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Encapsulating these substances in liposomes improves their bioavailability and solubility and protects them from harmful environmental factors. The influence of liposomes as advanced lipid nanocarriers is increasing enormously due to their remarkable properties and protection of bioactive substances. For this reason, mango (Mangifera indica L.) peel extract (MPE), previously characterized and rich in various natural substances, including ellagic acid, gallic acid, and catechin, has been encapsulated in liposomes. The investigation focused on the impact of different liposome synthesis process parameters on their size, size distribution, stability, and encapsulation efficiency, and on in vitro release as a potential advanced MPE delivery system with suitable characteristics. An important study on the influence of the organic solvent used in liposome synthesis on the above properties is described. The thin lipid film hydration method using 5-mm glass beads and ethanol as an organic solvent was the most favorable method for synthesizing a stable and monodisperse lipid\u2013MPE delivery system. MPE was successfully encapsulated in liposomes with the highest encapsulation efficiency of 53.7%. The sustained release of MPE from the liposomes was achieved, and the antibacterial properties of MPE, incorporated into the liposomes, were retained. For the first time, MPE has been encapsulated in liposomes, and with the remarkable results obtained, the extract represents a formulation with high added value that can be used in various fields, especially for the enrichment of different products such as cosmetic creams and lotion.<\/jats:p>","DOI":"10.3390\/ijms27135934","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:41:38Z","timestamp":1782909698000},"page":"5934","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liposomal Formulation of Bioactive Substances from Mangifera indica Peels for Potential Cosmetic Applications"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2483-5401","authenticated-orcid":false,"given":"Nika","family":"Ku\u010duk","sequence":"first","affiliation":[{"name":"Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-713X","authenticated-orcid":false,"given":"Mateja","family":"Primo\u017ei\u010d","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-607X","authenticated-orcid":false,"given":"\u017deljko","family":"Knez","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia"},{"name":"Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9303-686X","authenticated-orcid":false,"given":"Maja","family":"Leitgeb","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia"},{"name":"Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lu, H., Zhang, S., Wang, J., and Chen, Q. 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