{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:24:43Z","timestamp":1783347883631,"version":"3.54.6"},"reference-count":38,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013704","name":"CONACYT","doi-asserted-by":"publisher","award":["6708"],"award-info":[{"award-number":["6708"]}],"id":[{"id":"10.13039\/501100013704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Rs9939609 marker in FTO Alpha-Ketoglutarate-Dependent Dioxygenase (FTO) gene, rs7895307 in Transcription Factor 7-Like 2 (TCF7L2) gene, and rs75493593 in Solute Carrier Family 16 Member 11 (SLC16A11) gene have been associated with anthropometric, metabolic, and clinical variables, but have not been concurrently studied in Mexican children and adolescents with adiposity or mental disorders. In this cross-sectional association study, we genotyped these markers by means of TaqMan real-time polymerase chain reaction in two at-risk pediatric cohorts recruited in Mexico City. Group 1 (n = 175) comprised children and adolescents with overweight\/obesity. Group 2 (n = 296) consisted of non-medicated adolescents meeting the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria for Attention Deficit\/Hyperactivity Disorder or a mood disorder. Anthropometric measurements (body mass index \u2014BMI\u2014, waist circumference, body fat percentage), metabolic indices (fasting glucose, lipid profile, Homeostatic Model Assessment for Insulin Resistance), and psychiatric diagnoses were evaluated. In Group 1, the FTO A allele (genotypes AA\/AT) was significantly associated with severe obesity according to BMI Z scores (p = 0.004, O.R. 3.33, 95% CI [1.42\u20137.77]), and it was a predictor of waist circumference (B = 6.16, 95% CI [1.78\u201310.55], p = 0.006) and muscle percentage (B = 4.21%, 95% CI [0.91\u20137.51%], p = 0.013) using linear regression models adjusted for age and sex. In Group 2, TCF7L2 AA genotype was associated with increased odds of depression (B = 0.83, p = 0.003, OR = 2.29, 95% CI [1.32\u20133.96]). While SLC16A11 G allele showed a possible association with insulin resistance or glucose levels, confirmation is needed. These exploratory results highlight the need for larger, well characterized cohort studies to confirm the associations.<\/jats:p>","DOI":"10.3390\/ijms27135948","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:51:25Z","timestamp":1783003885000},"page":"5948","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Metabolic Parameters and FTO Alpha-Ketoglutarate-Dependent Dioxygenase (FTO), Transcription Factor 7-like 2 (TCF7L2), and Solute Carrier Family 16 Member 11 (SLC16A11) Alleles in Mexican Children and Adolescents"],"prefix":"10.3390","volume":"27","author":[{"given":"Adriana","family":"D\u00edaz-Anzald\u00faa","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica, Direcci\u00f3n de Investigaciones Biom\u00e9dicas en Salud Mental, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Octavio","family":"Hern\u00e1ndez-Lagunas","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Direcci\u00f3n de Investigaciones Biom\u00e9dicas en Salud Mental, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Garc\u00eda-Sibaja","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Direcci\u00f3n de Investigaciones Biom\u00e9dicas en Salud Mental, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Mandujano-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Direcci\u00f3n de Investigaciones Biom\u00e9dicas en Salud Mental, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-6677","authenticated-orcid":false,"given":"Alfonso","family":"Cabrera Lagunes","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaciones Biom\u00e9dicas en Salud Mental, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Palacios-Cruz","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaciones Biom\u00e9dicas en Salud Mental, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodriguez-Ventura","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Desarrollo Celular, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"},{"name":"Departamento de Embriolog\u00eda y Gen\u00e9tica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"s218","DOI":"10.21149\/14762","article-title":"Prevalencias de Sobrepeso y Obesidad En Poblaci\u00f3n Escolar y Adolescente de M\u00e9xico. 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