{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:03:30Z","timestamp":1785420210882,"version":"3.56.0"},"reference-count":91,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammatory bowel disease is an inflammatory disorder associated with systemic immune activation, contributing to neuroinflammation, behavioral impairments and disruption of the gut\u2013brain axis. The present study investigated the effects of p-Coumaric acid derivatives: Artepillin C (ART-C), Baccharin (BAC), and Drupanin (DRU) on colonic damage, behavioral alterations, and oxidative stress in a dextran sulfate sodium (DSS)-induced colitis by administration of 3% DSS. Mice were treated with p-Coumaric acid derivatives (0.3, 1, or 3 mg\/kg, p.o.), and disease activity index and colon length were evaluated as clinical parameters. Behavioral assessments included the open field test, novel object recognition test, elevated plus maze, and tail suspension test. Oxidative stress and inflammatory markers were quantified in colon, serum, cortex, and hippocampus, alongside histological analysis of colonic tissue. DSS administration induced clinical and histopathological alterations, increased oxidative stress, and impaired recognition memory, as well as anxiety- and depressive-like behaviors. p-Coumaric acid derivatives attenuated colonic damage, preserved tissue architecture, improved recognition memory, and reduced anxiety- and depressive-like behaviors, particularly at higher doses. These effects were associated with modulation of antioxidant defenses and reduction of lipid peroxidation and inflammatory markers. p-Coumaric acid derivatives exert protective effects in DSS-induced colitis, highlighting their potential as therapeutic agents for intestinal and neurobehavioral alterations associated with IBD.<\/jats:p>","DOI":"10.3390\/ijms27135929","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:41:01Z","timestamp":1782902461000},"page":"5929","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenylated p-Coumaric Acid Derivatives Mitigate Neurobehavioral and Neuroinflammatory Alterations Associated with Experimental Colitis"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-646X","authenticated-orcid":false,"given":"Camila A.","family":"Cazarin","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Postgraduate Program, University of Vale do Itaja\u00ed, Itaja\u00ed 88302901, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-5390","authenticated-orcid":false,"given":"Bruna","family":"Longo","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology Applied to the Gastrointestinal Tract and its Interactions, Department of Pharmacology, Federal University of Santa Catarina, Florian\u00f3polis 88037000, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda R.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Postgraduate Program, University of Vale do Itaja\u00ed, Itaja\u00ed 88302901, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgana S.","family":"Machado","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Postgraduate Program, University of Vale do Itaja\u00ed, Itaja\u00ed 88302901, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Bas\u00edlio","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Postgraduate Program, University of Vale do Itaja\u00ed, Itaja\u00ed 88302901, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauani C. 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Care Clin. Off. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/ueg2.12319","article-title":"Environmental Risk Factors for Inflammatory Bowel Disease","volume":"10","author":"Singh","year":"2022","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ku\u017aniar, J., Kozubek, P., Czaja, M., and Leszek, J. (2024). Correlation between Alzheimer\u2019s Disease and Gastrointestinal Tract Disorders. Nutrients, 16.","DOI":"10.3390\/nu16142366"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota\u2013Gut\u2013Brain Axis and Its Therapeutic Applications in Neurodegenerative Diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41575-023-00890-0","article-title":"Gastrointestinal and Brain Barriers: Unlocking Gates of Communication across the Microbiota\u2013Gut\u2013Brain Axis","volume":"21","author":"Aburto","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Rostagno, A.A. (2023). Pathogenesis of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010107"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Xie, J., Van Hoecke, L., and Vandenbroucke, R.E. (2022). The Impact of Systemic Inflammation on Alzheimer\u2019s Disease Pathology. Front. 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Food Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mou, Y., Du, Y., Zhou, L., Yue, J., Hu, X., Liu, Y., Chen, S., Lin, X., Zhang, G., and Xiao, H. (2022). Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.796288"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"101397","DOI":"10.1016\/j.arr.2021.101397","article-title":"Western Diet as a Trigger of Alzheimer\u2019s Disease: From Metabolic Syndrome and Systemic Inflammation to Neuroinflammation and Neurodegeneration","volume":"70","author":"Wydrych","year":"2021","journal-title":"Ageing Res. 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Plants, 9.","DOI":"10.3390\/plants9091102"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s10787-019-00649-7","article-title":"Role of the Antioxidant Properties in the Gastroprotective and Gastric Healing Activity Promoted by Brazilian Green Propolis and the Healing Efficacy of Artepillin C","volume":"28","author":"Costa","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jep.2018.08.006","article-title":"Artepillin C, Drupanin, Aromadendrin-4\u2019-O-Methyl-Ether and Kaempferide from Brazilian Green Propolis Promote Gastroprotective Action by Diversified Mode of Action","volume":"226","author":"Costa","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_21","first-page":"5833840","article-title":"Baccharis Dracunculifolia DC Hydroalcoholic Extract Improves Intestinal and Hippocampal Inflammation and Decreases Behavioral Changes of Colitis Mice","volume":"2022","author":"Ribeiro","year":"2022","journal-title":"Evid. Based. Complement. Altern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s10787-018-0467-z","article-title":"Brazilian Green Propolis Hydroalcoholic Extract Reduces Colon Damages Caused by Dextran Sulfate Sodium-Induced Colitis in Mice","volume":"26","author":"Mariano","year":"2018","journal-title":"Inflammopharmacology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"156475","DOI":"10.1016\/j.phymed.2025.156475","article-title":"Fructosyl-Mangiferin Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice via the STAT3\/M1\/Th17 Axis","volume":"139","author":"Aigner","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Katsandegwaza, B., Horsnell, W., and Smith, K. (2022). Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169344"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7479540","DOI":"10.1155\/2021\/7479540","article-title":"An Update of Research Animal Models of Inflammatory Bowel Disease","volume":"2021","author":"Baydi","year":"2021","journal-title":"Sci. World J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically Induced Mouse Models of Acute and Chronic Intestinal Inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1038\/s41467-022-32505-8","article-title":"Mannose Ameliorates Experimental Colitis by Protecting Intestinal Barrier Integrity","volume":"13","author":"Dong","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"15.25.1","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3892\/mmr.2022.12632","article-title":"Molecular Mechanism of the TGF-\u03b2\/Smad7 Signaling Pathway in Ulcerative Colitis","volume":"25","author":"Bai","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"G989","DOI":"10.1152\/ajpgi.00086.2016","article-title":"Modulation of the Microbiota-Gut-Brain Axis by Probiotics in a Murine Model of Inflammatory Bowel Disease","volume":"310","author":"Emge","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Liu, N., Wang, Y., He, L., Sun, J., Wang, X., and Li, H. (2022). Inflammatory Bowel Disease and Risk of Dementia: An Updated Meta-Analysis. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.962681"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41575-022-00634-6","article-title":"Depression and Anxiety in Inflammatory Bowel Disease: Epidemiology, Mechanisms and Treatment","volume":"19","author":"Bisgaard","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e2312275","DOI":"10.1002\/adma.202312275","article-title":"Microalgae-Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression","volume":"36","author":"Zhong","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Qian, Y., Chen, Y., Liu, L., Wu, T., Chen, X., and Ma, G. (2025). Depression and Anxiety in Inflammatory Bowel Disease: Mechanisms and Emerging Therapeutics Targeting the Microbiota-Gut-Brain Axis. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1676160"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"108831","DOI":"10.1016\/j.pharmthera.2025.108831","article-title":"Inflammatory Bowel Disease and Neuropsychiatric Disorders: Mechanisms and Emerging Therapeutics Targeting the Microbiota-Gut-Brain Axis","volume":"269","author":"Petracco","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"138326","DOI":"10.1016\/j.neulet.2025.138326","article-title":"Neuronal Dysfunction in the Amygdala Is Involved in Anxiety-like Behaviors Accompanying Ulcerative Colitis","volume":"864","author":"Takahashi","year":"2025","journal-title":"Neurosci. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"116237","DOI":"10.1016\/j.intimp.2026.116237","article-title":"Dihydromyricetin Improves DSS-Induced Colitis and Behavioral Disorders by Regulating the Microbiota-Gut-Brain Axis Balance and Inhibiting the Activation of NLRP3 Inflammasome","volume":"173","author":"Cong","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e14723","DOI":"10.1111\/cns.14723","article-title":"Peripheral Inflammation Triggering Central Anxiety through the Hippocampal Glutamate Metabolized Receptor 1","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"100091","DOI":"10.1016\/j.crphar.2022.100091","article-title":"Dihydroquercetin Ameliorates LPS-Induced Neuroinflammation and Memory Deficit","volume":"3","author":"Alam","year":"2022","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbi.2022.03.001","article-title":"Colitis-Associated Microbiota Drives Changes in Behaviour in Male Mice in the Absence of Inflammation","volume":"102","author":"Vicentini","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1021\/acschemneuro.3c00846","article-title":"Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders","volume":"15","author":"Risen","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1053\/j.gastro.2020.06.038","article-title":"IL1B Increases Intestinal Tight Junction Permeability by Up-Regulation of MIR200C-3p, Which Degrades Occludin MRNA","volume":"159","author":"Rawat","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"114255","DOI":"10.1016\/j.jep.2021.114255","article-title":"Baccharin and P-Coumaric Acid from Green Propolis Mitigate Inflammation by Modulating the Production of Cytokines and Eicosanoids","volume":"278","author":"Ferreira","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"115919","DOI":"10.1016\/j.jep.2022.115919","article-title":"Gegen Qinlian Decoction Activates AhR\/IL-22 to Repair Intestinal Barrier by Modulating Gut Microbiota-Related Tryptophan Metabolism in Ulcerative Colitis Mice","volume":"302","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00535-017-1401-7","article-title":"Clinical Importance of IL-22 Cascade in IBD","volume":"53","author":"Mizoguchi","year":"2018","journal-title":"J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"G123","DOI":"10.1152\/ajpgi.00260.2023","article-title":"IL-22 Regulates MASTL Expression in Intestinal Epithelial Cells","volume":"327","author":"Pravoverov","year":"2024","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Arshad, T., Mansur, F., Palek, R., Manzoor, S., and Liska, V. (2020). A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.02148"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.3748\/wjg.v19.i17.2638","article-title":"Expression of Interleukin-22\/STAT3 Signaling Pathway in Ulcerative Colitis and Related Carcinogenesis","volume":"19","author":"Yu","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"154052","DOI":"10.1016\/j.phymed.2022.154052","article-title":"Huangqin Decoction Ameliorates DSS-Induced Ulcerative Colitis: Role of Gut Microbiota and Amino Acid Metabolism, MTOR Pathway and Intestinal Epithelial Barrier","volume":"100","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"121707","DOI":"10.1016\/j.biomaterials.2022.121707","article-title":"Oral Delivery of IL-22 MRNA-Loaded Lipid Nanoparticles Targeting the Injured Intestinal Mucosa: A Novel Therapeutic Solution to Treat Ulcerative Colitis","volume":"288","author":"Sung","year":"2022","journal-title":"Biomaterials"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in Inflammatory Bowel Disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12974-015-0281-0","article-title":"Chronic Intestinal Inflammation Alters Hippocampal Neurogenesis","volume":"12","author":"Zonis","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1038\/s41423-021-00757-x","article-title":"The Blood-Brain Barrier in Systemic Infection and Inflammation","volume":"18","author":"Galea","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Lee, A.J., and Ashkar, A.A. (2018). The Dual Nature of Type I and Type II Interferons. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02061"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.tins.2022.10.007","article-title":"Interferon \u03b3: A Master Cytokine in Microglia-Mediated Neural Network Dysfunction and Neurodegeneration","volume":"45","author":"Kann","year":"2022","journal-title":"Trends Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pneurobio.2017.05.003","article-title":"Brain Interference: Revisiting the Role of IFN\u03b3 in the Central Nervous System","volume":"156","author":"Monteiro","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrendo.2012.189","article-title":"The Vagus Nerve and the Inflammatory Reflex--Linking Immunity and Metabolism","volume":"8","author":"Pavlov","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the Microbiota, Immune and Nervous Systems in Health and Disease","volume":"20","author":"Fung","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/intimm\/dxab039","article-title":"Vagus Nerve-Mediated Intestinal Immune Regulation: Therapeutic Implications of Inflammatory Bowel Diseases","volume":"34","author":"Mikami","year":"2022","journal-title":"Int. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e70137","DOI":"10.1002\/acr2.70137","article-title":"Vagus Nerve Stimulation in Autoimmune Conditions: A Systematic Review","volume":"7","author":"Lombo","year":"2025","journal-title":"ACR Open Rheumatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e2017762118","DOI":"10.1073\/pnas.2017762118","article-title":"Acetylcholine Ameliorates Colitis by Promoting IL-10 Secretion of Monocytic Myeloid-Derived Suppressor Cells through the NAChR\/ERK Pathway","volume":"118","author":"Zheng","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ruzafa, L.R., Cedillo, J.L., and Hone, A.J. (2021). Nicotinic Acetylcholine Receptor Involvement in Inflammatory Bowel Disease and Interactions with Gut Microbiota. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031189"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/apt.15433","article-title":"Review Article: The Role of the Autonomic Nervous System in the Pathogenesis and Therapy of IBD","volume":"50","author":"Mogilevski","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1021\/acschemneuro.5c00426","article-title":"Neurotransmitters in Neural Circuits and Neurological Diseases","volume":"16","author":"Gholami","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13205-022-03123-4","article-title":"Hippocampus and Its Involvement in Alzheimer\u2019s Disease: A Review","volume":"12","author":"Rao","year":"2022","journal-title":"3 Biotech"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.acra.2025.07.061","article-title":"Novel Non-Invasive PET Imaging of Reactive Oxygen Species Using [18F]ROStrace in Three Proteinopathy-Associated Neurodegenerative Mouse Models","volume":"33","author":"Zhu","year":"2025","journal-title":"Acad. Radiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/jmf.2023.K.0154","article-title":"Effects of Huzhangoside C on Dextran Sodium Sulfate-Stimulated Colitis in Mice","volume":"27","author":"Shen","year":"2024","journal-title":"J. Med. Food"},{"key":"ref_68","first-page":"2934552","article-title":"Gegen Qinlian Decoction Relieves Ulcerative Colitis via Adjusting Dysregulated Nrf2\/ARE Signaling","volume":"2022","author":"Lin","year":"2022","journal-title":"Evid. Based. Complement. Altern. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.1021\/acsomega.5c10397","article-title":"Neuroinflammation and Oxidative Stress in Parkinson\u2019s Disease, Alzheimer\u2019s Disease, and COVID-19: Microglia-Neutrophil Interaction","volume":"11","author":"Azul","year":"2026","journal-title":"ACS Omega"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"116372","DOI":"10.1016\/j.bmc.2021.116372","article-title":"Synthesis, Antitumor Activity and in Silico Analyses of Amino Acid Derivatives of Artepillin C, Drupanin and Baccharin from Green Propolis","volume":"47","author":"Rodrigues","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"112922","DOI":"10.1016\/j.jpba.2019.112922","article-title":"Effect of Light, Oxygen and Temperature on the Stability of Artepillin C and p-Coumaric Acid from Brazilian Green Propolis","volume":"178","author":"Arruda","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/mnfr.201400630","article-title":"Pea (Pisum sativum L.) Seed Albumin Extracts Show Anti-Inflammatory Effect in the DSS Model of Mouse Colitis","volume":"59","author":"Utrilla","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The Open Field Test for Measuring Locomotor Activity and Anxiety-Like Behavior","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"112945","DOI":"10.1016\/j.bbr.2020.112945","article-title":"Usnic Acid Enantiomers Restore Cognitive Deficits and Neurochemical Alterations Induced by A\u03b21\u201342 in Mice","volume":"397","author":"Cazarin","year":"2021","journal-title":"Behav. Brain Res."},{"key":"ref_75","first-page":"55718","article-title":"Novel Object Recognition Test for the Investigation of Learning and Memory in Mice","volume":"2017","author":"Lueptow","year":"2017","journal-title":"J. Vis. Exp."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1080\/14786419.2020.1737052","article-title":"Plumieride Exerts Anxiolytic-like Effect Mediated by GABAergic and Monoaminergic Systems","volume":"35","author":"Dalmagro","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The Use of a Plus-Maze to Measure Anxiety in the Mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.vascn.2013.05.003","article-title":"Animal Models of Anxiety: A Comprehensive Review","volume":"68","author":"Kumar","year":"2013","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"105666","DOI":"10.1016\/j.yrtph.2024.105666","article-title":"The Need for Guidance in Antidepressant Drug Development: Revisiting the Role of the Forced Swim Test and Tail Suspension Test","volume":"151","author":"Trunnell","year":"2024","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1002\/cpim.83","article-title":"Using Evans Blue Dye to Determine Blood-Brain Barrier Integrity in Rodents","volume":"126","author":"Goldim","year":"2019","journal-title":"Curr. Protoc. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.fct.2012.09.026","article-title":"Ethanolic Extract of Roots from Arctium lappa L. Accelerates the Healing of Acetic Acid-Induced Gastric Ulcer in Rats: Involvement of the Antioxidant System","volume":"51","author":"Allemand","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/jcbfm.2008.59","article-title":"Tissue Inhibitor of Metalloproteinases Protect Blood-Brain Barrier Disruption in Focal Cerebral Ischemia","volume":"28","author":"Fujimoto","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of Total, Protein-Bound, and Nonprotein Sulfhydryl Groups in Tissue with Ellman\u2019s Reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for Lipid Peroxides in Animal Tissues by Thiobarbituric Acid Reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.71.10.3879","article-title":"The Identity of Glutathione S Transferase B with Ligandin, a Major Binding Protein of Liver","volume":"71","author":"Habig","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in Vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Investig. Dermatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF01967298","article-title":"Edema and Cell Infiltration in the Phorbol Ester-Treated Mouse Ear Are Temporally Separate and Can Be Differentially Modulated by Pharmacologic Agents","volume":"26","author":"Kheifets","year":"1989","journal-title":"Agents Actions"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jep.2015.09.006","article-title":"Evidence of Gastric Ulcer Healing Activity of Maytenus Robusta Reissek: In Vitro and in Vivo Studies","volume":"175","author":"Boeing","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1101\/pdb.prot102269","article-title":"Bradford Assay for Determining Protein Concentration","volume":"2020","author":"Kielkopf","year":"2020","journal-title":"Cold Spring Harb. Protoc."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/5929\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:46:21Z","timestamp":1782902781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/5929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":91,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ijms27135929"],"URL":"https:\/\/doi.org\/10.3390\/ijms27135929","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}