{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:12:33Z","timestamp":1785413553820,"version":"3.56.0"},"reference-count":89,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This paper was supported by Konkuk University"},{"id":[{"id":"https:\/\/ror.org\/025h1m602","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hair loss is closely associated with oxidative stress, which impairs the function of human follicle dermal papilla cells (HFDPCs) and disrupts hair follicle homeostasis. Current pharmacological treatments, such as minoxidil and finasteride, are effective but may cause adverse effects, highlighting the need for safer alternatives. In this study, we utilized a patented high-pressure processing method to produce black ginseng concentrate (BGC), which is significantly enriched with rare bioactive ginsenosides, including Rg3, Rg5, and Rk1, through optimized chemical transformation. We aimed to elucidate the protective effects of BGC against oxidative stress-induced damage in HFDPCs. BGC significantly reduced intracellular reactive oxygen species (ROS) levels. BGC also improved mitochondrial function, including an increased oxygen consumption rate (OCR). In addition, BGC activated hair growth-related signaling pathways by upregulating Wnt\/\u03b2-catenin and increasing the phosphorylation levels of ERK and AKT. Collectively, these findings demonstrate that BGC protects HFDPCs from oxidative stress, improves mitochondrial function, and supports key signaling pathways associated with hair growth. This study suggests that BGC has potential as a natural agent for preventing oxidative stress-induced cellular dysfunction related to hair loss.<\/jats:p>","DOI":"10.3390\/ijms27135889","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:26:15Z","timestamp":1782807975000},"page":"5889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Black Ginseng Concentrate Restores Hair Loss-Associated Dysfunction in Human Follicle Dermal Papilla Cells"],"prefix":"10.3390","volume":"27","author":[{"given":"Jung Un","family":"Shin","sequence":"first","affiliation":[{"name":"Research Institute for Biomedical and Health Science, Konkuk University, Chungju 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Hoo","family":"Jo","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical and Health Science, Konkuk University, Chungju 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minha","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical and Health Science, Konkuk University, Chungju 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungwon","family":"Min","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical and Health Science, Konkuk University, Chungju 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Suwon R&D Center, Hanbit Flavor & Fragrance, 101-1511, Digital Empire 2, 88, Sinwonro, Yeongtong-gu, Suwon-si 16681, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong Bae","family":"Jeon","sequence":"additional","affiliation":[{"name":"Suwon R&D Center, Hanbit Flavor & Fragrance, 101-1511, Digital Empire 2, 88, Sinwonro, Yeongtong-gu, Suwon-si 16681, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uk Sun","family":"Jung","sequence":"additional","affiliation":[{"name":"Suwon R&D Center, Hanbit Flavor & Fragrance, 101-1511, Digital Empire 2, 88, Sinwonro, Yeongtong-gu, Suwon-si 16681, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Suwon R&D Center, Hanbit Flavor & Fragrance, 101-1511, Digital Empire 2, 88, Sinwonro, Yeongtong-gu, Suwon-si 16681, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui Soon","family":"Kim","sequence":"additional","affiliation":[{"name":"Suwon R&D Center, Hanbit Flavor & Fragrance, 101-1511, Digital Empire 2, 88, Sinwonro, Yeongtong-gu, Suwon-si 16681, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Beauty Fragrance, Graduate School of Bio-Wellness Convergence, Konkuk University, Chungju 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Beauty Fragrance, Graduate School of Bio-Wellness Convergence, Konkuk University, Chungju 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-2566","authenticated-orcid":false,"given":"Dong Wook","family":"Shin","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical and Health Science, Konkuk University, Chungju 27478, Republic of Korea"},{"name":"Department of Beauty Fragrance, Graduate School of Bio-Wellness Convergence, Konkuk University, Chungju 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/0192623316631843","article-title":"The Hair Follicle: A Comparative Review of Canine Hair Follicle Anatomy and Physiology","volume":"44","author":"Welle","year":"2016","journal-title":"Toxicol. 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