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This metal-free protocol enables efficient synthesis of new mono and difunctional acrolein derivatives in high isolated yields under mild conditions. Importantly, the reaction proceeds in the absence of external additives or oxidants, and requires only low organocatalyst loadings, thereby facilitating the straightforward isolation of structurally defined sulfur-containing acrolein derivatives in both symmetric and asymmetric forms. The resulting functional acrolein derivatives are the hitherto underexplored class of functional building blocks with promising potential for biomedical materials, including drug delivery systems and other biomaterials applications.<\/jats:p>","DOI":"10.3390\/ijms27135941","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:50:33Z","timestamp":1782924633000},"page":"5941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organocatalytic Thioesterification of a Conjugated \u03b1,\u03b2-Unsaturated Dialdehyde"],"prefix":"10.3390","volume":"27","author":[{"given":"Kamil","family":"Hanek","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University in Pozna\u0144, Uniwersytetu Pozna\u0144skiego St. 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacper","family":"Grzegorczyk","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University in Pozna\u0144, Uniwersytetu Pozna\u0144skiego St. 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-4030","authenticated-orcid":false,"given":"Micha\u0142","family":"Dutkiewicz","sequence":"additional","affiliation":[{"name":"Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Rubiez St. 46, 61-612 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9138-2416","authenticated-orcid":false,"given":"Patrycja","family":"\u017bak","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University in Pozna\u0144, Uniwersytetu Pozna\u0144skiego St. 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.52336\/acm.2023.016","article-title":"Cosmetics containing turmeric in the light of the results of scientific research","volume":"12","author":"Kryst","year":"2023","journal-title":"Aesth. 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