u00e1s, A., Marruecos, L., G\u00f3mez, D., Soler, C., Condom, E., Cajal, S.R.Y., and Hern\u00e1ndez-Losa, J. (2013). The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer. Front. Physiol., 4.","DOI":"10.3389\/fphys.2013.00283"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2010.10.066","article-title":"Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo","volume":"651","author":"Jang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12790","DOI":"10.1074\/jbc.M413548200","article-title":"A novel potassium channel in lymphocyte mitochondria","volume":"280","author":"Bock","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"118996","DOI":"10.1016\/j.biopha.2026.118996","article-title":"New mitochondrial KV1.3 conjugates are potent and specific inducers of apoptosis in cancer models","volume":"195","author":"Fois","year":"2026","journal-title":"Biomed. Pharmacother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bbrc.2010.06.011","article-title":"Identification of a voltage-gated potassium channel in gerbil hippocampal mitochondria","volume":"397","author":"Bednarczyk","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"107874","DOI":"10.1016\/j.pharmthera.2021.107874","article-title":"Mitochondrial K+ channels and their implications for disease mechanisms","volume":"227","author":"Checchetto","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"14861","DOI":"10.1073\/pnas.0804236105","article-title":"Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes","volume":"105","author":"Bock","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ccell.2017.03.003","article-title":"Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo","volume":"31","author":"Leanza","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13046-022-02249-w","article-title":"Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model","volume":"41","author":"Severin","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ceca.2009.03.014","article-title":"Intermediate conductance Ca2+-activated potassium channel (KCa3.1) in the inner mitochondrial membrane of human colon cancer cells","volume":"45","author":"Sassi","year":"2009","journal-title":"Cell Calcium"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41419-022-05463-8","article-title":"Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo","volume":"13","author":"Bachmann","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s00424-022-02748-x","article-title":"Functional expression of mitochondrial KCa3.1 channels in non-small cell lung cancer cells","volume":"474","author":"Bulk","year":"2022","journal-title":"Pfl\u00fcgers Arch."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s00424-016-1891-9","article-title":"KCa3.1 (IK) modulates pancreatic cancer cell migration, invasion and proliferation: Anomalous effects on TRAM-34","volume":"468","author":"Bonito","year":"2016","journal-title":"Pfl\u00fcgers Arch."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/leu.2014.37","article-title":"Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade","volume":"28","author":"Weiss","year":"2014","journal-title":"Leukemia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbrc.2017.10.072","article-title":"Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer","volume":"494","author":"Jiang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kovalenko, I., Glasauer, A., Sch\u00f6ckel, L., Sauter, D.R.P., Ehrmann, A., Sohler, F., H\u00e4gebarth, A., Novak, I., and Christian, S. (2016). Identification of KCa3.1 Channel as a Novel Regulator of Oxidative Phosphorylation in a Subset of Pancreatic Carcinoma Cell Lines. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160658"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1152\/physrev.00018.2011","article-title":"Role of ion channels and transporters in cell migration","volume":"92","author":"Schwab","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"188355","DOI":"10.1016\/j.bbcan.2020.188355","article-title":"HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential","volume":"1873","author":"He","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA)-Rev. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Staudacher, I., Jehle, J., Staudacher, K., Pledl, H.-W., Lemke, D., Schweizer, P.A., Becker, R., Katus, H.A., and Thomas, D. (2014). Herg K+ Channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088164"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/14728222.2024.2318449","article-title":"Targeting the hERG1 and \u03b21 integrin complex for cancer treatment","volume":"28","author":"Arcangeli","year":"2024","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/s42003-025-08917-9","article-title":"Activation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation","volume":"8","author":"Eskandari","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41420-022-01152-9","article-title":"KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway","volume":"8","author":"Lin","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15014","DOI":"10.1021\/acs.jmedchem.1c00378","article-title":"Selective TASK-1 Inhibitor with a Defined Structure\u2013Activity Relationship Reduces Cancer Cell Proliferation and Viability","volume":"65","author":"Bedoya","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Leithner, K., Hirschmugl, B., Li, Y., Tang, B., Papp, R., Nagaraj, C., Stacher, E., Stiegler, P., Lindenmann, J., and Olschewski, A. (2016). TASK-1 Regulates Apoptosis and Proliferation in a Subset of Non-Small Cell Lung Cancers. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157453"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"18074","DOI":"10.1021\/jacs.5c03781","article-title":"Decoding Potassium Homeostasis in Cancer Metastasis and Drug Resistance: Insights from a Highly Selective DNAzyme-Based Intracellular K+ Sensor","volume":"147","author":"Yang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41392-022-00890-7","article-title":"Elevated Kir2.1\/nuclear N2ICD defines a highly malignant subtype of non-WNT\/SHH medulloblastomas","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1158\/0008-5472.CAN-17-3776","article-title":"Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2\u2013MEK1\/2\u2013ERK1\/2 Signaling","volume":"78","author":"Ji","year":"2018","journal-title":"Cancer Res."},{"key":"ref_53","first-page":"83","article-title":"Novel insights into biomarkers associated with renal cell carcinoma","volume":"16","author":"Chen","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.tcb.2018.12.005","article-title":"Ion Channel Conformations Regulate Integrin-Dependent Signaling","volume":"29","author":"Becchetti","year":"2019","journal-title":"Trends Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"107992","DOI":"10.1016\/j.phrs.2025.107992","article-title":"KV11.1 (hERG1)-centered macromolecular membrane complexes regulate proliferation in B cell lymphomas and constitute novel pharmacological targets","volume":"221","author":"Sala","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: A graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.33594\/000000823","article-title":"Identification of Novel Kv1.3 Channel-Interacting Proteins Using Proximity Labelling in T-Cells","volume":"59","author":"Kour","year":"2025","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"102757","DOI":"10.1016\/j.coi.2026.102757","article-title":"Functional interactions of Kv1.3 channels in microglia and T cells and their implications in neurodegeneration","volume":"100","author":"Kour","year":"2026","journal-title":"Curr. Opin. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"W534","DOI":"10.1093\/nar\/gkaf388","article-title":"TIMER3: An enhanced resource for tumor immune analysis","volume":"53","author":"Cui","year":"2025","journal-title":"Nucleic Acids Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/5862\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:23:07Z","timestamp":1782969787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/5862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":59,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ijms27135862"],"URL":"https:\/\/doi.org\/10.3390\/ijms27135862","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}